Cited by 576Hyperglycemia and glycemic control in critically ill and hospitalized patientsDiabetes Management and ResearchIntensive Care Unit Cognitive Disorders

The DOI matches its Crossref record; 70 of the 70 references it cites were found in a registry or an index.

Hyperglycemia-related mortality in critically ill patients varies with admission diagnosis

Open access

Falciglia, Mercedes, Freyberg, Ron W., Almenoff, Peter L., D’Alessio, David A., Render, Marta L.·2009·Critical Care Medicine

DOI 10.1097/ccm.0b013e3181b083f7PMC PMC2905804

Open this paper in CoChat — free account

Abstract

OBJECTIVES: Hyperglycemia during critical illness is common and is associated with increased mortality. Intensive insulin therapy has improved outcomes in some, but not all, intervention trials. It is unclear whether the benefits of treatment differ among specific patient populations. The purpose of the study was to determine the association between hyperglycemia and risk- adjusted mortality in critically ill patients and in separate groups stratified by admission diagnosis. A secondary purpose was to determine whether mortality risk from hyperglycemia varies with intensive care unit type, length of stay, or diagnosed diabetes. DESIGN: Retrospective cohort study. SETTING: One hundred seventy-three U.S. medical, surgical, and cardiac intensive care units. PATIENTS: Two hundred fifty-nine thousand and forty admissions from October 2002 to September 2005; unadjusted mortality rate, 11.2%. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: A two-level logistic regression model determined the relationship between glycemia and mortality. Age, diagnosis, comorbidities, and laboratory variables were used to calculate a predicted mortality rate, which was then analyzed with mean glucose to determine the association of hyperglycemia with hospital mortality. Hyperglycemia was associated with increased mortality independent of illness severity. Compared with normoglycemic individuals (70-110 mg/dL), adjusted odds of mortality (odds ratio, [95% confidence interval]) for mean glucose 111-145, 146-199, 200-300, and >300 mg/dL was 1.31 (1.26-1.36), 1.82 (1.74-1.90), 2.13 (2.03-2.25), and 2.85 (2.58-3.14), respectively. Furthermore, the adjusted odds of mortality related to hyperglycemia varied with admission diagnosis, demonstrating a clear association in some patients (acute myocardial infarction, arrhythmia, unstable angina, pulmonary embolism) and little or no association in others. Hyperglycemia was associated with increased mortality independent of intensive care unit type, length of stay, and diabetes. CONCLUSIONS: The association between hyperglycemia and mortality implicates hyperglycemia as a potentially harmful and correctable abnormality in critically ill patients. The finding that hyperglycemia-related risk varied with admission diagnosis suggests differences in the interaction between specific medical conditions and injury from hyperglycemia. The design and interpretation of future trials should consider the primary disease states of patients and the balance of medical conditions in the intensive care unit studied.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1097/ccm.0b013e3181b083f7

Cites

70 of 70 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Intensive insulin therapy in critically ill patients.
Van den Berghe, G., Wouters, P., Weekers, F., Verwaest, C., Bruyninckx, F., Schetz, M., Vlasselaers, D., Ferdinande, P., Lauwers, P., & Bouillon, R. (2001) · New England Journal of Medicine · doi:10.1056/nejmoa011300 · Cited by 9,977
Comorbidity measures for use with administrative data.
Elixhauser, A., Steiner, C., Harris, D. R., & Coffey, R. M. (1998) · Medical Care · doi:10.1097/00005650-199801000-00004 · Cited by 9,921
Intensive versus Conventional Glucose Control in Critically Ill Patients
(2009) · New England Journal of Medicine · doi:10.1056/nejmoa0810625 · Cited by 5,119
Intensive insulin therapy in the medical ICU
Van den Berghe, G., Wilmer, A., Hermans, G., Meersseman, W., Wouters, P. J., Milants, I., Van Wijngaerden, E., Bobbaers, H., & Bouillon, R. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa052521 · Cited by 3,639
The APACHE III Prognostic System
Knaus, W. A., Wagner, D. P., Draper, E. A., Zimmerman, J. E., Bergner, M., BASTOS, P. G., Sirio, C., Murphy, D. J., Lotring, T., Damiano, A., et al. (1991) · CHEST Journal · doi:10.1378/chest.100.6.1619 · Cited by 3,539
Intensive insulin therapy and pentastarch resuscitation in severe sepsis
Brunkhorst, F. M., Engel, C., Bloos, F., Meier-Hellmann, A., Ragaller, M., Weiler, N., Moerer, O., Gruendling, M., Oppert, M., Grond, S., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa070716 · Cited by 2,921
The APACHE III Prognostic System
Teres, D., & Lemeshow, S. A. (1992) · CHEST Journal · doi:10.1378/chest.102.6.1919b · Cited by 2,896
Hyperglycemia: an independent marker of in-hospital mortality in patients with undiagnosed diabetes
Umpierrez, G. E., Isaacs, S. D., Bazargan, N., You, X., Thaler, L. M., & Kitabchi, A. E. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.87.3.8341 · Cited by 2,195
Stress hyperglycaemia and increased risk of death after myocardial infarction in patients with and without diabetes: A systematic overview
Capes, S. E., Hunt, D., Malmberg, K., & Gerstein, H. C. (2000) · The Lancet · doi:10.1016/s0140-6736(99)08415-9 · Cited by 2,187 · cited 1×
“Our analysis extends previous findings of the relative risk from hyperglycemia in patients with and without antecedent diagnoses of diabetes (3, 4, 10, 12, 51, 59).”
Result
Stress Hyperglycemia and Prognosis of Stroke in Nondiabetic and Diabetic Patients: A Systematic Overview
Capes, S. E., Hunt, D., Malmberg, K., Pathak, P., & Gerstein, H. C. (2001) · Stroke · doi:10.1161/hs1001.096194 · Cited by 1,824

Flagged first, then by citations

Show all 70 references

Sorted by citations

Management of hyperglycemia in hospitalized patients in non-critical care setting: an Endocrine Society clinical practice guideline
Umpierrez, G. E., Hellman, R., Korytkowski, M. T., Kosiborod, M., Maynard, G. A., Montori, V. M., Seley, J. J., & Van den Berghe, G. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-2098 · Cited by 1,126
Prevalence and clinical outcome of hyperglycemia in the perioperative period in noncardiac surgery
Frisch, A., Chandra, P., Smiley, D., Peng, L., Rizzo, M., Gatcliffe, C., Hudson, M., Mendoza, J., Johnson, R., Lin, E., et al. (2010) · Diabetes Care · doi:10.2337/dc10-0304 · Cited by 739
American Association of Clinical Endocrinologists and American College of Endocrinology – Clinical Practice Guidelines for Developing A Diabetes Mellitus Comprehensive Care Plan – 2015 — Executive Summary
Handelsman, Y., Bloomgarden, Z. T., Grunberger, G., Umpierrez, G. E., Zimmerman, R. S., Bailey, T. S., Blonde, L., Bray, G. A., Cohen, A. J., Dagogo-Jack, S. E., et al. (2015) · Endocrine Practice · doi:10.4158/ep15672.gl · Cited by 646
Relative Hyperglycemia, a Marker of Critical Illness: Introducing the Stress Hyperglycemia Ratio
Roberts, G. W., Quinn, S. J., Valentine, N. A., Alhawassi, T. M., O'Dea, H., Stranks, S. N., Burt, M. G., & Doogue, M. P. (2015) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2015-2660 · Cited by 641
Guidelines for the use of an insulin infusion for the management of hyperglycemia in critically ill patients
Jacobi, J., Bircher, N. G., Krinsley, J. S., Agus, M. S. D., Braithwaite, S. S., Deutschman, C. S., Freire, A. X., Geehan, D., Kohl, B., Nasraway, S. A., et al. (2012) · Critical Care Medicine · doi:10.1097/ccm.0b013e3182653269 · Cited by 581
American Association of Clinical Endocrinologists and American College of Endocrinology - clinical practice guidelines for developing a diabetes mellitus comprehensive care plan - 2015
Handelsman, Y., Bloomgarden, Z. T., Grunberger, G., Umpierrez, G., Zimmerman, R. S., Bailey, T. S., Blonde, L., Bray, G. A., Cohen, A. J., Dagogo-Jack, S., et al. (2015) · Endocrine Practice · doi:10.4158/ep15672.glsuppl · Cited by 559
Metabolic response to the stress of critical illness
Preiser, J., Ichaï, C., Orban, J., & Groeneveld, A. B. J. (2014) · British Journal of Anaesthesia · doi:10.1093/bja/aeu187 · Cited by 513
American Association of Clinical Endocrinology Clinical Practice Guideline: Developing a Diabetes Mellitus Comprehensive Care Plan-2022 Update.
Blonde, L., Umpierrez, G. E., Reddy, S. S., McGill, J. B., Berga, S. L., Bush, M., Chandrasekaran, S., DeFronzo, R. A., Einhorn, D., Galindo, R. J., et al. (2022) · Endocrine Practice · doi:10.1016/j.eprac.2022.08.002 · Cited by 507
Diabetic status and the relation of the three domains of glycemic control tomortality in critically ill patients: an international multicenter cohort study
Krinsley, J. S., Egi, M., Kiss, A., Devendra, A. N., Schüetz, P., Maurer, P., Schultz, M. J., van Hooijdonk, R. T. M., Kiyoshi, M., Mackenzie, I. M. J., et al. (2013) · Critical Care · doi:10.1186/cc12547 · Cited by 376
Diabetes and infection: assessing the association with glycaemic control in population-based studies
Pearson‐Stuttard, J., Blundell, S., Harris, T. J., Cook, D. G., & Critchley, J. (2015) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(15)00379-4 · Cited by 325
Randomized Controlled Trial of Intensive Versus Conservative Glucose Control in Patients Undergoing Coronary Artery Bypass Graft Surgery: GLUCO-CABG Trial
Umpierrez, G., Cardona, S., Pasquel, F., Jacobs, S., Peng, L., Unigwe, M., Newton, C. A., Smiley-Byrd, D., Vellanki, P., Halkos, M., et al. (2015) · Diabetes Care · doi:10.2337/dc15-0303 · Cited by 281
Clinical characteristics and outcomes of sepsis-related vs non-sepsis-related ARDS.
Sheu, C.-C., Gong, M. N., Zhai, R., Chen, F., Bajwa, E. K., Clardy, P. F., Gallagher, D. C., Thompson, B. T., & Christiani, D. C. (2010) · Chest · doi:10.1378/chest.09-2933 · Cited by 260
The interaction of chronic and acute glycemia with mortality in critically ill patients with diabetes*
Egi, M., Bellomo, R., Stachowski, E., French, C., Hart, G. K., Taori, G., Hegarty, C., & Bailey, M. (2010) · Critical Care Medicine · doi:10.1097/ccm.0b013e3181feb5ea · Cited by 234
Dysglycaemia in the critically ill and the interaction of chronic and acute glycaemia with mortality
Plummer, M. P., Bellomo, R., Cousins, C. E., Annink, C. E., Sundararajan, K., Reddi, B. A. J., Raj, J. P., Chapman, M. J., Horowitz, M., & Deane, A. M. (2014) · Intensive Care Medicine · doi:10.1007/s00134-014-3287-7 · Cited by 235
Randomized Study Comparing a Basal-Bolus With a Basal Plus Correction Insulin Regimen for the Hospital Management of Medical and Surgical Patients With Type 2 Diabetes
Umpierrez, G. E., Smiley, D., Hermayer, K., Khan, A., Olson, D. E., Newton, C., Jacobs, S., Rizzo, M., Peng, L., Reyes, D., et al. (2013) · Diabetes Care · doi:10.2337/dc12-1988 · Cited by 222
Mild hypoglycemia is independently associated with increased mortality in the critically ill
Krinsley, J. S., Schultz, M. J., Spronk, P. E., Harmsen, R. E., Houckgeest, F. V. B., van der Sluijs, J. P., Mélot, C., & Preiser, J. (2011) · Critical Care · doi:10.1186/cc10322 · Cited by 181
Time in blood glucose range 70 to 140 mg/dl >80% is strongly associated with increased survival in non-diabetic critically ill adults
Krinsley, J. S., & Preiser, J.-C. (2015) · Critical Care · doi:10.1186/s13054-015-0908-7 · Cited by 174
Tight blood-glucose control without early parenteral nutrition in the ICU
Gunst, J., Debaveye, Y., Güiza, F., Dubois, J., De Bruyn, A., Dauwe, D., De Troy, E., Casaer, M. P., De Vlieger, G., Haghedooren, R., et al. (2023) · New England Journal of Medicine · doi:10.1056/nejmoa2304855 · Cited by 163
Management of Inpatient Hyperglycemia and Diabetes in Older Adults
Umpierrez, G. E., & Pasquel, F. J. (2017) · Diabetes Care · doi:10.2337/dc16-0989 · Cited by 175
Society of Critical Care Medicine Guidelines on Glycemic Control for Critically Ill Children and Adults 2024
Honarmand, K., Sirimaturos, M., Hirshberg, E. L., Bircher, N. G., Agus, M. S. D., Carpenter, D. L., Downs, C. R., Farrington, E. A., Freire, A. X., Grow, A., et al. (2024) · Critical Care Medicine · doi:10.1097/ccm.0000000000006174 · Cited by 177
Stress-Induced Hyperglycemia: Consequences and Management
Vedantam, D., Poman, D. S., Motwani, L., Asif, N., Patel, A., & Anne, K. K. (2022) · Cureus · doi:10.7759/cureus.26714 · Cited by 175
Update to the Centers for Disease Control and Prevention and the Healthcare Infection Control Practices Advisory Committee Guideline for the Prevention of Surgical Site Infection (2017): A summary, review, and strategies for implementation
O’Hara, L. M., Thom, K. A., & Preas, M. A. (2018) · American Journal of Infection Control · doi:10.1016/j.ajic.2018.01.018 · Cited by 146
Continuous glucose monitoring in the ICU: clinical considerations and consensus
Krinsley, J. S., Chase, J. G., Gunst, J., Mårtensson, J., Schultz, M. J., Taccone, F. S., Wernerman, J., Bohé, J., Block, C. E. M. D., Desaive, T., et al. (2017) · Critical Care · doi:10.1186/s13054-017-1784-0 · Cited by 150
Association between intensive care unit-acquired dysglycemia and in-hospital mortality.
Badawi, O., Waite, M. D., Fuhrman, S. A., & Zuckerman, I. H. (2012) · Critical Care Medicine · doi:10.1097/ccm.0b013e3182656ae5 · Cited by 142
Glycemic control in non-diabetic critically ill patients
Farrokhi, F., Smiley, D. D., & Umpierrez, G. E. (2011) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2011.05.004 · Cited by 142
Guidelines for Perioperative Care in Cytoreductive Surgery (CRS) with or without hyperthermic IntraPEritoneal chemotherapy (HIPEC): Enhanced Recovery After Surgery (ERAS®) Society Recommendations — Part II: Postoperative management and special considerations
Hübner, M., Kusamura, S., Villeneuve, L., Al‐Niaimi, A., Alyami, M. S., Balonov, K., Bell, J., Bristow, R. E., Guiral, D. C., Fagotti, A., et al. (2020) · European Journal of Surgical Oncology · doi:10.1016/j.ejso.2020.08.006 · Cited by 143
Tight glycemic control in critical care – The leading role of insulin sensitivity and patient variability: A review and model-based analysis
Chase, J. G., Compte, A. J. L., Suhaimi, F. M., Shaw, G. M., Lynn, A. M., Lin, J., Pretty, C. G., Razak, N. N. A., Parente, J. D., Hann, C. E., et al. (2010) · Computer Methods and Programs in Biomedicine · doi:10.1016/j.cmpb.2010.11.006 · Cited by 133
The effect of diabetes mellitus on the association between measures of glycaemiccontrol and ICU mortality: a retrospective cohort study
Sechterberger, M. K., Bosman, R. J., Straaten, H. M. O., Siegelaar, S. E., Hermanides, J., Hoekstra, J. B. L., & DeVries, J. H. (2013) · Critical Care · doi:10.1186/cc12572 · Cited by 130
The Effect of Sustained Inflammation on Hepatic Mevalonate Pathway Results in Hyperglycemia
Okin, D. A., & Medzhitov, R. M. (2016) · Cell · doi:10.1016/j.cell.2016.02.023 · Cited by 126
Comparison of basal-bolus and premixed insulin regimens in hospitalized patients with type 2 diabetes
Bellido, V., Suarez, L., Rodriguez, M. G., Sanchez, C., Dieguez, M., Riestra, M., Casal, F., Delgado, E., Menendez, E., & Umpierrez, G. E. (2015) · Diabetes Care · doi:10.2337/dc15-0160 · Cited by 118
Insulin Therapy for the Management of Hyperglycemia in Hospitalized Patients
McDonnell, M. E., & Umpierrez, G. E. (2012) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2012.01.001 · Cited by 125
A practical guide for the management of steroid induced hyperglycaemia in the hospital
Aberer, F., Hochfellner, D. A., Sourij, H., & Mader, J. K. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10102154 · Cited by 110
Endocrine Responses to Critical Illness: Novel Insights and Therapeutic Implications
Boonen, E., & Van den Berghe, G. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-4115 · Cited by 105
Management of sepsis in neutropenic patients: 2014 updated guidelines from the Infectious Diseases Working Party of the German Society of Hematology and Medical Oncology (AGIHO)
Penack, O., Becker, C., Buchheidt, D., Christopeit, M., Kiehl, M. G., von Lilienfeld‐Toal, M., Hentrich, M., Reinwald, M., Salwender, H. J., Schalk, E., et al. (2014) · Annals of Hematology · doi:10.1007/s00277-014-2086-0 · Cited by 100
Pre-morbid glycemic control modifies the interaction between acute hypoglycemia and mortality
Egi, M., Krinsley, J. S., Maurer, P., Amin, D., Kanazawa, T., Ghandi, S., Morita, K., Bailey, M., & Bellomo, R. (2016) · Intensive Care Medicine · doi:10.1007/s00134-016-4216-8 · Cited by 102
Parenteral Nutrition–Associated Hyperglycemia in Non–Critically Ill Inpatients Increases the Risk of In-Hospital Mortality (Multicenter Study)
Olveira, G., Tapia, M. J., Ocón, J., Cabrejas-Gómez, C., Ballesteros-Pomar, M. D., Vidal‐Casariego, A., Irigoyen, C. A., Olivares, J., Conde-García, M. D. C., García‐Manzanares, Á., et al. (2012) · Diabetes Care · doi:10.2337/dc12-1379 · Cited by 94
Perioperative management of hyperglycemia and diabetes in cardiac surgery patients
Galindo, R. J., Fayfman, M., & Umpierrez, G. E. (2018) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2017.10.005 · Cited by 95
The impact of premorbid diabetic status on the relationship between the three domains of glycemic control and mortality in critically ill patients
Krinsley, J. S., Meyfroidt, G., den Berghe, G. V., Egi, M., & Bellomo, R. (2012) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e32834f0009 · Cited by 98
Association Between a Virtual Glucose Management Service and Glycemic Control in Hospitalized Adult Patients: An Observational Study
Rushakoff, R. J., Sullivan, M. M., MacMaster, H. W., Shah, A. D., Rajkomar, A., Glidden, D. V., & Kohn, M. A. (2017) · Annals of Internal Medicine · doi:10.7326/m16-1413 · Cited by 91
The Interaction of Acute and Chronic Glycemia on the Relationship of Hyperglycemia, Hypoglycemia, and Glucose Variability to Mortality in the Critically Ill*
Krinsley, J. S., Rule, P., Pappy, L., Ahmed, A., Huley-Rodrigues, C., Prevedello, D., & Preiser, J. (2020) · Critical Care Medicine · doi:10.1097/ccm.0000000000004599 · Cited by 90
Computerized intensive insulin dosing can mitigate hypoglycemia and achieve tight glycemic control when glucose measurement is performed frequently and on time
Juneja, R., Roudebush, C. P., Nasraway, S. A., Golas, A. A., Jacobi, J., Carroll, J., Nelson, D., Abad, V. J., & Flanders, S. J. (2009) · Critical Care · doi:10.1186/cc8129 · Cited by 86
Glucose control in the ICU
Gunst, J., De Bruyn, A., & Van den Berghe, G. (2019) · Current Opinion in Anaesthesiology · doi:10.1097/aco.0000000000000706 · Cited by 84
Glycemic Control in the ICU
Egi, M., Finfer, S. R., & Bellomo, R. (2011) · CHEST Journal · doi:10.1378/chest.10-1478 · Cited by 86
Usefulness of Glycemic Gap to Predict ICU Mortality in Critically Ill Patients With Diabetes
Liao, W.-I., Wang, J., Chang, W., Hsu, C.-W., Chu, C., & Tsai, S. (2015) · Medicine · doi:10.1097/md.0000000000001525 · Cited by 86
Perioperative Tight Glucose Control Reduces Postoperative Adverse Events in Nondiabetic Cardiac Surgery Patients
Bláha, J., Mráz, M., Kopecký, P., Stříteský, M., Lipš, M., Matias, M., Kunstýř, J., Pořízka, M., Kotulák, T., Kolníková, I., et al. (2015) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2015-1959 · Cited by 81
Mean glucose during ICU admission is related to mortality by a U-shaped curve in surgical and medical patients: A retrospective cohort study.
Siegelaar, S. E., Hermanides, J., Oudemans-van Straaten, H. M., van der Voort, P. H., Bosman, R. J., Zandstra, D. F., & DeVries, J. H. (2010) · Critical Care · doi:10.1186/cc9369 · Cited by 82
Hyperglycemia in Critically Ill Patients: Management and Prognosis
Godinjak, A., Iglica, A., Bureković, A., Jusufović, S., Ajanovic, A., Tančica, I., & Kukuljac, A. (2015) · Medical Archives · doi:10.5455/medarh.2015.69.157-160 · Cited by 84
Mild hypoglycemia is strongly associated with increased intensive care unit length of stay
Krinsley, J. S., Schultz, M. J., Spronk, P. E., Houckgeest, F. V. B., van der Sluijs, J. P., Mélot, C., & Preiser, J. (2011) · Annals of Intensive Care · doi:10.1186/2110-5820-1-49 · Cited by 86
Stress hyperglycemia in general surgery: Why should we care?
Davis, G., Fayfman, M., Reyes-Umpierrez, D., Hafeez, S., Pasquel, F. J., Vellanki, P., Haw, J. S., Peng, L., Jacobs, S., & Umpierrez, G. E. (2018) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2017.11.010 · Cited by 80
Glucose Control in the ICU
Preiser, J., Chase, J. G., Hovorka, R., Joseph, J. I., Krinsley, J. S., Block, C. E. M. D., Desaive, T., Foubert, L. A., Kalfon, P., Pielmeier, U., et al. (2016) · Journal of Diabetes Science and Technology · doi:10.1177/1932296816648713 · Cited by 82
Association of time in blood glucose range with outcomes following cardiac surgery
Omar, A. S., Salama, A., Allam, M., El-Gohary, Y., Mohammed, S., Tuli, A. K., & Singh, R. (2015) · BMC Anesthesiology · doi:10.1186/1471-2253-15-14 · Cited by 81
Relationship between stress hyperglycaemic ratio (SHR) and critical illness: a systematic review
Song, G., Liu, X., Lu, Z., Guan, J., Chen, X., Li, Y., Liu, G., Wang, G., & Ma, F. (2025) · Cardiovascular Diabetology · doi:10.1186/s12933-025-02751-3 · Cited by 94
The effect of diabetes on mortality in critically ill patients: a systematic review and meta-analysis
Siegelaar, S. E., Hickmann, M., Hoekstra, J. B. L., Holleman, F., & DeVries, J. H. (2011) · Critical Care · doi:10.1186/cc10440 · Cited by 77
Dysglycaemia in the critically ill – significance and management
Deane, A. M., & Horowitz, M. (2013) · Diabetes Obesity and Metabolism · doi:10.1111/dom.12078 · Cited by 78
The impact of immobilisation and inflammation on the regulation of muscle mass and insulin resistance: different routes to similar end‐points
Crossland, H., Skirrow, S., Puthucheary, Z., Constantin‐Teodosiu, D., & Greenhaff, P. L. (2018) · The Journal of Physiology · doi:10.1113/jp275444 · Cited by 84
Risk Factors for Inpatient Hypoglycemia during Subcutaneous Insulin Therapy in Non-Critically Ill Patients with Type 2 Diabetes
Farrokhi, F., Klindukhova, O., Chandra, P., Peng, L., Smiley, D. D., Newton, C. A., Pasquel, F. J., Fereira, M. E., & Umpierrez, G. E. (2012) · Journal of Diabetes Science and Technology · doi:10.1177/193229681200600505 · Cited by 73
Individualised versus conventional glucose control in critically-ill patients: the CONTROLING study-a randomized clinical trial.
Bohé, J., Abidi, H., Brunot, V., Klich, A., Klouche, K., Sédillot, N., Tchénio, X., Quenot, J., Roudaut, J.-B., Mottard, N., et al. (2021) · Europe PMC (PubMed Central) · doi:10.1007/s00134-021-06526-8 · Cited by 76
Diabetes and the Association of Postoperative Hyperglycemia With Clinical and Economic Outcomes in Cardiac Surgery
Greco, G., Ferket, B. S., D’Alessandro, D. A., Shi, W., Horvath, K. A., Rosen, A., Welsh, S., Bagiella, E., Neill, A. E., Williams, D. L., et al. (2016) · Diabetes Care · doi:10.2337/dc15-1817 · Cited by 74
Prevalence and Impact of Unknown Diabetes in the ICU
Carpenter, D. L., Gregg, S., Xu, K., Buchman, T. G., & Coopersmith, C. M. (2015) · Critical Care Medicine · doi:10.1097/ccm.0000000000001353 · Cited by 73
Endocrine and Metabolic Alterations in Sepsis and Implications for Treatment
Ingels, C., Gunst, J., & den Berghe, G. V. (2017) · Critical Care Clinics · doi:10.1016/j.ccc.2017.08.006 · Cited by 69
Glycemic Control in the Intensive Care Unit and during the Postoperative Period
Lena, D., Kalfon, P., Preiser, J., Ichaï, C., & Riou, B. (2011) · Anesthesiology · doi:10.1097/aln.0b013e3182078843 · Cited by 69
Blood glucose amplitude variability as predictor for mortality in surgical and medical intensive care unit patients: a multicenter cohort study
Meynaar, I. A., Eslami, S., Abu–Hanna, A., der Voort, P. V., de Lange, D. W., & de Keizer, N. F. (2012) · Journal of Critical Care · doi:10.1016/j.jcrc.2011.11.004 · Cited by 68
Near-Continuous Glucose Monitoring Makes Glycemic Control Safer in ICU Patients*
Preiser, J., Lheureux, O., Thooft, A., Brimioulle, S., GOLDSTEIN, J. P., & Vincent, J. (2018) · Critical Care Medicine · doi:10.1097/ccm.0000000000003157 · Cited by 67
Safety and Efficacy of Personalized Glycemic Control in Critically ill Patients: A 2-Year Before and After Interventional Trial
Krinsley, J. S., Preiser, J., & Hirsch, I. B. (2016) · Endocrine Practice · doi:10.4158/ep161532.or · Cited by 66
Is intensive glucose control bad for critically ill patients? A systematic review and meta-analysis
Yao, R.-Q., Ren, C., Wu, G., Zhu, Y., Xia, Z., & Yao, Y.-M. (2020) · International Journal of Biological Sciences · doi:10.7150/ijbs.43447 · Cited by 64
Stress Hyperlactatemia Modifies the Relationship Between Stress Hyperglycemia and Outcome
Kaukonen, K., Bailey, M., Egi, M., Orford, N. R., Glassford, N. J., Marik, P. E., & Bellomo, R. (2014) · Critical Care Medicine · doi:10.1097/ccm.0000000000000214 · Cited by 68
A systematic review supporting the endocrine society clinical practice guideline for the management of hyperglycemia in adults hospitalized for noncritical illness or undergoing elective surgical procedures
Seisa, M. O., Saadi, S., Nayfeh, T., Muthusamy, K., Shah, S. H., Firwana, M., Hasan, B., Jawaid, T., Abd-Rabu, R., Korytkowski, M. T., et al. (2022) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgac277 · Cited by 65
Barriers to the effective treatment of sepsis: antimicrobial agents, sepsis definitions, and host‐directed therapies
Lyle, N. H., Pena, O. M., Boyd, J. H., & Hancock, R. E. W. (2014) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12444 · Cited by 63
Management of hyperglycemia in hospitalized patients
Smiley, D. D., & Umpierrez, G. E. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05805.x · Cited by 65
A systematic scoping review on the consequences of stress-related hyperglycaemia
Olariu, E., Pooley, N., Danel, A., Miret, M., & Preiser, J. (2018) · PLoS ONE · doi:10.1371/journal.pone.0194952 · Cited by 64
Glucose management in critically ill adults and children
Mesotten, D., Preiser, J., & Kosiborod, M. (2015) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(15)00223-5 · Cited by 61
Inpatient Management of Hyperglycemia and Diabetes
Magaji, V., & Johnston, J. M. (2011) · Clinical Diabetes · doi:10.2337/diaclin.29.1.3 · Cited by 64
Dysglycemia and Glucose Control During Sepsis
Plummer, M. P., & Deane, A. M. (2016) · Clinics in Chest Medicine · doi:10.1016/j.ccm.2016.01.010 · Cited by 68
Glucose control in critical care
Clain, J. M. (2015) · World Journal of Diabetes · doi:10.4239/wjd.v6.i9.1082 · Cited by 65
An Elevated Glycemic Gap is Associated with Adverse Outcomes in Diabetic Patients with Acute Myocardial Infarction
Liao, W.-I., Lin, C., Lee, C., Wu, Y.-C., Chang, W., Hsu, C.-W., Wang, J., & Tsai, S. (2016) · Scientific Reports · doi:10.1038/srep27770 · Cited by 65
The association of admission blood glucose level with the clinical picture and prognosis in cardiogenic shock – Results from the CardShock Study
Kataja, A., Tarvasmäki, T., Lassus, J. P. E., Silva‐Cardoso, J., Mebazaa, A., Køber, L., Sionís, A., Špinar, J., Carubelli, V., Banaszewski, M., et al. (2016) · International Journal of Cardiology · doi:10.1016/j.ijcard.2016.10.033 · Cited by 60
Clinical aspects of changes in water and sodium homeostasis in the elderly
Koch, C. A., & Fülöp, T. (2017) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-017-9420-5 · Cited by 61
Machine learning for initial insulin estimation in hospitalized patients
Nguyen, M., Jankovic, I., Kalesinskas, L., Baiocchi, M., & Chen, J. H. (2021) · Journal of the American Medical Informatics Association · doi:10.1093/jamia/ocab099 · Cited by 59
Usefulness of glycated hemoglobin A1c-based adjusted glycemic variables in diabetic patients presenting with acute ischemic stroke
Yang, C., Liao, W.-I., Wang, J., Tsai, C., Lee, J.-T., Peng, G.-S., Lee, C., Hsu, C.-W., & Tsai, S. (2017) · The American Journal of Emergency Medicine · doi:10.1016/j.ajem.2017.03.049 · Cited by 56
Usefulness of the plasma glucose concentration-to-HbA1c ratio in predicting clinical outcomes during acute illness with extreme hyperglycaemia
Su, Y., Hsu, C., Guo, Y., & Chen, H.-S. (2016) · Diabetes & Metabolism · doi:10.1016/j.diabet.2016.07.036 · Cited by 56
Glucose Control, Diabetes Status, and Mortality in Critically Ill Patients
Krinsley, J. S., Maurer, P., Holewinski, S., Hayes, R. L., McComsey, D., Umpierrez, G. E., & Nasraway, S. A. (2017) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2017.04.015 · Cited by 58
Glycemic control in critically ill patients
Hsu, C.-W. (2012) · World Journal of Critical Care Medicine · doi:10.5492/wjccm.v1.i1.31 · Cited by 57
Novel Model to Predict Gastrointestinal Bleeding During Left Ventricular Assist Device Support
Yin, M. Y., Ruckel, S., Kfoury, A. G., McKellar, S. H., Taleb, I., Gilbert, E. M., Nativi-Nicolau, J. N., Stehlik, J., Reid, B. B., Koliopoulou, A. G., et al. (2018) · Circulation Heart Failure · doi:10.1161/circheartfailure.118.005267 · Cited by 54
Clinical review: Strict or loose glycemic control in critically ill patients - implementing best available evidence from randomized controlled trials
Schultz, M. J., Harmsen, R. E., & Spronk, P. E. (2010) · Critical Care · doi:10.1186/cc8966 · Cited by 53
Glucose control positively influences patient outcome: A retrospective study
Penning, S., Pretty, C. G., Preiser, J., Shaw, G. M., Desaive, T., & Chase, J. G. (2014) · Journal of Critical Care · doi:10.1016/j.jcrc.2014.12.013 · Cited by 54
Hyperglycemia and Physical Impairment in Frail Hypertensive Older Adults
Pansini, A., Lombardi, A., Morgante, M., Frullone, S., Marro, A., Rizzo, M., Martinelli, G., Boccalone, E., Luca, A. D., Santulli, G., et al. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.831556 · Cited by 54
Liberal Glycemic Control in Critically Ill Patients With Type 2 Diabetes: An Exploratory Study
Kar, P., Plummer, M. P., Bellomo, R., Jenkins, A. J., Januszewski, A. S., Chapman, M. J., Jones, K. L., Horowitz, M., & Deane, A. M. (2016) · Critical Care Medicine · doi:10.1097/ccm.0000000000001815 · Cited by 52
Heavy Metal in the Intensive Care Unit: A Review of Current Literature on Trace Element Supplementation in Critically Ill Patients
Rech, M., To, L., Tovbin, A., Smoot, T., & Mlynarek, M. (2014) · Nutrition in Clinical Practice · doi:10.1177/0884533613515724 · Cited by 50
Continuous Insulin Infusion: When, Where, and How?
Kelly, J. L. (2014) · Diabetes Spectrum · doi:10.2337/diaspect.27.3.218 · Cited by 53
Continuous glucose monitors
Lane, J. E., Shivers, J. P., & Zisser, H. (2013) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0b013e32835edb9d · Cited by 50
Medical Nutrition Therapy in Hospitalized Patients with Diabetes
Gosmanov, A. R., & Umpierrez, G. E. (2011) · Current Diabetes Reports · doi:10.1007/s11892-011-0236-5 · Cited by 48
Is Incretin-Based Therapy Ready for the Care of Hospitalized Patients With Type 2 Diabetes?
Umpierrez, G. E., & Korytkowski, M. (2013) · Diabetes Care · doi:10.2337/dc12-2233 · Cited by 49
Elevated Admission Glucose and Mortality in Patients With Acute Pulmonary Embolism
Scherz, N., Labarère, J., Aujesky, D., & Méan, M. (2011) · Diabetes Care · doi:10.2337/dc11-1379 · Cited by 46
Hyper/hypoglycemia and acute kidney injury in critically ill patients
Fiaccadori, E., Sabatino, A., Morabito, S., Bozzoli, L., Donadio, C., Maggiore, U., & Regolisti, G. (2015) · Clinical Nutrition · doi:10.1016/j.clnu.2015.04.006 · Cited by 47
Pharmacotherapy for Hyperglycemia in Noncritically Ill Hospitalized Patients
Mendez, C. E., & Umpierrez, G. E. (2014) · Diabetes Spectrum · doi:10.2337/diaspect.27.3.180 · Cited by 48
Intensive Insulin Therapy in the Neurocritical Care Setting is Associated with Poor Clinical Outcomes
Graffagnino, C., Gurram, A. R., Kolls, B. J., & Olson, D. M. (2010) · Neurocritical Care · doi:10.1007/s12028-010-9469-4 · Cited by 45
Update on glucose in critical care
Lheureux, O., Prevedello, D., & Preiser, J. (2018) · Nutrition · doi:10.1016/j.nut.2018.06.027 · Cited by 49
Insulin Therapy in Hospitalized Patients
Pérez, A., Ramos, A., & Carreras, G. (2019) · American Journal of Therapeutics · doi:10.1097/mjt.0000000000001078 · Cited by 47
Reexamining the evidence for inpatient glucose control: New recommendations for glycemic targets
Moghissi, E. S. (2010) · American Journal of Health-System Pharmacy · doi:10.2146/ajhp100171 · Cited by 45
Inpatient hyperglycemia management: A practical review for primary medical and surgical teams
Lansang, M. C., & Umpierrez, G. E. (2016) · Cleveland Clinic Journal of Medicine · doi:10.3949/ccjm.83.s1.06 · Cited by 46

Authors: Falciglia, M., Freyberg, R. W., Almenoff, P. L., D’Alessio, D. A., & Render, M. L.
Affiliations: University of Cincinnati (US)
Cincinnati VA Medical Center (US)
The University of Kansas Health System (US)
ORCID: Falciglia, Mercedes
D’Alessio, David A.
Venue: Critical Care Medicine
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2009-12
Volume: 37
Issue: 12
Pages: 3001-3009
ISSN: 0090-3493 (ISSN-L)
DOI: 10.1097/ccm.0b013e3181b083f7
PMC: PMC2905804
OpenAlex: W2025416505
Cited by: 576
References: 70
Citations by year: 2026: 20 · 2025: 24 · 2024: 24 · 2023: 32 · 2022: 37 · 2021: 33 · 2020: 33 · 2019: 35 · 2018: 32 · 2017: 42 · 2016: 43 · 2015: 50 · 2014: 50 · 2013: 28 · 2012: 28
FWCI: 22.51
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Critical Care Medicine (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: U.S. Department of Veterans Affairs
National Institute of Diabetes and Digestive and Kidney Diseases (DK K23 74440, DK R01 57900, R01DK057900, K23DK074440)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hyperglycemia and glycemic control in critically ill and hospitalized patients
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Intensive Care Unit Cognitive Disorders
Keywords: critically ill patients, mortality, admission diagnosis, intensive care unit, length of hospital stay, diabetes mellitus, acute myocardial infarction, cardiac arrhythmias, unstable angina, pulmonary embolism, risk-adjusted mortality, glycemia, intensive insulin therapy, disease severity, trauma, sepsis, respiratory failure, renal failure, liver failure
MeSH terms: Adult, Aged, Female, Humans, Hyperglycemia, Male, Middle Aged, Patient Admission, Retrospective Studies, Risk Factors, Cohort Studies, Critical Illness

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Hyperglycemia-related mortality in critically ill patients varies with admission diagnosis

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks