Cited by 210Treatment of Major DepressionChild and Adolescent Psychosocial and Emotional DevelopmentAnxiety, Depression, Psychometrics, Treatment, Cognitive Processes

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Escitalopram in the Treatment of Adolescent Depression: A Randomized Placebo-Controlled Multisite Trial

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Emslie, Graham J., Ventura, Daniel, Korotzer, Andrew, Tourkodimitris, Stavros·2009·Journal of the American Academy of Child & Adolescent Psychiatry

DOI 10.1097/chi.0b013e3181a2b304

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Abstract

Objective This article presents the results from a prospective, randomized, double-blind, placebo-controlled trial of escitalopram in adolescent patients with major depressive disorder. Method Male and female adolescents (aged 12-17 years) with DSM-IV-defined major depressive disorder were randomly assigned to 8 weeks of double-blind treatment with escitalopram 10 to 20 mg/day (n = 155) or placebo (n = 157). The primary efficacy parameter was change from baseline to week 8 in Children's Depression Rating Scale-Revised (CDRS-R) score using the last observation carried forward approach. Results A total of 83% patients (259/312) completed 8 weeks of double-blind treatment. Mean CDRS-R score at baseline was 57.6 for escitalopram and 56.0 for placebo. Significant improvement was seen in the escitalopram group relative to the placebo group at endpoint in CDRS-R score (-22.1 versus -18.8, p =.022; last observation carried forward). Adverse events occurring in at least 10% of escitalopram patients were headache, menstrual cramps, insomnia, and nausea; only influenza-like symptoms occurred in at least 5% of escitalopram patients and at least twice the incidence of placebo (7.1% versus 3.2%). Discontinuation rates due to adverse events were 2.6% for escitalopram and 0.6% for placebo. Serious adverse events were reported by 2.6% and 1.3% of escitalopram and placebo patients, respectively, and incidence of suicidality was similar for both groups. Conclusions In this study, escitalopram was effective and well tolerated in the treatment of depressed adolescents.

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Self-citation

Authors: Emslie, G. J., Ventura, D., Korotzer, A., & Tourkodimitris, S.
Affiliations: The University of Texas Southwestern Medical Center (US)
Corresponding author: Emslie, Graham J.
ORCID: Emslie, Graham J.
Venue: Journal of the American Academy of Child & Adolescent Psychiatry
Publisher: Elsevier BV
Published: 2009-07
Volume: 48
Issue: 7
Pages: 721-729
ISSN: 0890-8567 (ISSN-L)
DOI: 10.1097/chi.0b013e3181a2b304
OpenAlex: W2003027810
Cited by: 210
References: 23
Citations by year: 2026: 10 · 2025: 12 · 2024: 14 · 2023: 12 · 2022: 17 · 2021: 12 · 2020: 10 · 2019: 16 · 2018: 11 · 2017: 9 · 2016: 11 · 2015: 5 · 2014: 9 · 2013: 17 · 2012: 16
FWCI: 10.29
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Journal of the American Academy of Child & Adolescent Psychiatry (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Keywords: escitalopram, adolescent depression, major depressive disorder, selective serotonin reuptake inhibitors, antidepressant efficacy, drug tolerability, adverse events, suicidality, Children's Depression Rating Scale-Revised
MeSH terms: Adolescent, Child, Major Depressive Disorder, Double-Blind Method, Female, Humans, Male, Patient Dropouts, Personality Assessment, Prospective Studies, Psychometrics, Citalopram, Adverse Drug Reaction Reporting Systems, Antidepressive Agents, Second-Generation

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Escitalopram in the Treatment of Adolescent Depression: A Randomized Placebo-Controlled Multisite Trial

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