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Cited by 15Sexual Differentiation and DisordersAdrenal Hormones and DisordersCardiovascular Health and Disease Prevention

The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.

Early central blood pressure elevation in adult patients with 21-hydroxylase deficiency

Rosenbaum, David, Gallo, Antonio, Lethielleux, Gaelle, Bruckert, Eric, Levy, Bernard I., Tanguy, Marie Laure, Dulon, Jérôme, Dahmoune, Nora, Salem, Joe Elie, Bittar, Randa, Leban, Monique, Girerd, Xavier, Touraine, Philippe, Bachelot, Anne·2019·Journal of Hypertension
DOI 10.1097/hjh.0000000000001850
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Abstract

CONTEXT: Controversial data exist on cardiovascular damages in patients with congenital adrenal hyperplasia (CAH). OBJECTIVE: To assess blood pressure and early cardiovascular damages on a large cohort of adult CAH patients and control individuals. DESIGN: Case-control study. SETTING: Referral Center for Rare Disease, Pitié Salpêtrière Hospital, Paris, France. PATIENTS OR OTHER PARTICIPANTS: Fifty-eight women and 26 men with CAH diagnosed in childhood and 85 controls matched-paired for sex, age and smoking status were prospectively included. INTERVENTION: Measurement of large arteries and microcirculatory anatomical and functional indices as well as hormonal status and cardiovascular risk factors evaluation. MAIN OUTCOME MEASURE: The primary objective was to compare carotid intima-media thickness (cIMT) in CAH patients and controls. The secondary objectives were to compare blood pressure (BP), radial augmentation index (rAI), central BP, carotid-femoral pulse wave velocity (PWV), skin microcirculation indices and inflammation parameters in CAH patients and controls. RESULTS: Although PWV and cIMT were identical in patients and controls, higher rAI (64.6 ± 1.7 vs. 59.9 ± 1.6%, P = 0.02) and higher central SBP (101.8 ± 1.5 vs. 95.1 ± 1.5 mmHg, P < 0.001) were observed in CAH patients. Regarding microcirculatory indices, there was a higher functional resting capacity and a lower anatomical capillary density in CAH patients. In multivariate analysis, we found an independant association between CAH and central SBP elevation. CONCLUSION: We found an early rise in central SBP in CAH patients whereas sublinical arterial damages markers were normal. Our study suggest that vascular damages and increased cardiovascular risk could be mainly BP-driven.

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Metadata

Authors
Rosenbaum, D., Gallo, A., Lethielleux, G., Bruckert, E., Levy, B. I., Tanguy, M. L., Dulon, J., Dahmoune, N., Salem, J. E., Bittar, R., Leban, M., Girerd, X., Touraine, P., & Bachelot, A.
Affiliations
  • Centre National de la Recherche Scientifique (FR)
  • Assistance Publique – Hôpitaux de Paris (FR)
  • Inserm (FR)
  • Sorbonne Université (FR)
Corresponding author
Bachelot, Anne
ORCID
Venue
Journal of Hypertension
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2019-01
Volume
37
Issue
1
Pages
175-181
ISSN
0263-6352 (ISSN-L)
DOI
10.1097/hjh.0000000000001850
OpenAlex
W2883903194
Cited by
15
References
9
Citations by year
2025: 1 · 2024: 3 · 2023: 3 · 2022: 2 · 2021: 1 · 2020: 1 · 2019: 2
FWCI
0.45
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Hypertension (publishedVersion)
  • PubMed (publishedVersion)
  • HAL (submittedVersion)
Funders
  • Assistance Publique - Hôpitaux de Paris
  • Assistance publique-Hôpitaux de Paris
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Sexual Differentiation and Disorders
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
Keywords
congenital adrenal hyperplasia, 21-hydroxylase deficiency, central blood pressure, hypertension, cardiovascular risk, carotid intima-media thickness, pulse wave velocity, radial augmentation index, skin microcirculation, capillary density, arterial stiffness, subclinical vascular damage
MeSH terms
Adrenal Hyperplasia, Congenital, Adult, Blood Pressure, Child, Female, Humans, Prospective Studies, Carotid Intima-Media Thickness, Pulse Wave Analysis

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