A meta-analysis of risk of pregnancy loss and caffeine and coffee consumption during pregnancy
Abstract
BACKGROUND: Previous reports of the relationship between pregnancy loss and caffeine/coffee consumption have been inconsistent. OBJECTIVES: To evaluate the association between pregnancy loss and caffeine and coffee consumption. SEARCH STRATEGY: PubMed was searched for reports published before September 2014, with the keywords "caffeine," "coffee," "beverage," "miscarriage," "spontaneous abortion," and "fetal loss." SELECTION CRITERIA: Case-control and cohort studies were included when they had been reported in English, the exposure of interest was caffeine/coffee consumption during pregnancy, the outcome of interest was spontaneous abortion or fetal death, and multivariate-adjusted odds ratios (ORs) or risk ratios were provided or could be calculated. DATA COLLECTION AND ANALYSIS: Data were extracted and combined ORs calculated. MAIN RESULTS: Overall, 26 studies were included (20 of caffeine and eight of coffee). After adjustment for heterogeneity, caffeine consumption was associated with an increased risk of pregnancy loss (OR 1.32, 95% confidence interval [CI] 1.24-1.40), as was coffee consumption (OR 1.11, 95% CI 1.02-1.21). A dose-response analysis suggested that risk of pregnancy loss rose by 19% for every increase in caffeine intake of 150 mg/day and by 8% for every increase in coffee intake of two cups per day. CONCLUSIONS: Consumption of caffeine and coffee during pregnancy seems to increase the risk of pregnancy loss.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Li et al. meta-analysis found that the risk of pregnancy loss increased by 19% for every additional 150 mg of caffeine consumed per day and by 8% for every additional 2 cups of coffee (about 200 mg) per day.
“Similar findings were reported by Li et al. (127), who found in a separate meta-analysis of 26 studies that the risk of pregnancy loss increased by 19% for every additional 150 mg of caffeine consumed per day and by 8% for every additional 2 cups of coffee (about 200 mg) per day (127).”
From The Safety of Ingested Caffeine: A Comprehensive Review (2017) · cites this paper as [127]
Cites
Bias in meta-analysis detected by a simple, graphical test
Egger, M., Smith, G. D., Schneider, M., & Minder, C. (1997) · BMJ · doi:10.1136/bmj.315.7109.629 · Cited by 56,722 · see citing works
Meta-analysis in clinical trials
DerSimonian, R., & Laird, N. (1986) · Controlled Clinical Trials · doi:10.1016/0197-2456(86)90046-2 · Cited by 39,552 · see citing works
Statistical Aspects of the Analysis of Data From Retrospective Studies of Disease
(1959) · JNCI: Journal of the National Cancer Institute · doi:10.1093/jnci/22.4.719 · Cited by 14,689 · cited 1× · see citing works
“The random effects model was used as the pooling method if an obvious between-study heterogeneity (I(2) N 50%) was found [10]; otherwise, the fixed effects model was used [11].”
MethodMethods for Trend Estimation from Summarized Dose-Response Data, with Applications to Meta-Analysis
Greenland, S., & Longnecker, M. P. (1992) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a116237 · Cited by 2,353 · see citing works
Lohmueller, K. E., Pearce, C. L., Pike, M., Lander, E. S., & Hirschhorn, J. N. (2003) · Nature Genetics · doi:10.1038/ng1071 · Cited by 1,900 · see citing works
Generalized Least Squares for Trend Estimation of Summarized Dose–response Data
Orsini, N., Bellocco, R., & Greenland, S. (2006) · The Stata Journal Promoting communications on statistics and Stata · doi:10.1177/1536867x0600600103 · Cited by 1,245 · see citing works
Cumulative Meta-Analysis of Therapeutic Trials for Myocardial Infarction
Lau, J., Antman, E. M., Jimenez-Silva, J., Kupelnick, B., Mosteller, F., & Chalmers, T. C. (1992) · New England Journal of Medicine · doi:10.1056/nejm199207233270406 · Cited by 1,140 · see citing works
Risk factors for first trimester miscarriage—results from a UK-population-based case-control study
Maconochie, N., Doyle, P., Prior, S., & Simmons, R. (2007) · BJOG: An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.2006.01193.x · Cited by 387 · see citing works
Weng, X., Odouli, R., & Li, D.-K. (2008) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2007.10.803 · Cited by 279 · see citing works
Caffeine metabolism in the newborn
Aldridge, A., Aranda, J. V., & Neims, A. H. (1979) · Clinical Pharmacology & Therapeutics · doi:10.1002/cpt1979254447 · Cited by 268 · see citing works
Caffeine Intake and the Risk of First-Trimester Spontaneous Abortion
Cnattingius, S., Signorello, L. B., Annerén, G., Clausson, B., Ekbom, A., Ljunger, E., Blot, W. J., McLaughlin, J. K., Petersson, G., Rane, A., et al. (2000) · New England Journal of Medicine · doi:10.1056/nejm200012213432503 · Cited by 264 · see citing works
Cigarette, alcohol, and caffeine consumption: risk factors for spontaneous abortion
Rasch, V. (2003) · Acta Obstetricia Et Gynecologica Scandinavica · doi:10.1034/j.1600-0412.2003.00078.x · Cited by 259 · see citing works
Cigarette, alcohol, and coffee consumption and spontaneous abortion.
Armstrong, B., McDonald, A. D., & Sloan, M. (1992) · American Journal of Public Health · doi:10.2105/ajph.82.1.85 · Cited by 212 · see citing works
Moderate alcohol intake during pregnancy and risk of fetal death
Andersen, A. N., Andersen, P. K., Olsen, J., Grønbæk, M., & Strandberg‐Larsen, K. (2012) · International Journal of Epidemiology · doi:10.1093/ije/dyr189 · Cited by 176 · see citing works
Grosso, L. M., & Bracken, M. B. (2005) · Annals of Epidemiology · doi:10.1016/j.annepidem.2004.12.011 · Cited by 170 · see citing works
Effect of pregnancy on the pharmacokinetics of caffeine
Knutti, R., Rothweiler, H., & Schlatter, C. (1981) · European Journal of Clinical Pharmacology · doi:10.1007/bf00637512 · Cited by 168 · see citing works
Robinson, G. E. (2013) · Best Practice & Research Clinical Obstetrics & Gynaecology · doi:10.1016/j.bpobgyn.2013.08.012 · Cited by 142 · see citing works
Moderate Caffeine Use and the Risk of Spontaneous Abortion and Intrauterine Growth Retardation
Mills, J. L. (1993) · JAMA · doi:10.1001/jama.1993.03500050071028 · Cited by 134 · see citing works
Fernandes, O. A., Sabharwal, M., Smiley, T., Pastuszak, A. L., Koren, G., & Einarson, T. R. (1998) · Reproductive Toxicology · doi:10.1016/s0890-6238(98)00024-0 · Cited by 128 · see citing works
Caffeine consumption during pregnancy and association with late spontaneous abortion
Srisuphan, W., & Bracken, M. B. (1986) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(86)90385-6 · Cited by 115 · see citing works
Fetal Loss Associated With Caffeine Intake Before and During Pregnancy
Infante‐Rivard, C. (1993) · JAMA · doi:10.1001/jama.1993.03510240052031 · Cited by 114 · see citing works
Risk Factors for Early Pregnancy Loss
Wilcox, A. J., Weinberg, C. R., & Baird, D. D. (1990) · Epidemiology · doi:10.1097/00001648-199009000-00008 · Cited by 94 · see citing works
The Associations of Maternal Caffeine Consumption and Nausea with Spontaneous Abortion
Wen, W., Shu, X., Jacobs, D. R., & Brown, J. E. (2001) · Epidemiology · doi:10.1097/00001648-200101000-00008 · Cited by 90 · see citing works
Maternal Caffeine Consumption and Spontaneous Abortion
Dlugosz, L., Belanger, K. D., HELLENBRAND, K. G., Holford, T. R., Leaderer, B. P., & Bracken, M. B. (1996) · Epidemiology · doi:10.1097/00001648-199605000-00006 · Cited by 87 · see citing works
Caffeine Consumption during Pregnancy and Spontaneous Abortion
Fenster, L., Eskenazi, B., Windham, G. C., & Swan, S. H. (1991) · Epidemiology · doi:10.1097/00001648-199105000-00002 · Cited by 87 · see citing works
The effect of caffeine consumption and nausea on the risk of miscarriage
Giannelli, M., Doyle, P., Roman, E., Pelerin, M., & Hermon, C. (2003) · Paediatric and Perinatal Epidemiology · doi:10.1046/j.1365-3016.2003.00523.x · Cited by 83 · see citing works
Risk factors for unexplained recurrent spontaneous abortion in a population from southern China
Zhang, B. Y., Wei, Y., Niu, J., Li, Y., Miao, Z., & Zi-neng, W. (2009) · International Journal of Gynecology & Obstetrics · doi:10.1016/j.ijgo.2009.09.019 · Cited by 78 · see citing works
Savitz, D. A., Chan, R. L., Herring, A. H., Howards, P. P., & Hartmann, K. E. (2008) · Epidemiology · doi:10.1097/ede.0b013e31815c09b9 · Cited by 77 · see citing works
Caffeine intake during pregnancy, late miscarriage and stillbirth
Greenwood, D. C., Alwan, N., Boylan, S., Cade, J. E., Charvill, J., Chipps, K. C., Cooke, M. S., Dolby, V. A., Hay, A. W. M., Kassam, S., et al. (2010) · European Journal of Epidemiology · doi:10.1007/s10654-010-9443-7 · Cited by 74 · see citing works
Caffeinated Beverages, Decaffeinated Coffee, and Spontaneous Abortion
Fenster, L., Hubbard, A., Swan, S. H., Windham, G. C., Waller, K., Hiatt, R. A., & Benowitz, N. L. (1997) · Epidemiology · doi:10.1097/00001648-199709000-00008 · Cited by 72 · see citing works
Spontaneous abortion in a hospital population: Are tobacco and coffee intake risk factors?
Rojas, V. D., de Juanes-Pardo, J. R., Astasio, P., Molina, P. O., & Gordillo-Florencio, E. (1994) · European Journal of Epidemiology · doi:10.1007/bf01719278 · Cited by 71 · see citing works
Inhibition of Cyclic Nucleotide Phosphodiesterases by Methylxanthines and Related Compounds
Francis, S. H., Sekhar, K. R., Ke, H., & Corbin, J. D. (2010) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-13443-2_4 · Cited by 68 · see citing works
Effects of Caffeine Ingestion during Pregnancy
Furuhashi, N., Sato, S., Suzuki, M., HIRUTA, M., Tanaka, M., & Takahashi, T. (2010) · Gynecologic and Obstetric Investigation · doi:10.1159/000299032 · Cited by 62 · see citing works
A prospective study of maternal smoking and spontaneous abortion
Wisborg, K., Kesmodel, U. S., Henriksen, T. B., Hedegaard, M. S., & Secher, N. J. (2003) · Acta Obstetricia Et Gynecologica Scandinavica · doi:10.1034/j.1600-0412.2003.00244.x · Cited by 55 · see citing works
Maternal caffeine consumption and sine causa recurrent miscarriage
Stefanidou, E., Caramellino, L., Patriarca, A., & Menato, G. (2011) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2011.04.024 · Cited by 52 · see citing works
Coffee consumption and risk of hospitalized miscarriage before 12 weeks of gestation
Parazzini, F., Chatenoud, L., Cintio, E. D., Mezzopane, R., Surace, M., Zanconato, G., Fedele, L., & Benzi, G. (1998) · Human Reproduction · doi:10.1093/humrep/13.8.2286 · Cited by 46 · see citing works
Discacciati, A., Orsini, N., & Wolk, A. (2013) · Annals of Oncology · doi:10.1093/annonc/mdt420 · Cited by 42 · see citing works
Maternal caffeine consumption and fetal death: a case–control study in Uruguay
Matijasevich, A., Barros, F. C., Santos, I. S., & Yemini, A. (2006) · Paediatric and Perinatal Epidemiology · doi:10.1111/j.1365-3016.2006.00706.x · Cited by 34 · see citing works
Risk Factors for Spontaneous Abortion: A Preliminary Study on Saudi Women
Al‐Ansary, L. A., & Babay, Z. A. (1994) · Journal of the Royal Society of Health · doi:10.1177/146642409411400403 · Cited by 26 · see citing works
Nonaka, T., Takakuwa, K., & Tanaka, K. (2011) · Journal of obstetrics and gynaecology research · doi:10.1111/j.1447-0756.2011.01529.x · Cited by 13 · see citing works
Agnesi, R., Valentini, F., Fedeli, U., Rylander, R., Meneghetti, M., Fadda, E., Buja, A., & Mastrangelo, G. (2010) · European Journal of Public Health · doi:10.1093/eurpub/ckq073 · Cited by 11 · see citing works
Caffeine as base analogue of adenine or guanine: A theoretical study
Ebrahimi, A. A., Habibi‐Khorassani, S. M., Akher, F. B., Farrokhzadeh, A., & Karimi, P. (2013) · Journal of Molecular Graphics and Modelling · doi:10.1016/j.jmgm.2013.02.012 · Cited by 7 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Coffee consumption and health: umbrella review of meta-analyses of multiple health outcomes
Poole, R., Kennedy, O. J., Roderick, P., Fallowfield, J. A., Hayes, P. C., & Parkes, J. (2017) · BMJ · doi:10.1136/bmj.j5024 · Cited by 835 · see citing works
The Safety of Ingested Caffeine: A Comprehensive Review
Temple, J. L., Bernard, C., Lipshultz, S. E., Czachor, J. D., Westphal, J. A., & Mestre, M. A. (2017) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2017.00080 · Cited by 557 · see citing works
Coffee, Caffeine, and Health Outcomes: An Umbrella Review
Grosso, G., Godos, J., Galvano, F., & Giovannucci, E. L. (2017) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-071816-064941 · Cited by 531 · see citing works
Macronutrient and Micronutrient Intake during Pregnancy: An Overview of Recent Evidence
Mousa, A., Naqash, A., & Lim, S. S. (2019) · Nutrients · doi:10.3390/nu11020443 · Cited by 449 · see citing works
Koletzko, B. V., Cremer, M., Flothkötter, M., Gräf, C., Hauner, H., Hellmers, C., Kersting, M., Krawinkel, M. B., Przyrembel, H., Röbl-Mathieu, M., et al. (2018) · Geburtshilfe und Frauenheilkunde · doi:10.1055/a-0713-1058 · Cited by 141 · see citing works
Influence of Various Factors on Caffeine Content in Coffee Brews
Olechno, E., Puścion‐Jakubik, A., Zujko, M. E., & Socha, K. (2021) · Foods · doi:10.3390/foods10061208 · Cited by 99 · see citing works
Factors associated with spontaneous abortion: a cross-sectional study of Chinese populations
Zheng, D., Li, C., Wu, T., & Tang, K. (2017) · Reproductive Health · doi:10.1186/s12978-017-0297-2 · Cited by 93 · see citing works
James, J. E. (2020) · BMJ Evidence-Based Medicine · doi:10.1136/bmjebm-2020-111432 · Cited by 98 · see citing works
Zhou, H., Liu, Y., Liu, L., Zhang, M., Chen, X., & Qi, Y. (2016) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2016.07.514 · Cited by 70 · see citing works
Lyngsø, J., Ramlau‐Hansen, C. H., Bay, B., Ingerslev, H. J., Hulmán, Á., & Kesmodel, U. S. (2017) · Clinical Epidemiology · doi:10.2147/clep.s146496 · Cited by 60 · see citing works
Dörsam, A. F., Preissl, H. T., Micali, N., Lörcher, S. B., Zipfel, S., & Giel, K. E. (2019) · Nutrients · doi:10.3390/nu11040840 · Cited by 55 · see citing works
Caffeine Intake During Pregnancy and Neonatal Anthropometric Parameters
Wierzejska, R. E., Jarosz, M. J., & Wojda, B. K. (2019) · Nutrients · doi:10.3390/nu11040806 · Cited by 45 · see citing works
Oechsle, A., Wensing, M., Ullrich, C., & Bombana, M. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17228626 · Cited by 43 · see citing works
Physiologically Based Pharmacokinetic/Pharmacodynamic Model for Caffeine Disposition in Pregnancy
Darakjian, L. I., & Kaddoumi, A. (2019) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.8b01276 · Cited by 34 · see citing works
Rossen, L., Mattick, R. P., Wilson, J., Clare, P. J., Burns, L., ALLSOP, S. J., Elliott, E. J., Jacobs, S., Olsson, C. A., & Hutchinson, D. M. (2019) · Maternal and Child Health Journal · doi:10.1007/s10995-019-02809-1 · Cited by 32 · see citing works
Pereira‐Figueiredo, D., Nascimento, A., Cunha-Rodrigues, M. C., Brito, R., & Calaza, K. D. C. (2021) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-021-01077-4 · Cited by 33 · see citing works
Lv, F., Fan, G., Wan, Y., Chen, Y., Ni, Y., Huang, J., Xu, D., Zhang, W., & Wang, H. (2021) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2021.147691 · Cited by 32 · see citing works
Chen, L., Murrin, C. M., Mehegan, J., Kelleher, C. C., & Phillips, C. M. (2019) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqz019 · Cited by 30 · see citing works
A Meta-Analysis of Erectile Dysfunction and Alcohol Consumption
Li, S., Song, J., Zhang, K., & Zhang, C. (2021) · Urologia Internationalis · doi:10.1159/000508171 · Cited by 28 · see citing works
Leviton, A. (2018) · Nutrients · doi:10.3390/nu10091152 · Cited by 27 · see citing works
Rah, Y. C., Yoo, M. H., Choi, J., Park, S., Park, H., Oh, K. H., Lee, S. H., & Kwon, S. Y. (2017) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2017.08.003 · Cited by 26 · see citing works
Min, H., Youn, E., & Shim, Y. (2020) · Nutrients · doi:10.3390/nu12051334 · Cited by 24 · see citing works
Jafari, A., Naghshi, S., Shahinfar, H., Salehi, S. O., Kiany, F., Askari, M., Surkan, P. J., & Azadbakht, L. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.886224 · Cited by 24 · see citing works
Kawanishi, Y., Kakigano, A., Kimura, T., Ikehara, S., Sato, T., Tomimatsu, T., Kimura, T., Iso, H., & on behalf of the Japan Environment and Children’s Study Group (2021) · Nutrients · doi:10.3390/nu13020343 · Cited by 20 · see citing works
Nkrumah, I., North, M., Kothe, E. J., Chai, T. L., Pirotta, S., Lim, S. S., & Hill, B. (2020) · Journal of Midwifery & Women s Health · doi:10.1111/jmwh.13112 · Cited by 20 · see citing works
Caffeine content in newborn hair correlates with maternal dietary intake
Lehtonen, A., Uusitalo, L., Auriola, S. O. K., Backman, K., Heinonen, S. T., Keski‐Nisula, L., Pasanen, M., Pekkanen, J., Tuomainen, T., Voutilainen, R., et al. (2020) · European Journal of Nutrition · doi:10.1007/s00394-020-02231-2 · Cited by 18 · see citing works
Corrales-Gutiérrez, I., Antequera, F. B., Gómez‐Baya, D., León-Larios, F., & Berjano, R. M. (2022) · Nutrients · doi:10.3390/nu14030557 · Cited by 18 · see citing works
Ahmed, R. G. (2018) · Toxicology Research · doi:10.1039/c8tx00227d · Cited by 18 · see citing works
Surma, S., & Witek, A. (2022) · Ginekologia Polska · doi:10.5603/gp.a2022.0061 · Cited by 17 · see citing works
Environmental factors affecting pregnancy outcomes
Sakali, A.-K., Papagianni, M., Bargiota, Α., Rašić-Marković, A., Μacut, D., & Mastorakos, G. P. (2023) · Endocrine · doi:10.1007/s12020-023-03307-9 · Cited by 17 · see citing works
Antenatal Care: A Comparative Review of Guidelines
Boureka, E., Tsakiridis, I., Kostakis, N., Giouleka, S., Mamopoulos, A., Kalogiannidis, I., Athanasiadis, A., & Dagklis, T. (2024) · Obstetrical & Gynecological Survey · doi:10.1097/ogx.0000000000001261 · Cited by 17 · see citing works
Lamy, S., Houivet, E., Bénichou, J., Marret, S., Thibaut, F., & for the Perinatal network of Upper-Normandy (2020) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-020-01105-2 · Cited by 17 · see citing works
Wootton, R., Lawn, R., Magnus, M., Treur, J., Corfield, E., Njølstad, P., Andreassen, O., Lawlor, D., Munafo, M., Håberg, S., et al. (2023) · BMC Medicine · doi:10.1186/s12916-023-02831-9 · Cited by 16 · see citing works
Beverages – a scoping review for Nordic Nutrition Recommendations 2023
Sonestedt, E., & Lukic, M. (2024) · Food & Nutrition Research · doi:10.29219/fnr.v68.10458 · Cited by 16 · see citing works
António, J., Antonio, B. B., Arent, S. M., Candow, D. G., Escalante, G., Evans, C., Forbes, S. C., Fukuda, D. H., Gibbons, M., Harty, P. S., et al. (2024) · Nutrients · doi:10.3390/nu17010067 · Cited by 18 · see citing works
Caffeine Intake during Pregnancy: What Are the Real Evidences?
Paula, T. D. M. D. E., Shang, F. L. T., Chiarini‐Garcia, H., & de Almeida, F. R. C. L. (2017) · Journal of Pharmacy and Pharmacology · doi:10.17265/2328-2150/2017.05.004 · Cited by 16 · see citing works
Maternal coffee intake and the risk of bleeding in early pregnancy: a cross-sectional analysis
Choi, H., Koo, S., & Park, H. (2020) · BMC Pregnancy and Childbirth · doi:10.1186/s12884-020-2798-1 · Cited by 15 · see citing works
Pregnancy-PBPK models: How are biochemical and physiological processes integrated?
Thépaut, É., Brochot, C., Chardon, K., Personne, S., & Zeman, F. (2023) · Computational Toxicology · doi:10.1016/j.comtox.2023.100282 · Cited by 14 · see citing works
Kukkonen, A., Hantunen, S., Voutilainen, A., Ruusunen, A. A., Backman, K., Kirjavainen, P. V., Ylilauri, M. P., Voutilainen, R., Pasanen, M., & Keski‐Nisula, L. (2024) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-024-07538-7 · Cited by 14 · see citing works
The Fetal Effect of Maternal Caffeine Consumption During Pregnancy—A Review
Dube, R., Kar, S. S., Bahutair, S. N., Goud, M., Shafi, S., Zaidi, H., Garg, H. C., Almas, Y. M., Kidwai, A., Zalat, R. A. F., et al. (2025) · Biomedicines · doi:10.3390/biomedicines13020390 · Cited by 13 · see citing works
Mannucci, C., Attard, E., Calapai, F., Facchinetti, F., D’Anna, R., Vannacci, A., Santamaria, A., Lenti, M. C., Righi, M., Perone, M., et al. (2020) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.1080/14767058.2020.1849120 · Cited by 13 · see citing works
COFFEE: A HEALTH FUEL-BLOT POPULAR DRINKING
Islam, M. T., de Alencar, M. V. O. B., Oliveira, G. A. L. D., da Mata, A. M. O. F., Silva, S. W. C., Paz, M. F. C. J., & Cavalcante, A. A. D. C. M. (2016) · International Journal of Pharmacy and Pharmaceutical Sciences · Cited by 12 · see citing works
Lee, Y., Choi, S., & Jung, H. (2022) · Risk Management and Healthcare Policy · doi:10.2147/rmhp.s360407 · Cited by 12 · see citing works
Román‐Gálvez, M. R., Martín‐Peláez, S., Hernández-Martínez, L., Ibáñez, N. C., Olmedo‐Requena, R., Martínez‐Galiano, J. M., Bueno‐Cavanillas, A., & Amezcua‐Prieto, C. (2022) · Nutrients · doi:10.3390/nu14245384 · Cited by 12 · see citing works
Aagaard, S. K., Larsen, A., Andreasen, M. F., Lesnikova, I., Telving, R., Vestergaard, A. L., Tørring, N., Uldbjerg, N., & Bor, P. (2018) · BMJ Open · doi:10.1136/bmjopen-2017-018390 · Cited by 12 · see citing works
Caffeine exposure during pregnancy: Is it safe?
Baptiste-Roberts, K., & Leviton, A. (2020) · Seminars in Fetal and Neonatal Medicine · doi:10.1016/j.siny.2020.101174 · Cited by 10 · see citing works
Risk score to stratify miscarriage risk levels in preconception women
Choo, X. H., Ku, C. W., Cheung, Y. B., Godfrey, K. M., Chong, Y. S., Shek, L. P., Tan, K. H., Tan, T. C., Nadarajah, S., Yap, F. K. P., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-91567-8 · Cited by 9 · see citing works
Borron, S. W., Watts, S. H., Herrera, J., Larson, J., Baeza, S., & Kingston, R. L. (2018) · Regulatory Toxicology and Pharmacology · doi:10.1016/j.yrtph.2018.05.008 · Cited by 9 · see citing works
Holakouie‐Naieni, K., Nematollahi, S., Mansournia, M. A., Shekari, M., Agha-Molayi, T., Alavi, A., Madani, A.-H., Holakouie-Naieni, N., Shabkhiz, H., Torabi, E., et al. (2018) · Europe PMC (PubMed Central) · Cited by 7 · see citing works
Bombana, M., Wensing, M., Wittenborn, L., & Ullrich, C. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph191811674 · Cited by 7 · see citing works
Misbeliefs and Biases in Health-Related Searches
Bondarenko, A., Shirshakova, E., Driker, M., Hagen, M., & Braslavski, P. (2021) · ACM International Conference on Information and Knowledge Management (CIKM) · doi:10.1145/3459637.3482141 · Cited by 6 · see citing works
Bunch, K. T., Peterson, M. B., Smith, M. B., & Bunch, T. J. (2023) · Current Cardiovascular Risk Reports · doi:10.1007/s12170-023-00716-3 · Cited by 6 · see citing works
Actividades preventivas en la mujer. Actualización PAPPS 2018
García‐Franco, A. L., Fernández, J. A. B., Muñoz, E. B., Piñeiro, M. J. I., del Cura-González, I., del Moral, A. O., Goñi, J. L., Alonso‐Coello, P., & Mir, L. A. (2018) · Atención Primaria · doi:10.1016/s0212-6567(18)30366-4 · Cited by 6 · see citing works
Prevalence and consumption pattern of kolanut among pregnant women in Ibadan metropolis
Atiba, F. A., Popoola, O. A., Odukogbe, A. A., & Ihunwo, A. O. (2023) · Scientific Reports · doi:10.1038/s41598-023-41754-6 · Cited by 5 · see citing works
EVALUATION OF CAFFEINE CONSUMPTION AND EFFECT DURING PREGNANCY AMONG WOMEN IN THE UAE
Alomar, M. J. (2016) · International Journal of Pharmacy and Pharmaceutical Sciences · Cited by 5 · see citing works
TLC Procedure for Determination of Approximate Contents of Caffeine in Food and Beverages
Palacios, C., Salatino, M. L. F., & Salatino, A. (2017) · World journal of chemical education · doi:10.12691/wjce-5-5-1 · Cited by 5 · see citing works
Maternal Caffeine Consumption and Racial Disparities in Fetal Telomere Length
Griffin, I. S., Ibrahimou, B., Navejar, N., Aggarwal, A., Myers, K. O., Mauck, D. E., Yusuf, K. K., Wudil, U. J., Aliyu, M. H., & Salihu, H. M. (2019) · International Journal of Maternal and Child Health and AIDS · doi:10.21106/ijma.290 · Cited by 4 · see citing works
Lisowska, A., Kasiak, P. S., & Rząca, M. (2023) · Clinical Nutrition ESPEN · doi:10.1016/j.clnesp.2023.06.041 · Cited by 4 · see citing works
Mak, J. K. L., Chau, Y.-P., Tan, K. C. B., Kung, A. W.-C., & Cheung, C. (2024) · Nutrients · doi:10.3390/nu16203536 · Cited by 4 · see citing works
Trans-ancestral Genome Wide Association Study of Sporadic and Recurrent MiscarriagePreprint
Reynoso, A., Nandakumar, P., Shi, J., Bielenberg, J., Holmes, M. V., & Aslibekyan, S. W. (2024) · medRxiv · doi:10.1101/2024.03.20.24304624 · Cited by 4 · see citing works
The regular consumption of coffee and development of type 2 diabetes mellitus
Al-Mssallem, M. Q. (2019) · Journal of Public Health · doi:10.1007/s10389-019-01055-7 · Cited by 3 · see citing works
Actividades preventivas en la mujer. Actualización PAPPS 2020
García‐Franco, A. L., Fernández, J. A. B., Muñoz, E. B., Piñeiro, M. J. I., del Moral, A. O., Alonso‐Coello, P., Cabello, C. R., Goñi, J. L., & Mir, L. A. (2020) · Atención Primaria · doi:10.1016/j.aprim.2020.09.001 · Cited by 3 · see citing works
Boeck, C. R., & da Silva, R. S. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-89773-0.00025-4 · Cited by 3 · see citing works
Habitual Coffee Consumption and Systemic Health Outcomes: A Comprehensive Review
Kwapien, E., Piszka, M., Czarnecki, F., Mesyasz, M., Owczarska, A., Dacyl, H., Banach, J., Kasprzyk, W. Z., Luczak, J. K., & Bartkowski, J. (2025) · Cureus · doi:10.7759/cureus.99094 · Cited by 2 · see citing works
Actividades preventivas en la mujer. Actualización PAPPS 2022
García‐Franco, A. L., Fernández, J. A. B., Piñeiro, M. J. I., Alonso‐Coello, P., Cabello, C. R., Iglesias, A. P., & Goñi, J. L. (2022) · Atención Primaria · doi:10.1016/j.aprim.2022.102471 · Cited by 2 · see citing works
Al-Ebadi, H. N. A., & Ali, I. K. A. (2022) · Iraqi National Journal of Nursing Specialties · doi:10.58897/injns.v34i2.572 · Cited by 3 · see citing works
The protective role of melatonin against the effect of caffeine on embryonic kidney
Yılmaz, S., Göçmen, A. Y., Üner, A. K., Akyüz, E., & Tokpınar, A. (2020) · Turkish Bulletin of Hygiene and Experimental Biology · doi:10.5505/turkhijyen.2020.77675 · Cited by 2 · see citing works
Myszkowska-Ryciak, J. (2025) · Journal of Health Inequalities · doi:10.5114/jhi.2025.150928 · Cited by 1 · see citing works
Maternal Caffeine Consumption and Pregnancy Outcomes
James, J. E. (2026) · Advances in experimental medicine and biology · doi:10.1007/978-3-032-12741-9_10 · Cited by 1 · see citing works
Nutrition and Pregnancy-Current Knowledge and Further Perspectives
Bala, C. G., Preda, A. P., & Kovács, T. (2017) · Romanian Journal of Diabetes Nutrition and Metabolic Diseases · doi:10.1515/rjdnmd-2017-0022 · Cited by 1 · see citing works
Pregnancy and Contraception in Central Hypersomnolence Disorders
Pascoe, M., & Foldvary‐Schaefer, N. (2021) · Current Sleep Medicine Reports · doi:10.1007/s40675-021-00221-2 · Cited by 1 · see citing works
Uechi, K., Arakaki, S., & Sasaki, S. (2022) · Journal of obstetrics and gynaecology research · doi:10.1111/jog.15461 · Cited by 1 · see citing works
Consumo de cafeína: o que aconselhar na preconceção e gravidez?
Médica Interna de Medicina Geral e Familiar.USF Novo Sentido, A. P. O., Matias, F., Jeri, A., Médica Interna de Medicina Geral e Familiar.USF Barão de Nova Sintra, A. P. O., Rodrigues, S. E., & Médica Interna de Medicina Geral e Familiar.USF Novo Sentido, A. P. O. (2017) · Revista Portuguesa de Clínica Geral · doi:10.32385/rpmgf.v33i1.12024 · Cited by 1 · see citing works
Social opportunity on coffee shop
Surya, N. K. A. R. (2019) · International journal of life sciences & earth sciences · doi:10.31295/ijle.v2n1.74 · Cited by 1 · see citing works
Central Nervous System Stimulants and Drugs That Suppress Appetite
Zahner, M. R., & Bello, N. T. (2016) · Side effects of drugs annual · doi:10.1016/bs.seda.2016.07.007
Nutritional aspects of behaviour and biology during pregnancy and postpartum
Lundqvist, A. (2016) · KTH Publication Database DiVA (KTH Royal Institute of Technology)
The Effect of Caffeine on Pregnancy-Fact or Myth?
Woldu, M. A. (2017) · Journal of Pregnancy and Child Health · doi:10.4172/2376-127x.1000333
Central Nervous System Stimulants and Drugs That Suppress Appetite
Bello, N. T., & Zahner, M. R. (2017) · Side effects of drugs annual · doi:10.1016/bs.seda.2017.07.007
Coffee: Does it Make Things Better?
Sarla, G. S. (2019) · Zenodo (CERN European Organization for Nuclear Research) · doi:10.5281/zenodo.3403487
Preconception and Pregnancy Health
Scott, M. L., & Stuart, L. (2020) · Elsevier eBooks · doi:10.1016/b978-0-323-43044-9.00211-9
Prevention and Management of Preterm Birth
Hayashi, M. (2020) · Nihon Ika Daigaku Igakkai Zasshi · doi:10.1272/manms.16.138
Wootton, R. E., Lawn, R., Magnus, M., Treur, J., Corfield, E., Njølstad, P., Andreassen, O., Lawlor, D., Munafò, M., Håberg, S., et al. (2022) · medRxiv · doi:10.1101/2022.03.22.22272772 · Cited by 1 · see citing works
Self-care Mobile Application for Pregnant Women at Work: Development and Usability Study (Preprint)Preprint
Lee, Y., Choi, S., & Jung, H. (2021) · doi:10.2196/preprints.27929
Yuan, S., Liu, J., & Larsson, S. C. (2022) · Fertility and Sterility · doi:10.1016/j.fertnstert.2022.09.023
Environmental Impact on Female Fertility and Pregnancy
Sakali, A.-K., Bargiota, Α., Papagianni, M., Rašić-Marković, A., & Mastorakos, G. P. (2023) · Endocrinology · doi:10.1007/978-3-030-38366-4_6-1
Environmental Impact on Female Fertility and Pregnancy
Sakali, A.-K., Bargiota, Α., Papagianni, M., Rašić-Marković, A., & Mastorakos, G. P. (2023) · Endocrinology · doi:10.1007/978-3-030-39044-0_6
Patel, P. H., & Burow, C. A. (2023) · Undergraduate Research in Natural and Clinical Science and Technology (URNCST) Journal · doi:10.26685/urncst.480
A Study of the Effect of Dietary Intake on the Health Status of Pregnant Women
(2023) · Middle East Journal of Applied Sciences · doi:10.36632/mejas/2023.13.3.23
Osman, M. M. A., Mullins, E., & Lees, C. C. (2024) · Journal of Hypertension · doi:10.1097/hjh.0000000000003734
NUTRIENTS' DEFICIENCY RISKS IN PREGNANT WOMEN DUE TO THEIR EATING HABITS
Chamova, R., & Panteleeva, M. (2024) · Journal of IMAB - Annual Proceeding (Scientific Papers) · doi:10.5272/jimab.2024303.5696
Coffee and tea consumption and pregnancy
Eshak, E. S., Teramoto, M., & Iso, H. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-13868-3.00020-x
Comparing coffee and tea consumption regarding DNA methylation
Budán, F., Szabó, L. G., Máthé, D., Szentpéteri, J. L., Szép, D., & Attila Gabor, S. I. K. (2024) · Coffee in Health and Disease Prevention · doi:10.1016/b978-0-443-13868-3.00011-9
Genetics of Recurrent Miscarriage and Pregnancy Loss in Women’s Reproductive HealthPreprint
Mirakbarova, Z., Pascat, V., Akramkhanova, S., Chu, C.-Y., Yusupov, U., Scapoli, C., Rakhmatullaev, A. I., Kapralova, Y., Nishanova, S., Nazirova, M., et al. (2025) · medRxiv · doi:10.1101/2025.02.15.25321247
Coffee – Influence on the Course of Pregnancy and the Health of the Mother and Child
Romańczyk, M., Surma, S., & Witek, A. (2025) · Royal Society of Chemistry eBooks · doi:10.1039/9781839166853-00367
Djordjevic, N. (2025) · Royal Society of Chemistry eBooks · doi:10.1039/9781839166853-00341
The impact of caffeine consumption on reproductive health. A literature review
Stawińska-Dudek, J., Brzoza, M., Bielecka, A., Aboud, A., & Stawińśka, K. (2025) · Polski Merkuriusz Lekarski · doi:10.36740/merkur202503119
Jabiry‐Zieniewicz, Z., Zembala, J., & Forma, A. (2025) · Springer eBooks · doi:10.1007/978-3-031-93459-9_11
Coffee: Threats and Recommendations During Pregnancy
Bytyçi, I., Surma, S., & Banach, M. (2025) · Springer eBooks · doi:10.1007/978-3-031-93459-9_41
Zhou, X., Fang, Y., Zhang, D.-W., Ma, L., & Yao, M.-M. (2025) · Medicine · doi:10.1097/md.0000000000045981
Wootton, R. E., Lawn, R. B., Magnus, M. C., Treur, J. L., Corfield, E. C., Njølstad, P. R., Andreassen, O. A., Lawlor, D. A., Munafo, M. R., Håberg, S. E., et al. (2023) · Figshare · doi:10.6084/m9.figshare.22623325
- Authors
- Li, J., Zhao, H., Song, J., Zhang, J., Tang, Y., & Xin, C.
- Affiliations
- Anhui Medical University (CN)
- Jiangsu Provincial Hospital of Traditional Chinese Medicine (CN)
- Kunming Medical University (CN)
- Second Affiliated Hospital of Anhui Medical University (CN)
- Corresponding author
- Xin, Chang‐Mao
- Venue
- International Journal of Gynecology & Obstetrics
- Publisher
- Wiley
- Published
- 2015-05-14
- Volume
- 130
- Issue
- 2
- Pages
- 116-122
- ISSN
- 0020-6695 (ISSN-L)
- 0020-7292
- 1879-3479
- OpenAlex
- W1632849677
- Cited by
- 102
- References
- 42
- Citations by year
- 2026: 3 · 2025: 10 · 2024: 10 · 2023: 11 · 2022: 12 · 2021: 9 · 2020: 13 · 2019: 10 · 2018: 7 · 2017: 12 · 2016: 5
- FWCI
- 1.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- International Journal of Gynecology & Obstetrics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology › Coffee research and impacts
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Pregnancy and Medication Impact
- Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
- Keywords
- caffeine consumption, coffee consumption, miscarriage, fetal death, dose-response relationship, maternal diet during pregnancy
- MeSH terms
- Abortion, Spontaneous, Caffeine, Coffee, Dose-Response Relationship, Drug, Female, Humans, Pregnancy, Risk
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
