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Drug adherence in hypertension: from methodological issues to cardiovascular outcomes
Open accessAbstract
: Adherence to treatment is now well recognized as a crucial key in the effectiveness of antihypertensive drugs; however, it is often overlooked in the management of hypertension because methodology to assess it is partly unreliable and limits its use in clinical practice. The available evidence suggests that nonadherence is highly prevalent in a chronic asymptomatic condition such as hypertension. It may undermine benefits expected from antihypertensive agents and therefore, may negatively impact cardiovascular, cerebrovascular and renal outcomes. In this review, we discuss the methodological issues related to the measurement of drug adherence in a research setting and clinical practice, the prevalence and the impact of drug nonadherence on blood pressure control and thus in apparent resistant hypertension, and on cardiovascular, cerebrovascular and renal outcomes.
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“Nevertheless, since non-adherence prevails, hypertension is not under desirable control [10, 11].”
From The effect of the mobile “blood pressure management application” on hypertension self-management enhancement: a randomized controlled trial (2021) · cites this paper as [10]
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Drug Adherence in Resistant Hypertension
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Self-citationKatayama, P. L. (2018) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.17.2018.tde-20072018-091306
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Ranieri, J., Guerra, F., Cilli, E., Giacomo, D. D., & Ferri, C. (2022) · Psychological applications and trends · doi:10.36315/2022inpact031
Metadata
- Authors
- Hamdidouche, I., Jullien, V., Boutouyrie, P., Billaud, E., Azizi, M., & Laurent, S.
- Affiliations
- Inserm (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Corresponding author
- Laurent, Stéphane
- Venue
- Journal of Hypertension
- Published
- 2017-06
- Volume
- 35
- Issue
- 6
- Pages
- 1133-1144
- ISSN
- 0263-6352 (ISSN-L)
- OpenAlex
- W2596282637
- Cited by
- 111
- References
- 88
- Citations by year
- 2026: 5 · 2025: 4 · 2024: 9 · 2023: 5 · 2022: 16 · 2021: 18 · 2020: 14 · 2019: 16 · 2018: 16 · 2017: 8
- FWCI
- 2.48
- Type
- journal article
- Language
- en
- Open access
- green
- hal.science
- Licence
- cc-by-nc-nd
- Locations
- Journal of Hypertension (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion, cc-by-nc-nd)
- Topics
- Health Sciences › Medicine › Family Practice › Medication Adherence and Compliance
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
- Keywords
- medication adherence, hypertension, antihypertensive drugs, adherence measurement methods, blood pressure control, resistant hypertension, cardiovascular outcomes, cerebrovascular outcomes, renal outcomes
- MeSH terms
- Assessment of Medication Adherence, Antihypertensive Agents, Cardiovascular System, Humans, Hypertension, Kidney, Biomarkers, Drug Monitoring, Medication Adherence
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