Cited by 158Fatty Acid Research and HealthCardiovascular and exercise physiologyMuscle metabolism and nutrition

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Fish Oil Reduces Heart Rate and Oxygen Consumption During Exercise

Peoples, Gregory E, McLennan, Peter L, Howe, Peter R C, Groeller, Herbert·2008·Journal of Cardiovascular Pharmacology

DOI 10.1097/fjc.0b013e3181911913

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Abstract

Dietary omega-3 polyunsaturated fatty acids (PUFAs) are readily incorporated into heart and skeletal muscle membranes where, in the heart, animal studies show they reduce O2 consumption. To test the hypothesis that omega-3 PUFAs alter O2 efficiency in humans, the effects of fish oil (FO) supplementation on O2 consumption during exercise were evaluated. Sixteen well-trained men (cyclists), randomly assigned to receive 8 x 1 g capsules per day of olive oil (control) or FO for 8 weeks in a double-blind, parallel design, completed the study (control: n = 7, age 27.1 +/- 2.7 years; FO: n = 9, age 23.2 +/- 1.2 years). Subjects used an electronically braked cycle ergometer to complete peak O2 consumption tests (VO 2peak) and sustained submaximal exercise tests at 55% of peak workload (from the VO 2peak test) before and after supplementation. Whole-body O2 consumption and indirect measurements of myocardial O2 consumption [heart rate and rate pressure product (RPP)] were assessed. FO supplementation increased omega-3 PUFA content of erythrocyte cell membranes. There were no differences in VO 2peak (mL kg(-1) min(-1)) (control: pre 66.8 +/- 2.4, post 67.2 +/- 2.3; FO: pre 68.3 +/- 1.4, post 67.2 +/- 1.2) or peak workload after supplementation. The FO supplementation lowered heart rate (including peak heart rate) during incremental workloads to exhaustion (P < 0.05). In addition, the FO supplementation lowered steady-state submaximal exercise heart rate, whole-body O2 consumption, and RPP (P < 0.01). Time to voluntary fatigue was not altered by FO supplementation. This study indicates that FOs may act within the healthy heart and skeletal muscle to reduce both whole-body and myocardial O2 demand during exercise, without a decrement in performance.

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Authors: Peoples, G. E., McLennan, P. L., Howe, P. R. C., & Groeller, H.
Affiliations: University of Wollongong (AU)
Corresponding author: Peoples, Gregory E
McLennan, Peter L
Howe, Peter R C
ORCID: Peoples, Gregory E
McLennan, Peter L
Howe, Peter R C
Groeller, Herbert
Venue: Journal of Cardiovascular Pharmacology
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2008-12
Volume: 52
Issue: 6
Pages: 540-547
ISSN: 0160-2446 (ISSN-L)
DOI: 10.1097/fjc.0b013e3181911913
OpenAlex: W1979240894
Cited by: 158
References: 59
Citations by year: 2026: 3 · 2025: 9 · 2024: 3 · 2023: 7 · 2022: 6 · 2021: 8 · 2020: 16 · 2019: 8 · 2018: 9 · 2017: 6 · 2016: 9 · 2015: 7 · 2014: 14 · 2013: 14 · 2012: 14
FWCI: 7.90
Type: journal article
Language: en
Open access: closed
Locations: Journal of Cardiovascular Pharmacology (publishedVersion)
PubMed (publishedVersion)
Research Online (University of Wollongong) (submittedVersion)
Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
Figshare (submittedVersion)
Topics: Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
Keywords: fish oil supplementation, omega-3 polyunsaturated fatty acids, exercise oxygen consumption, heart rate, myocardial oxygen consumption, rate-pressure product, erythrocyte membrane fatty acid composition, submaximal exercise, peak oxygen uptake, endurance performance
MeSH terms: Administration, Oral, Adult, Capsules, Docosahexaenoic Acids, Double-Blind Method, Erythrocyte Membrane, Fish Oils, Heart Rate, Humans, Male, Membrane Lipids, Myocardium, Oxygen Consumption, Time Factors, Eicosapentaenoic Acid, Exercise, Muscle, Skeletal, Muscle Fatigue, Dietary Supplements, Young Adult

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Fish Oil Reduces Heart Rate and Oxygen Consumption During Exercise

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