Accuracy of Quick Sequential Organ Failure Assessment Score to Predict Sepsis Mortality in 121 Studies Including 1,716,017 Individuals: A Systematic Review and Meta-Analysis
Open accessAbstract
Objectives: We performed a meta-analysis to assess whether the newly introduced quick Sequential Organ Failure Assessment score could predict sepsis outcomes and compared its performance to systematic inflammatory response syndrome, the previously widely used screening criteria for sepsis. Data Sources: We searched multiple electronic databases including MEDLINE, the Cochrane Library, Embase, Web of Science, and Google Scholar (up to March 1, 2019) that evaluated quick Sequential Organ Failure Assessment score, systemic inflammatory response syndrome, or both (International Prospective Register of Systematic Reviews [PROSPERO]: CRD42018103327). Study Selection: Studies were included if the outcome was mortality, organ dysfunction, admission to ICU, ventilatory support, or prolonged ICU stay and if prediction performance was reported as either area under the curve, odds ratio, sensitivity, or specificity. Data Extraction: The criterion validity of the quick Sequential Organ Failure Assessment score and systemic inflammatory response syndrome criteria were assessed by measuring its predictive validity for primary (mortality) and secondary outcomes in pooled metrics as mentioned. The data were analyzed using random effects model, and heterogeneity was explored using prespecified subgroups analyses. Data Synthesis: We screened 1,340 studies, of which 121 studies (including data for 1,716,017 individuals) were analyzed. For mortality prediction, the pooled area under the curve was higher for quick Sequential Organ Failure Assessment score (0.702; 95% CI, 0.685–0.718; I2 = 99.41%; p < 0.001) than for systemic inflammatory response syndrome (0.607; 95% CI, 0.589–0.624; I2 = 96.49%; p < 0.001). Quick Sequential Organ Failure Assessment score consistently outperformed systemic inflammatory response syndrome across all subgroup analyses (area under the curve of quick Sequential Organ Failure Assessment vs. area under the curve of systemic inflammatory response syndrome p < 0.001), including patient populations (emergency department vs ICU), study design (retrospective vs prospective), and countries (developed vs resource-limited). Quick Sequential Organ Failure Assessment score was more specific (specificity, 74.58%; 95% CI, 73.55–75.61%) than systemic inflammatory response syndrome (specificity, 35.24%; 95% CI, 22.80–47.69%) but less sensitive (56.39%; 95% CI, 50.52–62.27%) than systemic inflammatory response syndrome (78.84%; 95% CI, 74.48–83.19%). Conclusions: Overall, quick Sequential Organ Failure Assessment score outperforms systemic inflammatory response syndrome in predicting sepsis outcome, but quick Sequential Organ Failure Assessment score has relative strengths/weaknesses (more specific but less sensitive) compared with systemic inflammatory response syndrome.
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Studies investigating qSOFA as a sepsis screening tool have produced contradictory results.
“Since that time numerous studies have investigated the potential use of the qSOFA as a screening tool for sepsis [40–42]. The results have been contradictory as to its usefulness.”
From Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021 (2021) · cites this paper as [41]
Neither SIRS nor qSOFA are ideal sepsis screening tools.
“Neither SIRS nor qSOFA are ideal screening tools for sepsis and the bedside clinician needs to understand the limitations of each.”
From Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021 (2021) · cites this paper as [41]
qSOFA is more specific but less sensitive than two of four SIRS criteria for early identification of infection-induced organ dysfunction.
“Studies have shown that qSOFA is more specific but less sensitive than having two of four SIRS criteria for early identification of infection induced organ dysfunction [40–43].”
From Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021 (2021) · cites this paper as [41]
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- Authors
- Herwanto, V., Shetty, A., Nalos, M., Chakraborty, M., McLean, A., Eslick, G. D., & Tang, B.
- Affiliations
- Nepean Hospital (AU)
- Westmead Hospital (AU)
- The University of Sydney (AU)
- Corresponding author
- Herwanto, Velma
- ORCID
- Venue
- Critical Care Explorations
- Published
- 2019-09
- Volume
- 1
- Issue
- 9
- Pages
- e0043
- ISSN
- 2639-8028 (ISSN-L)
- PMC
- PMC7063937
- OpenAlex
- W2974728555
- Cited by
- 58
- References
- 25
- Citations by year
- 2026: 5 · 2025: 10 · 2024: 12 · 2023: 15 · 2022: 6 · 2021: 6 · 2020: 3 · 2018: 1
- FWCI
- 2.85
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by-nc-nd
- Locations
- Critical Care Explorations (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Sepsis Diagnosis and Treatment
- Life Sciences › Immunology and Microbiology › Immunology › Inflammation biomarkers and pathways
- Health Sciences › Medicine › Nephrology › Acute Kidney Injury Research
- Keywords
- sepsis mortality prediction, systemic inflammatory response syndrome, organ dysfunction, intensive care unit admission, ventilatory support, prolonged ICU stay, diagnostic accuracy, criterion validity, emergency department, resource-limited settings, sepsis severity scoring systems, area under the curve, specificity, sensitivity, prognostic performance
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