Relationship Between Excessive Gestational Weight Gain and Neonatal Adiposity in Women With Mild Gestational Diabetes Mellitus
Open accessAbstract
OBJECTIVE: To evaluate the relationships among excessive gestational weight gain, neonatal adiposity, and adverse obstetric outcomes in women with mild gestational diabetes mellitus. METHODS: This is a secondary analysis of a multicenter randomized clinical trial of women with mild gestational diabetes mellitus. Based on self-reported prepregnancy body weight, gestational weight gain was categorized as excessive if it was greater than 2009 Institute of Medicine guidelines. Maternal outcomes and neonatal anthropomorphic characteristics were compared between women with excessive weight gain and those without excessive weight gain. Multiple linear and logistic regression analyses were performed to adjust for confounding factors. RESULTS: We studied 841 women who participated in the main trial and had prepregnancy body mass index (BMI) and delivery information available (n=431 treatment group, n=410 no treatment). After adjustment for factors including treatment and prepregnancy BMI, excessive weight gain remained associated with large for gestational age (adjusted odds ratio [OR] 2.94, 95% confidence interval [CI] 1.81–4.93), birth weight greater than 4,000 g (adjusted OR 2.56, 95% CI 1.54–4.40), preeclampsia (adjusted OR 2.96, 95% CI 1.35–7.03), and cesarean delivery for labor arrest (adjusted OR 2.37, 95% CI 1.30–4.44). In addition, excessive weight gain was independently associated with increased total neonatal fat (P<.001) and birth weight (P<.001). CONCLUSION: In women with both treated and untreated mild gestational diabetes mellitus, excessive gestational weight gain was independently associated with both greater birth weight and adiposity.
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Approximately 36% of pregnant women gained weight above the IOM's guidelines.
“there is still approximately 36% of pregnant women gained weight above the IOM’s guidelines [12–14].”
From Associations of maternal pre-pregnancy BMI and gestational weight gain with the risks of adverse pregnancy outcomes in Chinese women with gestational diabetes mellitus (2023) · cites this paper as [12]
The Introduction (page unavailable) estimates that approximately 40–50% of all pregnant women exceed IOM weight-gain guidelines, not 36%. The Results (page unavailable) report rates of 40.4% and 54.2% in the study’s treated and untreated mild-GDM groups, respectively. (LLM, conf=0.88)
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Cites
A Multicenter, Randomized Trial of Treatment for Mild Gestational Diabetes
Landon, M. B., Spong, C. Y., Thom, E., Carpenter, M. W., Ramin, S. M., Casey, B., Wapner, R. J., Varner, M. W., Rouse, D. J., Thorp, J. M., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0902430 · Cited by 2,122 · see citing works
Self-citationGestational weight gain and child adiposity at age 3 years
Oken, E., Taveras, E. M., KLEINMAN, K. P., Rich-Edwards, J. W., & Gillman, M. W. (2007) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2006.11.027 · Cited by 759 · see citing works
Siega-Riz, A. M., Viswanathan, M., Moos, M.-K., Deierlein, A., Mumford, S., Knaack, J., Thieda, P., Lux, L. J., & Lohr, K. N. (2009) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2009.07.002 · Cited by 708 · see citing works
Nohr, E. A., Væth, M., Baker, J. L., Sørensen, T. I. A., Olsen, J., & Rasmussen, K. M. (2008) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/87.6.1750 · Cited by 649 · see citing works
Increased fetal adiposity: a very sensitive marker of abnormal in utero development
Catalano, P. M., Thomas, A., Huston-Presley, L., & Amini, S. B. (2003) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(03)00828-7 · Cited by 519 · see citing works
Self-citationEffects of gestational weight gain and body mass index on obstetric outcome in Sweden
Cedergren, M. I. (2006) · International Journal of Gynecology & Obstetrics · doi:10.1016/j.ijgo.2006.03.002 · Cited by 486 · see citing works
Reproducibility and Validity of Maternal Recall of Pregnancy-Related Events
Ryan, C. T., Rich-Edwards, J. W., Michels, K. B., Berkey, C. S., Hunter, D. J., Frazier, A. L., Willett, W. C., & Buka, S. L. (1999) · Epidemiology · doi:10.1097/00001648-199911000-00022 · Cited by 459 · see citing works
Maternal Gestational Weight Gain and Offspring Weight in Adolescence
Oken, E., Rifas‐Shiman, S. L., Field, A. E., Frazier, A. L., & Gillman, M. W. (2008) · Obstetrics and Gynecology · doi:10.1097/aog.0b013e31818a5d50 · Cited by 368 · see citing works
The effect of gestational weight gain by body mass index on maternal and neonatal outcomes
Crane, J. M. G., White, J., Murphy, P., Burrage, L., & Hutchens, D. (2009) · Journal of Obstetrics and Gynaecology Canada · doi:10.1016/s1701-2163(16)34050-6 · Cited by 363 · see citing works
Gestational Weight Gain and Adverse Neonatal Outcome Among Term Infants
Stotland, N. E., Cheng, Y. W., Hopkins, L. M., & Caughey, A. B. (2006) · Obstetrics and Gynecology · doi:10.1097/01.aog.0000228960.16678.bd · Cited by 323 · see citing works
Chu, S. Y., Callaghan, W. M., Bish, C. L., & D’Angelo, D. V. (2009) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2008.09.879 · Cited by 292 · see citing works
Schack‐Nielsen, L., Michaelsen, K. F., Gamborg, M., Mortensen, E. L., & Sørensen, T. I. A. (2009) · International Journal of Obesity · doi:10.1038/ijo.2009.206 · Cited by 280 · see citing works
Alexander, G. R., Kogan, M. D., & Himes, J. H. (1999) · Maternal and Child Health Journal · doi:10.1023/a:1022381506823 · Cited by 250 · see citing works
Optimal Gestational Weight Gain for Body Mass Index Categories
Cedergren, M. I. (2007) · Obstetrics and Gynecology · doi:10.1097/01.aog.0000279450.85198.b2 · Cited by 249 · see citing works
Margerison-Zilko, C. E., Rehkopf, D. H., & Abrams, B. F. (2010) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2009.12.007 · Cited by 245 · see citing works
Anthropometric estimation of neonatal body composition
Catalano, P. M., Thomas, A., Avallone, D. A., & Amini, S. B. (1995) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(95)91348-3 · Cited by 221 · see citing works
Self-citationMaternal and Child Obesity: The Causal Link
Oken, E. (2009) · Obstetrics and Gynecology Clinics of North America · doi:10.1016/j.ogc.2009.03.007 · Cited by 203 · see citing works
Pregnancy Weight Gain and Risk of Neonatal Complications
Hedderson, M. M., Weiss, N. S., Sacks, D. A., Pettitt, D. J., Selby, J. V., Quesenberry, C. P., & Ferrara, A. M. (2006) · Obstetrics and Gynecology · doi:10.1097/01.aog.0000242568.75785.68 · Cited by 193 · see citing works
Gestational Weight Gain and Gestational Diabetes Mellitus
Cheng, Y. W., Chung, J. M., Block-Kurbisch, I. J., Inturrisi, M., Shafer, S., & Caughey, A. B. (2008) · Obstetrics and Gynecology · doi:10.1097/aog.0b013e31818b5dd9 · Cited by 130 · see citing works
Egan, A. M., Dennedy, M. C., Al-Ramli, W., Heerey, A., Avalos, G., & Dunne, F. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-2684 · Cited by 125 · see citing works
Weight Gain Recommendations in Pregnancy and the Obesity Epidemic
Artal, R., Lockwood, C. J., & Brown, H. L. (2010) · Obstetrics & Gynecology · doi:10.1097/aog.0b013e3181c51908 · Cited by 125 · see citing works
A Review of Maternal and Fetal Growth Factors in Diabetic Pregnancy
Higgins, M., & Auliffe, F. M. (2010) · Current Diabetes Reviews · doi:10.2174/157339910790909431 · Cited by 81 · see citing works
Phenotype of Infants of Mothers with Gestational Diabetes
Catalano, P. M., Thomas, A., Huston-Presley, L., & Amini, S. B. (2007) · Diabetes Care · doi:10.2337/dc07-s209 · Cited by 49 · see citing works
Self-citationRussell, A., Gillespie, S., Satya, S., & Gaudet, L. (2013) · Journal of Obstetrics and Gynaecology Canada · doi:10.1016/s1701-2163(15)30836-7 · Cited by 43 · see citing works
Excess Gestational Weight Gain Amplifies Risks Among Obese Mothers
Oken, E. (2008) · Epidemiology · doi:10.1097/ede.0b013e3181880ef5 · Cited by 23 · see citing works
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Research works printed but not linked: 1
- [2]Rasmussen KM Yaktine AL Weight Gain During Pregnancy: Reexamining the Guidelines 2009 Washington (DC 20669500
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Weight gain adequacy and pregnancy outcomes in gestational diabetes: a meta‐analysis
Viecceli, C., Remonti, L. R., Hirakata, V. N., Mastella, L. S., Gnielka, V., Oppermann, M. L. R., Silveiro, S. P., & Reichelt, A. J. (2017) · Obesity Reviews · doi:10.1111/obr.12521 · Cited by 90 · see citing works
Gestational diabetes: weight gain during pregnancy and its relationship to pregnancy outcomes
Gou, B.-H., Guan, H.-M., Bi, Y.-X., & Ding, B.-J. (2019) · Chinese Medical Journal · doi:10.1097/cm9.0000000000000036 · Cited by 91 · see citing works
Ke, J.-F., Liu, S., Ge, R.-L., Ma, L., & Li, M.-F. (2023) · BMC Pregnancy and Childbirth · doi:10.1186/s12884-023-05657-8 · Cited by 50 · see citing works
- Authors
- Blackwell, S. C., Landon, M. B., Mele, L., Reddy, U. M., Casey, B. M., Wapner, R. J., Varner, M. W., Rouse, D. J., Thorp, J. M., Sciscione, A., Catalano, P., Saade, G., Caritis, S. N., Sorokin, Y., Grobman, W. A., & for the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Maternal-Fetal Medicine Units (MFMU) Network
- Affiliations
- University of North Carolina at Chapel Hill (US)
- Northwestern University (US)
- ORCID
- Venue
- Obstetrics & Gynecology
- Published
- 2016-12
- Volume
- 128
- Issue
- 6
- Pages
- 1325-1332
- ISSN
- 0029-7844 (ISSN-L)
- PMC
- PMC5123848
- OpenAlex
- W2555022744
- Semantic Scholar
- 5db97f14680bfa05bbcbe50641a95e0edfd91bbb
- Cited by
- 33
- References
- 26
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 1 · 2023: 5 · 2022: 1 · 2021: 7 · 2019: 8 · 2018: 4 · 2017: 3
- FWCI
- 6.46
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Obstetrics and Gynecology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (UL1TR000439)
- National Center for Research Resources (C06RR011234, M01RR000080, UL1RR024989, UL1RR025764, M01RR000034)
- National Center for Advancing Translational Sciences
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (U01HD036801, U10HD040544, U10HD034208, U10HD040512, UG1HD034116, UG1HD053097, U10HD027915, U10HD040545, U10HD040560, U10HD027917, U10HD036801, U10HD027860, U10HD021410, U10HD053097, U10HD034116, U10HD040500, U10HD040485, P2CHD050924, U10HD053118, U10HD027869, U10HD034136, UG1HD034208, U24HD036801, UG1HD040500, UG1HD040512, UG1HD027869, UG1HD040544, UG1HD040485, UG1HD027915, UG1HD040560, UG1HD040545)
- Topics
- Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Health Sciences › Health Professions › General Health Professions › Maternal and Neonatal Healthcare
- Keywords
- gestational weight gain, excessive weight gain, gestational diabetes mellitus, neonatal adiposity, birth weight, large for gestational age, preeclampsia, cesarean section, adverse obstetric outcomes, pre-pregnancy body mass index
- MeSH terms
- Adult, Birth Weight, Cesarean Section, Female, Fetal Macrosomia, Humans, Infant, Newborn, Obesity, Pre-Eclampsia, Pregnancy, Weight Gain, Body Mass Index, Diabetes, Gestational, Adiposity, Young Adult
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