Cited by 111Medication Adherence and ComplianceBlood Pressure and Hypertension StudiesAtrial Fibrillation Management and Outcomes

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Drug adherence in hypertension: from methodological issues to cardiovascular outcomes

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Hamdidouche, Idir, Jullien, Vincent, Boutouyrie, Pierre, Billaud, Eliane, Azizi, Michel, Laurent, Stéphane·2017·Journal of Hypertension

DOI 10.1097/hjh.0000000000001299

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Abstract

: Adherence to treatment is now well recognized as a crucial key in the effectiveness of antihypertensive drugs; however, it is often overlooked in the management of hypertension because methodology to assess it is partly unreliable and limits its use in clinical practice. The available evidence suggests that nonadherence is highly prevalent in a chronic asymptomatic condition such as hypertension. It may undermine benefits expected from antihypertensive agents and therefore, may negatively impact cardiovascular, cerebrovascular and renal outcomes. In this review, we discuss the methodological issues related to the measurement of drug adherence in a research setting and clinical practice, the prevalence and the impact of drug nonadherence on blood pressure control and thus in apparent resistant hypertension, and on cardiovascular, cerebrovascular and renal outcomes.

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See all 111

Authors: Hamdidouche, I., Jullien, V., Boutouyrie, P., Billaud, E., Azizi, M., & Laurent, S.
Affiliations: Inserm (FR)
Assistance Publique – Hôpitaux de Paris (FR)
Corresponding author: Laurent, Stéphane
ORCID: Jullien, Vincent
Boutouyrie, Pierre
Azizi, Michel
Laurent, Stéphane
Venue: Journal of Hypertension
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2017-06
Volume: 35
Issue: 6
Pages: 1133-1144
ISSN: 0263-6352 (ISSN-L)
DOI: 10.1097/hjh.0000000000001299
OpenAlex: W2596282637
Cited by: 111
References: 88
Citations by year: 2026: 5 · 2025: 4 · 2024: 9 · 2023: 5 · 2022: 16 · 2021: 18 · 2020: 14 · 2019: 16 · 2018: 16 · 2017: 8
FWCI: 2.48
Type: journal article
Language: en
Open access: green
hal.science
Licence: cc-by-nc-nd
Locations: Journal of Hypertension (publishedVersion)
PubMed (publishedVersion)
HAL (submittedVersion, cc-by-nc-nd)
Topics: Health Sciences › Medicine › Family Practice › Medication Adherence and Compliance
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
Keywords: medication adherence, hypertension, antihypertensive drugs, adherence measurement methods, blood pressure control, resistant hypertension, cardiovascular outcomes, cerebrovascular outcomes, renal outcomes
MeSH terms: Assessment of Medication Adherence, Antihypertensive Agents, Cardiovascular System, Humans, Hypertension, Kidney, Biomarkers, Drug Monitoring, Medication Adherence

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Drug adherence in hypertension: from methodological issues to cardiovascular outcomes

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