The DOI matches its Crossref record; 88 of the 88 references it cites were found in a registry or an index.
Drug adherence in hypertension: from methodological issues to cardiovascular outcomes
Open accessAbstract
: Adherence to treatment is now well recognized as a crucial key in the effectiveness of antihypertensive drugs; however, it is often overlooked in the management of hypertension because methodology to assess it is partly unreliable and limits its use in clinical practice. The available evidence suggests that nonadherence is highly prevalent in a chronic asymptomatic condition such as hypertension. It may undermine benefits expected from antihypertensive agents and therefore, may negatively impact cardiovascular, cerebrovascular and renal outcomes. In this review, we discuss the methodological issues related to the measurement of drug adherence in a research setting and clinical practice, the prevalence and the impact of drug nonadherence on blood pressure control and thus in apparent resistant hypertension, and on cardiovascular, cerebrovascular and renal outcomes.
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“Nevertheless, since non-adherence prevails, hypertension is not under desirable control [10, 11].”
From The effect of the mobile “blood pressure management application” on hypertension self-management enhancement: a randomized controlled trial (2021) · cites this paper as [10]
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Cites
1 retracted
Retracted: Predictive Validity of a Medication Adherence Measure in an Outpatient Setting
Morisky, D. E., Ang, A., Krousel‐Wood, M., & Ward, H. J. (2008) · The Journal of Clinical Hypertension · doi:10.1111/j.1751-7176.2008.07572.x · Cited by 2,877
RetractedOsterberg, L., & Blaschke, T. (2005) · New England Journal of Medicine · doi:10.1056/nejmra050100 · Cited by 7,974
Lopez, A. D., Mathers, C. D., Ezzati, M., Jamison, D. T., & Murray, C. J. (2006) · The Lancet · doi:10.1016/s0140-6736(06)68770-9 · Cited by 5,630
Concurrent and Predictive Validity of a Self-reported Measure of Medication Adherence
Morisky, D. E., Green, L. W., & Levine, D. M. (1986) · Medical Care · doi:10.1097/00005650-198601000-00007 · Cited by 5,399
A systematic review of the associations between dose regimens and medication compliance
Claxton, A. J., Cramer, J., & Pierce, C. (2001) · Clinical Therapeutics · doi:10.1016/s0149-2918(01)80109-0 · Cited by 2,388
Resistant Hypertension: Diagnosis, Evaluation, and Treatment
Calhoun, D. A., Jones, D. W., Textor, S. C., Goff, D. C., Murphy, T. P., Toto, R. D., White, A. J., Cushman, W. C., White, W. B., Sica, D. A., et al. (2008) · Circulation · doi:10.1161/circulationaha.108.189141 · Cited by 2,240
A new taxonomy for describing and defining adherence to medications
Vrijens, B., De Geest, S., Hughes, D. A., Przemyslaw, K., Demonceau, J., Ruppar, T., Dobbels, F., Fargher, E., Morrison, V., Lewek, P., et al. (2012) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.2012.04167.x · Cited by 2,028
Medication Adherence: Its Importance in Cardiovascular Outcomes
Ho, P. M., Bryson, C. L., & Rumsfeld, J. S. (2009) · Circulation · doi:10.1161/circulationaha.108.768986 · Cited by 1,488
A meta-analysis of the association between adherence to drug therapy and mortality
Simpson, S. H., Eurich, D. T., Majumdar, S. R., Padwal, R. S., Tsuyuki, R. T., Varney, J., & Johnson, J. A. (2006) · BMJ · doi:10.1136/bmj.38875.675486.55 · Cited by 1,353 · cited 1×
“[70], in a meta-analysis, showed effectively a reduction of risk of mortality in patients with high adherence to the active drug therapy and even to the placebo.”
The assessment of refill compliance using pharmacy records: Methods, validity, and applications
Steiner, J. F., & Prochazka, A. V. (1997) · Journal of Clinical Epidemiology · doi:10.1016/s0895-4356(96)00268-5 · Cited by 1,198
Cited by
Sorted by citations
Adherence in Hypertension: A Review of Prevalence, Risk Factors, Impact, and Management
Burnier, M., & Egan, B. M. (2019) · Circulation Research · doi:10.1161/circresaha.118.313220 · Cited by 878
Nonadherence to antihypertensive drugs: A systematic review and meta-analysis
Abegaz, T. M., Shehab, A., Gebreyohannes, E. A., Bhagavathula, A. S., & Elnour, A. A. (2017) · Medicine · doi:10.1097/md.0000000000005641 · Cited by 525
Medication adherence among patients with apparent treatment-resistant hypertension
Durand, H., Hayes, P., Morrissey, E. C., Newell, J., Casey, M., Murphy, A. W., & Molloy, G. J. (2017) · Journal of Hypertension · doi:10.1097/hjh.0000000000001502 · Cited by 198
Lee, E. K. P., Poon, P. K.-M., Yip, B. H. K., Bo, Y., Zhu, M., Yu, C., Ngai, A. C. H., Wong, M. C. S., & Wong, S. Y. S. (2022) · Journal of the American Heart Association · doi:10.1161/jaha.122.026582 · Cited by 196
Hamrahian, S. M., Maarouf, O. H., & Fülöp, T. (2022) · Patient Preference and Adherence · doi:10.2147/ppa.s368784 · Cited by 212
Metadata
- Authors
- Hamdidouche, I., Jullien, V., Boutouyrie, P., Billaud, E., Azizi, M., & Laurent, S.
- Affiliations
- Inserm (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Corresponding author
- Laurent, Stéphane
- Venue
- Journal of Hypertension
- Published
- 2017-06
- Volume
- 35
- Issue
- 6
- Pages
- 1133-1144
- ISSN
- 0263-6352 (ISSN-L)
- OpenAlex
- W2596282637
- Cited by
- 111
- References
- 88
- Citations by year
- 2026: 5 · 2025: 4 · 2024: 9 · 2023: 5 · 2022: 16 · 2021: 18 · 2020: 14 · 2019: 16 · 2018: 16 · 2017: 8
- FWCI
- 2.48
- Type
- journal article
- Language
- en
- Open access
- green
- hal.science
- Licence
- cc-by-nc-nd
- Locations
- Journal of Hypertension (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion, cc-by-nc-nd)
- Topics
- Health Sciences › Medicine › Family Practice › Medication Adherence and Compliance
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
- Keywords
- medication adherence, hypertension, antihypertensive drugs, adherence measurement methods, blood pressure control, resistant hypertension, cardiovascular outcomes, cerebrovascular outcomes, renal outcomes
- MeSH terms
- Assessment of Medication Adherence, Antihypertensive Agents, Cardiovascular System, Humans, Hypertension, Kidney, Biomarkers, Drug Monitoring, Medication Adherence
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