The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Incidence of cardiovascular events in white-coat, masked and sustained hypertension versus true normotension: a meta-analysis
Abstract
OBJECTIVE: To perform a meta-analysis on the incidence of cardiovascular events in white-coat hypertension (WCHT), masked and sustained hypertension in comparison with true normotension. METHODS: We searched for individual studies, in which the adjusted relative risk of incident cardiovascular events was assessed in patients with WCHT, masked and sustained hypertension versus normotension in the same study population. For each type of hypertension, the weighted overall hazard ratio (HR) and 95% confidence intervals (CI) were calculated. RESULTS: Seven studies were identified, involving a total of 11 502 participants. Four studies were performed in the population, two in primary care and one in specialist care. Two studies were exclusively on treated hypertensive patients; individuals on antihypertensive treatment were included in all the other studies except one. Cut-off blood pressure was 140/90 mmHg for office blood pressure in all studies and 135/85 mmHg (83 in one study) for out-of-office blood pressure. The average age of the study populations was 63 years; 53% were men. The endpoint consisted of cardiovascular death in one study and of various aggregates of fatal and non-fatal cardiovascular events in the others. During an average follow-up of 8.0 years, there were 912 first cardiovascular events. The overall adjusted HR versus normotension was 1.12 (95% CI 0.84-1.50) for WCHT (P = 0.59), 2.00 (1.58-2.52) for masked hypertension (P < 0.001), and 2.28 (1.87-2.78) for sustained hypertension (P < 0.001). CONCLUSION: The meta-analysis indicates that the incidence of cardiovascular events is not significantly different between WCHT and true normotension, whereas the outcome is worse in patients with masked or sustained hypertension.
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Citations
Cites
Prognostic Value of Ambulatory Blood-Pressure Recordings in Patients with Treated Hypertension
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Cited by
2018 ESC/ESH Guidelines for the management of arterial hypertension
Williams, B., Mancia, G., Spiering, W., Agabiti Rosei, E., Azizi, M., Burnier, M., Clement, D. L., Coca, A., de Simone, G., Dominiczak, A., et al. (2018) · European Heart Journal · doi:10.1093/eurheartj/ehy339 · Cited by 10,286
Self-citationWhelton, P. K., Carey, R. M., Aronow, W. S., Casey, D. E., Collins, K. J., Dennison Himmelfarb, C., DePalma, S. M., Gidding, S., Jamerson, K. A., Jones, D. W., et al. (2018) · Hypertension · doi:10.1161/hyp.0000000000000065 · Cited by 7,391
Whelton, P. K., Carey, R. M., Aronow, W. S., Casey, D. E., Collins, K. J., Dennison Himmelfarb, C., DePalma, S. M., Gidding, S., Jamerson, K. A., Jones, D. W., et al. (2018) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2017.11.006 · Cited by 6,616
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Metadata
- Authors
- Fagard, R. H., & Cornelissen, V. A.
- Venue
- Journal of Hypertension
- Published
- 2007-11
- Volume
- 25
- Issue
- 11
- Pages
- 2193-2198
- ISSN
- 0263-6352 (ISSN-L)
- OpenAlex
- W2088993478
- Cited by
- 480
- References
- 2
- FWCI
- 2.61
- Type
- journal article
- Language
- en
- Open access
- closed
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- Fagard, R. H., & Cornelissen, V. A. (2007). Incidence of cardiovascular events in white-coat, masked and sustained hypertension versus true normotension: a meta-analysis. Journal of Hypertension. https://doi.org/10.1097/hjh.0b013e3282ef6185
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