Pharmacokinetics of caffeine during and after pregnancy
Abstract
The pharmacokinetic parameters of caffeine were measured in 9 pregnant women and 4 women 4 days post partum. The results show a significant prolongation of caffeine elimination in pregnant women. Normal pharmacokinetic parameters seem to be restored as soon as 4 days post partum. Steroids hormones (estriol, estradiol, and progesterone) were measured in both cases.
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The half-life of caffeine is on average 8.3 h longer during pregnancy and may be as much as 16 h longer than usual.
“The half-life of caffeine is on average 8.3 h longer during pregnancy and may be as much as 16 h longer than usual (60, 61).”
From The Safety of Ingested Caffeine: A Comprehensive Review (2017) · cites this paper as [61]
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- Authors
- Brazier, J. L., Ritter, J., Berland, M., Khenfer, D., & Faucon, G.
- Affiliations
- Lyon 1 Université (FR)
- Hôpital Edouard Herriot (FR)
- Venue
- Developmental Pharmacology and Therapeutics
- Publisher
- S. Karger AG
- Published
- 2017-08-11
- Volume
- 6
- Issue
- 5
- Pages
- 315-322
- ISSN
- 0379-8305 (ISSN-L)
- 2504-2505
- OpenAlex
- W2463761670
- Cited by
- 155
- References
- 0
- Citations by year
- 2025: 3 · 2024: 2 · 2023: 3 · 2022: 3 · 2021: 4 · 2020: 59 · 2019: 6 · 2018: 3 · 2017: 4 · 2016: 3 · 2015: 5 · 2014: 3 · 2013: 2 · 2012: 3
- FWCI
- 13.78
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Developmental Pharmacology and Therapeutics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology › Coffee research and impacts
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Pregnancy and Medication Impact
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
- Keywords
- caffeine, pharmacokinetics, pregnancy, postpartum period, estriol, estradiol, progesterone, steroid hormones
- MeSH terms
- Adult, Caffeine, Female, Humans, Kinetics, Pregnancy, Regression Analysis, Postpartum Period
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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