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Cited by 118Sepsis Diagnosis and TreatmentSelenium in Biological SystemsClinical Nutrition and Gastroenterology

The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.

The Effect of Selenium Therapy on Mortality in Patients With Sepsis Syndrome: A Systematic Review and Meta-Analysis of Randomized Controlled Trials*

Alhazzani, Waleed, Jacobi, Judith, Sindi, Anees, Hartog, Christiane, Reinhart, Konrad, Kokkoris, Stelios, Gerlach, Herwig, Andrews, Peter, Drabek, Tomas, Manzanares, William, Cook, Deborah J., Jaeschke, Roman Z.·2013·Critical Care Medicine
DOI 10.1097/ccm.0b013e31828a24c6
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Abstract

BACKGROUND: Patients with sepsis syndrome commonly have low serum selenium levels. Several randomized controlled trials have examined the efficacy of selenium supplementation on mortality in patients with sepsis. OBJECTIVE: To determine the efficacy and safety of high-dose selenium supplementation compared to placebo for the reduction of mortality in patients with sepsis. SOURCES OF DATA: We searched Cochrane Central Register of Controlled Trials, MEDLINE, EMBASE, SciFinder, and Clinicaltrials.gov. SELECTION CRITERIA: Randomized controlled parallel group trials comparing selenium supplementation in doses greater than daily requirement to placebo on the outcome of mortality in patients with sepsis syndrome. DATA COLLECTION AND ANALYSIS: Two reviewers independently applied eligibility criteria, assessed quality, and extracted data. The primary outcome was mortality; secondary outcomes were ICU length of stay, nosocomial pneumonia, and adverse events. Trial authors were contacted for additional or clarifying information. RESULTS: Nine trials enrolling a total of 792 patients were included. Selenium supplementation in comparison to placebo was associated with lower mortality (odds ratio, 0.73; 95% CI, 0.54, 0.98; p = 0.03; I = 0%). Among patients receiving and not receiving selenium, there was no difference in ICU length of stay (mean difference, 2.03; 95% CI, -0.51, 4.56; p = 0.12; I = 0%) or nosocomial pneumonia (odds ratio, 0.83; 95% CI, 0.28, 2.49; p = 0.74; I = 56%). Significant heterogeneity among trials in adverse event reporting precluded pooling of results. CONCLUSIONS: In patients with sepsis, selenium supplementation at doses higher than daily requirement may reduce mortality. We observed no impact of selenium on ICU length of stay or risk of nosocomial pneumonia.

Overview

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Registry

Crossref · 10.1097/ccm.0b013e31828a24c6

Cites

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Citations

Cites

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Research works printed but not linked: 3

  1. Dodig, 2004, Acta Pharm, 54, 261
  2. Forceville, 2001, Therapie, 56, 653
  3. Montoya, 2009, Rev Asoc Mex Med Crit y Ter Int, 23, 199

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Metadata

Authors
Alhazzani, W., Jacobi, J., Sindi, A., Hartog, C., Reinhart, K., Kokkoris, S., Gerlach, H., Andrews, P., Drabek, T., Manzanares, W., Cook, D. J., & Jaeschke, R. Z.
Affiliations
  • McMaster University (CA)
  • Methodist Hospital (US)
  • Jena University Hospital (DE)
  • Western General Hospital (GB)
  • Vivantes Klinikum (DE)
  • University of Edinburgh (GB)
  • Universidad de la República de Uruguay (UY)
ORCID
Venue
Critical Care Medicine
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2013-06
Volume
41
Issue
6
Pages
1555-1564
ISSN
0090-3493 (ISSN-L)
DOI
10.1097/ccm.0b013e31828a24c6
OpenAlex
W2071813212
Cited by
118
References
35
Citations by year
2026: 1 · 2025: 5 · 2024: 1 · 2023: 6 · 2022: 4 · 2021: 9 · 2020: 5 · 2019: 6 · 2018: 5 · 2017: 11 · 2016: 14 · 2015: 17 · 2014: 21 · 2013: 13
FWCI
2.57
Type
journal article
Language
en
Open access
closed
Locations
  • Critical Care Medicine (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Sepsis Diagnosis and Treatment
  • Health Sciences › Nursing › Nutrition and Dietetics › Selenium in Biological Systems
  • Health Sciences › Nursing › Nutrition and Dietetics › Clinical Nutrition and Gastroenterology
Keywords
selenium supplementation, sepsis, mortality, serum selenium, ICU length of stay, nosocomial pneumonia, adverse events, critically ill patients
MeSH terms
Antioxidants, Cross Infection, Humans, Intensive Care Units, Length of Stay, Pneumonia, Selenium, Randomized Controlled Trials as Topic, Systemic Inflammatory Response Syndrome

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