Probiotics enhance the clearance of human papillomavirus-related cervical lesions: a prospective controlled pilot study
Abstract
Probiotics have been proposed for a number of urogenital infectious conditions. In this study, we examine a possible effect on human papillomavirus (HPV)-related precancerous lesions in cervical cytology. We conducted a prospective controlled pilot study, in which 54 women with an HPV+low-grade squamous intraepithelial lesion diagnosis in their PAP smear were followed for 6 months. The intervention group consumed a daily probiotic drink during the study period; the control group received no treatment, according to common care policy. Outcome measures were the control PAP smear and HPV status after 6 months. Probiotic users had a twice as high chance of clearance of cytological abnormalities (60 vs. 31%, P=0.05). HPV was cleared in 19% of control patients versus 29% of probiotic users (P=0.41). This exploratory pilot study suggests that the probiotic studied promotes the clearance of HPV-related cytological abnormalities. If confirmed, this would represent an entirely new option to manage cervical cancer precursors.
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After daily consumption of a probiotic drink, HPV was cleared in 29% of patients using probiotics compared with 19% of control patients.
“The researchers concluded that after the daily consumption of a probiotic drink, HPV was cleared in 29% of the patients using the probiotics compared with 19% of the control patients [175].”
From The Potential Impact of Probiotics on Human Health: An Update on Their Health-Promoting Properties (2024) · cites this paper as [175]
In that study, HPV was cleared in 19% of control patients versus 29% of probiotic users (P=0.41).
“HPV was cleared in 19% of control patients versus 29% of probiotic users (P=0.41).”
From Viral Infections, the Microbiome, and Probiotics (2021) · cites this paper as Verhoeven et al., 2013
In a prospective controlled study of 54 women with HPV and low grade squamous intraepithelial lesion, after daily probiotic drink, intervention group had twice as high chance of clearance of cytological abnormalities compared to control (60 vs 31%, P=0.05).
“A prospective controlled study with 54 women with HPV and low grade squamous intraepithelial lesion diagnosis in their PAP smear were followed for 6 months (Verhoeven et al., 2013). After daily consumption of a probiotic drink, the intervention group had a twice as high chance of clearance of cytological abnormalities compared to the control group (60 vs. 31%, P=0.05).”
From Viral Infections, the Microbiome, and Probiotics (2021) · cites this paper as Verhoeven et al., 2013
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- Authors
- Verhoeven, V., Renard, N., Makar, A., Royen, P. V., Bogers, J.-P., Lardon, F., Peeters, M., & Baay, M.
- Affiliations
- ZNA Middelheim Hospital (BE)
- University of Antwerp (BE)
- Venue
- European Journal of Cancer Prevention
- Published
- 2013-01
- Volume
- 22
- Issue
- 1
- Pages
- 46-51
- ISSN
- 0959-8278 (ISSN-L)
- OpenAlex
- W1992893880
- Cited by
- 135
- References
- 32
- Citations by year
- 2026: 9 · 2025: 17 · 2024: 22 · 2023: 20 · 2022: 14 · 2021: 15 · 2020: 6 · 2019: 5 · 2018: 5 · 2017: 2 · 2016: 10 · 2015: 4 · 2014: 3 · 2013: 3
- FWCI
- 2.39
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Cancer Prevention (publishedVersion)
- PubMed (publishedVersion)
- Ghent University Academic Bibliography (Ghent University) (submittedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Cervical Cancer and HPV Research
- Life Sciences › Immunology and Microbiology › Microbiology › Reproductive tract infections research
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Keywords
- probiotics, human papillomavirus, low-grade squamous intraepithelial lesion, HPV clearance, cervical cancer precursors, probiotic beverages, cervical cytology, urogenital infections
- MeSH terms
- Adult, Uterine Cervical Neoplasms, Female, Humans, Pilot Projects, Prospective Studies, Up-Regulation, Neoplasms, Squamous Cell, Probiotics, Papillomaviridae, Papillomavirus Infections, Young Adult
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