Prognostic Accuracy of the Quick Sequential Organ Failure Assessment for Mortality in Patients With Suspected Infection: A Systematic Review and Meta-analysis
Abstract
Background: The quick Sequential Organ Failure Assessment (qSOFA) has been proposed for prediction of mortality in patients with suspected infection. Purpose: To summarize and compare the prognostic accuracy of qSOFA and the systemic inflammatory response syndrome (SIRS) criteria for prediction of mortality in adult patients with suspected infection. Data Sources: Four databases from inception through November 2017. Study Selection: English-language studies using qSOFA for prediction of mortality (in-hospital, 28-day, or 30-day) in adult patients with suspected infection in the intensive care unit (ICU), emergency department (ED), or hospital wards. Data Extraction: Two investigators independently extracted data and assessed study quality using standard criteria. Data Synthesis: Thirty-eight studies were included (n = 385 333). qSOFA was associated with a pooled sensitivity of 60.8% (95% CI, 51.4% to 69.4%) and a pooled specificity of 72.0% (CI, 63.4% to 79.2%) for mortality. The SIRS criteria were associated with a pooled sensitivity of 88.1% (CI, 82.3% to 92.1%) and a pooled specificity of 25.8% (CI, 17.1% to 36.9%). The pooled sensitivity of qSOFA was higher in the ICU population (87.2% [CI, 75.8% to 93.7%]) than the non-ICU population (51.2% [CI, 43.6% to 58.7%]). The pooled specificity of qSOFA was higher in the non-ICU population (79.6% [CI, 73.3% to 84.7%]) than the ICU population (33.3% [CI, 23.8% to 44.4%]). Limitation: Potential risk of bias in included studies due to qSOFA interpretation and patient selection. Conclusion: qSOFA had poor sensitivity and moderate specificity for short-term mortality. The SIRS criteria had sensitivity superior to that of qSOFA, supporting their use for screening of patients and as a prompt for treatment initiation. Primary Funding Source: Canadian Association of Emergency Physicians. (PROSPERO: CRD42017075964).
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Studies investigating qSOFA as a sepsis screening tool have produced contradictory results.
“Since that time numerous studies have investigated the potential use of the qSOFA as a screening tool for sepsis [40–42]. The results have been contradictory as to its usefulness.”
From Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021 (2021) · cites this paper as [40]
qSOFA is more specific but less sensitive than two of four SIRS criteria for early identification of infection-induced organ dysfunction.
“Studies have shown that qSOFA is more specific but less sensitive than having two of four SIRS criteria for early identification of infection induced organ dysfunction [40–43].”
From Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021 (2021) · cites this paper as [40]
Neither SIRS nor qSOFA are ideal sepsis screening tools.
“Neither SIRS nor qSOFA are ideal screening tools for sepsis and the bedside clinician needs to understand the limitations of each.”
From Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021 (2021) · cites this paper as [40]
Cites
Preferred Reporting Items for Systematic Reviews and Meta-Analyses: the PRISMA statement
Moher, D., Liberati, A., Tetzlaff, J., Altman, D. G., & for the PRISMA Group (2009) · BMJ · doi:10.1136/bmj.b2535 · Cited by 83,823 · see citing works
Preferred reporting items for systematic reviews and meta-analyses: the PRISMA Statement.
(2009) · PubMed Central · Cited by 44,859 · see citing works
The third international consensus definitions for sepsis and septic shock (Sepsis-3).
Singer, M., Deutschman, C. S., Seymour, C. W., Shankar-Hari, M., Annane, D., Bauer, M., Bellomo, R., Bernard, G. R., Chiche, J.-D., Coopersmith, C. M., et al. (2016) · JAMA · doi:10.1001/jama.2016.0287 · Cited by 28,250 · see citing works
QUADAS-2: a revised tool for the quality assessment of diagnostic accuracy studies
Whiting, P. F., Rutjes, A. W. S., Westwood, M. E., Mallett, S., Deeks, J. J., Reitsma, J. B., Leeflang, M. M. G., Sterne, J. A. C., Bossuyt, P. M. M., & the QUADAS-2 Group* (2011) · Annals of Internal Medicine · doi:10.7326/0003-4819-155-8-201110180-00009 · Cited by 14,199 · see citing works
Bone, R. C., BALK, R. A., Cerra, F. B., Dellinger, R. P., Fein, A. M., Knaus, W. A., Schein, R. M. H., & Sibbald, W. J. (1992) · CHEST Journal · doi:10.1378/chest.101.6.1644 · Cited by 13,192 · see citing works
GRADE guidelines: 3. Rating the quality of evidence
Balshem, H., Helfand, M., Schünemann, H. J., Oxman, A. D., Kunz, R., Brozek, J., Vist, G. E., Falck-Ytter, Y., Meerpohl, J., & Norris, S. (2011) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2010.07.015 · Cited by 8,285 · see citing works
Seymour, C. W., Liu, V. X., Iwashyna, T. J., Brunkhorst, F. M., Rea, T. D., Scherag, A., Rubenfeld, G., Kahn, J. M., Shankar-Hari, M., Singer, M., et al. (2016) · JAMA · doi:10.1001/jama.2016.0288 · Cited by 3,939 · see citing works
Fleischmann, C., Scherag, A., Adhikari, N. K. J., Hartog, C. S., Tsaganos, T., Schlattmann, P., Angus, D. C., & Reinhart, K. (2016) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201504-0781oc · Cited by 3,548 · see citing works
Time to treatment and mortality during mandated emergency care for sepsis.
Seymour, C. W., Gesten, F., Prescott, H. C., Friedrich, M. E., Iwashyna, T. J., Phillips, G. S., Lemeshow, S., Osborn, T., Terry, K. M., & Levy, M. M. (2017) · New England Journal of Medicine · doi:10.1056/nejmoa1703058 · Cited by 2,225 · see citing works
The Natural History of the Systemic Inflammatory Response Syndrome (SIRS)
Rangel-Frausto, M. S., Pittet, D., Costigan, M., Hwang, T., Davis, C. S., & Wenzel, R. P. (1995) · JAMA · doi:10.1001/jama.273.2.117 · Cited by 2,090 · see citing works
A hierarchical regression approach to meta‐analysis of diagnostic test accuracy evaluations
Rutter, C. M., & Gatsonis, C. (2001) · Statistics in Medicine · doi:10.1002/sim.942 · Cited by 1,510 · see citing works
Raith, E. P., Udy, A. A., Bailey, M., McGloughlin, S., MacIsaac, C., Bellomo, R., Pilcher, D. V., & for the Australian and New Zealand Intensive Care Society (ANZICS) Centre for Outcomes and Resource Evaluation (CORE) (2017) · JAMA · doi:10.1001/jama.2016.20328 · Cited by 1,279 · see citing works
Systemic Inflammatory Response Syndrome Criteria in Defining Severe Sepsis
Kaukonen, K., Bailey, M., Pilcher, D. V., Cooper, D. J., & Bellomo, R. (2015) · New England Journal of Medicine · doi:10.1056/nejmoa1415236 · Cited by 1,178 · see citing works
Systematic Reviews of Diagnostic Test Accuracy
Leeflang, M. M. G., Deeks, J. J., Gatsonis, C., & Bossuyt, P. M. M. (2008) · Annals of Internal Medicine · doi:10.7326/0003-4819-149-12-200812160-00008 · Cited by 1,124 · see citing works
Hospital deaths in patients with sepsis from 2 independent cohorts.
Liu, V. X., Escobar, G., Greene, J., Soule, J., Whippy, A., Angus, D., & Iwashyna, T. (2014) · Journal of the American Medical Association (JAMA) · doi:10.1001/jama.2014.5804 · Cited by 946 · see citing works
Freund, Y., Lemachatti, N., Krastinova, E., Laer, M. V., Claessens, Y.-É., Avondo, A., Occelli, C., Féral‐Pierssens, A., Truchot, J., Ortega, M., et al. (2017) · JAMA · doi:10.1001/jama.2016.20329 · Cited by 708 · see citing works
Churpek, M. M., Snyder, A., Han, X., Sokol, S., Pettit, N., Howell, M. D., & Edelson, D. P. (2017) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201604-0854oc · Cited by 689 · see citing works
Levy, M. M., Rhodes, A., Phillips, G. S., Townsend, S. R., Schorr, C., Beale, R. J., Osborn, T. M., Lemeshow, S. A., Chiche, J., Artigas, A., et al. (2014) · Critical Care Medicine · doi:10.1097/ccm.0000000000000723 · Cited by 566 · see citing works
The epidemiology of the systemic inflammatory response
Brun‐Buisson, C. (2000) · Intensive Care Medicine · doi:10.1007/s001340051121 · Cited by 534 · see citing works
Dear SIRS, I'm sorry to say that I don't like you
Vincent, J. (1997) · Critical Care Medicine · doi:10.1097/00003246-199702000-00029 · Cited by 442 · see citing works
Williams, J. M., Greenslade, J. H., McKenzie, J. V., Chu, K., Brown, A. F., & Lipman, J. (2016) · CHEST Journal · doi:10.1016/j.chest.2016.10.057 · Cited by 293 · see citing works
SIRS, qSOFA and new sepsis definition
Marik, P. E., & Taeb, A. M. (2017) · Journal of Thoracic Disease · doi:10.21037/jtd.2017.03.125 · Cited by 288 · see citing works
Askim, Å., Moser, F., Gustad, L. T., Stene, H., Gundersen, M., Åsvold, B. O., Dale, J., Bjørnsen, L. P., Damås, J. K., & Solligård, E. (2017) · Scandinavian Journal of Trauma Resuscitation and Emergency Medicine · doi:10.1186/s13049-017-0399-4 · Cited by 247 · see citing works
Finkelsztein, E. J., Jones, D. S., Ma, K. C., Pabón, M. A., Delgado, T., Nakahira, K., Arbo, J. E., Berlin, D., Schenck, E. J., Choi, A. M. K., et al. (2017) · Critical Care · doi:10.1186/s13054-017-1658-5 · Cited by 231 · see citing works
Sprung, C. L., Sakr, Y. L., Vincent, J., Gall, J. L., Reinhart, K., Ranieri, V. M., Gerlach, H., Fielden, J., Groba, C. B., & Payen, D. M. (2006) · Intensive Care Medicine · doi:10.1007/s00134-005-0039-8 · Cited by 201 · see citing works
Evaluation of Definitions for Sepsis
Knaus, W. A., Sun, X., Nyström, P.-O., & Wagner, D. P. (1992) · CHEST Journal · doi:10.1378/chest.101.6.1656 · Cited by 186 · see citing works
Ranzani, O., Prina, E., Menéndez, R., Ceccato, A., Cillóniz, C., Méndez, R., Gabarrús, A., Barbeta, E., Bassi, G. L., Ferrer, M., et al. (2017) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201611-2262oc · Cited by 180 · see citing works
qSOFA does not replace SIRS in the definition of sepsis
Vincent, J., Martin, G. S., & Levy, M. M. (2016) · Critical Care · doi:10.1186/s13054-016-1389-z · Cited by 167 · see citing works
Search strategies to identify diagnostic accuracy studies in MEDLINE and EMBASE
Beynon, R., Leeflang, M., McDonald, S. J., Eisinga, A., Mitchell, R. L., Whiting, P. F., & Glanville, J. (2013) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.mr000022.pub3 · Cited by 145 · see citing works
Revised National Estimates of Emergency Department Visits for Sepsis in the United States*
Wang, H. E., Jones, A. R., & Donnelly, J. P. (2017) · Critical Care Medicine · doi:10.1097/ccm.0000000000002538 · Cited by 145 · see citing works
Assessment of Sepsis-3 criteria and quick SOFA in patients with cirrhosis and bacterial infections
Piano, S. S., Bartoletti, M., Tonon, M., Baldassarre, M., Chies, G., Romano, A., Viale, P., Vettore, E., Domenicali, M., Stanco, M., et al. (2017) · Gut · doi:10.1136/gutjnl-2017-314324 · Cited by 145 · see citing works
Validation of the new Sepsis-3 definitions: proposal for improvement in early risk identification
Giamarellos‐Bourboulis, E. J., Τσαγανός, Θ., Tsangaris, I., Lada, M., Routsi, C., Sinapidis, D., Koupetori, M., Bristianou, M., Adamis, G., Mandragos, K. E., et al. (2016) · Clinical Microbiology and Infection · doi:10.1016/j.cmi.2016.11.003 · Cited by 139 · see citing works
Comparison of QSOFA score and SIRS criteria as screening mechanisms for emergency department sepsis
Haydar, S. A., Spanier, M., Weems, P., Wood, S. L., & Strout, T. D. (2017) · The American Journal of Emergency Medicine · doi:10.1016/j.ajem.2017.07.001 · Cited by 131 · see citing works
Wang, J., Chen, Y., Guo, S., Mei, X., & Yang, P. (2016) · The American Journal of Emergency Medicine · doi:10.1016/j.ajem.2016.06.015 · Cited by 125 · see citing works
Identifying Patients With Sepsis on the Hospital Wards
Bhattacharjee, P., Edelson, D. P., & Churpek, M. M. (2017) · Chest · doi:10.1016/j.chest.2016.06.020 · Cited by 120 · see citing works
Khwannimit, B., Bhurayanontachai, R., & Vattanavanit, V. (2017) · Journal of Critical Care · doi:10.1016/j.jcrc.2017.10.023 · Cited by 120 · see citing works
Donnelly, J. P., Safford, M. M., Shapiro, N. I., Baddley, J. W., & Wang, H. E. (2017) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(17)30117-2 · Cited by 119 · see citing works
Hwang, S. Y., Jo, I. J., Lee, S. U., Lee, T. R., Yoon, H. J., Cha, W. C., Sim, M. S., & Shin, T. G. (2017) · Annals of Emergency Medicine · doi:10.1016/j.annemergmed.2017.05.022 · Cited by 115 · see citing works
Henning, D. J., Puskarich, M. A., Self, W. H., Howell, M. D., Donnino, M. W., Yealy, D. M., Jones, A. E., & Shapiro, N. I. (2017) · Annals of Emergency Medicine · doi:10.1016/j.annemergmed.2017.01.008 · Cited by 96 · see citing works
The Impact of the Sepsis-3 Septic Shock Definition on Previously Defined Septic Shock Patients*
Sterling, S. A., Puskarich, M. A., Glass, A. F., Guirgis, F. W., & Jones, A. E. (2017) · Critical Care Medicine · doi:10.1097/ccm.0000000000002512 · Cited by 91 · see citing works
Red blood cell distribution width is associated with mortality in elderly patients with sepsis
Wang, A.-Y., Ma, H., Kao, W., Tsai, S., & Chang, C.-K. (2017) · The American Journal of Emergency Medicine · doi:10.1016/j.ajem.2017.10.056 · Cited by 91 · see citing works
Chen, Y., Wang, J., & Guo, S. (2016) · Critical Care · doi:10.1186/s13054-016-1351-0 · Cited by 86 · see citing works
Surveillance search techniques identified the need to update systematic reviews
Sampson, M., Shojania, K. G., McGowan, J., Daniel, R., Rader, T., Iansavitchene, A., Ji, J., Ansari, M. T., & Moher, D. (2008) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2007.10.003 · Cited by 84 · see citing works
MetaDAS: A SAS macro for meta-analysis of diagnostic accuracy studies
Takwoingi, Y., & Deeks, J. J. (2010) · Cited by 80 · see citing works
de Groot, B., Stolwijk, F., Warmerdam, M., Lucke, J. A., Singh, G. K., Abbas, M., Mooijaart, S. P., Ansems, A., Cuevas, L. M. E., & Rijpsma, D. (2017) · Scandinavian Journal of Trauma Resuscitation and Emergency Medicine · doi:10.1186/s13049-017-0436-3 · Cited by 80 · see citing works
April, M. D., Aguirre, J., Tannenbaum, L., Moore, T. M., Pingree, A., Thaxton, R. E., Sessions, D. J., & Lantry, J. H. (2016) · Journal of Emergency Medicine · doi:10.1016/j.jemermed.2016.10.012 · Cited by 73 · see citing works
Churpek, M. M., Snyder, A. M., Sokol, S. S., Pettit, N. N., & Edelson, D. P. (2017) · Critical Care Medicine · doi:10.1097/ccm.0000000000002648 · Cited by 73 · see citing works
Quinten, V. M., van Meurs, M., Wolffensperger, A. E., ter Maaten, J. C., & Ligtenberg, J. J. M. (2017) · European Journal of Emergency Medicine · doi:10.1097/mej.0000000000000460 · Cited by 72 · see citing works
Park, H., Kim, W. Y., Kim, M. C., Jung, W., & Ko, B. S. (2017) · Journal of Critical Care · doi:10.1016/j.jcrc.2017.06.020 · Cited by 63 · see citing works
Herwanto, V., Shetty, A., Nalos, M., Chakraborty, M., McLean, A., Eslick, G. D., & Tang, B. (2019) · Critical Care Explorations · doi:10.1097/cce.0000000000000043 · Cited by 58 · see citing works
Comparison of the qSOFA and CRB-65 for risk prediction in patients with community-acquired pneumonia
on behalf of the CAPNETZ Study Group, Kolditz, M., Scherag, A., Rohde, G. G. U., Ewig, S., Welte, T., & Pletz, M. W. (2016) · Intensive Care Medicine · doi:10.1007/s00134-016-4517-y · Cited by 50 · see citing works
representing the Infectious Disease Group of the Spanish Emergency Medicine Society (see addendum), del Castillo, J. M. G., Julián-Jiménez, A., González-Martínez, F., Álvarez-Manzanares, J., Piñera, P., Navarro-Bustos, C., de Zárate, M. M.-O., Llopis, F., Fernández, M. D., et al. (2017) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-017-3068-7 · Cited by 49 · see citing works
Kim, M., Ahn, S., Kim, W. Y., Sohn, C. H., Seo, D. W., Lee, Y., & Lim, K. S. (2017) · Supportive Care in Cancer · doi:10.1007/s00520-016-3567-6 · Cited by 48 · see citing works
qSOFA for Identifying Sepsis Among Patients With Infection
Lamontagne, F., Harrison, D. A., & Rowan, K. (2017) · JAMA · doi:10.1001/jama.2016.19684 · Cited by 43 · see citing works
Moskowitz, A. L., Patel, P. V., Grossestreuer, A. V., Chase, M., Shapiro, N. I., Berg, K. M., Cocchi, M. N., Holmberg, M. J. J., & Donnino, M. W. (2017) · Critical Care Medicine · doi:10.1097/ccm.0000000000002622 · Cited by 42 · see citing works
Amland, R. C., & Sutariya, B. B. (2017) · American Journal of Medical Quality · doi:10.1177/1062860617692034 · Cited by 39 · see citing works
Huson, M. A. M., Kalkman, R., Grobusch, M. P., & van der Poll, T. (2016) · Travel Medicine and Infectious Disease · doi:10.1016/j.tmaid.2016.10.014 · Cited by 38 · see citing works
Siddiqui, S., Chua, M., Venkatesan, K., & Choo, R. W. M. (2017) · Journal of Critical Care · doi:10.1016/j.jcrc.2017.05.017 · Cited by 38 · see citing works
Huson, M. A. M., Katete, C., Chunda, L., Ngoma, J., Wallrauch, C., Heller, T., van der Poll, T., & Grobusch, M. P. (2017) · Infection · doi:10.1007/s15010-017-1057-5 · Cited by 35 · see citing works
Guirgis, F. W., Puskarich, M. A., Smotherman, C. R., Sterling, S. A., Gautam, S., Moore, F. A., & Jones, A. E. (2017) · Journal of Intensive Care Medicine · doi:10.1177/0885066617741284 · Cited by 34 · see citing works
LeGuen, M., Ballueer, Y., McKay, R., Eastwood, G. M., Bellomo, R., & Jones, D. A. (2017) · Resuscitation · doi:10.1016/j.resuscitation.2017.11.036 · Cited by 29 · see citing works
Defining and Diagnosing Sepsis
Scott, M. C. (2016) · Emergency Medicine Clinics of North America · doi:10.1016/j.emc.2016.08.002 · Cited by 27 · see citing works
Umemura, Y., Ogura, H., Gando, S., Kushimoto, S., Saitoh, D., Mayumi, T., Fujishima, S., Abe, T., Ikeda, H., Kotani, J., et al. (2017) · Journal of Infection and Chemotherapy · doi:10.1016/j.jiac.2017.07.005 · Cited by 22 · see citing works
Predictive validity of the qSOFA criteria for sepsis in non-ICU inpatients
Forward, E., Koneçny, P., Burston, J., Adhikari, S., Doolan, H., & Jensen, T. Ø. (2017) · Intensive Care Medicine · doi:10.1007/s00134-017-4776-2 · Cited by 20 · see citing works
qSOFA score: Predictive validity in Enterobacteriaceae bloodstream infections
Burnham, J. P., & Kollef, M. H. (2017) · Journal of Critical Care · doi:10.1016/j.jcrc.2017.09.011 · Cited by 11 · see citing works
Amland, R. C., & Sutariya, B. B. (2018) · JAMIA Open · doi:10.1093/jamiaopen/ooy013 · Cited by 7 · see citing works
Weigle, H., Trigonis, R. A., Bunn, D., Krakauer, D. M., Long, L., & Perkins, J. (2016) · Annals of Emergency Medicine · doi:10.1016/j.annemergmed.2016.08.361 · Cited by 4 · see citing works
18: EXTERNAL VALIDATION OF THE SEPSIS-3 GUIDELINES
Johnson, A. E. W., Celi, L. A., Raffa, J. D., Pollard, T., & Stone, D. J. (2016) · Critical Care Medicine · doi:10.1097/01.ccm.0000508736.93826.b5 · Cited by 3 · see citing works
Sepsis surveillance: an examination of parameter sensitivity and alert reliability
Amland, R. C., Burghart, M., & Overhage, J. M. (2019) · JAMIA Open · doi:10.1093/jamiaopen/ooz014 · Cited by 3 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021
Evans, L., Rhodes, A., Alhazzani, W., Antonelli, M., Coopersmith, C. M., French, C., Machado, F. R., Mcintyre, L., Ostermann, M., Prescott, H. C., et al. (2021) · Intensive Care Medicine · doi:10.1007/s00134-021-06506-y · Cited by 5,082 · see citing works
Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2021.
Evans, L., Rhodes, A., Alhazzani, W., Antonelli, M., Coopersmith, C. M., French, C., Machado, F. R., Mcintyre, L., Ostermann, M., Prescott, H. C., et al. (2021) · Critical Care Medicine · doi:10.1097/ccm.0000000000005337 · Cited by 2,935 · see citing works
Sepsis and Septic Shock – Basics of diagnosis, pathophysiology and clinical decision making
Font, M. D., Thyagarajan, B., & Khanna, A. K. (2020) · Medical Clinics of North America · doi:10.1016/j.mcna.2020.02.011 · Cited by 429 · see citing works
Liu, Z., Meng, Z., Li, Y., Zhao, J., Wu, S., Gou, S., & Wu, H. (2019) · Scandinavian Journal of Trauma Resuscitation and Emergency Medicine · doi:10.1186/s13049-019-0609-3 · Cited by 343 · see citing works
Fernando, S. M., Tran, A., Cheng, W., Rochwerg, B. N., Kyeremanteng, K., SEELY, A. J. E., Inaba, K., & Perry, J. J. (2018) · Annals of Surgery · doi:10.1097/sla.0000000000002774 · Cited by 318 · see citing works
Self-citationRationalizing antimicrobial therapy in the ICU: a narrative review
Timsit, J., Bassetti, M., Cremer, O. L., Daikos, G. L., Waele, J. J. D., Kalil, A. C., Kipnis, É., Kollef, M. H., Laupland, K. B., Paiva, J.-A., et al. (2019) · Intensive Care Medicine · doi:10.1007/s00134-019-05520-5 · Cited by 275 · see citing works
Fernando, S. M., Tran, A., Cheng, W., Klompas, M., Kyeremanteng, K., Mehta, S., English, S. W., Muscedere, J., Cook, D. J., Torres, A., et al. (2020) · Intensive Care Medicine · doi:10.1007/s00134-020-06036-z · Cited by 236 · see citing works
Self-citationSepsis and septic shock: Guideline-based management
Dugar, S. P., Choudhary, C., & Duggal, A. (2020) · Cleveland Clinic Journal of Medicine · doi:10.3949/ccjm.87a.18143 · Cited by 231 · see citing works
Rudd, K. E., Seymour, C. W., Aluisio, A. R., Augustin, M. E., Bagenda, D. S., Beane, A., Byiringiro, J. C., Chang, C.-C. H., Colas, L. N., Day, N., et al. (2018) · JAMA · doi:10.1001/jama.2018.6229 · Cited by 227 · see citing works
Kochanek, M., Schalk, E., von Bergwelt‐Baildon, M., Beutel, G., Buchheidt, D., Hentrich, M., Henze, L., Kiehl, M. G., Liebregts, T., von Lilienfeld‐Toal, M., et al. (2019) · Annals of Hematology · doi:10.1007/s00277-019-03622-0 · Cited by 185 · see citing works
Fernando, S. M., Rochwerg, B. N., & SEELY, A. J. E. (2018) · Canadian Medical Association Journal · doi:10.1503/cmaj.170149 · Cited by 154 · see citing works
Self-citationSurviving Sepsis Campaign: international guidelines for management of sepsis and septic shock 2026
Prescott, H. C., Antonelli, M. M., Alhazzani, W. A., Møller, M. H., Alshamsi, F. E., Azevedo, L. C. P., Belley‐Côté, E. P., Waele, J. D., Derde, L. P. G., Dionne, J. C., et al. (2026) · Intensive Care Medicine · doi:10.1007/s00134-026-08361-1 · Cited by 134 · see citing works
Self-citationRole of disseminated intravascular coagulation in severe sepsis
Gando, S., Shiraishi, A., Yamakawa, K., Ogura, H., Saitoh, D., Fujishima, S., Mayumi, T., Kushimoto, S., Abe, T., Shiino, Y., et al. (2019) · Thrombosis Research · doi:10.1016/j.thromres.2019.04.025 · Cited by 129 · see citing works
Surviving Sepsis campaign: international guidelines for Management of Sepsis and Septic Shock 2026
Prescott, H. C., Antonelli, M., Alhazzani, W., Møller, M. H., Alshamsi, F., Azevedo, L. C. P., Belley-Cote, E., De Waele, J., Derde, L., Dionne, J. C., et al. (2026) · Critical Care Medicine · doi:10.1097/ccm.0000000000007075 · Cited by 117 · see citing works
Self-citationFernando, S. M., McIsaac, D. I., Perry, J. J., Rochwerg, B. N., Bagshaw, S. M., Thavorn, K., SEELY, A. J. E., Forster, A. J., Fiest, K. M., Dave, C. V., et al. (2019) · Critical Care Medicine · doi:10.1097/ccm.0000000000003831 · Cited by 85 · see citing works
Self-citationHuang, Y., Chen, C.-J., Shao, S., Li, C.-H., Hsiao, C.-H., Niu, K.-Y., & Yen, C. (2023) · Critical Care Medicine · doi:10.1097/ccm.0000000000005820 · Cited by 85 · see citing works
Panday, R. S. N., Lammers, E. M. J., Alam, N., & Nanayakkara, P. W. B. (2019) · Critical Care · doi:10.1186/s13054-019-2431-8 · Cited by 85 · see citing works
Sepsis prediction model for determining sepsis vs SIRS, qSOFA, and SOFA
Schertz, A. R., Lenoir, K. M., Bertoni, A. G., Levine, B. J., Mongraw-Chaffin, M., & Thomas, K. W. (2023) · JAMA Network Open · doi:10.1001/jamanetworkopen.2023.29729 · Cited by 78 · see citing works
Society for Maternal-Fetal Medicine Consult Series #67: Maternal sepsis
Shields, A. D., Plante, L. A., Pacheco, L. D., & Louis, J. M. (2023) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2023.05.019 · Cited by 79 · see citing works
Fernando, S. M., Tran, A., Cheng, W., Rochwerg, B. N., Taljaard, M., Thiruganasambandamoorthy, V., Kyeremanteng, K., & Perry, J. J. (2018) · Academic Emergency Medicine · doi:10.1111/acem.13649 · Cited by 76 · see citing works
Self-citationMachine learning for the prediction of sepsis-related death: a systematic review and meta-analysis
Zhang, Y., Xu, W., Yang, P. C., & Zhang, A. (2023) · BMC Medical Informatics and Decision Making · doi:10.1186/s12911-023-02383-1 · Cited by 65 · see citing works
Fernando, S. M., Reardon, P. M., Rochwerg, B. N., Shapiro, N. I., Yealy, D. M., SEELY, A. J. E., Perry, J. J., Barnaby, D. P., Murphy, K., Tanuseputro, P., et al. (2018) · CHEST Journal · doi:10.1016/j.chest.2018.05.004 · Cited by 64 · see citing works
Self-citationElhadi, M., Alsoufi, A., Abusalama, A., Alkaseek, A. M., Abdeewi, S., Yahya, M., Mohammed, A. A. K., Abdelkabir, M., Huwaysh, M., Amkhatirah, E., et al. (2021) · PLoS ONE · doi:10.1371/journal.pone.0251085 · Cited by 63 · see citing works
Combining procalcitonin with the qSOFA and sepsis mortality prediction
Yu, H., Nie, L., Liu, A., Wu, K., Hsein, Y.-C., Yen, D. W., Lee, M.-T. G., & Lee, C. (2019) · Medicine · doi:10.1097/md.0000000000015981 · Cited by 59 · see citing works
Battle, S., Augustine, M. R., Watson, C. M., Bookstaver, P. B., Kohn, J. E., Owens, W. B., Baddour, L. M., & Al‐Hasan, M. N. (2019) · Infection · doi:10.1007/s15010-019-01277-7 · Cited by 59 · see citing works
Herwanto, V., Shetty, A., Nalos, M., Chakraborty, M., McLean, A., Eslick, G. D., & Tang, B. (2019) · Critical Care Explorations · doi:10.1097/cce.0000000000000043 · Cited by 58 · see citing works
Anand, V., Zhang, Z., Kadri, S. S., Klompas, M., & Rhee, C. (2019) · CHEST Journal · doi:10.1016/j.chest.2019.03.032 · Cited by 57 · see citing works
Machado, F. R., Cavalcanti, A. B., Monteiro, M. B., Sousa, J. L., Bossa, A. S., Bafi, A. T., Dal‐Pizzol, F., de Freitas, F. G. R., Lisboa, T. C., Westphal, G. A., et al. (2020) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201905-0917oc · Cited by 57 · see citing works
Lo, R. S. L., Leung, L. Y., Brabrand, M., Yeung, C. Y., Chan, S. Y., Lam, C., Hung, K. K. C., & Graham, C. A. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8010061 · Cited by 54 · see citing works
Independent Predictors of Mortality Among Patients With NAFLD Hospitalized With COVID‐19 Infection
Younossi, Z. M., Stepanova, M., Lam, B. P., Cable, R., Felix, S. C., Jeffers, T., Younossi, E., Pham, H., Srishord, M. K., Austin, P. W., et al. (2021) · Hepatology Communications · doi:10.1002/hep4.1802 · Cited by 53 · see citing works
Fernando, S. M., Rochwerg, B. N., Reardon, P. M., Thavorn, K., SEELY, A. J. E., Perry, J. J., Barnaby, D. P., Tanuseputro, P., & Kyeremanteng, K. (2018) · Critical Care · doi:10.1186/s13054-018-2096-8 · Cited by 51 · see citing works
Self-citationGando, S., Shiraishi, A., Abe, T., Kushimoto, S., Mayumi, T., Fujishima, S., Hagiwara, A., Shiino, Y., Shiraishi, S., Hifumi, T., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-64314-8 · Cited by 48 · see citing works
Liu, Y., Luo, Y., Zhang, X., Shou, S., Gao, Y., Bin, L., Li, C., & Chai, Y. (2019) · Internal and Emergency Medicine · doi:10.1007/s11739-019-02036-0 · Cited by 46 · see citing works
Kovach, C. P., Fletcher, G. S., Rudd, K. E., Grant, R. M., & Carlbom, D. (2019) · PLoS ONE · doi:10.1371/journal.pone.0222563 · Cited by 45 · see citing works
Supervised classification techniques for prediction of mortality in adult patients with sepsis
Rodríguez, A., Mendoza, D., Ascuntar, J., & Jaimes, F. A. (2020) · The American Journal of Emergency Medicine · doi:10.1016/j.ajem.2020.09.013 · Cited by 42 · see citing works
Fernando, S. M., Fox‐Robichaud, A., Rochwerg, B. N., Cardinal, P., SEELY, A. J. E., Perry, J. J., McIsaac, D. I., Tran, A., Skitch, S., Tam, B., et al. (2019) · Critical Care · doi:10.1186/s13054-019-2355-3 · Cited by 40 · see citing works
Self-citationReview: sepsis guidelines and core measure bundles
Desposito, L., & Bascara, C. J. (2024) · Postgraduate Medicine · doi:10.1080/00325481.2024.2388021 · Cited by 39 · see citing works
Application Prospect of the SOFA Score and Related Modification Research Progress in Sepsis
Wang, X., Guo, Z., Chai, Y., Wang, Z., Liao, H., Wang, Z., & Wang, Z. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12103493 · Cited by 37 · see citing works
Caraballo, C., Ascuntar, J., Hincapié, C., Restrepo, C., Bernal, E., & Jaimes, F. A. (2019) · Revista Brasileira de Terapia Intensiva · doi:10.5935/0103-507x.20190011 · Cited by 36 · see citing works
Application of the Sepsis-3 Consensus Criteria in a Geriatric Acute Care Unit: A Prospective Study
Bastoni, D., Ticinesi, A., Lauretani, F., Calamai, S., Catalano, M. L., Catania, P., Cecchia, M., Cerundolo, N., Galluzzo, C., Giovini, M., et al. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8030359 · Cited by 35 · see citing works
Franchini, S., Scarallo, L., Carlucci, M., Cabrini, L., & Tresoldi, M. (2018) · Internal and Emergency Medicine · doi:10.1007/s11739-018-1965-0 · Cited by 34 · see citing works
Lalueza, A., Lora‐Tamayo, J., de la Calle, C., Catalán, J. S., Arrieta, E., Maestro, G., Mancheño‐Losa, M., Marchán-López, Á., Díaz‐Simón, R., García-García, R., et al. (2020) · Revista Clínica Española · doi:10.1016/j.rce.2020.10.004 · Cited by 34 · see citing works
Tan, T. L., Tang, Y., Ching, L. J., Abdullah, N., & Neoh, H. (2018) · Scientific Reports · doi:10.1038/s41598-018-35144-6 · Cited by 34 · see citing works
Hirai, J., Kinjo, T., Koga, T., Haranaga, S., Motonaga, E., & Fujita, J. (2020) · BMC Infectious Diseases · doi:10.1186/s12879-020-05564-9 · Cited by 33 · see citing works
Infection, Sepsis and the Inflammatory Response: Mechanisms and Therapy
Lonsdale, D., Shah, R. V., & Lipman, J. (2020) · Frontiers in Medicine · doi:10.3389/fmed.2020.588863 · Cited by 33 · see citing works
Abdullah, S. M. O. B., Sørensen, R. H., Dessau, R. B., Sattar, S. M. R. U., Wiese, L., & Nielsen, F. E. (2019) · Emergency Medicine Journal · doi:10.1136/emermed-2019-208456 · Cited by 32 · see citing works
S3-Leitlinie Sepsis – Prävention, Diagnose, Therapie und Nachsorge – Update 2025
Brunkhorst, F. M., Adamzik, M., Axer, H., Bauer, M. W., Bode, C., Bone, H.-G., Brenner, T., Bucher, M., David, S., Dietrich, M., et al. (2025) · Medizinische Klinik - Intensivmedizin und Notfallmedizin · doi:10.1007/s00063-025-01317-1 · Cited by 32 · see citing works
Kim, T., Tae, Y., Yeo, H. J., Jang, J. H., Cho, K., Yoo, D., Lee, Y., Ahn, S., Kim, Y., Lee, N., et al. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12227156 · Cited by 30 · see citing works
Association Between Red Cell Distribution Width and Hospital Mortality in Patients with Sepsis
Li, Y., She, Y., Fu, L., Zhou, R., Xiang, W., & Luo, L. (2021) · Journal of International Medical Research · doi:10.1177/03000605211004221 · Cited by 30 · see citing works
On behalf of Atrium Health ACORN Investigators, Kowalkowski, M., Chou, S.-H., McWilliams, A., Lashley, C., Murphy, S., Rossman, W., Papali, A., Heffner, A., Russo, M., et al. (2019) · Trials · doi:10.1186/s13063-019-3792-7 · Cited by 29 · see citing works
Zhang, K., Zhang, X., Ding, W., Xuan, N., Tian, B., Huang, T., Zhang, Z., Cui, W., Huang, H., & Zhang, G. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2021.704358 · Cited by 28 · see citing works
Pre-hospital qSOFA as a predictor of sepsis and mortality
Shu, E., Tallman, C. I., Frye, W., Boyajian, J. G., Farshidpour, L., Young, M., & Campagne, D. D. (2018) · The American Journal of Emergency Medicine · doi:10.1016/j.ajem.2018.09.025 · Cited by 28 · see citing works
Baumann, B. M., Greenwood, J. C., Lewis, K., Nuckton, T. J., Darger, B., Shofer, F. S., Troeger, D., Jung, S. Y., Kilgannon, J. H., & Rodriguez, R. M. (2019) · The American Journal of Emergency Medicine · doi:10.1016/j.ajem.2019.07.003 · Cited by 28 · see citing works
Ramos, J. G. R., Passos, R. D. H., Teixeira, M. B., Gobatto, A. L. N., Coutinho, R. V. D. S., Caldas, J. R., da Guarda, S. N. F., Ribeiro, M. P., & Batista, P. B. P. (2018) · Journal of Critical Care · doi:10.1016/j.jcrc.2018.07.008 · Cited by 27 · see citing works
Chen, Y., Li, Y., Deng, P., Yang, Z., Zhong, K., Zhang, L.-G., Yang, C., Zhi, H.-Y., Hu, X.-Y., Gu, J., et al. (2022) · BMC Anesthesiology · doi:10.1186/s12871-022-01625-5 · Cited by 26 · see citing works
Gershkovich, B., Fernando, S. M., Herritt, B., Castellucci, L. A., Rochwerg, B. N., Munshi, L., Mehta, S., SEELY, A. J. E., McIsaac, D. I., Tran, A., et al. (2019) · Critical Care · doi:10.1186/s13054-019-2568-5 · Cited by 26 · see citing works
Self-citationEarly Diagnosis of Sepsis: The Role of Biomarkers and Rapid Microbiological Tests
Plata-Menchaca, E. P., Ruiz‐Rodríguez, J. C., & Ferrer, R. (2024) · Seminars in Respiratory and Critical Care Medicine · doi:10.1055/s-0044-1787270 · Cited by 25 · see citing works
Schmedding, M., Adégbitè, B. R., Gould, S., Beyeme, J. O., Adégnika, A. A., Grobusch, M. P., & Huson, M. A. M. (2018) · American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.18-0577 · Cited by 25 · see citing works
Timeliness of antibiotics for patients with sepsis and septic shock
Schinkel, M., Panday, R. S. N., Wiersinga, W. J., & Nanayakkara, P. W. B. (2020) · Journal of Thoracic Disease · doi:10.21037/jtd.2019.10.35 · Cited by 25 · see citing works
Sepsis and Septic Shock Definitions in Patients With Cancer Admitted in ICU
Nathan, N., Sculier, J., Ameye, L., Paesmans, M., Bogdan-Dragos, G., & Meert, A. (2019) · Journal of Intensive Care Medicine · doi:10.1177/0885066619894933 · Cited by 24 · see citing works
Xie, Y., Li, B., Lin, Y., Shi, F., Chen, W., Wu, W., Zhang, W., Fei, Y., Zou, S., & Yao, C. (2020) · Medical Science Monitor · doi:10.12659/msm.929527 · Cited by 24 · see citing works
Liu, N., Chee, M. L., Foo, M. Z. Q., Pong, J. Z., Guo, D., Koh, Z. X., Ho, A. F. W., Niu, C., Chong, S., & Ong, M. E. H. (2021) · PLoS ONE · doi:10.1371/journal.pone.0249868 · Cited by 24 · see citing works
Developing a shared sepsis data infrastructure: a systematic review and concept map to FHIR
Brant, E. B., Kennedy, J. N., King, A. J., Gerstley, L. D., Mishra, P., Schlessinger, D., Shalaby, J., Escobar, G. J., Angus, D. C., Seymour, C. W., et al. (2022) · npj Digital Medicine · doi:10.1038/s41746-022-00580-2 · Cited by 24 · see citing works
Pong, J. Z., Fook-Chong, S. M. C., Koh, Z. X., Samsudin, M. I., Tagami, T., Chiew, C. J., Wong, T. H., Ho, A. F. W., Ong, M. E. H., & Liu, N. (2019) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph16101725 · Cited by 24 · see citing works
Lind, M. L., Phipps, A. I., Mooney, S. J., Liu, C., Fohner, A. E., Patel, K. B., Ueda, M., & Pergam, S. A. (2020) · Clinical Infectious Diseases · doi:10.1093/cid/ciaa214 · Cited by 24 · see citing works
Dheman, K., Giordano, M., Thomas, C., Schilk, P., & Magno, M. (2024) · IEEE/ACM International Conference on Internet-of-Things Design and Implementation (IoTDI) · doi:10.1109/iotdi61053.2024.00013 · Cited by 22 · see citing works
Singer, M., & Shankar‐Hari, M. (2018) · Annals of Internal Medicine · doi:10.7326/m17-3415 · Cited by 22 · see citing works
Makino, Y., Miyake, K., Okada, A., Ikeda, Y., & Okada, Y. (2022) · Journal of obstetrics and gynaecology research · doi:10.1111/jog.15292 · Cited by 21 · see citing works
Ruan, H., Ke, D., & Liao, D. (2022) · Emergency Medicine International · doi:10.1155/2022/1802707 · Cited by 20 · see citing works
Elbaset, M. A., Zahran, M. H., Hashem, A., Ghobrial, F. K., Elrefaie, E., Badawy, M., Shokeir, A. A., & Ibrahim, M. (2019) · Journal of Infection and Chemotherapy · doi:10.1016/j.jiac.2019.04.008 · Cited by 20 · see citing works
Green, S. L., Smith, M. T. D., Cairns, C., Clarke, D., Bruce, J. L., Bekker, W., Kong, V. Y., & Laing, G. L. (2019) · World Journal of Surgery · doi:10.1007/s00268-019-05181-x · Cited by 20 · see citing works
Public health programmes for vitamin A deficiency control
Bruins, M. J., & Kraemer, K. (2013) · Community Eye Health Journal · doi:10.56920/cehj.681 · Cited by 20 · see citing works
Goodbye SIRS? Innate, trained and adaptive immunity and pathogenesis of organ dysfunction
Ghnewa, Y. G., Fish, M., Jennings, A. R., Carter, M. J., & Shankar‐Hari, M. (2020) · Medizinische Klinik - Intensivmedizin und Notfallmedizin · doi:10.1007/s00063-020-00683-2 · Cited by 20 · see citing works
Gebretekle, G. B., Mariam, D. H., Mac, S., Abebe, W., Alemayehu, T., Degu, W. A., Libman, M., Yansouni, C. P., Fenta, T. G., Semret, M., et al. (2021) · BMJ Open · doi:10.1136/bmjopen-2020-047515 · Cited by 20 · see citing works
Back to Basics: Recognition of Sepsis with New Definition
Horák, J., Martínková, V., Raděj, J., & Matějovič, M. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8111838 · Cited by 20 · see citing works
Wentowski, C. C., Mewada, N., & Nielsen, N. D. (2018) · Anaesthesia & intensive care medicine · doi:10.1016/j.mpaic.2018.11.009 · Cited by 19 · see citing works
Graham, C. A., Leung, L. Y., Lo, R. S. L., Yeung, C. Y., Chan, S. Y., & Hung, K. K. C. (2020) · Annals of Medicine · doi:10.1080/07853890.2020.1782462 · Cited by 19 · see citing works
Nanotechnology Applications in Sepsis: Essential Knowledge for Clinicians
Vasconcelos, I., & Santos, T. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15061682 · Cited by 19 · see citing works
Stastny, T., Koenigshof, A. M., Brado, G. E., Chan, E. K., & Levy, N. A. (2021) · Journal of Veterinary Emergency and Critical Care · doi:10.1111/vec.13101 · Cited by 18 · see citing works
Regina, J., Pogam, M. L., Niemi, T., Akrour, R., Pepe, S., Lehn, I., Wasserfallen, J., Calandra, T., & Meylan, S. (2023) · PLoS ONE · doi:10.1371/journal.pone.0285151 · Cited by 18 · see citing works
Potjo, M., Theron, A. J., Cockeran, R., Sipholi, N. N., Steel, H. C., Bale, T. V., Meyer, P. W. A., Anderson, R., & Tintinger, G. R. (2019) · Cytokine · doi:10.1016/j.cyto.2019.05.015 · Cited by 18 · see citing works
Disposable Paper-on-CMOS Platform for Real-Time Simultaneous Detection of Metabolites
Hu, C., Annese, V. F., Velugotla, S., Al-Rawhani, M. A., Cheah, B. C., Grant, J. P., Barrett, M. P., & Cumming, D. R. S. (2020) · IEEE Transactions on Biomedical Engineering · doi:10.1109/tbme.2019.2962239 · Cited by 18 · see citing works
Fernando, S. M., Guo, K., Lukasik, M., Rochwerg, B. N., Cook, D. J., Kyeremanteng, K., & Perry, J. J. (2020) · Canadian Journal of Emergency Medicine · doi:10.1017/cem.2020.377 · Cited by 18 · see citing works
Self-citationPeng, Y., Guan, X., Wang, J., & Ma, J. (2020) · Journal of International Medical Research · doi:10.1177/0300060520941317 · Cited by 18 · see citing works
Performance of the quick SOFA in very old ICU patients admitted with sepsis
Haas, L. E. M., Termorshuizen, F., de Lange, D. W., van Dijk, D., & de Keizer, N. F. (2019) · Acta Anaesthesiologica Scandinavica · doi:10.1111/aas.13536 · Cited by 18 · see citing works
Lam, R. P. K., Dai, Z., Lau, E. H. Y., Ip, C. Y. T., Chan, H. C., Zhao, L., Tsang, T. C., Tsui, M. S. H., & Rainer, T. H. (2024) · World Journal of Emergency Medicine · doi:10.5847/wjem.j.1920-8642.2024.052 · Cited by 17 · see citing works
Fukui, S., Inui, A., Saita, M., Kobayashi, D., & Naito, T. (2022) · Journal of International Medical Research · doi:10.1177/03000605211065658 · Cited by 17 · see citing works
Cusinato, M., Sivayoham, N., & Planche, T. (2022) · Infection · doi:10.1007/s15010-022-01956-y · Cited by 17 · see citing works
Sequential organ failure assessment scores to predict outcomes: from adults to neonates
Fleiss, N., & Polin, R. A. (2022) · Current Opinion in Pediatrics · doi:10.1097/mop.0000000000001207 · Cited by 17 · see citing works
Lalueza, A., Lora‐Tamayo, J., de la Calle, C., Catalán, J. S., Arrieta, E., Maestro, G., Mancheño‐Losa, M., Marchán-López, Á., Díaz‐Simón, R., García-García, R., et al. (2021) · Revista Clínica Española (English Edition) · doi:10.1016/j.rceng.2020.10.004 · Cited by 17 · see citing works
Targeting the NLRP3 inflammasome in sepsis: Molecular mechanisms and therapeutic strategies
Ma, Y., Meng, J., Sun, F., & Lei, M. (2025) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2025.09.006 · Cited by 16 · see citing works
Abdullah, S. M. O. B., Grand, J., Sijapati, A., Puri, P. R., & Nielsen, F. E. (2019) · The American Journal of Emergency Medicine · doi:10.1016/j.ajem.2019.05.037 · Cited by 16 · see citing works
Zhang, G., Zhang, K., Zheng, X., Cui, W., Hong, Y., & Zhang, Z. (2019) · Emergency Medicine Journal · doi:10.1136/emermed-2019-208901 · Cited by 16 · see citing works
Eun, S., Kim, H., Kim, H. Y., Lee, M., Bae, G. E., Kim, H., Koo, C. M., Kim, M. K., & Yoon, S. H. (2021) · Scientific Reports · doi:10.1038/s41598-021-01271-w · Cited by 16 · see citing works
Hu, H., Jiang, J., & Yao, N. (2021) · World Journal of Emergency Medicine · doi:10.5847/wjem.j.1920-8642.2022.027 · Cited by 16 · see citing works
Sivayoham, N., Blake, L. A., Tharimoopantavida, S. E., Chughtai, S., Hussain, A. N., Cecconi, M., & Rhodes, A. (2019) · BMJ Open · doi:10.1136/bmjopen-2019-030922 · Cited by 16 · see citing works
Giordano, M., Dheman, K., & Magno, M. (2024) · IEEE Sensors Journal · doi:10.1109/jsen.2024.3424655 · Cited by 15 · see citing works
Risk factors of sepsis among patients with qSOFA<2 in the emergency department
Shibata, J., Osawa, I., Ito, H., Soeno, S., Hara, K., Sonoo, T., Nakamura, K., & Goto, T. (2021) · The American Journal of Emergency Medicine · doi:10.1016/j.ajem.2021.09.035 · Cited by 15 · see citing works
Gueta, I., Ovadia, Y. P., Markovits, N., Schacham, Y. N., Epsztein, A., & Loebstein, R. (2020) · Scientific Reports · doi:10.1038/s41598-020-66941-7 · Cited by 14 · see citing works
Kowalkowski, M. A., Eaton, T. A., McWilliams, A. D., Tapp, H., Rios, A., Murphy, S., Burns, R., Gutnik, B., O’Hare, K., McCurdy, L., et al. (2021) · BMC Health Services Research · doi:10.1186/s12913-021-06521-1 · Cited by 14 · see citing works
- Authors
- Fernando, S. M., Tran, A., Taljaard, M., Cheng, W., Rochwerg, B., Seely, A. J. E., & Perry, J. J.
- Affiliations
- University of Ottawa (CA)
- Ottawa Hospital Research Institute (CA)
- McMaster University (CA)
- ORCID
- Venue
- Annals of Internal Medicine
- Publisher
- American College of Physicians
- Published
- 2018-02-20
- Volume
- 168
- Issue
- 4
- Pages
- 266-275
- ISSN
- 0003-4819 (ISSN-L)
- 1539-3704
- OpenAlex
- W2788736459
- Cited by
- 281
- References
- 69
- Citations by year
- 2026: 24 · 2025: 18 · 2024: 23 · 2023: 36 · 2022: 34 · 2021: 33 · 2020: 38 · 2019: 49 · 2018: 25 · 2013: 1
- FWCI
- 5.18
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annals of Internal Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Sepsis Diagnosis and Treatment
- Life Sciences › Immunology and Microbiology › Immunology › Inflammation biomarkers and pathways
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Abdominal Surgery and Complications
- Keywords
- qSOFA, systemic inflammatory response syndrome, mortality prediction, suspected infection, prognostic accuracy, sensitivity and specificity, intensive care unit, emergency department, sepsis screening
- MeSH terms
- Decision Support Techniques, Emergency Service, Hospital, Humans, Intensive Care Units, Predictive Value of Tests, Prognosis, Hospital Mortality, Systemic Inflammatory Response Syndrome, Sepsis, Organ Dysfunction Scores
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
