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Cited by 23Gestational Diabetes Research and ManagementOvarian function and disordersDiabetes, Cardiovascular Risks, and Lipoproteins

Continuous Glucose Monitoring During Pregnancy in Women With Polycystic Ovary Syndrome

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Dmitrovic, Romana, Katcher, Heather I., Kunselman, Allen R., Legro, Richard S.·2011·Obstetrics & Gynecology
DOI 10.1097/aog.0b013e31822c887fPMC PMC3642370
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Abstract

OBJECTIVE: To estimate whether women with polycystic ovary syndrome (PCOS) will display ambient hyperglycemia (as measured by continuous glucose monitoring) early in pregnancy that progressively exacerbates with advancing pregnancy. METHODS: This was a case-control study during singleton pregnancies of 17 women with PCOS and 17 healthy women. A 75-g oral glucose tolerance test (OGTT) followed by 24-hour continuous glucose monitoring was obtained four times throughout the pregnancy (visit 1: 6-10 weeks; visit 2: 12-16 weeks; visit 3: 24-28 weeks; visit 4: 34-38 weeks). RESULTS: Eight women with PCOS (47%) and two women in the control group (12%) developed gestational diabetes mellitus (GDM) as defined by World Health Organization criteria. Women with PCOS had a higher area under the curve for glucose during the OGTT at visit 1, visit 2, and visit 3, and for insulin at visit 1, compared with the control group. No differences were found between groups for any of the continuous glucose monitoring parameters studied. The free androgen index significantly decreased over the course of the study in both groups with a stronger decrease in the PCOS group at visit 1 (P=.003), visit 2 (P=.07), and visit 3 (P=.04). The difference in birth weight between groups was not significant: 3,346 g in women with PCOS and 3,633 g in women in the control group, and there was no perinatal morbidity. CONCLUSION: Women with PCOS are at increased risk for GDM, which manifests early in pregnancy and is detectable by OGTT. Serial 24-hour glucose monitoring did not reveal changes in glucose metabolism, although our sample size was small. Hyperandrogenemia improves with progressive pregnancy in women with PCOS. LEVEL OF EVIDENCE: II.

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Cited by

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Authors
Dmitrovic, R., Katcher, H. I., Kunselman, A. R., & Legro, R. S.
Affiliations
Pennsylvania State University (US)
ORCID
Venue
Obstetrics & Gynecology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2011-10
Volume
118
Issue
4
Pages
878-885
ISSN
0029-7844 (ISSN-L)
DOI
10.1097/aog.0b013e31822c887f
PMC
PMC3642370
OpenAlex
W2083924917
Cited by
23
References
10
Citations by year
2026: 1 · 2024: 3 · 2023: 1 · 2022: 1 · 2021: 1 · 2020: 2 · 2019: 3 · 2017: 1 · 2015: 3 · 2014: 1 · 2013: 2 · 2012: 4
FWCI
2.89
Type
journal article
Language
en
Open access
Locations
  • Obstetrics and Gynecology (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Center for Research Resources (M01 RR10732, C06RR016499, M01RR010732)
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (U54-HD34449, U54HD034449, R01HD056510)
Topics
  • Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
  • Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords
polycystic ovary syndrome, gestational diabetes mellitus, continuous glucose monitoring, hyperglycemia in pregnancy, oral glucose tolerance test, free androgen index, hyperandrogenemia, birth weight, insulin
MeSH terms
Adult, Androgens, Birth Weight, Blood Glucose, Female, Glucose Tolerance Test, Humans, Insulin, Polycystic Ovary Syndrome, Pregnancy, Blood Glucose Self-Monitoring, Case-Control Studies, Diabetes, Gestational

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