Cited by 576Hyperglycemia and glycemic control in critically ill and hospitalized patientsDiabetes Management and ResearchIntensive Care Unit Cognitive Disorders

The DOI matches its Crossref record; 70 of the 70 references it cites were found in a registry or an index.

Hyperglycemia-related mortality in critically ill patients varies with admission diagnosis

Open access

Falciglia, Mercedes, Freyberg, Ron W., Almenoff, Peter L., D’Alessio, David A., Render, Marta L.·2009·Critical Care Medicine

DOI 10.1097/ccm.0b013e3181b083f7PMC PMC2905804

Open this paper in CoChat — free account

Abstract

OBJECTIVES: Hyperglycemia during critical illness is common and is associated with increased mortality. Intensive insulin therapy has improved outcomes in some, but not all, intervention trials. It is unclear whether the benefits of treatment differ among specific patient populations. The purpose of the study was to determine the association between hyperglycemia and risk- adjusted mortality in critically ill patients and in separate groups stratified by admission diagnosis. A secondary purpose was to determine whether mortality risk from hyperglycemia varies with intensive care unit type, length of stay, or diagnosed diabetes. DESIGN: Retrospective cohort study. SETTING: One hundred seventy-three U.S. medical, surgical, and cardiac intensive care units. PATIENTS: Two hundred fifty-nine thousand and forty admissions from October 2002 to September 2005; unadjusted mortality rate, 11.2%. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: A two-level logistic regression model determined the relationship between glycemia and mortality. Age, diagnosis, comorbidities, and laboratory variables were used to calculate a predicted mortality rate, which was then analyzed with mean glucose to determine the association of hyperglycemia with hospital mortality. Hyperglycemia was associated with increased mortality independent of illness severity. Compared with normoglycemic individuals (70-110 mg/dL), adjusted odds of mortality (odds ratio, [95% confidence interval]) for mean glucose 111-145, 146-199, 200-300, and >300 mg/dL was 1.31 (1.26-1.36), 1.82 (1.74-1.90), 2.13 (2.03-2.25), and 2.85 (2.58-3.14), respectively. Furthermore, the adjusted odds of mortality related to hyperglycemia varied with admission diagnosis, demonstrating a clear association in some patients (acute myocardial infarction, arrhythmia, unstable angina, pulmonary embolism) and little or no association in others. Hyperglycemia was associated with increased mortality independent of intensive care unit type, length of stay, and diabetes. CONCLUSIONS: The association between hyperglycemia and mortality implicates hyperglycemia as a potentially harmful and correctable abnormality in critically ill patients. The finding that hyperglycemia-related risk varied with admission diagnosis suggests differences in the interaction between specific medical conditions and injury from hyperglycemia. The design and interpretation of future trials should consider the primary disease states of patients and the balance of medical conditions in the intensive care unit studied.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1097/ccm.0b013e3181b083f7

Cites

70 of 70 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Intensive insulin therapy in critically ill patients.
Van den Berghe, G., Wouters, P., Weekers, F., Verwaest, C., Bruyninckx, F., Schetz, M., Vlasselaers, D., Ferdinande, P., Lauwers, P., & Bouillon, R. (2001) · New England Journal of Medicine · doi:10.1056/nejmoa011300 · Cited by 9,977
Comorbidity measures for use with administrative data.
Elixhauser, A., Steiner, C., Harris, D. R., & Coffey, R. M. (1998) · Medical Care · doi:10.1097/00005650-199801000-00004 · Cited by 9,921
Intensive versus Conventional Glucose Control in Critically Ill Patients
(2009) · New England Journal of Medicine · doi:10.1056/nejmoa0810625 · Cited by 5,119
Intensive insulin therapy in the medical ICU
Van den Berghe, G., Wilmer, A., Hermans, G., Meersseman, W., Wouters, P. J., Milants, I., Van Wijngaerden, E., Bobbaers, H., & Bouillon, R. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa052521 · Cited by 3,639
The APACHE III Prognostic System
Knaus, W. A., Wagner, D. P., Draper, E. A., Zimmerman, J. E., Bergner, M., BASTOS, P. G., Sirio, C., Murphy, D. J., Lotring, T., Damiano, A., et al. (1991) · CHEST Journal · doi:10.1378/chest.100.6.1619 · Cited by 3,539
Intensive insulin therapy and pentastarch resuscitation in severe sepsis
Brunkhorst, F. M., Engel, C., Bloos, F., Meier-Hellmann, A., Ragaller, M., Weiler, N., Moerer, O., Gruendling, M., Oppert, M., Grond, S., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa070716 · Cited by 2,921
The APACHE III Prognostic System
Teres, D., & Lemeshow, S. A. (1992) · CHEST Journal · doi:10.1378/chest.102.6.1919b · Cited by 2,896
Hyperglycemia: an independent marker of in-hospital mortality in patients with undiagnosed diabetes
Umpierrez, G. E., Isaacs, S. D., Bazargan, N., You, X., Thaler, L. M., & Kitabchi, A. E. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.87.3.8341 · Cited by 2,195
Stress hyperglycaemia and increased risk of death after myocardial infarction in patients with and without diabetes: A systematic overview
Capes, S. E., Hunt, D., Malmberg, K., & Gerstein, H. C. (2000) · The Lancet · doi:10.1016/s0140-6736(99)08415-9 · Cited by 2,187 · cited 1×
“Our analysis extends previous findings of the relative risk from hyperglycemia in patients with and without antecedent diagnoses of diabetes (3, 4, 10, 12, 51, 59).”
Result
Stress Hyperglycemia and Prognosis of Stroke in Nondiabetic and Diabetic Patients: A Systematic Overview
Capes, S. E., Hunt, D., Malmberg, K., Pathak, P., & Gerstein, H. C. (2001) · Stroke · doi:10.1161/hs1001.096194 · Cited by 1,824

Flagged first, then by citations

Show all 70 references

Sorted by citations

Items 201–300 of 575

High Mortality Associated with Hyperglycemia, Neutrophilia, and Lymphopenia in Critically Ill Patients
Jiménez-Ibáñez, E. O., Castillejos-López, M. D. J., Hernández, A., Gorocica, P., & Alvarado‐Vásquez, N. (2012) · The Tohoku Journal of Experimental Medicine · doi:10.1620/tjem.226.213 · Cited by 16
Improving Glycemic Control Safely in Critical Care Patients: A Collaborative Systems Approach in Nine Hospitals
Maynard, G. A., Holdych, J., Kendall, H. E., Harrison, K., Montgomery, P. A., & Kulasa, K. M. (2017) · Endocrine Practice · doi:10.4158/ep161569.or · Cited by 17
Predictors of in-hospital mortality among cardiogenic shock patients. Prognostic and therapeutic implications
Li, X., Sousa-Casasnovas, I., Devesa, C., Juárez, M., Fernández‐Avilés, F., & Martínez‐Sellés, M. (2016) · International Journal of Cardiology · doi:10.1016/j.ijcard.2016.09.019 · Cited by 16
Establishment and Validation of GV-SAPS II Scoring System for Non-Diabetic Critically Ill Patients
Liu, W., Lin, S., Zhu, G., Poucke, S. V., Braddock, M., Zhang, Z., Mao, Z., Shen, F., & Zheng, M. (2016) · PLoS ONE · doi:10.1371/journal.pone.0166085 · Cited by 16
Knowledge, Attitudes, and Decision Making in Hospital Glycemic Management: are Faculty up to Speed?
Pichardo-Lowden, A. R., Kong, L., & Haidet, P. (2015) · Endocrine Practice · doi:10.4158/ep14246.or · Cited by 16
Association between stress hyperglycemia ratio and all-cause mortality in critically ill patients with sepsis: results from the MIMIC-IV database
Zhang, S., Shen, H., Wang, Y., Ning, M., Zhou, J., Liang, X., Chang, Y. S., Gao, W., & Li, T. (2025) · European journal of medical research · doi:10.1186/s40001-025-02281-4 · Cited by 20
Elevated Glycemic Gap Predicts Acute Respiratory Failure and In-hospital Mortality in Acute Heart Failure Patients with Diabetes
Liao, W.-I., Wang, J., Lin, C., Yang, C.-J., Hsu, C.-C., Chu, S.-J., Chu, C., & Tsai, S. (2019) · Scientific Reports · doi:10.1038/s41598-019-42666-0 · Cited by 15
Insulin Infusion Therapy in Critically Ill Patients
Boutin, J., & Gauthier, L. (2014) · Canadian Journal of Diabetes · doi:10.1016/j.jcjd.2014.01.016 · Cited by 15
Inpatient Management of T2DM and Hyperglycemia in Older Adults
DeCarlo, K., & Wallia, A. (2019) · Current Diabetes Reports · doi:10.1007/s11892-019-1209-3 · Cited by 15
Updates in Glycemic Management in the Hospital
Mongkolpun, W., Provenzano, B. C., & Preiser, J. (2019) · Current Diabetes Reports · doi:10.1007/s11892-019-1274-7 · Cited by 15
Maximal Glycemic Difference, the Possible Strongest Glycemic Variability Parameter to Predict Mortality in ICU Patients
Issarawattana, T., & Bhurayanontachai, R. (2020) · Critical Care Research and Practice · doi:10.1155/2020/5071509 · Cited by 15
Spontaneous and iatrogenic hypoglycaemia related to mortality in the ICU
Cichosz, S. L., Redke, F., & Hejlesen, O. K. (2019) · Diabetes & Metabolism · doi:10.1016/j.diabet.2019.02.001 · Cited by 14
Insulin resistance in critical illness: consequences for nutrition therapy and glucose management
Gunst, J., & Verbruggen, S. C. A. T. (2023) · Current Opinion in Critical Care · doi:10.1097/mcc.0000000000001055 · Cited by 14
Relationship between time-weighted average glucose and mortality in critically ill patients: a retrospective analysis of the MIMIC-IV database
Feng, M., & Zhou, J. (2024) · Scientific Reports · doi:10.1038/s41598-024-55504-9 · Cited by 14
A Multicenter Study Evaluating Perceptions and Knowledge of Inpatient Glycemic Control Among Resident Physicians: Analyzing Themes to Inform and Improve Care
Horton, W. B., Law, S., Darji, M., Conaway, M. R., Akbashev, M. Y., Kubiak, N. T., Kirby, J. L., & Thigpen, S. (2019) · Endocrine Practice · doi:10.4158/ep-2019-0299 · Cited by 16
Admission blood glucose level and outcome in patients requiring venoarterial extracorporeal membrane oxygenation
Bemtgen, X., Rilinger, J., Jäckel, M., Zotzmann, V., Supady, A., Benk, C., Bode, C., Wengenmayer, T., Lother, A., & Staudacher, D. L. (2021) · Clinical Research in Cardiology · doi:10.1007/s00392-021-01862-7 · Cited by 14
Incidence and Impact of Dysglycemia in Patients with Sepsis Under Moderate Glycemic Control
Fujishima, S., Gando, S., Saitoh, D., Kushimoto, S., Ogura, H., Abe, T., Shiraishi, A., Mayumi, T., Sasaki, J., Kotani, J., et al. (2021) · Shock · doi:10.1097/shk.0000000000001794 · Cited by 14
Glucose Levels in Patients With Acute Respiratory Failure Requiring Mechanical Ventilation
Edriss, H., Selvan, K. C., Sigler, M., & NUGENT, K. M. (2016) · Journal of Intensive Care Medicine · doi:10.1177/0885066616636013 · Cited by 15
Evaluation and Perioperative Management of the Diabetic Patient
Cook, K. D., Borzok, J., Sumrein, F., & Opler, D. J. (2018) · Clinics in Podiatric Medicine and Surgery · doi:10.1016/j.cpm.2018.08.004 · Cited by 14
A Comparison of Inpatient Cost Per Day in General Surgery Patients with Type 2 Diabetes Treated with Basal-Bolus versus Sliding Scale Insulin Regimens
Phillips, V. L., Byrd, A. L., Adeel, S., Peng, L., Smiley, D. D., & Umpierrez, G. E. (2017) · PharmacoEconomics - Open · doi:10.1007/s41669-017-0020-9 · Cited by 13
Diabetesmanagement im Krankenhaus (Update 2023)
Mader, J. K., Brix, J. M., Aberer, F., Vonbank, A., Resl, M., Hochfellner, D. A., Ress, C., Pieber, T. R., Stechemesser, L., & Sourij, H. (2023) · Wiener klinische Wochenschrift · doi:10.1007/s00508-023-02177-5 · Cited by 13
On how to feed critically ill children in intensive care: A slowly shifting paradigm
Gunst, J., Vanhorebeek, I., Verbruggen, S. C. A. T., Dulfer, K., Joosten, K. F. M., & den Berghe, G. V. (2025) · Clinical Nutrition · doi:10.1016/j.clnu.2025.02.003 · Cited by 13
Biological and Hemodynamic Effects of Low Doses of Fludrocortisone and Hydrocortisone, Alone or in Combination, in Healthy Volunteers With Hypoaldosteronism
Laviolle, B., Maguet, P. L., Verdier, M.-C., Massart, C., Donal, E., Lainé, F., Lavenu, A., Pape, D., & Bellissant, É. (2010) · Clinical Pharmacology & Therapeutics · doi:10.1038/clpt.2010.83 · Cited by 16
Liraglutide as an alternative to insulin for glycemic control in intensive care unit: A randomized, open-label, clinical study
Singh, Y., Nakra, M., Verma, V., Shankar, K., Nachankar, A. S., & Kumar, K. V. S. (2017) · Indian Journal of Critical Care Medicine · doi:10.4103/ijccm.ijccm_105_17 · Cited by 13
Duration of Time on Intensive Insulin Therapy Predicts Severe Hypoglycemia in the Surgically Critically Ill Population
Mowery, N. T., Gunter, O. L., Kauffmann, R. M., Diaz, J. J., Collier, B. C., & May, A. K. (2011) · World Journal of Surgery · doi:10.1007/s00268-011-1356-4 · Cited by 13
Management of Patients with Type 1 Diabetes in the Hospital
Yogi-Morren, D., & Lansang, M. C. (2014) · Current Diabetes Reports · doi:10.1007/s11892-013-0458-9 · Cited by 13
Acute hyperglycemia and insulin resistance in acute heart failure syndromes without previously known diabetes
Lazzeri, C., Valente, S., Attanà, P., Chiostri, M., Picariello, C., & Gensini, G. F. (2011) · Internal and Emergency Medicine · doi:10.1007/s11739-011-0597-4 · Cited by 13
Retrospective evaluation of the association between admission blood glucose and l ‐lactate concentrations in ponies and horses with gastrointestinal disease (2008‐2016): 545 cases
Dunkel, B., Mason, C. J., & Chang, Y. (2019) · Journal of Veterinary Emergency and Critical Care · doi:10.1111/vec.12851 · Cited by 13
Study protocol and statistical analysis plan for the Liberal Glucose Control in Critically Ill Patients with Pre-existing Type 2 Diabetes (LUCID) trial
Poole, A. P., Finnis, M., Anstey, J. R., Bellomo, R., Bihari, S., Biradar, V., Doherty, S., Eastwood, G. M., Finfer, S. R., French, C., et al. (2020) · Critical Care and Resuscitation · doi:10.51893/2020.2.oa3 · Cited by 13
Special considerations for the diabetic patient in the ICU; targets for treatment and risks of hypoglycaemia
Siegelaar, S. E., Hoekstra, J. B. L., & DeVries, J. H. (2011) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2011.03.004 · Cited by 13
COVID 19 and low-glucose levels: Is there a link?
Piarulli, F., & Lapolla, A. (2020) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2020.108283 · Cited by 13
Variation in monitoring: Glucose measurement in the ICU as a case study to preempt spurious correlations
Teotia, K., Jia, Y., Woite, N. L., Celi, L. A., de Matos, J. C. R. G., & Struja, T. (2024) · Journal of Biomedical Informatics · doi:10.1016/j.jbi.2024.104643 · Cited by 12
Sweeteners: erythritol, xylitol and cardiovascular risk—friend or foe?
Wölnerhanssen, B. K., Meyer‐Gerspach, A. C., Arduini, A., D’Alessandro, A., Gronda, E., Carugo, S., Bonomini, M., Gallieni, M. A., Masola, V., Angelillo‐Scherrer, A., et al. (2025) · Cardiovascular Research · doi:10.1093/cvr/cvaf091 · Cited by 13
Practical implementation of incretin-based therapy in hospitalized patients with type 2 diabetes
Schwartz, S. S., DeFronzo, R. A., & Umpierrez, G. E. (2014) · Postgraduate Medicine · doi:10.1080/00325481.2015.996504 · Cited by 12
Differences in inpatient glycemic control and response to subcutaneous insulin therapy between medicine and surgery patients with type 2 diabetes
Smiley, D. D., Umpierrez, G. E., Hermayer, K. L., Newton, C. A., Jacobs, S., Olson, D. E., Khan, A., Rizzo, M., Peng, L., Reyes, D., et al. (2013) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2013.05.007 · Cited by 13
Glycemic control in acute illness
Egi, M., Furushima, N., Makino, S., & Mizobuchi, S. (2017) · Korean Journal of Anesthesiology · doi:10.4097/kjae.2017.70.6.591 · Cited by 13
Quantification of stress‐induced hyperglycaemia associated with key diagnostic categories using the stress hyperglycaemia ratio
Roberts, G. W., Larwood, C., & Krinsley, J. S. (2022) · Diabetic Medicine · doi:10.1111/dme.14930 · Cited by 14
Effects of Hyperglycemia and Continuous Intravenous Insulin on Outcomes of Surgical Patients
Schlussel, A. T., Holt, D. B., Crawley, E. A., Lustik, M. B., Wade, C. E., & UYEHARA, C. F. T. (2011) · Journal of Surgical Research · doi:10.1016/j.jss.2011.07.004 · Cited by 12
Does High-Dose Metformin Cause Lactic Acidosis in Type 2 Diabetic Patients after CABG Surgery? A Double Blind Randomized Clinical Trial
Baradari, A. G., Habibi, M. R., Darvishi‐Khezri, H., Aarabi, M., Khademloo, M., Jalali, Z., & Ghafari, R. (2011) · Heart International · doi:10.4081/hi.2011.e8 · Cited by 12
Failure to achieve euglycemia despite aggressive insulin control signals abnormal physiologic response to trauma
Mowery, N. T., Gunter, O. L., Dossett, L. A., Dortch, M. J., Morris, J. A., May, A. K., & Diaz, J. J. (2011) · Journal of Critical Care · doi:10.1016/j.jcrc.2010.10.015 · Cited by 13
Perspectives on Learning and Clinical Practice Improvement for Diabetes in the Hospital: A Review of Educational Interventions for Providers
Pichardo-Lowden, A. R., Haidet, P., & Umpierrez, G. E. (2017) · Endocrine Practice · doi:10.4158/ep161634.ra · Cited by 12
Sitagliptin for the prevention of stress hyperglycemia in patients without diabetes undergoing coronary artery bypass graft (CABG) surgery
Cardona, S., TSEGKA, K. G., Pasquel, F. J., Fayfman, M., Peng, L., Jacobs, S., Vellanki, P., Halkos, M. E., Guyton, R. A., Thourani, V. H., et al. (2019) · BMJ Open Diabetes Research & Care · doi:10.1136/bmjdrc-2019-000703 · Cited by 12
Association between stress hyperglycemia on admission and unfavorable neurological outcome in OHCA patients receiving ECPR
Taira, T., Inoue, A., Nishimura, T., Takahashi, R., Isobe, M., Maemura, S., Suga, M., Ijuin, S., Masano, T., Matsuyama, S., et al. (2022) · Clinical Research in Cardiology · doi:10.1007/s00392-022-02057-4 · Cited by 12
Metabolic and Clinical Effects of the Supplementation of a Functional Mixture of Amino Acids in Cerebral Hemorrhage
Laviano, A., Aghilone, F., Colagiovanni, D., Fiandra, F., Giambarresi, R., Tordiglione, P., Molfino, A., Muscaritoli, M., Rosa, G., & Fanelli, F. R. (2010) · Neurocritical Care · doi:10.1007/s12028-010-9461-z · Cited by 12
Intensive Control of Diabetes in the Hospital: Why, How, and What is in the Future?
Hsia, E., & Draznin, B. (2011) · Journal of Diabetes Science and Technology · doi:10.1177/193229681100500637 · Cited by 13
Characteristics and feeding intolerance in critically ill adult patients receiving peptide-based enteral nutrition: A retrospective cross-sectional study
Nguyen, D. L., Schott, L. L., Lowen, C. C., Desai, A. M., Baumer, D. L., Miranowski, M. K., Cao, Z., & Torres, K. A. (2023) · Clinical Nutrition ESPEN · doi:10.1016/j.clnesp.2023.12.007 · Cited by 11
Association between dysglycemia and the Charlson Comorbidity Index among hospitalized patients with diabetes
Khan, S. A., Shields, S. A., Abusamaan, M. S., & Mathioudakis, N. N. (2022) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2022.108305 · Cited by 12
BNP and Admission Glucose as In-Hospital Mortality Predictors in Non-ST Elevation Myocardial Infarction
Takada, J. Y., Ramos, R. B., Avakian, S. D., dos Santos, S. M., Ramires, J. A. F., & Mansur, A. D. P. (2012) · The Scientific World JOURNAL · doi:10.1100/2012/397915 · Cited by 11
Vascular Glucose Sensor Symposium
Joseph, J. I., Torjman, M. C., & Strasma, P. J. (2015) · Journal of Diabetes Science and Technology · doi:10.1177/1932296815587938 · Cited by 11
Consensus recommendations for the management of hyperglycaemia in critically ill patients in the Indian setting.
Mukherjee, J. J., Chatterjee, P., Saikia, M., Muruganathan, A., & Das, A. K. (2014) · PubMed · Cited by 11
Diabetes-Specific Formulae Versus Standard Formulae as Enteral Nutrition to Treat Hyperglycemia in Critically Ill Patients: Protocol for a Randomized Controlled Feasibility Trial
Doola, R., Todd, A. S., Forbes, J. M., Deane, A. M., Presneill, J., & Sturgess, D. J. (2018) · JMIR Research Protocols · doi:10.2196/resprot.9374 · Cited by 11
Insulin therapy and blood glucose management in critically ill patients: a 1-day cross-sectional observational study in 69 French intensive care units
Desgrouas, M., Demiselle, J., Stiel, L., Brunot, V., Marnai, R., Sarfati, S., Fiancette, M., Lambiotte, F., Thille, A. W., Leloup, M., et al. (2023) · Annals of Intensive Care · doi:10.1186/s13613-023-01142-9 · Cited by 11
Review of Insulin Therapy and Pen Use in Hospitalized Patients
Davis, E. M., Foral, P. A., Dull, R. B., & Smith, A. N. (2013) · Hospital Pharmacy · doi:10.1310/hpj4805-396 · Cited by 10
Premixed Insulin Analogue Compared with Basal-Plus Regimen for Inpatient Glycemic Control
Gracia‐Ramos, A. E., Cruz-Domínguez, M. P., Madrigal‐Santillán, E., Morales‐González, J. A., Madrigal‐Bujaidar, E., & Aguilar-Faisal, L. (2016) · Diabetes Technology & Therapeutics · doi:10.1089/dia.2016.0176 · Cited by 10
Hyperglycemia and glucose variability are associated with worse survival in mechanically ventilated COVID-19 patients: the prospective Maastricht Intensive Care Covid Cohort
van Herpt, T. T. W., van Rosmalen, F., Hulsewé, H. P. M. G., van der Horst‐Schrivers, A. N. A., Driessen, M., Jetten, R., Zelis, N., de Galan, B. E., van Kuijk, S. M. J., van der Horst, I. C. C., et al. (2023) · Diabetology & Metabolic Syndrome · doi:10.1186/s13098-023-01228-1 · Cited by 10
Hyperglycemia on admission and hospitalization outcomes in patients with atrial fibrillation
Akirov, A., Grossman, A., Shochat, T., & Shimon, I. (2017) · Clinical Cardiology · doi:10.1002/clc.22801 · Cited by 10
Transition from intravenous insulin to subcutaneous long-acting insulin in critical care patients on enteral or parenteral nutrition
Ramos, A., Zapata, L., Vera, P., Betbese, A. J., & Pérez, A. (2017) · Endocrinología Diabetes y Nutrición · doi:10.1016/j.endinu.2017.08.005 · Cited by 10
Estimating Enhanced Endogenous Glucose Production in Intensive Care Unit Patients with Severe Insulin Resistance
Anane, Y., Szlávecz, Á., Knopp, J. L., Razak, N. N. A., Abu-Samah, A., Shaw, G. M., Chase, J. G., & Benyó, B. I. (2021) · Journal of Diabetes Science and Technology · doi:10.1177/19322968211018260 · Cited by 10
Intensive insulin therapy to control hyperglycemia in the critically ill: a look back at the evidence shapes the challenges ahead
Krinsley, J. S., & Preiser, J. (2010) · Critical Care · doi:10.1186/cc9275 · Cited by 10
Are closed-loop systems for intensive insulin therapy ready for prime time in the ICU?
Okabayashi, T., & Shima, Y. (2013) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0000000000000026 · Cited by 10
Correction to: Prognostic impact of baseline glucose levels in acute myocardial infarction complicated by cardiogenic shock—a substudy of the IABP-SHOCK II-trial
Abdin, A., Pöss, J., Fuernau, G. F., Ouarrak, T., Desch, S., Eitel, I., de Waha, S., Zeymer, U., Böhm, M., & Thiele, H. (2018) · Clinical Research in Cardiology · doi:10.1007/s00392-018-1225-3 · Cited by 10
Hyperglycemia Risk Evaluation of Hydrocortisone Intermittent Boluses vs Continuous Infusion in Septic Shock: A Retrospective Study
Mitwally, H., Saad, M. O., Mahmoud, S., & Mohamed, A. (2021) · Indian Journal of Critical Care Medicine · doi:10.5005/jp-journals-10071-23501 · Cited by 9
Association between early blood glucose dynamic trajectory and mortality for critically ill patients with heart failure: Insights from real-world data
Ning, Y.-L., Xu, X., Ma, Q., Zhang, Y., Zhou, J., & Sun, C. (2024) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2024.111822 · Cited by 9
Deep reinforcement learning for personalized insulin dosing and glucose control of hospitalized in ICU patients
Symeonidis, P., Rizos, E. C., Andras, C., Hairistanidis, S., Manolopoulos, Y., & Zanker, M. (2025) · International Journal of Data Science and Analytics · doi:10.1007/s41060-025-00857-1 · Cited by 9
Hypoglycemia Reduction Strategies in the ICU
Braithwaite, S. S., Bavda, D. B., Idrees, T., Qureshi, F. M., & Soetan, O. T. (2017) · Current Diabetes Reports · doi:10.1007/s11892-017-0963-3 · Cited by 10
Using a mentoring approach to implement an inpatient glycemic control program in United States hospitals
Rushakoff, R. J., Sullivan, M. M., Seley, J. J., Sadhu, A., O’Malley, C. W., Manchester, C. S., Peterson, E. D., & Rogers, K. M. (2014) · Healthcare · doi:10.1016/j.hjdsi.2014.06.004 · Cited by 9
Understanding Glycemic Control in the Critically Ill: 2011 Update
Krinsley, J. S. (2011) · Hospital Practice · doi:10.3810/hp.2011.04.394 · Cited by 9
The Use of Non-Insulin Anti-Diabetic Agents to Improve Glycemia Without Hypoglycemia in the Hospital Setting: Focus on Incretins
Schwartz, S. S., & DeFronzo, R. A. (2014) · Current Diabetes Reports · doi:10.1007/s11892-013-0466-9 · Cited by 9
Inpatient Management of Diabets Mellitus Among Noncritically Ill Patients at the University Hospital of Puerto Rico
Allende-Vigo, M. Z., González-Rosario, R. A., González, L., Sánchez, V. M., Vega, M., Alvarado, M., & Ramón, R. O. (2013) · Endocrine Practice · doi:10.4158/ep13199.or · Cited by 10
Diabetesmanagement im Krankenhaus (Update 2019)
Mader, J. K., Aberer, F., Brix, J. M., Föger, B., Hochfellner, D. A., Kietaibl, A.-T., Ludvik, B., Resl, M., Ress-Winkel, C., Stechemesser, L., et al. (2019) · Wiener klinische Wochenschrift · doi:10.1007/s00508-019-1447-z · Cited by 9
Consensus evidence-based guidelines for in-patient management of hyperglycaemia in non-critical care setting as per Indian clinical practice.
Gangopadhyay, K. K., Bantwal, G., Talwalkar, P., Muruganathan, A., & Das, A. K. (2014) · PubMed · Cited by 9
Glycemic Management in the Inpatient Setting
Schmeltz, L. R., & Ferrise, C. (2012) · Hospital Practice · doi:10.3810/hp.2012.04.969 · Cited by 9
Effect of Diabetes Mellitus on Outcomes of Hyperglycemia in a Mixed Medical Surgical Intensive Care Unit
Schlussel, A. T., Holt, D. B., Crawley, E. A., Lustik, M. B., Wade, C. E., & UYEHARA, C. F. T. (2011) · Journal of Diabetes Science and Technology · doi:10.1177/193229681100500328 · Cited by 9
Glycemic patterns and impact of early hyperglycaemia in patients with cardiogenic shock on mechanical circulatory support
Nair, R. M., Chawla, S., Mentias, A. G., Saleem, T., Vural, A., Ko, T., Rampersad, P. P., Cremer, P. C., & Menon, V. (2023) · European Heart Journal Acute Cardiovascular Care · doi:10.1093/ehjacc/zuad032 · Cited by 8
Should Guidelines for Glycemic Control of the Critically Ill Be Individualized?: Weighing the Evidence From Randomized and Observational Investigations
Krinsley, J. S. (2014) · Hospital Practice · doi:10.3810/hp.2014.04.1099 · Cited by 8
Hyperglycemia Control of the Nil Per Os Patient in the Intensive Care Unit: Introduction of a Simple Subcutaneous Insulin Algorithm
Kim, S., Rushakoff, R. J., Sullivan, M. M., & MacMaster, H. W. (2012) · Journal of Diabetes Science and Technology · doi:10.1177/193229681200600622 · Cited by 8
The prevalence of hyperglycaemia and its relationship with mortality, readmissions and length of stay in an older acute surgical population: a multicentre study
Myint, P. K., Owen, S., Pearce, L. E., Greig, M., Tay, H. S., McCormack, C., McCarthy, K., Moug, S. J., Stechman, M., & Hewitt, J. (2016) · Postgraduate Medical Journal · doi:10.1136/postgradmedj-2015-133777 · Cited by 8
Association between Blood Glucose Levels the Day after Targeted Temperature Initiation and Outcome in Traumatic Brain Injury: A Post-Hoc Analysis of the B-HYPO Study
Kobata, H., Sugie, A., Suehiro, E., Dohi, K., Kaneko, T., Fujita, M., Oda, Y., Kuroda, Y., Yamashita, S., Maekawa, T., et al. (2016) · Journal of Neurotrauma · doi:10.1089/neu.2016.4662 · Cited by 8
Clinical impact of hyperglycemia on days 0–7 after allogeneic stem cell transplantation
Kawajiri, A., Fuji, S., Tanaka, Y., Kono, C., Hirakawa, T., Tanaka, T., Ito, R., Inoue, Y., Okinaka, K., Kurosawa, S., et al. (2017) · Bone Marrow Transplantation · doi:10.1038/bmt.2017.27 · Cited by 8
The relationship between inpatient hyperglycaemia and mortality is modified by baseline glycaemic status
Rayyan‐Assi, H., Feldman, B., Leventer‐Roberts, M., Akriv, A., & Raz, I. (2020) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.3420 · Cited by 8
Expert Group Recommendations on the Effective Use of Bolus Insulin in the Management of Type 2 Diabetes Mellitus
Chawla, R., Mukherjee, J. J., Chawla, M. S., Kanungo, A. K., Shunmugavelu, M., & Das, A. K. (2021) · Medical Sciences · doi:10.3390/medsci9020038 · Cited by 8
Etiology and Outcomes of ARDS in the Elderly Population in an Intensive Care Unit in North India
Agarwal, R., Sehgal, I. S., & Prasad, K. T. (2021) · Indian Journal of Critical Care Medicine · doi:10.5005/jp-journals-10071-23878 · Cited by 8
Inpatient glycemic control and outcome of COVID-19 patients: A retrospective cohort
Lesniak, C., Ong, R. K. S., Akula, M. S., Douedi, S., Akoluk, A., Soomro, R., Copca-Alvarez, A., Purewal, T., Patel, I. A., Upadhyaya, V. D., et al. (2021) · SAGE Open Medicine · doi:10.1177/20503121211039105 · Cited by 8
Molecular Characterization of Carbapenem-Resistant Acinetobacter baumannii Isolated from the Intensive Care Unit in a Tertiary Teaching Hospital in Malaysia
Woon, J. J., Teh, C. S. J., Chong, C. W., Jabar, K. A., Ponnampalavanar, S. S. L., & Idris, N. (2021) · Antibiotics · doi:10.3390/antibiotics10111340 · Cited by 8
Impact of tight blood glucose control within normal fasting ranges with insulin titration prescribed by the Leuven algorithm in adult critically ill patients: the TGC-fast randomized controlled trial
Gunst, J., Mebis, L., Wouters, P. J., Hermans, G., Dubois, J., Wilmer, A. P., Hoste, E. A. J., Benoît, D., & den Berghe, G. V. (2022) · Trials · doi:10.1186/s13063-022-06709-8 · Cited by 9
Hyperglycemia Risk Evaluation of Hydrocortisone Intermittent Boluses versus Continuous Infusion in Septic Shock
Ram, G. K., Shekhar, S., Singh, R. B., Anand, R., De, R. R., & Kumar, N. (2022) · Anesthesia Essays and Researches · doi:10.4103/aer.aer_115_22 · Cited by 8
Hyperglycemia in Acute Heart Failure: An Opportunity to Intervene?
Lazzeri, C., Valente, S., & Gensini, G. F. (2014) · Current Heart Failure Reports · doi:10.1007/s11897-014-0205-9 · Cited by 8
Non-diabetic Hyperglycemia and Some of Its Correlates in ICU Hospitalized Patients Receiving Enteral Nutrition.
Hasanloei, M. A. V., Shariatpanahi, Z. V., Vahabzadeh, D., Vahabzadeh, Z., Nasiri, L., & Shargh, A. (2017) · Europe PMC (PubMed Central) · Cited by 8
Sensory nerve conduction study of median ulnar and radial nerves in type 2 diabetic individuals in the age group 40–80 years
Sepat, P., & Wasnik, S. (2020) · Heliyon · doi:10.1016/j.heliyon.2020.e05318 · Cited by 7
Impact of prolonged requirement for insulin on 90-day mortality in critically ill patients without previous diabetic treatments: a post hoc analysis of the CONTROLING randomized control trial
Thouy, F., Bohé, J., Souweine, B., Abidi, H., Quenot, J., Thiollière, F., Dellamonica, J., Preiser, J., Timsit, J., Brunot, V., et al. (2022) · Critical Care · doi:10.1186/s13054-022-04004-1 · Cited by 7
Association between time in range 70-180 mg/dl in early stage and severity with in patients acute pancreatitis
Meng, C., Zhang, J., Wang, Y., Ye, X., & Zhuang, S. (2023) · BMC Endocrine Disorders · doi:10.1186/s12902-023-01414-2 · Cited by 7
Stress, Hyperglycemia, and Insulin Resistance Correlate With Neutrophil Activity and Impact Acute Myocardial Infarction Outcomes
Barbu, E., Mihaila, A. C., Filippi, A., Stoenescu, A. I., Ciortan, L., Butoi, E. D., Beiu, C., Popescu, M. N., & Balanescu, S. M. (2024) · Cureus · doi:10.7759/cureus.63731 · Cited by 7
Stress hyperglycaemia ratio is an independent predictor of in-hospital heart failure among patients with anterior ST-segment elevation myocardial infarction
Zia-ul-Sabah, Alqahtani, S. A. M., Wani, J. I., Aziz, S., Durrani, H. K., Patel, A. A., Rangraze, I. R., Mirdad, R. T., Alfayea, M. A., & Shahrani, S. (2024) · BMC Cardiovascular Disorders · doi:10.1186/s12872-024-04362-4 · Cited by 7
The role of the leukocyte glucose index in predicting clinical outcomes in acute methanol toxicity
Nafea, O. E., Abdelhamid, W. G., & Ibrahim, F. A. A. (2025) · Toxicology Reports · doi:10.1016/j.toxrep.2025.101994 · Cited by 7
Comparative Simulation Study of Glucose Control Methods Designed for Use in the Intensive Care Unit Setting via a Novel Controller Scoring Metric
DeJournett, J., & DeJournett, L. (2017) · Journal of Diabetes Science and Technology · doi:10.1177/1932296817711297 · Cited by 7
Association Between Ethnicity and Postoperative Hyperglycemia in a Southeast Asian Population Undergoing Cardiac Surgery
Moorthy, V., Sim, M. A., Liu, W., Ti, L. K., & Chew, S. T. H. (2018) · Journal of Cardiothoracic and Vascular Anesthesia · doi:10.1053/j.jvca.2018.03.010 · Cited by 7
Importance of the Madras Diabetes Research Foundation-Indian Diabetes Risk Score (MDRF-IDRS) for mass screening of type 2 diabetes and its complications at primary health care centers of North India
Khan, M., Sonkar, G., Singh, S., & Sonkar, S. (2019) · International Journal of Diabetes in Developing Countries · doi:10.1007/s13410-018-0710-6 · Cited by 5
A simplified critical illness severity scoring system (CISSS): Development and internal validation
Fortis, S., O’Shea, A. M. J., Beck, B. F., Nair, R., Goto, M., Schmidt, G. A., Kaboli, P. J., Perencevich, E. N., Reisinger, H. S., & Vaughan‐Sarrazin, M. (2020) · Journal of Critical Care · doi:10.1016/j.jcrc.2020.09.029 · Cited by 7
Insulin therapy associated relative hypoglycemia during critical illness
Kwan, T. N., Marhoon, N., Young, M., Holmes, N. E., & Bellomo, R. (2022) · Journal of Critical Care · doi:10.1016/j.jcrc.2022.154018 · Cited by 8
Quantile Regression for Nonignorable Missing Data with Its Application of Analyzing Electronic Medical Records
Yu, A., Zhong, Y., Feng, X., & Wei, Y. (2022) · Biometrics · doi:10.1111/biom.13723 · Cited by 8

Authors: Falciglia, M., Freyberg, R. W., Almenoff, P. L., D’Alessio, D. A., & Render, M. L.
Affiliations: University of Cincinnati (US)
Cincinnati VA Medical Center (US)
The University of Kansas Health System (US)
ORCID: Falciglia, Mercedes
D’Alessio, David A.
Venue: Critical Care Medicine
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2009-12
Volume: 37
Issue: 12
Pages: 3001-3009
ISSN: 0090-3493 (ISSN-L)
DOI: 10.1097/ccm.0b013e3181b083f7
PMC: PMC2905804
OpenAlex: W2025416505
Cited by: 576
References: 70
Citations by year: 2026: 20 · 2025: 24 · 2024: 24 · 2023: 32 · 2022: 37 · 2021: 33 · 2020: 33 · 2019: 35 · 2018: 32 · 2017: 42 · 2016: 43 · 2015: 50 · 2014: 50 · 2013: 28 · 2012: 28
FWCI: 22.51
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Critical Care Medicine (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: U.S. Department of Veterans Affairs
National Institute of Diabetes and Digestive and Kidney Diseases (DK K23 74440, DK R01 57900, R01DK057900, K23DK074440)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hyperglycemia and glycemic control in critically ill and hospitalized patients
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Intensive Care Unit Cognitive Disorders
Keywords: critically ill patients, mortality, admission diagnosis, intensive care unit, length of hospital stay, diabetes mellitus, acute myocardial infarction, cardiac arrhythmias, unstable angina, pulmonary embolism, risk-adjusted mortality, glycemia, intensive insulin therapy, disease severity, trauma, sepsis, respiratory failure, renal failure, liver failure
MeSH terms: Adult, Aged, Female, Humans, Hyperglycemia, Male, Middle Aged, Patient Admission, Retrospective Studies, Risk Factors, Cohort Studies, Critical Illness

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Hyperglycemia-related mortality in critically ill patients varies with admission diagnosis

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks