The effects of chronic cocaine exposure on impulsivity in rats
Open accessAbstract
Chronic exposure to cocaine increases impulsive behavior, leading to a reduced preference for a larger, delayed reinforcer over a smaller, immediate reinforcer. This study examined the development of impulsivity over multiple days of cocaine exposure and cessation of cocaine. Male Sprague-Dawley rats were trained on a discrete-trials delay-discounting task, during which they chose between a small, immediate reinforcer of one food pellet and a large reinforcer of 3 food pellets after an adjusted delay (0, 10, 20, 40, and 60 s). When stable preferences were established, rats received daily injections of deionized water or cocaine (3, 7.5, 15 mg/kg) 5 min before the delay-discounting task for 9 days. All groups showed an increased preference for the smaller reinforcer as delay to the larger reinforcer increased. Repeated exposure to 7.5 or 15 mg/kg cocaine further decreased preference for the larger reinforcer over the 9 days. When cocaine administration was discontinued, preference for the larger reinforcer returned to baseline levels in the 7.5 mg/kg group, but remained depressed in the 15 mg/kg group. These findings indicate that continuing exposure to cocaine dose-dependently decreases choice for the large reinforcer over time, and that the bias remains when cocaine is no longer administered, and that the recovery after high doses of cocaine occurs slowly.
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Prospective studies suggest that high discounting rates may indicate vulnerability for the development of substance abuse/dependence across species.
“prospective studies suggest that high discounting rates may indicate vulnerability for the development of such problems across species”
From DAT1 and COMT effects on delay discounting and trait impulsivity in male adolescents with attention deficit/hyperactivity disorder and healthy controls (2010) · cites this paper as Dandy and Gatch, 2009
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- Authors
- Dandy, K. L., & Gatch, M. B.
- Affiliations
- Texas Christian University (US)
- Corresponding author
- Gatch, Michael B.
- ORCID
- Gatch, Michael B.
- Venue
- Behavioural Pharmacology
- Published
- 2009-09
- Volume
- 20
- Issue
- 5-6
- Pages
- 400-405
- ISSN
- 0955-8810 (ISSN-L)
- PMC
- PMC3867254
- OpenAlex
- W2081092567
- Cited by
- 50
- References
- 19
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 2 · 2023: 1 · 2022: 1 · 2020: 5 · 2019: 5 · 2018: 3 · 2017: 3 · 2016: 2 · 2015: 2 · 2014: 7 · 2013: 4 · 2012: 6
- FWCI
- 1.80
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Behavioural Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Drug Abuse (N01 DA028822)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Social Sciences › Decision Sciences › General Decision Sciences › Decision-Making and Behavioral Economics
- Keywords
- chronic cocaine exposure, impulsivity, delay discounting, cocaine withdrawal, dose-dependent effects, reinforcer preference, rats
- MeSH terms
- Analysis of Variance, Animals, Choice Behavior, Cocaine, Conditioning, Operant, Dose-Response Relationship, Drug, Impulsive Behavior, Male, Reaction Time, Reinforcement, Psychology, Reinforcement Schedule, Self Administration, Time Factors, Rats, Sprague-Dawley, Dopamine Uptake Inhibitors, Rats
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