The DOI matches its Crossref record; 109 of the 109 references it cites were found in a registry or an index.
The Use of Virtual Reality Technology in the Treatment of Anxiety and Other Psychiatric Disorders
Open accessAbstract
LEARNING OBJECTIVES: After participating in this activity, learners should be better able to:• Evaluate the literature regarding the effectiveness of incorporating virtual reality (VR) in the treatment of psychiatric disorders• Assess the use of exposure-based intervention for anxiety disorders ABSTRACT: Virtual reality (VR) allows users to experience a sense of presence in a computer-generated, three-dimensional environment. Sensory information is delivered through a head-mounted display and specialized interface devices. These devices track head movements so that the movements and images change in a natural way with head motion, allowing for a sense of immersion. VR, which allows for controlled delivery of sensory stimulation via the therapist, is a convenient and cost-effective treatment. This review focuses on the available literature regarding the effectiveness of incorporating VR within the treatment of various psychiatric disorders, with particular attention to exposure-based intervention for anxiety disorders. A systematic literature search was conducted in order to identify studies implementing VR-based treatment for anxiety or other psychiatric disorders. This article reviews the history of the development of VR-based technology and its use within psychiatric treatment, the empirical evidence for VR-based treatment, and the benefits for using VR for psychiatric research and treatment. It also presents recommendations for how to incorporate VR into psychiatric care and discusses future directions for VR-based treatment and clinical research.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Experiencing presence when immersed in VR has been reported to be an important factor for the implementation of effective interventions in VR (Maples-Keller et al., 2017).”
From iSenseVR: bringing VR exposure therapy outside the laboratory (2019) · cites this paper as Maples-Keller et al., 2017
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“VR exposure therapy allows the controlled delivery of sensory stimulation (Maples-Keller et al., 2017).”
From iSenseVR: bringing VR exposure therapy outside the laboratory (2019) · cites this paper as Maples-Keller et al., 2017
The cited source says what the claim attributes to it.
In the citing paper
“For instance, virtual reality (VR) technology, accessed through head-mounted displays, provides an immersive experience similar to real-life situations and has been used in controlled environments [7].”
The cited source says what the claim attributes to it.
In the citing paper
“However, when traditional graded exposure becomes complex to set up due to difficulties to control specific environment cues, VR offers opportunities for highly controllable settings empowering sensory exposure with the presence of the therapist, which would not be possible otherwise (Maples-Keller et al., 2017).”
From iSenseVR: bringing VR exposure therapy outside the laboratory (2019) · cites this paper as Maples-Keller et al., 2017
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Ressler, K. J., Rothbaum, B. O., Tannenbaum, L., Anderson, P., Graap, K., Zimand, E., Hodges, L., & Davis, M. (2004) · Archives of General Psychiatry · doi:10.1001/archpsyc.61.11.1136 · Cited by 1,063
Self-citationParsons, T. D., & Rizzo, A. A. (2008) · Journal of Behavior Therapy and Experimental Psychiatry · doi:10.1016/j.jbtep.2007.07.007 · Cited by 994 · cited 1×
“…treatment research has been conducted for anxiety disorders, and broadly, results suggest the VRE is related to large declines in anxiety symptoms, 12 demonstrates similar efficacy compared to traditional exposure interventions, has a powerful real-life impact, and demonstrates good stability of…”
ResultVirtual reality exposure therapy for anxiety disorders: A meta-analysis
Powers, M. B., & Emmelkamp, P. M. G. (2008) · Journal of Anxiety Disorders · doi:10.1016/j.janxdis.2007.04.006 · Cited by 904 · cited 1×
“14 There is evidence that treatment gains made in VRE generalize to real life, as meta-analytic results suggest that VRE patients, compared to wait-list patients, perform significantly better on behavioral assessments post-treatment, and found no significant differences between VRE and in-vivo…”
BackgroundSutherland, I. E. (1965) · Cited by 754
What's real about virtual reality?
Brooks, F. P. (1999) · IEEE Computer Graphics and Applications · doi:10.1109/38.799723 · Cited by 737
Virtual reality social cognition training for young adults with high-functioning autism
Kandalaft, M. R., Didehbani, N., Krawczyk, D. C., Allen, T. T., & Chapman, S. B. (2013) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-012-1544-6 · Cited by 697
Effectiveness of computer-generated (virtual reality) graded exposure in the treatment of acrophobia
(1995) · American Journal of Psychiatry · doi:10.1176/ajp.152.4.626 · Cited by 694 · cited 1×
“In particular, VR is effective in treating acrophobia based on both within-group,(38) and controlled between-group, data.(10,39,40) Similar effects have been observed in RCTs for treating arachnophobia (fear of spiders) and, in one multiple-baseline study, fear of driving.”
BackgroundSelf-citationVirtual reality exposure therapy in anxiety disorders: a quantitative meta-analysis
Opriş, D., Pintea, S., García-Palacios, A., Botella, C., Szamosközi, Ş., & David, D. (2012) · Depression and Anxiety · doi:10.1002/da.20910 · Cited by 636 · cited 1×
“13 Meta-analytic results for VRE for anxiety disorders even suggest a small effect size favoring VRE over in-vivo conditions, despite most studies not demonstrating an advantage when considered in isolation.”
BackgroundDinh, H. Q., Walker, N., Hodges, L. F., Song, C., & Kobayashi, A. (2003) · Proceedings IEEE Virtual Reality (Cat. No. 99CB36316) · doi:10.1109/vr.1999.756955 · Cited by 566 · cited 2×
“control of sensory cues, particularly for auditory, tactile, and olfactory systems, increases the sense of realism and memory of the virtual environment.(1,4,5)”
BackgroundEfficacy of treatments for anxiety disorders: a meta-analysis
Bandelow, B., Reitt, M., Röver, C., Michaelis, S., Görlich, Y., & Wedekind, D. (2015) · International Clinical Psychopharmacology · doi:10.1097/yic.0000000000000078 · Cited by 555 · cited 1×
“Anxiety Disorders Awide body of research has suggested large treatment effects for exposure-based therapy for anxiety disorders.(11) Modern exposure therapy is based on emotion-processing theory, which posits that fearmemories are structures that contain information regarding fear stimuli, responses, and meaning.”
Background
Cited by
Sorted by citations
Items 801–860 of 860
Virtual reality usage to improve well-being and quality of life
Calabrò, R. S., & Maggio, M. G. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-27346-9.00015-7
Pedram, S., & Pickard, J. A. (2026) · JMIR Human Factors · doi:10.2196/93212
Ethical considerations of virtual reality use in clinical settings
Rossi, C., Pupillo, C., & Rabarbari, E. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-36741-0.00006-1
Kurniawan, S. J., Wiyono, B. D., & Kholidya, C. F. (2026) · European Journal of Trauma & Dissociation · doi:10.1016/j.ejtd.2026.100705
Li, J., Ding, F., Chen, J., Ma, X., Wang, X., Hong, Q., & (32376), H. L. (2026) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2026.113226
Jaffery, Z., Al-Helu, N., Sapong, I., Palmer, P., Forty, L., & Hassoulas, A. (2026) · doi:10.2196/preprints.101786
Choheili, S., Marashian, F. S., Safarzadeh, S., & Asgari, P. (2026) · Preventing School Failure Alternative Education for Children and Youth · doi:10.1080/1045988x.2026.2681181
Gao, Y., Zhao, C., Li, S., Yang, S., Sun, X., Zhang, Z., Zhang, W., Meng, H., & Zhang, T. (2026) · European Journal of Forest Research · doi:10.1007/s10342-026-01923-4
“…as they appreciated land-scapes, while virtual reality (VR) could provide a more immersive experience (Browning et al. 2020; Depledge et al. 2011; Duan et al. 2024; Huang et al. 2024; Jerdan et al. 2018 ; Kjellgren and Buhrkall 2010; Maples-Keller et al. 2017; Smith 2015; White et al. 2018 ).”
Emotion regulation in immersive virtual reality environments: a scoping review
Macey, A.-L., Macey, J., & Hamari, J. (2026) · Interacting with Computers · doi:10.1093/iwc/iwag029
Deniz, E. U., Eren, R., & Kaya, H. S. (2026) · BMC Medical Education · doi:10.1186/s12909-026-09575-z
“It is also known that virtual reality systems can be difficult to install and can frequently malfunction, preventing their use [42, 43].”
Rogowski, Ł., Kowalska, J., Kusztal, M. A., Stefańska, M., Zembroń-Łacny, A., Gołębiowski, T., & Dziubek, W. (2026) · Applied Sciences · doi:10.3390/app16125897
Efficacy of VR-based Interventions in Social Anxiety Disorder: a Systematic Review and Meta-analysis
Cavallaro, A., Frolli, A., Romberg, H., Penna, I. L., Posele, G., Romano, M., & Gennaro, A. (2026) · Journal of Technology in Behavioral Science · doi:10.1007/s41347-026-00662-y
Caltabiano, A., Voruganti, A., Nesi, J. L., Krebs, G., Burke, T. A., Simplicio, M. C. D., & Zalk, N. V. (2026) · JMIR Serious Games · doi:10.2196/78169
“…been successfully used to deliver therapy for various conditions such as posttraumatic stress disorder, addiction, eating disorders, and acute and chronic pain, as well as for many anxiety-related disorders, such as generalized anxiety disorder, social anxiety disorder, and numerous phobias [26].”
Değirmenci, N., İNEL, Y., & Çetin, T. (2026) · Anadolu Üniversitesi Eğitim Fakültesi Dergisi · doi:10.34056/aujef.1893312
Social Work Practice In The Metaverse
Vincent (2026) · Eduschool Journal of Sociology and Social Work (EJSSW) · doi:10.63090/ejssw/3139.4701.0005
Therapy Island: Translating Worksheet-Based CBT Micro-Skills into Therapist-Mediated Virtual Reality
Bhatnagar, S., Chung, C.-F., & Jung, H.-T. (2026) · ACM Interactive Health Conference · doi:10.1145/3786579.3804945
“In contrast, relatively little work has examined therapist-mediated VR touchpoints embedded within ongoing CBT sessions, where workflow integration and shared interpretive dialogue must be maintained [25, 44].”
de Araujo, D. D., Zeferino, S. P., & Galas, F. R. B. G. (2026) · MethodsX · doi:10.1016/j.mex.2026.104029
“Grounded in the limited capacity theory of attention, highly immersive distractors exhaust finite cognitive resources, modulating shared cortical networks [3] and triggering neurochemical responses, such as endorphin release, to effectively reduce perceived pain intensity [4].”
Alshathri, I. A. (2026) · Lecture notes in computer science · doi:10.1007/978-3-032-29653-5_28
Rojas-Rincón, J., Ampatzoglou, A., Gámiz, M., Fernández-Cardellach, C., Medrano, S. N., Soler-Dominguez, J. L., Márquez, A. C., Fernández-Capo, M., Garolera, M., Pons-Tomas, P., et al. (2026) · Lecture notes in computer science · doi:10.1007/978-3-032-31421-5_24
Powering the Movement Towards Smart Hospitals
Wong, M., Lau, Y. Y. J., & Lam, C. Y. (2026) · Springer eBooks · doi:10.1007/978-981-95-2175-3_5
Creating Calming Virtual Reality Environments for Anxiety Relief
Evans, K., & Semwal, S. K. (2026) · Lecture notes in networks and systems · doi:10.1007/978-3-032-26214-1_10
The use of virtual reality in treating sexual disorders – a scoping systematic review
Szymańska, A., Waligórski, J., Urbanek, A., Kuhny, A., Kubicki, P., Bucki, S., Storman, D., & Jemioło, P. (2026) · Mental Health and Digital Technologies · doi:10.1108/mhdt-09-2025-0059
Hadjiat, Y., Marchand, S., & Poisbeau, P. (2025) · Dunod eBooks · doi:10.3917/dunod.poisb.2025.01.1706
Rossi, C., Frisone, F., Corrò, C., Pagnoncelli, G., Sanna, M., CONFALONIERI, E. M., Oasi, O., Chittaro, L., & Riva, G. (2026) · The Arts in Psychotherapy · doi:10.1016/j.aip.2026.102505
Soni, V., Chattoraj, H. M., & Dutt, V. (2026) · Lecture notes in networks and systems · doi:10.1007/978-3-032-20612-1_34
Sîngeap, M. S., Onita, C. A., Matei, D. V., Dobrin, R., Gotcă, I., Rădeanu, M., Petrescu-Miron, D., & Mocanu, V. (2026) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2026.1881373 · Cited by 1
“Consequently, the choice of a VR stress paradigm extends beyond methodological considerations, in fl uencing both theoretical interpretation and practical application (38, 39).”
Sabbar, M. B., Ushaw, G., & Davison, R. (2026) · Multimodal Technologies and Interaction · doi:10.3390/mti10080078
Reflections on using virtual reality exposure therapy in an anxiety disorders programme
Kirwan, S., & Donohue, G. (2026) · British Journal of Mental Health Nursing · doi:10.12968/bjmh.2026.0011
Rahin, S. A., Li, W., & McKinney, B. A. (2026) · International Conference on Bioinformatics and Computational Biology (ICBCB) · doi:10.1109/icbcb69424.2026.11621303
Hosseini, F. A., Bahman, K., Shaygan, M., & Yektatalab, S. (2026) · PLoS ONE · doi:10.1371/journal.pone.0354610
Felemban, R. G., Alzahrani, R. R., Alrefaei, N. F., Alharbi, N. M., Alghamdi, A. S., & Alqadi, S. (2026) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2026.1857109 · Cited by 1
Flooding et exposition en imagination
Aouizerate, B., Servant, D., Bouvard, A., & Josse, F. (2025) · Elsevier eBooks · doi:10.1016/b978-2-294-77965-7.00053-8
Yöntem, E. A. (2026) · Studies in big data · doi:10.1007/978-3-032-18562-4_17
Hung, C.-H., Yang, S.-Y., Chang, H.-J., Chen, Y.-J., Shih, H.-S., & Fan, S.-C. (2026) · OTJR Occupational Therapy Journal of Research · doi:10.1177/15394492261476591
Martins, S., Vairinhos, M., Soares, S. C., Félix, A. L. S., Araújo, C. A., & Diniz, F. (2026) · Lecture notes in computer science · doi:10.1007/978-3-032-33500-5_31
Krumnikl, M., Němec, M., Vilímková, A., Huser, F., & Jaremová, V. (2026) · Frontiers in Virtual Reality · doi:10.3389/frvir.2026.1916925
McCafferty, P., Marshall, G., Cushnan, J., Booth, N., Brady, B., Quinn, A., & Best, P. (2026) · The British Journal of Social Work · doi:10.1093/bjsw/bcag162
Dupont, L., Lepage, M., Couture, S., Raucher-Chéné, D., Mercier, N., Voyer, C., Beauchamps, P., & Thibaudeau, E. (2026) · Archives of Psychiatric Nursing · doi:10.1016/j.apnu.2026.152220
Carrasco, K., Escarzaga, A. M., Gonzalez, M., Rosenfelder, A., Beltrán, N., Ford, C., Miguel, K., Scott, L. C. A., & Carrasco, A. (2026) · PLoS ONE · doi:10.1371/journal.pone.0356395
Wicaksana, I. G. A. T., Harta, I. P. A. N., Kamaryati, N. P., & Putra, I. N. A. M. (2025) · Nurse Professional Education Journal · doi:10.67958/nurseedu.v1i1.14
Fang, H., Huang, Z., Zhu, L., Dai, Q., Hong, M., Guo, H., & Wang, E. (2026) · Frontiers in Public Health · doi:10.3389/fpubh.2026.1874822 · Cited by 1
“In the virtual exposure module, the system simulated typical academic stress contexts through VR scenarios, allowing participants to complete gradual exposure exercises in a relatively controlled virtual environment (15, 29, 30).”
Lewis-Fung, S. E., Geitz, V., Tchao, D., Inthiran, A., Malik, K., Gray, H. G., Gold, D. A., Bui, E., & Appel, L. (2026) · doi:10.2196/preprints.110718
Applications and outcomes of virtual reality in inpatient psychiatry: A systematic review
Fontaine-Dussault, Z., Hazel, L., Dupont, L., Jeffrey, C., Bernard-Gilbert, C., Fontaine, F., Soucy, C., Wang, M., Lepage, M., & Thibaudeau, É. (2026) · Psychological Medicine · doi:10.1017/s0033291726105662
Wang, C.-Y., Yu, Z., Zhao, J., & Zhang, A. (. S. (2026) · British Journal of Guidance and Counselling · doi:10.1080/03069885.2026.2687582
Hu, S., Zhu, J., Liu, W., Wang, F., Liu, J., Gao, X., Zhi, Y., & Kim, D. (2026) · Journal of Spinal Cord Medicine · doi:10.1080/10790268.2026.2724660
P‐4.5: A Review of Emotion‐Driven Personalized Recommendation for VR‐Based Stress Reduction
Zhou, Z., Li, Z., & Wang, L. (2026) · SID Symposium Digest of Technical Papers · doi:10.1002/sdtp.70003_320
Stepping into fear safely: A case study on mixed reality exposure in spider phobia
Moritz, S., Meinhart, A., Miegel, F. S., Blömer, J., & Rojahn, K. M. (2026) · Bulletin of the Menninger Clinic · doi:10.1521/bumc.2026.90.3.221
The influence of virtual reality on anxiety and pain in breast cancer patients: A systematic review
Kundarti, F. I., Triwiyanto, T., Titisari, I., Sujianto, U., Nurlaili, A., & Azmi, Z. F. (2026) · Technical Innovations & Patient Support in Radiation Oncology · doi:10.1016/j.tipsro.2026.100436
“…the shortest duration of 5 min per session in patients with low back pain [65] and the longest 60 min per session in stroke patients [66] with the shortest intervention duration of 4 weeks in stroke patients [66] and the longest duration of 12 weeks in patients with Social anxiety & phobia [67].”
Applications of Virtual Reality in Psychiatry. Systematic Review of the Scientific Literature
Ştefănescu, B., Vieru, D. S., MD, P. S., & Ciopeică, V. C. (2026) · Bulletin of Integrative Psychiatry · doi:10.36219/bpi.2026.3.08
Pizzoli, S. F. M., Josupeit, J., Savioni, L., & Triberti, S. (2026) · Frontiers in Psychology · doi:10.3389/fpsyg.2026.1891764
Swędrak, R., Dobrakowska, Z., & Klepacz, J. (2026) · International Journal of Innovative Technologies in Social Science · doi:10.31435/ijitss.3(51).2026.6622
Augmented Reality in Mental Health: Current Use, Perspectives and Limitations
Gonçalves, L. L. (2026) · IntechOpen eBooks · doi:10.5772/intechopen.1017873
Health Care Workers’ Perspectives on Virtual Reality in Mental Health: Qualitative Interview Study
Szczegielniak, A. R., Możaryn, J., Kunert, Ł., Florek, S., & Pudło, R. (2026) · JMIR Human Factors · doi:10.2196/80851
“VR-based interventions have demonstrated efficacy for anxiety disorders through VR exposure therapy, which allows patients to confront fear-inducing stimuli in a safe, controlled environment [6,9,10].”
Bozkurt, H. T., Brewer, B. W., Çelikcan, U., Türkçapar, M. H., & Koruç, Z. (2026) · The Sport Psychologist · doi:10.1123/tsp.2025-0127
Obuća, F., Ünal‐Aydın, P., & Aydın, O. (2026) · Clinical and Experimental Health Sciences · doi:10.33808/clinexphealthsci.1760552
Łapot, M., Hober, K., Krupnik, D., Skowron, W., Skowron, M., Bzdak, W., Szwemińska, P., Górak, J., & Neumann, W. (2026) · International Journal of Innovative Technologies in Social Science · doi:10.31435/ijitss.3(51).2026.6235
Tan, Y., 郑晓晖, li, H., Liu, T., Zhou, Y., Xin, J., Luo, J., Zhou, Y., Gao, P., Ge, M., et al. (2026) · doi:10.2196/preprints.114217
Chapter 12. The Future of Addictive Video Games
Noureddine, C., & Parkerson, J. (2025) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9798894551456.lg12
Heriot-Maitland, C., Brown, P., & Hardy, K. V. (2026) · Santé mentale au Québec · doi:10.7202/1129189ar
Addagada, G. C., Tandon, V., Yadav, S., Agrawal, D., Gupta, D., Raheja, A., Nehra, A., Kumar, N., & Poodipedi, S. C. (2026) · Journal of Clinical Neuroscience · doi:10.1016/j.jocn.2026.112338
Metadata
- Authors
- Maples-Keller, J. L., Bunnell, B. E., Kim, S.-J., & Rothbaum, B. O.
- Affiliations
- Emory University (US)
- Venue
- Harvard Review of Psychiatry
- Published
- 2017-05
- Volume
- 25
- Issue
- 3
- Pages
- 103-113
- ISSN
- 1067-3229 (ISSN-L)
- 1465-7309
- PMC
- PMC5421394
- OpenAlex
- W2611287876
- Cited by
- 862
- References
- 108
- Citations by year
- 2026: 111 · 2025: 147 · 2024: 115 · 2023: 93 · 2022: 113 · 2021: 117 · 2020: 85 · 2019: 51 · 2018: 24 · 2017: 5
- FWCI
- 4.40
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Harvard Review of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Genentech
- National Institute of Mental Health (R01MH094757, R01MH070880)
- Topics
- Physical Sciences › Computer Science › Human-Computer Interaction › Virtual Reality Applications and Impacts
- Social Sciences › Psychology › Applied Psychology › Digital Mental Health Interventions
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Keywords
- virtual reality, anxiety disorders, mental illness, exposure therapy, virtual reality exposure therapy, immersive virtual reality, head-mounted displays, treatment effectiveness, psychiatric treatment
- MeSH terms
- Anxiety Disorders, Humans, Randomized Controlled Trials as Topic, Treatment Outcome, Virtual Reality Exposure Therapy
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review