Impulsive choice as a predictor of acquisition of IV cocaine self-administration and reinstatement of cocaine-seeking behavior in male and female rats.
Abstract
Drug abuse and impulsive choice are related in humans. In female rats, impulsive choice predicted the rate of acquisition of IV cocaine self-administration. The objectives of the present experiments were to: (a) compare impulsive choice in males and females, (b) extend previous research on impulsive choice and acquisition of cocaine self-administration to males, and (c) compare males and females during maintenance, extinction, and reinstatement of cocaine-seeking behavior. Male and female rats were trained on an adjusting delay task in which a response on one of two levers yielded one food pellet immediately, and a response on the other resulted in three pellets after an adjusting delay that decreased after responses on the immediate lever and increased after responses on the delay lever. A mean adjusted delay (MAD) was used as the quantitative measure of impulsivity. In Experiment 1, MADs were analyzed for sex differences. In Experiment 2, acquisition of cocaine self-administration was examined in rats selected for high (HiI; MADs < or =9 seconds) or low (LoI; MADs > or =13 seconds) impulsivity. In Experiment 3, HiI and LoI groups were compared on maintenance and extinction of cocaine self-administration and cocaine-primed reinstatement of drug-seeking behavior. There were no sex differences in impulsive choice; however, HiI male and female rats acquired cocaine self-administration faster than their LoI counterparts. LoI females responded more on a cocaine-associated lever during maintenance and extinction than HiI females, but HiI females showed greater reinstatement of cocaine-seeking behavior than all other groups at the highest dose tested (15 mg/kg). Thus, individual differences in impulsive choice were associated with differences in cocaine-seeking behavior. Impulsive choice and sex may be additive vulnerability factors in certain phases of drug abuse.
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Male and female rats that mostly choose smaller-sooner food are more likely to acquire low-dose cocaine self-administration than rats that prefer to wait for a larger food reward.
“Male and female rats that predominantly choose smaller-sooner food rewards are more likely to acquire low-dose cocaine self-administration than rats that prefer to wait for a larger food reward”
From Changing Delay Discounting and Impulsive Choice: Implications for Addictions, Prevention, and Human Health (2019) · cites this paper as Perry et al., 2008
Some evidence suggests impulsive choice predicts greater reinstatement of drug-seeking.
“and greater reinstatement of drug-seeking (Perry et al., 2008).”
From Changing Delay Discounting and Impulsive Choice: Implications for Addictions, Prevention, and Human Health (2019) · cites this paper as Perry et al., 2008
Some evidence suggests impulsive choice predicts higher cocaine or methylphenidate intake.
“some evidence suggests impulsive choice is predictive of higher cocaine or methylphenidate intake”
From Changing Delay Discounting and Impulsive Choice: Implications for Addictions, Prevention, and Human Health (2019) · cites this paper as Perry et al., 2008
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Self-citation
- Authors
- Perry, J. L., Nelson, S. E., & Carroll, M. E.
- Affiliations
- University of Minnesota (US)
- Venue
- Experimental and Clinical Psychopharmacology
- Published
- 2008-04
- Volume
- 16
- Issue
- 2
- Pages
- 165-177
- ISSN
- 1064-1297 (ISSN-L)
- 1936-2293
- OpenAlex
- W2063281891
- Cited by
- 200
- References
- 45
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 1 · 2023: 7 · 2022: 6 · 2021: 6 · 2020: 10 · 2019: 7 · 2018: 10 · 2017: 7 · 2016: 11 · 2015: 19 · 2014: 13 · 2013: 25 · 2012: 12
- FWCI
- 8.07
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Experimental and Clinical Psychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Drug Abuse (DA03240-23, K05 DA15267-06, F31 DA020237-01)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Keywords
- impulsive choice, cocaine self-administration, cocaine-seeking behavior, reinstatement, sex differences, impulsivity, individual differences, extinction, maintenance, cocaine priming, vulnerability factors, drug abuse
- MeSH terms
- Animals, Behavior, Animal, Choice Behavior, Cocaine, Conditioning, Operant, Disease Models, Animal, Female, Impulsive Behavior, Male, Motor Activity, Reaction Time, Reinforcement, Psychology, Self Administration, Sex Characteristics, Rats, Wistar, Dopamine Uptake Inhibitors, Cocaine-Related Disorders, Rats
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