CoChat
Sign Up
Cited by 206Ovarian function and disordersGestational Diabetes Research and ManagementAssisted Reproductive Technology and Twin Pregnancy

Obstetric outcome in women with polycystic ovarian syndrome

Mikola, M.·2001·Human Reproduction
DOI 10.1093/humrep/16.2.226
Open this paper in CoChat — free account

Abstract

Women with polycystic ovarian syndrome (PCOS) often have insulin resistance and hyperinsulinaemia and may therefore be at an increased risk for gestational diabetes mellitus (GDM). Hyperinsulinaemia may also be associated with pre-eclampsia. Information concerning outcome of pregnancies in PCOS women is scanty and somewhat controversial. Therefore, 99 pregnancies were retrospectively evaluated in women with PCOS and the findings were compared with an unselected control population. The average body mass index (BMI) in PCOS patients was greater than that in controls (25.6 versus 23.0) (P < 0.0001), and PCOS patients were more often nulliparous than controls (76 versus 42%) (P < 0.001). The multiple pregnancy rate was 9.1% in PCOS patients and 1.1% in controls [odds ratio (OR) 9.0; 95% confidence interval (CI) 3.5-23.3]. GDM developed in 20% of the PCOS patients and in 8.9% of the controls (P < 0.001). After logistic regression analysis, BMI >25 seemed to be the greatest predictor for GDM (adjusted OR 5.1; CI 3.2-8.3), while PCOS remained as another independent predictor (adjusted OR 1.9; CI 1.0-3.5). In contrast, PCOS was not a significant predictor for pre-eclampsia, which was merely associated with nulliparity. Premature delivery (16.1% in PCOS and 6.5% in controls) was explained to a large extent by multiple pregnancies and marginally by nulliparity and PCOS. In singleton pregnancies, there was no difference in birth weights, Apgar scores or perinatal morbidity of infants. In conclusion, PCOS slightly increases the risk for GDM, but does not have an important effect on the rate of premature delivery and pre-eclampsia.

Integrity signals

Registry

Crossref · 10.1093/humrep/16.2.226

Cites

3 of 3 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • More than twice the percentage of pregnancies with GDM was observed in women previously treated for polycystic ovary syndrome.

    “More than twice the percentage of pregnancies with GDM was observed in women that were previously treated for polycystic ovary syndrome (PCOS) [20].”

    From Gestational Diabetes Mellitus—Recent Literature Review (2022) · cites this paper as [20]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Related

Authors
Mikola, M.
Affiliations
Helsinki University Hospital (FI)
Corresponding author
Mikola, M.
Venue
Human Reproduction
Publisher
Oxford University Press (OUP)
Published
2001-02-01
Volume
16
Issue
2
Pages
226-229
ISSN
  • 0268-1161 (ISSN-L)
  • 1460-2350
DOI
10.1093/humrep/16.2.226
OpenAlex
W2143877744
Cited by
206
References
3
Citations by year
2026: 4 · 2024: 6 · 2023: 3 · 2022: 9 · 2021: 7 · 2020: 9 · 2019: 5 · 2018: 10 · 2017: 4 · 2016: 6 · 2015: 10 · 2014: 12 · 2013: 7 · 2012: 7
FWCI
8.26
Type
journal article
Language
en
Open access
closed
Locations
  • Human Reproduction (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
  • Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Assisted Reproductive Technology and Twin Pregnancy
Keywords
polycystic ovary syndrome, pregnancy outcomes, gestational diabetes mellitus, preeclampsia, preterm birth, multiple pregnancy, body mass index, nulliparity, insulin resistance, hyperinsulinemia, birth weight, perinatal morbidity
MeSH terms
Adult, Female, Humans, Infant, Newborn, Insulin Resistance, Obstetric Labor, Premature, Polycystic Ovary Syndrome, Pre-Eclampsia, Pregnancy, Pregnancy Complications, Pregnancy Outcome, Pregnancy, Multiple, Risk Factors, Case-Control Studies, Diabetes, Gestational

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review