The DOI matches its Crossref record; 119 of the 119 references it cites were found in a registry or an index.
Glaucoma as a neurodegenerative disease
Abstract
PURPOSE OF REVIEW: Glaucoma is a leading cause of irreversible world vision loss characterized by progressive retinal ganglion cell death. Elevated eye pressure is a major risk factor for glaucoma; however, despite effective medical and surgical therapies to reduce intraocular pressure, progressive vision loss among glaucoma patients is common. These observations suggest that mechanisms independent of intraocular pressure are also implicated in glaucomatous degeneration. Numerous similarities exist between glaucoma and neurodegenerative diseases such as Alzheimer's and Parkinson's diseases. Similarities include the selective loss of neuron populations, transsynaptic degeneration in which disease spreads from injured neurons to connected neurons, and common mechanisms of cell injury and death. RECENT FINDINGS: Glaucomatous injury to retinal ganglion cells has profound effects on target vision structures within the brain, including the lateral geniculate nucleus and visual cortex in experimental primate and human glaucoma. Mechanisms involved in central visual system damage in glaucoma include oxidative injury and glutamate toxicity, as seen in neurodegenerative diseases. SUMMARY: Glaucoma as a neurodegenerative disease is a valid working hypothesis to understand neural injury in the visual system. This paradigm may stimulate the discovery of innovative intraocular pressure-independent strategies to help prevent loss of vision in glaucoma patients.
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Cites
The number of people with glaucoma worldwide in 2010 and 2020
Quigley, H. A. (2006) · British Journal of Ophthalmology · doi:10.1136/bjo.2005.081224 · Cited by 7,394
Mitochondrial Dysfunction and Oxidative Stress in Neurodegenerative Diseases
Lin, M. T., & Beal, M. F. (2006) · Nature · doi:10.1038/nature05292 · Cited by 6,455
Signal integration in the endoplasmic reticulum unfolded protein response
Ron, D., & Walter, P. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2199 · Cited by 6,296
Heijl, A. (2002) · Archives of Ophthalmology · doi:10.1001/archopht.120.10.1268 · Cited by 3,320
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Giasson, B. I., Duda, J. E., Murray, I. V. J., Chen, Q., Souza, J. M., Hurtig, H. I., Ischiropoulos, H., Trojanowski, J. Q., & -Y. Lee, V. M. (2000) · Science · doi:10.1126/science.290.5493.985 · Cited by 1,546
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Dada, T., Mittal, D., Mohanty, K., Faiq, M. A., Bhat, M. A., Yadav, R. K., Sihota, R., Sidhu, T., Velpandian, T., Kalaivani, M., et al. (2018) · Journal of Glaucoma · doi:10.1097/ijg.0000000000001088 · Cited by 135
Neuroprotection in Glaucoma: Animal Models and Clinical Trials
Almasieh, M., & Levin, L. A. (2017) · Annual Review of Vision Science · doi:10.1146/annurev-vision-102016-061422 · Cited by 111
Alzheimer’s Disease and Glaucoma: Mechanistic Similarities and Differences
Ghiso, J. A. (2013) · Journal of Glaucoma · doi:10.1097/ijg.0b013e3182934af6 · Cited by 107
Neuroprotection for glaucoma: Requirements for clinical translation
Levin, L. A., Crowe, M. E., Quigley, H. A., Cordeiro, M. F., Donoso, L. A., Liao, Y. J., Libby, R. T., Masland, R. H., Nickells, R. W., Sieving, P. A., et al. (2017) · Experimental Eye Research · doi:10.1016/j.exer.2016.12.005 · Cited by 66
Metadata
- Authors
- Gupta, N., & Yücel, Y. H.
- Venue
- Current Opinion in Ophthalmology
- Published
- 2007-03
- Volume
- 18
- Issue
- 2
- Pages
- 110-114
- ISSN
- 1040-8738 (ISSN-L)
- OpenAlex
- W2023691343
- Cited by
- 422
- References
- 119
- FWCI
- 12.27
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
