Cited by 90Blood Pressure and Hypertension StudiesBalance, Gait, and Falls PreventionDementia and Cognitive Impairment Research

Hypertension and lower walking speed in the elderly: the three-City study

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Dumurgier, Julien, Elbaz, Alexis, Dufouil, Carole, Tavernier, Béatrice, Tzourio, Christophe·2010·Journal of Hypertension

Abstract

OBJECTIVE: The brain is one of the main targets of hypertension. However, little is known about the relation between hypertension and motor performances. We studied the association between hypertension and walking speed in a cohort of elderly people. METHODS: Analyses are based on participants (65-85 years) from the Dijon (France) center of the Three-City study (n = 3604), followed every 2 years. Persistent hypertension was defined by the use of antihypertensive drugs at baseline or at first follow-up, or by high blood pressure (> or =140/90 mmHg) at baseline and first follow-up. Walking speed was measured over 6 m, at baseline and fourth follow-up (n = 1774) after a mean (SD) duration of 7.0 (0.5) years. Brain MRI was performed in 1590 participants. Generalized linear models were used to assess the relation between hypertension and baseline walking speed or walking speed change. RESULTS: At baseline, mean (SD) walking speed (m/s) was lower in hypertensive patients [1.51 (0.31)] than in nonhypertensive individuals [1.59 (0.30), P < 0.001]. During follow-up, hypertensive patients had a higher mean annual decline in walking speed [cm/s per year; 2.30 (3.4)] than nonhypertensive individuals [1.87 (3.3), P = 0.004]. The number of antihypertensive drugs was associated with lower walking speed at baseline and higher walking speed decline. Adjustment for MRI white matter abnormalities attenuated these relations. CONCLUSION: Persistent hypertension was associated with both lower walking speed and higher decline in walking speed in the elderly. These results may be partly explained by white matter abnormalities and support the hypothesis of a contribution of vascular risk factors to motor dysfunction.

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  • In older people, chronic medical conditions such as hypertension, diabetes mellitus, and dyslipidemia are associated with lower walking speed and greater decline in walking speed.

    “Chronic medical conditions such as hypertension, diabetes mellitus, and dyslipidemia were associated with lower walking speed and greater decline in walking speed in older people (106, 107).”

    From Health Consequences of Sarcopenic Obesity: A Narrative Review (2020) · cites this paper as [106]

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  1. Allison PD. Imputation of categorical variables with PROC MI. SUGI 30 Proceedings. 2005:1-14.

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Authors
Dumurgier, J., Elbaz, A., Dufouil, C., Tavernier, B., & Tzourio, C.
Affiliations
  • Inserm (FR)
  • CHU Dijon Bourgogne (FR)
Corresponding author
Dumurgier, Julien
Venue
Journal of Hypertension
Published
2010-07
Volume
28
Issue
7
Pages
1506-1514
ISSN
0263-6352 (ISSN-L)
OpenAlex
W2074842713
Cited by
90
References
41
Citations by year
2026: 2 · 2025: 3 · 2024: 6 · 2023: 4 · 2022: 8 · 2021: 4 · 2020: 9 · 2019: 6 · 2018: 6 · 2017: 8 · 2016: 4 · 2015: 7 · 2014: 8 · 2013: 8 · 2012: 4
FWCI
3.29
Type
journal article
Language
en
Open access
Locations
  • Journal of Hypertension (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
  • HAL (submittedVersion, other-oa)
Funders
  • Sanofi
  • Institut National de la Santé et de la Recherche Médicale
  • Fondation pour la Recherche Médicale
  • Fondation de France
  • Mutuelle Générale de l'Education Nationale
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
  • Health Sciences › Health Professions › Physical Therapy, Sports Therapy and Rehabilitation › Balance, Gait, and Falls Prevention
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Keywords
hypertension, walking speed, older adults, motor performance, white matter abnormalities, antihypertensive drugs, brain MRI, vascular risk factors, motor impairment, Three-City Study
MeSH terms
Aged, Brain, Female, Humans, Hypertension, Magnetic Resonance Imaging, Male, Risk Factors, Walking

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