The Role of Mitochondrial Stress in Muscle Wasting Following Severe Burn Trauma
Open accessAbstract
Increased resting metabolic rate and skeletal muscle wasting are hallmarks of the pathophysiological stress response to severe burn trauma. However, whether these two responses occur independently in burn patients or are in fact related remains unclear. In light of recent evidence demonstrating that increased proteolysis in skeletal muscle of burned patients is accompanied by mitochondrial hypermetabolism, oxidative stress, and protein damage; in this article, we discuss the evidence for a role for the mitochondrion in skeletal muscle wasting following severe burn trauma. In particular, we focus on the role of mitochondrial superoxide production in oxidative stress and subsequent proteolysis, and discuss the role of the mitochondrion as a signaling organelle resulting in protein catabolism in other cellular compartments following severe burn trauma.
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Alterations in mitochondrial distribution, morphology, and function are present in atrophic muscles in aging, muscle disuse, burn injury, intensive care unit-acquired weakness, insulin resistance, chronic obstructive pulmonary disease, cancer cachexia, and different neuromuscular disorders.
“Alterations in mitochondrial distribution, morphology, and function are present in atrophic muscles in aging [148–150], muscle disuse [151, 152], burn injury [153], intensive care unit-acquired weakness [154], insulin resistance [155] chronic obstructive pulmonary disease (COPD) [156], cancer cachexia [157–159], and different neuromuscular disorders [160].”
From The connection between the dynamic remodeling of the mitochondrial network and the regulation of muscle mass (2021) · cites this paper as [153]
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- [54]Ogunbileje JO Porter C Herndon DN Chao T Abdelrahman DR Papadimitriou A Chondronikola M Zimmers TA Reidy PT Rasmussen BB Sidossis LS Hypermetabolism and hypercatabolism of skeletal muscle accompany mitochondrial stress following severe burn trauma American journal of physiology Endocrinology and metabolism 311 E436 448 2016 27382037 PMC5005969
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Metabolic and Hormonal Changes in Pediatric Burn Patients: Mechanisms, Evidence, and Care Strategies
Pelizzo, G., Calcaterra, V., Marinaro, M., Baldassarre, P., Canonica, C. P. M., & Zuccotti, G. (2025) · European Burn Journal · doi:10.3390/ebj6020017 · Cited by 8 · see citing works
Wallace, R. G., Kenealy, M.-R., Brady, A. J., Twomey, L. C., Duffy, E., Degryse, B., Caballero‐Lima, D., Moyna, N. M., Custaud, M., Meade‐Murphy, G., et al. (2020) · Burns · doi:10.1016/j.burns.2020.04.036 · Cited by 7 · see citing works
Farnesysltransferase Inhibitor Prevents Burn Injury-Induced Metabolome Changes in Muscle
Nakazawa, H., Wong, L. P., Shelton, L. M., Sadreyev, R. I., & Kaneki, M. (2022) · Metabolites · doi:10.3390/metabo12090800 · Cited by 6 · see citing works
Rikihisa, N., Shimanouchi, K., Saito, Y., Sakai, H., & Mitsukawa, N. (2022) · Burns · doi:10.1016/j.burns.2022.03.009 · Cited by 5 · see citing works
Buckwheat trypsin inhibitors: novel nutraceuticals for mitochondrial homeostasis
Li, S. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-90256-4.00009-6 · Cited by 4 · see citing works
Kingren, M. S., Barre, M., Barlow, A., Hall, J., Varisco, A., & Porter, C. C. (2025) · Journal of Burn Care & Research · doi:10.1093/jbcr/iraf026 · Cited by 2 · see citing works
Self-citationShielding Burn Patients from Oxidative Stress: The Therapeutic Potential of Antioxidant MembranesPreprint
Haller, H. L., Sander, F., Nischwitz, S. P., Luze, H., Bandke, D., Rapp, M., Rapp, S., Hartmann, B. R., Demircan, M., & Kamolz, L. (2023) · Preprints.org · doi:10.20944/preprints202306.1065.v1 · Cited by 1 · see citing works
An Investigation of Muscle Mechanical Properties in Acute Burns and Burn Types
Ramazanoğlu, E., Usgu, S., Yakut, Y., Çınar, M. A., Bayramlar, K., Güneş, A., & Erkılıç, A. (2025) · Journal of Clinical Medicine · doi:10.3390/jcm14072344 · Cited by 1 · see citing works
Sivayoganathan, T. (2018) · TSpace (University of Toronto) · Cited by 1 · see citing works
HOUSING TEMPERATURE ALTERS BURN-INDUCED HYPERMETABOLISM IN MICE
Kingren, M. S., Hall, J. S., Taylor Joseph Ross, T., Barre, M., Barlow, A., Morales, M. A. L., Treas, L. D., Maxson, R. T., Teo, E. H., & Porter, C. C. (2024) · Shock · doi:10.1097/shk.0000000000002476
Self-citation
- Authors
- Ogunbileje, J. O., Herndon, D. N., Murton, A. J., & Porter, C.
- Affiliations
- Shriners Hospitals for Children - Galveston (US)
- Corresponding author
- Porter, Craig
- Venue
- Journal of Burn Care & Research
- Publisher
- Oxford University Press (OUP)
- Published
- 2017-12-27
- Volume
- 39
- Issue
- 1
- Pages
- 100-108
- ISSN
- 1559-047X (ISSN-L)
- 1559-0488
- PMC
- PMC5650955
- OpenAlex
- W2608634715
- Cited by
- 18
- References
- 82
- Citations by year
- 2025: 3 · 2024: 1 · 2023: 2 · 2022: 4 · 2021: 1 · 2020: 4 · 2019: 1 · 2018: 1 · 2017: 1
- FWCI
- 0.25
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Burn Care & Research (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of General Medical Sciences (P50GM060338, R01GM056687, T32GM008256)
- Topics
- Health Sciences › Medicine › Epidemiology › Burn Injury Management and Outcomes
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Keywords
- mitochondrial stress, skeletal muscle atrophy, mitochondrial superoxide, oxidative stress, muscle protein degradation, resting metabolic rate, mitochondrial signaling, protein degradation
- MeSH terms
- Basal Metabolism, Burns, Humans, Mitochondria, Muscular Atrophy, Superoxides, Oxidative Stress, Muscle, Skeletal
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