Neuroprotection in Glaucoma: Animal Models and Clinical Trials

Improving Bioscience Research Reporting: The ARRIVE Guidelines for Reporting Animal Research

Kilkenny, C., Browne, W. J., Cuthill, I. C., Emerson, M., & Altman, D. G. (2010) · PLoS Biology · doi:10.1371/journal.pbio.1000412 · Cited by 7,300 · see citing works

Improving bioscience research reporting: The ARRIVE guidelines for reporting animal research

Kilkenny, C., Browne, W. J., Cuthill, I. C., Emerson, M., & Altman, D. G. (2010) · Journal of Pharmacology and Pharmacotherapeutics · doi:10.4103/0976-500x.72351 · Cited by 6,277 · see citing works

Poly Lactic-co-Glycolic Acid (PLGA) as Biodegradable Controlled Drug Delivery Carrier

Makadia, H. K., & Siegel, S. J. (2011) · Polymers · doi:10.3390/polym3031377 · Cited by 4,816 · see citing works

The Ocular Hypertension Treatment Study

Kass, M. A. (2002) · Archives of Ophthalmology · doi:10.1001/archopht.120.6.701 · Cited by 3,715 · see citing works

Phototransduction by retinal ganglion cells that set the circadian clock

Berson, D. M., Dunn, F. A., & Takao, M. (2002) · Science · doi:10.1126/science.1067262 · Cited by 3,629 · see citing works

Reduction of Intraocular Pressure and Glaucoma Progression

Heijl, A. (2002) · Archives of Ophthalmology · doi:10.1001/archopht.120.10.1268 · Cited by 3,407 · see citing works

Diffusion tensor imaging detects and differentiates axon and myelin degeneration in mouse optic nerve after retinal ischemia

Song, S.-K., Sun, S.-W., Ju, W.-K., Lin, S.-J., Cross, A. H., & Neufeld, A. H. (2003) · NeuroImage · doi:10.1016/j.neuroimage.2003.07.005 · Cited by 1,738 · see citing works

Update of the Stroke Therapy Academic Industry Roundtable Preclinical Recommendations

Fisher, M., Feuerstein, G., Howells, D. W., Hurn, P. D., Kent, T. A., Savitz, S. I., & Lo, E. H. (2009) · Stroke · doi:10.1161/strokeaha.108.541128 · Cited by 1,352 · see citing works

A Novel Human Opsin in the Inner Retina

Provencio, I., Rodriguez, I. R., Jiang, G., Hayes, W. P., Moreira, E. F., & Rollag, M. D. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-02-00600.2000 · Cited by 1,290 · see citing works

Parallel processing in the mammalian retina

Wässle, H. (2004) · Nature reviews. Neuroscience · doi:10.1038/nrn1497 · Cited by 1,253 · see citing works

The Neuronal Organization of the Retina

Masland, R. H. (2012) · Neuron · doi:10.1016/j.neuron.2012.10.002 · Cited by 1,155 · see citing works

Effect of intravenous corticosteroids on death within 14 days in 10 008 adults with clinically significant head injury (MRC CRASH trial): randomised placebo-controlled trial

(2004) · The Lancet · doi:10.1016/s0140-6736(04)17188-2 · Cited by 1,111 · see citing works

The molecular basis of retinal ganglion cell death in glaucoma

Almasieh, M., Wilson, A. M., Morquette, B., Vargas, J. L. C., & Polo, A. D. (2011) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2011.11.002 · Cited by 974 · see citing works

Glia–neuron interactions in the mammalian retina

Vecino, E., Rodriguez, F. D., Ruzafa, N., Pereiro, X., & Sharma, S. C. (2015) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2015.06.003 · Cited by 827 · see citing works

Comparison of Treatment Effects between Animal Experiments and Clinical Trials: Systematic Review

Perel, P., Roberts, I., Sena, E., Wheble, P., Briscoe, C., Sandercock, P., Macleod, M., Mignini, L. E., Jayaram, P., & Khan, K. S. (2007) · BMJ · doi:10.1136/bmj.39048.407928.be · Cited by 827 · see citing works

The Types of Retinal Ganglion Cells: Current Status and Implications for Neuronal Classification

Sanes, J. R., & Masland, R. H. (2015) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-071714-034120 · Cited by 789 · see citing works

The Two Cultures and the Scientific Revolution

Sumner, W. L. (1959) · Nature · doi:10.1038/184411a0 · Cited by 742 · see citing works

Transcellular degradation of axonal mitochondria

Davis, C.-H. O., Kim, K.-Y., Bushong, E. A., Mills, E. A., Boassa, D., Shih, T., Kinebuchi, M., Phan, S., Zhou, Y., Bihlmeyer, N. A., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1404651111 · Cited by 673 · see citing works

Latanoprost for open-angle glaucoma (UKGTS): a randomised, multicentre, placebo-controlled trial

Garway‐Heath, D. F., Crabb, D. P., Bunce, C., Lascaratos, G., Amalfitano, F., Anand, N., Azuara‐Blanco, A., Bourne, R., Broadway, D. C., Cunliffe, I. A., et al. (2014) · The Lancet · doi:10.1016/s0140-6736(14)62111-5 · Cited by 667 · see citing works

Axons of retinal ganglion cells are insulted in the optic nerve early in DBA/2J glaucoma

Howell, G. R., Libby, R. T., Jakobs, T., Smith, R. S., Phalan, F. C., Barter, J. W., Barbay, J. M., Marchant, J. K., Nagaraju, M., Porciatti, V., et al. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200706181 · Cited by 593 · see citing works

Ciliary neurotrophic factor (CNTF) for human retinal degeneration: Phase I trial of CNTF delivered by encapsulated cell intraocular implants

Sieving, P. A., Caruso, R. C., Tao, W., Coleman, H. R., Thompson, D. J. S., Fullmer, K. R., & Bush, R. A. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0600236103 · Cited by 591 · see citing works

A randomized placebo-controlled trial of idebenone in Leber’s hereditary optic neuropathy.

Klopstock, T., Yu-Wai-Man, P., Dimitriadis, K., Rouleau, J., Heck, S., Bailie, M., Atawan, A., Chattopadhyay, S., Schubert, M., Garip, A., et al. (2011) · Brain · doi:10.1093/brain/awr170 · Cited by 578 · see citing works

Essential iris atrophy, pigment dispersion, and glaucoma in DBA/2J mice.

John, S. W. M., Smith, R. S., Savinova, O. V., Hawes, N. L., Chang, B., Turnbull, D., Davisson, M. T., Roderick, T. H., & Heckenlively, J. R. (1998) · PubMed · Cited by 549 · see citing works

Effect of Acetazolamide on Visual Function in Patients With Idiopathic Intracranial Hypertension and Mild Visual Loss

Wall, M., McDermott, M., Kieburtz, K. D., Corbett, J. J., Feldon, S. E., Friedman, D. I., Katz, D. M., Keltner, J. L., SCHRON, E. B., & Kupersmith, M. J. (2014) · JAMA · doi:10.1001/jama.2014.3312 · Cited by 548 · see citing works

A Rat Model of Chronic Pressure-induced Optic Nerve Damage

MORRISON, J. C., Moore, C. G., DEPPMEIER, L. M. H., Gold, B. G., Meshul, C. K., & Johnson, E. C. (1997) · Experimental Eye Research · doi:10.1006/exer.1996.0184 · Cited by 520 · see citing works

Where is the evidence that animal research benefits humans?

Pound, P., Ebrahim, S. B. J., Sandercock, P. A., Bracken, M. B., & Roberts, I. (2004) · BMJ · doi:10.1136/bmj.328.7438.514 · Cited by 507 · see citing works

Ganglion cell losses underlying visual field defects from experimental glaucoma.

Harwerth, R. S., Carter‐Dawson, L. D., Shen, F., Smith, E. L., III, & Crawford, M. L. J. (1999) · PubMed · Cited by 472 · see citing works

Glaucoma as a neurodegenerative disease

Gupta, N., & Yücel, Y. H. (2007) · Current Opinion in Ophthalmology · doi:10.1097/icu.0b013e3280895aea · Cited by 423 · see citing works

A Randomized Trial of Brimonidine Versus Timolol in Preserving Visual Function: Results From the Low-pressure Glaucoma Treatment Study

Krupin, T., Liebmann, J. M., Greenfield, D. S., Ritch, R. H., & Gardiner, S. K. (2011) · American Journal of Ophthalmology · doi:10.1016/j.ajo.2010.09.026 · Cited by 394 · see citing works

The Microbead Occlusion Model: A Paradigm for Induced Ocular Hypertension in Rats and Mice

Sappington, R. M., Carlson, B. J., Crish, S. D., & Calkins, D. J. (2010) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.09-3947 · Cited by 391 · see citing works

Retinal ganglion cell degeneration is topological but not cell type specific in DBA/2J mice

Jakobs, T., Libby, R. T., Ben, Y., John, S. W. M., & Masland, R. H. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200506099 · Cited by 378 · see citing works

Molecular basis of glutamate toxicity in retinal ganglion cells

Sucher, N. J., Lipton, S. A., & Dreyer, E. B. (1997) · Vision Research · doi:10.1016/s0042-6989(97)00047-3 · Cited by 377 · see citing works

Inhibition of nitric-oxide synthase 2 by aminoguanidine provides neuroprotection of retinal ganglion cells in a rat model of chronic glaucoma

Neufeld, A. H., Sawada, A., & BECKER, B. A. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.17.9944 · Cited by 376 · see citing works

The Relationship between Glaucoma Medication Adherence, Eye Drop Technique, and Visual Field Defect Severity

Sleath, B. L., Blalock, S. J., COVERT, D. W., Stone, J. L., Skinner, A. C., Muir, K. W., & Robin, A. L. (2011) · Ophthalmology · doi:10.1016/j.ophtha.2011.05.013 · Cited by 367 · see citing works

Retinal Ganglion Cell Apoptosis in Glaucoma Is Related to Intraocular Pressure and IOP-Induced Effects on Extracellular Matrix

Guo, L., Moss, S. E., Alexander, R., Ali, R. R., Fitzke, F. W., & Cordeiro, M. F. (2004) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.04-0832 · Cited by 351 · see citing works

Under Pressure: Cellular and Molecular Responses During Glaucoma, a Common Neurodegeneration with Axonopathy

Nickells, R. W., Howell, G. R., Soto, I., & John, S. W. M. (2012) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.051508.135728 · Cited by 338 · see citing works

The probability of blindness from open-angle glaucoma

Hattenhauer, M. G., Johnson, D. H., Ing, H. H., Herman, D. C., Hodge, D. O., Yawn, B. P., Butterfield, L. C., & Gray, D. T. (1998) · Ophthalmology · doi:10.1016/s0161-6420(98)91133-2 · Cited by 328 · see citing works

Glaucoma 2.0: Neuroprotection, Neuroregeneration, Neuroenhancement

Chang, E. E., & Goldberg, J. L. (2012) · Ophthalmology · doi:10.1016/j.ophtha.2011.11.003 · Cited by 327 · see citing works

Neuroprotection of retinal ganglion cells by brimonidine in rats with laser-induced chronic ocular hypertension.

WoldeMussie, E., Ruíz, G., Wijono, M., & Wheeler, L. A. (2001) · PubMed · Cited by 326 · see citing works

Translimbal laser photocoagulation to the trabecular meshwork as a model of glaucoma in rats.

Levkovitch-Verbin, H., Quigley, H. A., Martin, K. R. G., Valenta, D. F., Baumrind, L. A., & Pease, M. E. (2002) · PubMed · Cited by 320 · see citing works

Chronic ocular hypertension following episcleral venous occlusion in rats

Shareef, S., Garcia-Valenzuela, E., Salierno, A., Walsh, J., & Sharma, S. C. (1995) · Experimental Eye Research · doi:10.1016/s0014-4835(05)80131-9 · Cited by 300 · see citing works

Recent Advances in Ophthalmic Drug Delivery

Kompella, U. B., Kadam, R. S., & Lee, V. H. L. (2010) · Therapeutic Delivery · doi:10.4155/tde.10.40 · Cited by 291 · see citing works

Understanding mechanisms of pressure-induced optic nerve damage

Morrison, J. C., Johnson, E. C., Cepurna, W. O., & Jia, L. (2004) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2004.08.003 · Cited by 261 · see citing works

Periocular routes for retinal drug delivery

Raghava, S., Hammond, M., & Kompella, U. B. (2004) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.1.1.99 · Cited by 257 · see citing works

Alpha2-adrenoreceptor agonists are neuroprotective in a rat model of optic nerve degeneration.

Yoles, E., Wheeler, L. A., & Schwartz, M. (1999) · PubMed · Cited by 246 · see citing works

Recommendations for Clinical Trial Evaluation of Acute Stroke Therapies

Roundtable, S. T. A. I. (2001) · Stroke · doi:10.1161/01.str.32.7.1598 · Cited by 244 · see citing works

Emergency medicine animal research: does use of randomization and blinding affect the results?

Bebarta, V., Luyten, D., & Heard, K. (2003) · Academic Emergency Medicine · doi:10.1111/j.1553-2712.2003.tb00056.x · Cited by 244 · see citing works

Recent Applications of Liposomes in Ophthalmic Drug Delivery

Mishra, G. P., Bagui, M., Tamboli, V., & Mitra, A. K. (2011) · Journal of Drug Delivery · doi:10.1155/2011/863734 · Cited by 232 · see citing works

Chronology of optic nerve head and retinal responses to elevated intraocular pressure.

Johnson, E. C., DEPPMEIER, L. M. H., Wentzien, S., Hsu, I., & Morrison, J. C. (2000) · PubMed · Cited by 230 · see citing works

The pig eye as a novel model of glaucoma

Ruiz‐Ederra, J., Garcı́a, M., Hernández, M., Urcola, A., Hernández-Barbáchano, E., Araiz, J., & Vecino, E. (2005) · Experimental Eye Research · doi:10.1016/j.exer.2005.03.014 · Cited by 226 · see citing works

Efficacy and Safety of Memantine Treatment for Reduction of Changes Associated with Experimental Glaucoma in Monkey, II: Structural Measures

Hare, W. A., WoldeMussie, E., Weinreb, R. N., Ton, H., Ruíz, G., Wijono, M., Feldmann, B., Zangwill, L. M., & Wheeler, L. A. (2004) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.03-0567 · Cited by 222 · see citing works

Retinal Ganglion Cell Death in Glaucoma: Mechanisms and Neuroprotective Strategies

Kuehn, M. H., Fingert, J. H., & Kwon, Y. H. (2005) · Ophthalmology Clinics of North America · doi:10.1016/j.ohc.2005.04.002 · Cited by 219 · see citing works

Myelination transition zone astrocytes are constitutively phagocytic and have synuclein dependent reactivity in glaucoma

Nguyen, J. V., Soto, I., Kim, K.-Y., Bushong, E. A., Oglesby, E., Valiente‐Soriano, F. J., Yang, Z., Davis, C.-H. O., Bedont, J. L., Son, J. L., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1013965108 · Cited by 213 · see citing works

Imaging individual neurons in the retinal ganglion cell layer of the living eye

Rossi, E. A., Granger, C. E., Sharma, R., Yang, Q., Saito, K., Schwarz, C., Walters, S., Nozato, K., Zhang, J., Kawakami, T., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1613445114 · Cited by 205 · see citing works

Oxygen and blood flow: players in the pathogenesis of glaucoma.

Mozaffarieh, M., Grieshaber, M. C., & Flammer, J. (2008) · PubMed Central · Cited by 199 · see citing works

Detection and measurement of clinically meaningful visual field progression in clinical trials for glaucoma

Moraes, C. G. D., Liebmann, J., & Levin, L. (2016) · Progress in retinal and eye research · doi:10.1016/j.preteyeres.2016.10.001 · Cited by 194 · see citing works

VEGF-A Is Necessary and Sufficient for Retinal Neuroprotection in Models of Experimental Glaucoma

Foxton, R. H., Finkelstein, A., Vijay, S., Dahlmann-Noor, A. H., Khaw, P. T., Morgan, J. E., Shima, D. T., & Ng, Y. (2013) · American Journal Of Pathology · doi:10.1016/j.ajpath.2012.12.032 · Cited by 189 · see citing works

Initial Arcuate Defects within the Central 10 Degrees in Glaucoma

Hood, D. C., Raza, A. S., Moraes, C. G. V. D., Odel, J. G., Greenstein, V. C., Liebmann, J. M., & Ritch, R. H. (2010) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.10-5803 · Cited by 185 · see citing works

Optic Neuropathy Due to Microbead-Induced Elevated Intraocular Pressure in the Mouse

Chen, H., Wei, X., Cho, K., Chen, G., Sappington, R. M., Calkins, D. J., & Chen, D. F. (2010) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.09-5115 · Cited by 184 · see citing works

Inhibition of the classical pathway of the complement cascade prevents early dendritic and synaptic degeneration in glaucoma

Williams, P. A., Tribble, J. R., Pepper, K. W., Cross, S. D., Morgan, B. P., Morgan, J. E., John, S. W. M., & Howell, G. R. (2016) · Molecular Neurodegeneration · doi:10.1186/s13024-016-0091-6 · Cited by 183 · see citing works

Excitotoxic Death of Retinal NeuronsIn VivoOccurs via a Non-Cell-Autonomous Mechanism

Lebrun-Julien, F., Duplan, L., Pernet, V., Osswald, I. K., Sapieha, P. S., Bourgeois, P., Dickson, K. M., Bowie, D., Barker, P. A., & Polo, A. D. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.0831-09.2009 · Cited by 182 · see citing works

Blindness and glaucoma: a comparison of patients progressing to blindness from glaucoma with patients maintaining vision

Oliver, J. E., Hattenhauer, M. G., Herman, D. C., Hodge, D. O., Kennedy, R., Fang-Yen, M., & Johnson, D. H. (2002) · American Journal of Ophthalmology · doi:10.1016/s0002-9394(02)01403-4 · Cited by 181 · see citing works

Selective Vulnerability of Specific Retinal Ganglion Cell Types and Synapses after Transient Ocular Hypertension

Ou, Y., Jo, R., Ullian, E. M., Wong, R., & Santina, L. D. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.0940-16.2016 · Cited by 178 · see citing works

Three experimental glaucoma models in rats: Comparison of the effects of intraocular pressure elevation on retinal ganglion cell size and death

Urcola, A., Hernández, M., & Vecino, E. (2006) · Experimental Eye Research · doi:10.1016/j.exer.2006.01.025 · Cited by 178 · see citing works

Functional and Cellular Responses in a Novel Rodent Model of Anterior Ischemic Optic Neuropathy

Bernstein, S. L., Guo, Y., Elman, M. J., Flower, R. W., & Johnson, M. A. (2003) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.03-0274 · Cited by 176 · see citing works

Persistence of the treatment effect of idebenone in Leber’s hereditary optic neuropathy

Klopstock, T., Metz, G., Yu‐Wai‐Man, P., Büchner, B., Gallenmüller, C., Bailie, M., Nwali, N., Griffiths, P. G., von Livonius, B., Reznicek, L., et al. (2013) · Brain · doi:10.1093/brain/aws279 · Cited by 175 · see citing works

Zebrafish—on the move towards ophthalmological research

Chhetri, J., Jacobson, G. A., & Gueven, N. (2014) · Eye · doi:10.1038/eye.2014.19 · Cited by 171 · see citing works

The immune system and glaucoma

Tezel, G., & Wax, M. B. (2004) · Current Opinion in Ophthalmology · doi:10.1097/00055735-200404000-00003 · Cited by 169 · see citing works

Inflammatory demyelination induces axonal injury and retinal ganglion cell apoptosis in experimental optic neuritis

Shindler, K. S., Ventura, E. S., Dutt, M., & Rostami, A. M. (2008) · Experimental Eye Research · doi:10.1016/j.exer.2008.05.017 · Cited by 153 · see citing works

Morphology of the murine optic nerve.

May, C. A., & Lütjen-Drecoll, E. (2002) · PubMed · Cited by 153 · see citing works

Melanopsin‐expressing ganglion cells on macaque and human retinas form two morphologically distinct populations

Liao, H., Ren, X., Peterson, B. B., MARSHAK, D. W., Yau, K., Gamlin, P. D., & Dacey, D. M. (2016) · The Journal of Comparative Neurology · doi:10.1002/cne.23995 · Cited by 153 · see citing works

The neurobiology of cell death in glaucoma

Vrabec, J. P., & Levin, L. A. (2007) · Eye · doi:10.1038/sj.eye.6702880 · Cited by 147 · see citing works

Prevalence of the breed‐related glaucomas in pure‐bred dogs in North America

Gelatt, K. N., & MacKay, E. O. (2004) · Veterinary Ophthalmology · doi:10.1111/j.1463-5224.2004.04006.x · Cited by 146 · see citing works

Efficacy and Safety of Memantine Treatment for Reduction of Changes Associated with Experimental Glaucoma in Monkey, I: Functional Measures

Hare, W. A., WoldeMussie, E., LAI, R. K., Ton, H., Ruíz, G., Chun, T., & Wheeler, L. A. (2004) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.03-0566 · Cited by 145 · see citing works

A Novel Method for the Induction of Experimental Glaucoma Using Magnetic Microspheres

Samsel, P. A., Kisiswa, L., Erichsen, J. T., Cross, S. D., & Morgan, J. E. (2010) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.09-3921 · Cited by 145 · see citing works

Differential Dendritic Shrinkage of α and β Retinal Ganglion Cells in Cats with Chronic Glaucoma

Shou, T., Liu, J., Wang, W., Zhou, Y., & Zhao, K. (2003) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.02-0620 · Cited by 142 · see citing works

The WldS gene delays axonal but not somatic degeneration in a rat glaucoma model

Beirowski, B., Babetto, E., Coleman, M. P., & Martin, K. R. G. (2008) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06426.x · Cited by 135 · see citing works

The Effect of Chronically Elevated Intraocular Pressure on the Rat Optic Nerve Head Extracellular Matrix

Johnson, E. C., MORRISON, J. C., Farrell, S. K., DEPPMEIER, L. M. H., Moore, C. G., & Mcginty, M. R. (1996) · Experimental Eye Research · doi:10.1006/exer.1996.0077 · Cited by 135 · see citing works

A critical appraisal of the NXY-059 neuroprotection studies for acute stroke: A need for more rigorous testing of neuroprotective agents in animal models of stroke

Savitz, S. T. (2007) · Experimental Neurology · doi:10.1016/j.expneurol.2007.03.003 · Cited by 134 · see citing works

Incidence of nonarteritic anterior ischemic optic neuropathy: increased risk among diabetic patients

Lee, M. S., Grossman, D., Arnold, A. C., & Sloan, F. A. (2011) · Ophthalmology · doi:10.1016/j.ophtha.2011.01.054 · Cited by 134 · see citing works

Effect of general anesthetics on IOP in rats with experimental aqueous outflow obstruction.

Jia, L., Cepurna, W. O., Johnson, E. C., & Morrison, J. C. (2000) · PubMed · Cited by 134 · see citing works

Neuroprotection in glaucoma: recent and future directions

Danesh-Meyer, H. V. (2011) · Current Opinion in Ophthalmology · doi:10.1097/icu.0b013e32834372ec · Cited by 133 · see citing works

Enhanced Insight into the Autoimmune Component of Glaucoma: IgG Autoantibody Accumulation and Pro-Inflammatory Conditions in Human Glaucomatous Retina

Gramlich, O. W., Gehrke-Beck, S., Hohenstein-Blaul, N. V. T. U., Boehm, N., Ziegler, A., Vetter, J. M., Pfeiffer, N., & Grus, F. H. (2013) · PLoS ONE · doi:10.1371/journal.pone.0057557 · Cited by 132 · see citing works

Sustained Ocular Hypertension Induces Dendritic Degeneration of Mouse Retinal Ganglion Cells That Depends on Cell Type and Location

Feng, L., Zhao, Y., Yoshida, M., Chen, H., Yang, J., Kim, T. S., Cang, J., Troy, J. B., & Liu, X. (2013) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.12-10791 · Cited by 127 · see citing works

Real-time imaging of single neuronal cell apoptosis in patients with glaucoma

Cordeiro, M. F., Normando, E. M., Cardoso, M. J., Miodragovic, S., Jeylani, S., Davis, B. M., Guo, L., Sebastien Ourselin, A., A’Hern, R., & Bloom, P. (2017) · Brain · doi:10.1093/brain/awx088 · Cited by 126 · see citing works

Demographic, systemic, and ocular factors associated with nonarteritic anterior ischemic optic neuropathy

Cestari, D. M., Gaier, E. D., Bouzika, P., Blachley, T. S., De Lott, L. B., Rizzo, J. F., Wiggs, J. L., Kang, J. H., Pasquale, L. R., & Stein, J. D. (2016) · Ophthalmology · doi:10.1016/j.ophtha.2016.08.017 · Cited by 125 · see citing works

Immunoregulation of retinal ganglion cell fate in glaucoma

Wax, M. B., & Tezel, G. (2009) · Experimental Eye Research · doi:10.1016/j.exer.2009.02.005 · Cited by 124 · see citing works

Parallel Processing in the Visual System: The Classification of Retinal Ganglion Cells and its Impact on the Neurobiology of Vision

Stone, J. (1983) · Medical Entomology and Zoology · Cited by 123 · see citing works

Missing Steps in the STAIR Case: A Translational Medicine Perspective on the Development of NXY-059 for Treatment of Acute Ischemic Stroke

Feuerstein, G., Zaleska, M. M., Krams, M., Wang, X., Day, M., Rutkowski, J., Finklestein, S. P., Pangalos, M. N., Poole, M., Stiles, G. L., et al. (2007) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600516 · Cited by 121 · see citing works

Experimental Mouse Ocular Hypertension: Establishment of the Model

Aihara, M., Lindsey, J. D., & Weinreb, R. N. (2003) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.03-0137 · Cited by 120 · see citing works

Circadian rhythm of intraocular pressure in the rat.

Moore, C., Johnson, E. C., & Morrison, J. C. (1996) · Current Eye Research · doi:10.3109/02713689608997412 · Cited by 118 · see citing works

Memantine Protects Neurons From Shrinkage in the Lateral Geniculate Nucleus in Experimental Glaucoma

Yücel, Y. H. (2006) · Archives of Ophthalmology · doi:10.1001/archopht.124.2.217 · Cited by 117 · see citing works

Neuroprotective Effect of Memantine in Different Retinal Injury Models in Rats

WoldeMussie, E., Yoles, E., Schwartz, M., Ruíz, G., & Wheeler, L. A. (2002) · Journal of Glaucoma · doi:10.1097/00061198-200212000-00003 · Cited by 117 · see citing works

Variability in patients with glaucomatous visual field damage is reduced using size V stimuli.

Wall, M., Kutzko, K. E., & Chauhan, B. C. (1997) · PubMed · Cited by 114 · see citing works

Superoxide is an associated signal for apoptosis in axonal injury

Kanamori, A., Catrinescu, M., Kanamori, N., Mears, K. A., Beaubien, R., & Levin, L. A. (2010) · Brain · doi:10.1093/brain/awq105 · Cited by 114 · see citing works

Imaging multiple phases of neurodegeneration: a novel approach to assessing cell death in vivo

Cordeiro, M. F., Guo, L., Coxon, K. M., Duggan, J., Nizari, S., Normando, E. M., Sensi, S. L., Sillito, A. M., Fitzke, F. W., Salt, T. E., et al. (2010) · Cell Death and Disease · doi:10.1038/cddis.2009.3 · Cited by 113 · see citing works

Long-Term Effect of Optic Nerve Axotomy on the Retinal Ganglion Cell Layer

Nadal-Nicolás, F. M., Sobrado‐Calvo, P., Jiménez-López, M., Vidal‐Sanz, M., & Agudo‐Barriuso, M. (2015) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.15-17195 · Cited by 112 · see citing works

Recommendations from the STAIR V meeting on acute stroke trials, technology and outcomes.

Fisher, M., Hanley, D., Howard, G., Jauch, E., & Warach, S. (2007) · Stroke · doi:10.1161/01.str.0000255951.37434.aa · Cited by 111 · see citing works

Intrinsic axonal degeneration pathways are critical for glaucomatous damage

Howell, G. R., Soto, I., Libby, R. T., & John, S. W. M. (2012) · Experimental Neurology · doi:10.1016/j.expneurol.2012.01.014 · Cited by 110 · see citing works

Retinal Ganglion Cell Dendritic Atrophy in DBA/2J Glaucoma

Williams, P. A., Howell, G. R., Barbay, J. M., Braine, C., Sousa, G. L., John, S. W. M., & Morgan, J. E. (2013) · PLoS ONE · doi:10.1371/journal.pone.0072282 · Cited by 110 · see citing works

Retinal ganglion cell death in glaucoma: Exploring the role of neuroinflammation

Russo, R., Varano, G. P., Adornetto, A., Nucci, C., Corasaniti, M. T., Bagetta, G., & Morrone, L. A. (2016) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2016.03.064 · Cited by 110 · see citing works

Endophthalmitis following intravitreal anti-vascular endothelial growth factor (VEGF) injection: a comprehensive review

Merani, R., & Hunyor, A. P. (2015) · International Journal of Retina and Vitreous · doi:10.1186/s40942-015-0010-y · Cited by 108 · see citing works

Prophylaxis for Second Eye Involvement in Leber Hereditary Optic Neuropathy: An Open-Labeled, Nonrandomized Multicenter Trial of Topical Brimonidine Purite

Newman, N. J., Biousse, V., David, R., Bhatti, M. T., Hamilton, S. R., Farris, B. K., Lesser, R. L., Newman, S. A., Turbin, R. E., Chen, K., et al. (2005) · American Journal of Ophthalmology · doi:10.1016/j.ajo.2005.03.058 · Cited by 105 · see citing works

Automated Pupil Perimetry Pupil Field Mapping in Patients and Normal Subjects

Kardon, R. H., Kirkali, P., & Thompson, H. S. (1991) · Ophthalmology · doi:10.1016/s0161-6420(91)32267-x · Cited by 105 · see citing works

Retinal Ganglion Cell Axotomy Induces an Increase in Intracellular Superoxide Anion

Lieven, C. J., Hoegger, M. J., Schlieve, C. R., & Levin, L. A. (2006) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.05-0921 · Cited by 102 · see citing works

The United Kingdom Glaucoma Treatment Study

Garway‐Heath, D. F., Lascaratos, G., Bunce, C., Crabb, D. P., Russell, R. A., & Shah, A. (2012) · Ophthalmology · doi:10.1016/j.ophtha.2012.07.028 · Cited by 97 · see citing works

Evaluation of Inducible Nitric Oxide Synthase in Glaucomatous Optic Neuropathy and Pressure-Induced Optic Nerve Damage

Pang, I.-H., Johnson, E. C., Jia, L., Cepurna, W. O., Shepard, A. R., Hellberg, M. R., Clark, A. F., & Morrison, J. C. (2005) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.04-0829 · Cited by 94 · see citing works

Sustained Secretion of Ciliary Neurotrophic Factor to the Vitreous, Using the Encapsulated Cell Therapy-Based NT-501 Intraocular Device

Thanos, C. G., Bell, W. J., O'Rourke, P., Kauper, K. A., Sherman, S., Stabila, P. F., & Tao, W. (2004) · Tissue Engineering · doi:10.1089/ten.2004.10.1617 · Cited by 94 · see citing works

Puerarin protected the brain from cerebral ischemia injury via astrocyte apoptosis inhibition

Wang, N., Zhang, Y., Wu, L., Wang, Y., Cao, Y., He, L., Li, X., & Zhao, J. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.12.004 · Cited by 94 · see citing works

Structural and functional neuroprotection in glaucoma: role of galantamine-mediated activation of muscarinic acetylcholine receptors

Almasieh, M., Zhou, Y., Kelly, M. E. M., Casanova, C., & Polo, A. D. (2010) · Cell Death and Disease · doi:10.1038/cddis.2009.23 · Cited by 92 · see citing works

Experimental glaucoma in the primate induced by latex microspheres

Weber, A. J., & Zelenak, D. (2001) · Journal of Neuroscience Methods · doi:10.1016/s0165-0270(01)00443-5 · Cited by 92 · see citing works

Feline glaucoma—a comprehensive review

McLellan, G. J., & Miller, P. E. (2011) · Veterinary Ophthalmology · doi:10.1111/j.1463-5224.2011.00912.x · Cited by 90 · see citing works

The Morphological Difference Between Glaucoma and Other Optic Neuropathies

Burgoyne, C. F. (2015) · Journal of Neuro-Ophthalmology · doi:10.1097/wno.0000000000000289 · Cited by 89 · see citing works

Optic Nerve Damage in Experimental Mouse Ocular Hypertension

Mabuchi, F., Aihara, M., Mackey, M. R., Lindsey, J. D., & Weinreb, R. N. (2003) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.03-0138 · Cited by 88 · see citing works

The non-human primate experimental glaucoma model

Burgoyne, C. F. (2015) · Experimental Eye Research · doi:10.1016/j.exer.2015.06.005 · Cited by 86 · see citing works

Neuroprotection: Extrapolating from Neurologic Diseases to the Eye

Danesh-Meyer, H. V., & Levin, L. A. (2009) · American Journal of Ophthalmology · doi:10.1016/j.ajo.2009.03.029 · Cited by 85 · see citing works

Who’s lost first? Susceptibility of retinal ganglion cell types in experimental glaucoma

Santina, L. D., & Ou, Y. (2016) · Experimental Eye Research · doi:10.1016/j.exer.2016.06.006 · Cited by 82 · see citing works

Glaucoma as a Neurodegenerative Disease

Danesh-Meyer, H. V., & Levin, L. A. (2015) · Journal of Neuro-Ophthalmology · doi:10.1097/wno.0000000000000293 · Cited by 79 · see citing works

Towards axonal regeneration and neuroprotection in glaucoma: Rho kinase inhibitors as promising therapeutics

de Velde, S. V., Groef, L. D., Stalmans, I., Moons, L., & Hove, I. V. (2015) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2015.06.002 · Cited by 76 · see citing works

Detecting Changes in Retinal Function: Analysis with Non-Stationary Weibull Error Regression and Spatial Enhancement (ANSWERS)

Zhu, H., Russell, R. A., Saunders, L. J., Ceccon, S., Garway‐Heath, D. F., & Crabb, D. P. (2014) · PLoS ONE · doi:10.1371/journal.pone.0085654 · Cited by 74 · see citing works

Evidence for preserved direct pupillary light response in Leber's hereditary optic neuropathy.

Wakakura, M., & Yokoe, J. (1995) · British Journal of Ophthalmology · doi:10.1136/bjo.79.5.442 · Cited by 73 · see citing works

Clinical trials for glaucoma neuroprotection are not impossible

Quigley, H. A. (2012) · Current Opinion in Ophthalmology · doi:10.1097/icu.0b013e32834ff490 · Cited by 71 · see citing works

Retinal ganglion cell dendrite pathology and synapse loss

Agostinone, J., & Di Polo, A. (2015) · Progress in Brain Research · doi:10.1016/bs.pbr.2015.04.012 · Cited by 68 · see citing works

Central Glaucomatous Damage of the Macula Can Be Overlooked by Conventional OCT Retinal Nerve Fiber Layer Thickness Analyses

Wang, D. L., Raza, A. S., Moraes, C. G. D., Chen, M. F., Alhadeff, P. A., Jarukatsetphorn, R., Ritch, R. H., & Hood, D. C. (2015) · Translational Vision Science & Technology · doi:10.1167/tvst.4.6.4 · Cited by 67 · see citing works

An intraocular drug delivery system using targeted nanocarriers attenuates retinal ganglion cell degeneration

Zhao, L., Chen, G., Li, J., Fu, Y., Mavlyutov, T. A., Yao, A., Nickells, R. W., Gong, S., & Guo, L. (2017) · Journal of Controlled Release · doi:10.1016/j.jconrel.2016.12.038 · Cited by 67 · see citing works

The role of lamina cribrosa cells in optic nerve head fibrosis in glaucoma

Wallace, D., & O'Brien, C. J. (2015) · Experimental Eye Research · doi:10.1016/j.exer.2014.12.006 · Cited by 66 · see citing works

Alpha-2 Adrenergic Receptor Agonists are Neuroprotective in Experimental Models of Glaucoma

Wheeler, L. A., & WoldeMussie, E. (2001) · European Journal of Ophthalmology · doi:10.1177/112067210101102s03 · Cited by 66 · see citing works

Protection of Mouse Retinal Ganglion Cell Axons and Soma from Glaucomatous and Ischemic Injury by Cytoplasmic Overexpression of Nmnat1

Zhu, Y., Zhang, L., Sasaki, Y., Milbrandt, J., & Gidday, J. M. (2012) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.12-10861 · Cited by 65 · see citing works

Retrograde and Wallerian Axonal Degeneration Occur Synchronously after Retinal Ganglion Cell Axotomy

Kanamori, A., Catrinescu, M., Bélisle, J. M., Costantino, S., & Levin, L. A. (2012) · American Journal Of Pathology · doi:10.1016/j.ajpath.2012.03.030 · Cited by 65 · see citing works

A novel nanoparticles impregnated ocular insert for enhanced bioavailability to posterior segment of eye: In vitro, in vivo and stability studies

Rathod, L. V., Kapadia, R., & Sawant, K. K. (2016) · Materials Science and Engineering C · doi:10.1016/j.msec.2016.10.017 · Cited by 65 · see citing works

BDNF Rescues RGCs But Not Intrinsically Photosensitive RGCs in Ocular Hypertensive Albino Rat Retinas

Valiente‐Soriano, F. J., Nadal-Nicolás, F. M., Salinas‐Navarro, M., Jiménez-López, M., Bernal-Garro, J. M., Villegas‐Pérez, M. P., Agudo‐Barriuso, M., & Vidal‐Sanz, M. (2015) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.15-16454 · Cited by 64 · see citing works

Calibration of the TonoLab Tonometer in Mice with Spontaneous or Experimental Glaucoma

Pease, M. E., Cone, F. E., Gelman, S. E., Son, J. L., & Quigley, H. A. (2010) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.10-5556 · Cited by 63 · see citing works

Optic Nerve Disease and Axon Pathophysiology

Ghaffarieh, A., & Levin, L. A. (2012) · International review of neurobiology · doi:10.1016/b978-0-12-398309-1.00002-0 · Cited by 62 · see citing works

A medical device/drug delivery system for treatment of glaucoma

Schultz, C. L., Poling, T. R., & Mint, J. O. (2009) · Clinical and Experimental Optometry · doi:10.1111/j.1444-0938.2009.00370.x · Cited by 62 · see citing works

Increased mitochondrial fission and volume density by blocking glutamate excitotoxicity protect glaucomatous optic nerve head astrocytes

Ju, W., Keun-young Kim, A., Noh, Y. H., Hoshijima, M., Lukas, T. J., Ellisman, M. H., Weinreb, R. N., & Perkins, G. A. (2014) · Glia · doi:10.1002/glia.22781 · Cited by 61 · see citing works

The glial cell modulator ibudilast attenuates neuroinflammation and enhances retinal ganglion cell viability in glaucoma through protein kinase A signaling

Vargas, J. L. C., Belforte, N., & Polo, A. D. (2016) · Neurobiology of Disease · doi:10.1016/j.nbd.2016.05.002 · Cited by 60 · see citing works

Experimental Glaucoma Causes Optic Nerve Head Neural Rim Tissue Compression: A Potentially Important Mechanism of Axon Injury

Fortune, B. A., Reynaud, J. F., Hardin, C., Wang, L., Sigal, I. A., & Burgoyne, C. F. (2016) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.16-20000 · Cited by 59 · see citing works

Accuracy of Pupil Assessment for the Detection of Glaucoma

Chang, D. S.-T., Xu, L., Boland, M. V., & Friedman, D. S. (2013) · Ophthalmology · doi:10.1016/j.ophtha.2013.04.012 · Cited by 57 · see citing works

Renin–angiotensin system regulates neurodegeneration in a mouse model of normal tension glaucoma

Semba, K., Namekata, K., Guo, X., Harada, C., Harada, T., & Mitamura, Y. (2014) · Cell Death and Disease · doi:10.1038/cddis.2014.296 · Cited by 57 · see citing works

The relationship between central visual field sensitivity and macular ganglion cell/inner plexiform layer thickness in glaucoma

Lee, J. W., Morales, E., Sharifipour, F., Amini, N., Yu, F., Afifi, A. A., Coleman, A. L., Caprioli, J., & Nouri‐Mahdavi, K. (2017) · British Journal of Ophthalmology · doi:10.1136/bjophthalmol-2016-309208 · Cited by 57 · see citing works

Amacrine cells coupled to ganglion cells via gap junctions are highly vulnerable in glaucomatous mouse retinas

Akopian, A., Kumar, S., Ramakrishnan, H., Viswanáthan, S., & Bloomfield, S. A. (2016) · The Journal of Comparative Neurology · doi:10.1002/cne.24074 · Cited by 52 · see citing works

Functional and Structural Changes in a Canine Model of Hereditary Primary Angle-Closure Glaucoma

Grozdanić, S. D., Kecova, H., Harper, M. M., Nilaweera, W. U., Kuehn, M. H., & Kardon, R. H. (2010) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.09-4081 · Cited by 52 · see citing works

Dendritic and Synaptic Protection: Is It Enough to Save the Retinal Ganglion Cell Body and Axon?

Morquette, J. B., & Di Polo, A. (2008) · Journal of Neuro-Ophthalmology · doi:10.1097/wno.0b013e318177edf0 · Cited by 51 · see citing works

Lost in Translation

Levin, L. A., & Danesh-Meyer, H. V. (2010) · JAMA · doi:10.1001/jama.2010.463 · Cited by 50 · see citing works

A cell‐permeable phosphine‐borane complex delays retinal ganglion cell death after axonal injury through activation of the pro‐survival extracellular signal‐regulated kinases 1/2 pathway

Almasieh, M., Lieven, C. J., Levin, L. A., & Polo, A. D. (2011) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2011.07382.x · Cited by 49 · see citing works

Tackling Glaucoma from within the Brain: An Unfortunate Interplay of BDNF and TrkB

Dekeyster, E., Geeraerts, E., Buyens, T., den Haute, C. V., Baekelandt, V., Groef, L. D., Salinas‐Navarro, M., & Moons, L. (2015) · PLoS ONE · doi:10.1371/journal.pone.0142067 · Cited by 49 · see citing works

The Effect of Stimulus Size on the Reliable Stimulus Range of Perimetry

Gardiner, S. K., Demirel, S., Goren, D., Mansberger, S. L., & Swanson, W. H. (2015) · Translational Vision Science & Technology · doi:10.1167/tvst.4.2.10 · Cited by 48 · see citing works

Comparison of the Efficacy of Topical Cyclosporine 0.05% Compared With Tobradex for the Treatment of Posterior Blepharitis

Rao, S. N. (2005) · Investigative Ophthalmology & Visual Science · Cited by 47 · see citing works

More Accurate Modeling of Visual Field Progression in Glaucoma: ANSWERS

Zhu, H., Crabb, D. P., Ho, T., & Garway‐Heath, D. F. (2015) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.15-16957 · Cited by 46 · see citing works

Reliability and Sensitivity of the TonoLab Rebound Tonometer in Awake Brown Norway Rats

Morrison, J. C., Jia, L., Cepurna, W. O., Guo, Y., & Johnson, E. C. (2009) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.08-2465 · Cited by 45 · see citing works

Solving the lost in translation problem: Improving the effectiveness of translational research

Ergorul, C., & Levin, L. A. (2012) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2012.08.005 · Cited by 44 · see citing works

A Comparison of Argon Laser and Diode Laser Photocoagulation of the Trabecular Meshwork to Produce the Glaucoma Monkey Model

Wang, R.-F., Schumer, R. A., Serle, J. B., & Podos, S. M. (1998) · Journal of Glaucoma · doi:10.1097/00061198-199802000-00009 · Cited by 40 · see citing works

Neuroprotective Effects of Transcription Factor Brn3b in an Ocular Hypertension Rat Model of Glaucoma

Stankowska, D. L., Minton, A. Z., Rutledge, M. A., Mueller, B., Phatak, N., He, S., Ma, H., Forster, M. J., Yorio, T., & Krishnamoorthy, R. R. (2015) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.14-15008 · Cited by 39 · see citing works

Clinical Evidence for Neuroprotection in Glaucoma

Cordeiro, M. F., & Levin, L. A. (2011) · American Journal of Ophthalmology · doi:10.1016/j.ajo.2011.06.015 · Cited by 39 · see citing works

Brain‐derived neurotrophic factor prevents dendritic retraction of adult mouse retinal ganglion cells

Binley, K. E., Ng, W. S., Barde, Y., Song, B., & Morgan, J. E. (2016) · European Journal of Neuroscience · doi:10.1111/ejn.13295 · Cited by 38 · see citing works

Proteomics Analyses of Activated Human Optic Nerve Head Lamina Cribrosa Cells following Biomechanical Strain

Rogers, R. S., Dharsee, M., Ackloo, S. Z., & Flanagan, J. G. (2012) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.11-8480 · Cited by 36 · see citing works

Retinal ganglion cell neuroprotection by an angiotensin II blocker in an ex vivo retinal explant model

White, A. J. R., Heller, J. P., Leung, J., Tassoni, A., & Martin, K. R. G. (2015) · Journal of the Renin-Angiotensin-Aldosterone System · doi:10.1177/1470320314566018 · Cited by 35 · see citing works

Neuroprotection in the treatment of glaucoma – A focus on connexin43 gap junction channel blockers

Chen, Y.-S., Green, C. R., Danesh-Meyer, H. V., & Rupenthal, I. D. (2015) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2015.01.031 · Cited by 33 · see citing works

Real-time imaging of RGC death with a cell-impermeable nucleic acid dyeing compound after optic nerve crush in a murine model

Tsuda, S., Tanaka, Y., Kunikata, H., Yokoyama, Y., Yasuda, M., Ito, A., & Nakazawa, T. (2016) · Experimental Eye Research · doi:10.1016/j.exer.2016.03.017 · Cited by 33 · see citing works

Autoimmune aspects in glaucoma

Hohenstein-Blaul, N. V. T. U., Bell, K. C., Pfeiffer, N., & Grus, F. H. (2016) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2016.04.031 · Cited by 32 · see citing works

In Vivo Imaging of Retinal Ganglion Cell Axons within the Nerve Fiber Layer

Kanamori, A., Catrinescu, M., Traistaru, M., Beaubien, R., & Levin, L. A. (2010) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.09-4021 · Cited by 31 · see citing works

A topical nitric oxide-releasing dexamethasone derivative: effects on intraocular pressure and ocular haemodynamics in a rabbit glaucoma model

Galassi, F., Masini, E., Giambene, B., Fabrizi, F., Uliva, C., Bolla, M., & Ongini, E. (2006) · British Journal of Ophthalmology · doi:10.1136/bjo.2006.099838 · Cited by 31 · see citing works

Identification and localization of lamina cribrosa cells in the human optic nerve head

Tovar-Vidales, T., Wordinger, R. J., & Clark, A. F. (2016) · Experimental Eye Research · doi:10.1016/j.exer.2016.05.006 · Cited by 31 · see citing works

Neuroprotection and regeneration in glaucoma.

Levin, L. A. (2005) · PubMed · doi:10.1016/j.ohc.2005.07.001 · Cited by 30 · see citing works

Autoimmune biomarkers in glaucoma patients

Gramlich, O. W., Bell, K. C., Hohenstein-Blaul, N. V. T. U., Wilding, C., Gehrke-Beck, S., Pfeiffer, N., & Grus, F. H. (2012) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2012.09.005 · Cited by 29 · see citing works

Effect of the Aβ Aggregation Modulator MRZ-99030 on Retinal Damage in an Animal Model of Glaucoma

Salt, T. E., Nizari, S., Cordeiro, M. F., Russ, H., & Danysz, W. (2014) · Neurotoxicity Research · doi:10.1007/s12640-014-9488-6 · Cited by 28 · see citing works

Animal and Culture Models of Glaucoma for Studying Neuroprotection

Levin, L. A. (2001) · European Journal of Ophthalmology · doi:10.1177/112067210101102s02 · Cited by 28 · see citing works

Central Visual Pathways in Glaucoma

Crish, S. D., & Calkins, D. J. (2015) · Journal of Neuro-Ophthalmology · doi:10.1097/wno.0000000000000291 · Cited by 27 · see citing works

Glaucoma-Induced Degeneration of Retinal Ganglion Cells Prevented by Hypoxic Preconditioning: A Model of Glaucoma Tolerance

Zhu, Y., Zhang, L., Schmidt, J. F., & Gidday, J. M. (2012) · Molecular Medicine · doi:10.2119/molmed.2012.00050 · Cited by 27 · see citing works

Controlled Release of Dexamethasone From an Intravitreal Delivery System Using Porous Silicon Dioxide

Hou, H., Wang, C., Nan, K., Freeman, W. R., Sailor, M. J., & Cheng, L. (2016) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.15-18559 · Cited by 26 · see citing works

Effect of Restricting Perimetry Testing Algorithms to Reliable Sensitivities on Test-Retest Variability

Gardiner, S. K., & Mansberger, S. L. (2016) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.16-20053 · Cited by 26 · see citing works

Superoxide signaling and cell death in retinal ganglion cell axotomy: Effects of metallocorroles

Catrinescu, M., Chan, W., Mahammed, A., Gross, Z., & Levin, L. A. (2012) · Experimental Eye Research · doi:10.1016/j.exer.2012.02.006 · Cited by 24 · see citing works

Identifying specific RGC types may shed light on their idiosyncratic responses to neuroprotection

Vidal‐Sanz, M., Nadal-Nicolás, F. M., Valiente‐Soriano, F. J., Agudo‐Barriuso, M., & Villegas-Pérez, M. (2015) · Neural Regeneration Research · doi:10.4103/1673-5374.162751 · Cited by 23 · see citing works

Targeting retinal ganglion cell recovery

Crowston, J. G., Fahy, E. T., Fry, L. E., Trounce, I. A., van Wijngaarden, P., Petrou, S., & Chrysostomou, V. (2017) · Eye · doi:10.1038/eye.2016.281 · Cited by 23 · see citing works

Stroke: the dashed hopes of neuroprotection

Hill, M. D. (2006) · The Lancet Neurology · doi:10.1016/s1474-4422(06)70658-5 · Cited by 20 · see citing works

Plate reader-based cell viability assays for glioprotection using primary rat optic nerve head astrocytes

Kaja, S., Payne, A. J., Naumchuk, Y., Levy, D., Zaidi, D., Altman, A. M., Nawazish, S., Ghuman, J. K., Gerdes, B. C., Moore, M. A., et al. (2015) · Experimental Eye Research · doi:10.1016/j.exer.2015.05.023 · Cited by 20 · see citing works

Retinal ganglion cell survival and axon regeneration in Wld S transgenic rats after optic nerve crush and lens injury

Lorber, B., Tassoni, A., Bull, N. D., Moschos, M. M., & Martin, K. R. G. (2012) · BMC Neuroscience · doi:10.1186/1471-2202-13-56 · Cited by 18 · see citing works

Introducing Harry A. Quigley, the 2004 Recipient of the Friedenwald Award

Anderson, D. R. (2005) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.04-1068 · Cited by 17 · see citing works

Life under pressure: The role of ocular cribriform cells in preventing glaucoma

Paula, J. S., O'Brien, C. J., & Stamer, W. D. (2016) · Experimental Eye Research · doi:10.1016/j.exer.2016.08.014 · Cited by 17 · see citing works

Pathophysiology of the Progressive Optic Neuropathy of Glaucoma

Levin, L. A. (2005) · Ophthalmology Clinics of North America · doi:10.1016/j.ohc.2005.05.010 · Cited by 17 · see citing works

Establishment of the ocular hypertension model using the common marmoset

Shimazawa, M., Nakamura, S., Miwa, M., Tsuruma, K., Aihara, M., Nakamura, K., & Hara, H. (2013) · Experimental Eye Research · doi:10.1016/j.exer.2013.03.010 · Cited by 15 · see citing works

High‐ versus low‐density multifocal pupillographic objective perimetry in glaucoma

Maddess, T., Essex, R. W., Kolic, M., Carle, C. F., & James, A. C. (2012) · Clinical and Experimental Ophthalmology · doi:10.1111/ceo.12016 · Cited by 15 · see citing works

Dock3-NMDA receptor interaction as a target for glaucoma therapy.

Kimura, A. K., Namekata, K., Guo, X., Harada, C., & Harada, T. (2017) · PubMed · doi:10.14670/hh-11-820 · Cited by 13 · see citing works

Translational Pharmacology in Glaucoma Neuroprotection

Levin, L. A. (2016) · Handbook of experimental pharmacology · doi:10.1007/164_2016_20 · Cited by 10 · see citing works

Astrocytes and glaucomatous neurodegeneration

Tamm, E. R., & Dowling, J. E. (2017) · Experimental Eye Research · doi:10.1016/j.exer.2017.02.013 · Cited by 9 · see citing works

Reprogramming to recover youthful epigenetic information and restore vision

Lu, Y., Brommer, B., Tian, X., Krishnan, A., Meer, M., Wang, C., Vera, D. L., Zeng, Q., Yu, D., Bonkowski, M. S., et al. (2020) · Nature · doi:10.1038/s41586-020-2975-4 · Cited by 820 · see citing works

Oxidative stress in the eye and its role in the pathophysiology of ocular diseases

Böhm, E. W., Buonfiglio, F., Voigt, A. M., Bachmann, P., Safi, T., Pfeiffer, N., & Gericke, A. (2023) · Redox Biology · doi:10.1016/j.redox.2023.102967 · Cited by 324 · see citing works

Neurotoxic Reactive Astrocytes Drive Neuronal Death after Retinal Injury

Guttenplan, K. A., Stafford, B. K., El-Danaf, R. N., Adler, D. I., Münch, A. E., Weigel, M. K., Huberman, A. D., & Liddelow, S. A. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.107776 · Cited by 221 · see citing works

Preservation of vision after CaMKII-mediated protection of retinal ganglion cells

Guo, X. V., Zhou, J., Starr, C. R., Mohns, E. J., Li, Y., Chen, E. P., Yoon, Y., Kellner, C. P., Tanaka, K., Wang, H., et al. (2021) · Cell · doi:10.1016/j.cell.2021.06.031 · Cited by 179 · see citing works

Prevalence of Primary Angle Closure Glaucoma in the Last 20 Years: A Meta-Analysis and Systematic Review

Zhang, N., Wang, J., Chen, B., Li, Y., & Jiang, B. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2020.624179 · Cited by 169 · see citing works

Apolipoprotein E4 impairs the response of neurodegenerative retinal microglia and prevents neuronal loss in glaucoma

Margeta, M. A., Yin, Z., Madore, C., Pitts, K. M., Letcher, S. M., Tang, J., Jiang, S., Gauthier, C. D., Silveira, S. R., Schroeder, C. M., et al. (2022) · Immunity · doi:10.1016/j.immuni.2022.07.014 · Cited by 130 · see citing works

Extraocular, periocular, and intraocular routes for sustained drug delivery for glaucoma

Kompella, U. B., Hartman, R. R., & Patil, M. A. (2020) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2020.100901 · Cited by 128 · see citing works

Core transcription programs controlling injury-induced neurodegeneration of retinal ganglion cells

Tian, F., Cheng, Y., Zhou, S., Wang, Q., Monavarfeshani, A., Gao, K., Jiang, W., Kawaguchi, R., Wang, Q., Tang, M., et al. (2022) · Neuron · doi:10.1016/j.neuron.2022.06.003 · Cited by 125 · see citing works

Addressing neurodegeneration in glaucoma: Mechanisms, challenges, and treatments

Ghanem, G. O. B., Wareham, L. K., & Calkins, D. J. (2024) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2024.101261 · Cited by 97 · see citing works

Retinal Neurodegeneration as an Early Manifestation of Diabetic Eye Disease and Potential Neuroprotective Therapies

Zafar, S., Sachdeva, M. M., Frankfort, B. J., & Channa, R. (2019) · Current Diabetes Reports · doi:10.1007/s11892-019-1134-5 · Cited by 83 · see citing works

Treatment of Glaucoma with Natural Products and Their Mechanism of Action: An Update

Sim, R. H., Sirasanagandla, S. R., Das, S., & Teoh, S. L. (2022) · Nutrients · doi:10.3390/nu14030534 · Cited by 76 · see citing works

Therapeutic Drugs and Devices for Tackling Ocular Hypertension and Glaucoma, and Need for Neuroprotection and Cytoprotective Therapies

Sharif, N. A. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.729249 · Cited by 74 · see citing works

Brain-Derived Neurotrophic Factor-Mediated Neuroprotection in Glaucoma: A Review of Current State of the Art

Lambuk, L., Lazaldin, M. A. M., Ahmad, S., Iezhitsa, I. N., Agarwal, R., Uskoković, V., & Mohamud, R. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.875662 · Cited by 69 · see citing works

Oxidative Stress: A Suitable Therapeutic Target for Optic Nerve Diseases?

Buonfiglio, F., Böhm, E. W., Pfeiffer, N., & Gericke, A. (2023) · Antioxidants · doi:10.3390/antiox12071465 · Cited by 68 · see citing works

Translational Preclinical Pharmacologic Disease Models for Ophthalmic Drug Development

Shah, M., Cabrera-Ghayouri, S., Christie, L., Held, K. S., & Viswanath, V. (2019) · Pharmaceutical Research · doi:10.1007/s11095-019-2588-5 · Cited by 59 · see citing works

Experimental Models of Glaucoma: A Powerful Translational Tool for the Future Development of New Therapies for Glaucoma in Humans—A Review of the Literature

Evangelho, K. D. S., Mastronardi, C. A., & de‐la‐Torre, A. (2019) · Medicina · doi:10.3390/medicina55060280 · Cited by 57 · see citing works

Association of <i>APOE</i> With Primary Open-Angle Glaucoma Suggests a Protective Effect for <i>APOE ε4</i>

Margeta, M. A., Letcher, S. M., Igo, R. P., Cooke Bailey, J. N., Pasquale, L. R., Haines, J. L., Butovsky, O., Wiggs, J. L., & for the NEIGHBORHOOD consortium (2020) · Investigative Opthalmology &amp; Visual Science · doi:10.1167/iovs.61.8.3 · Cited by 51 · see citing works

Can Treatment With Citicoline Eyedrops Reduce Progression in Glaucoma? The Results of a Randomized Placebo-controlled Clinical Trial

Rossetti, L. M., Iester, M., Tranchina, L., Ottobelli, L., Coco, G., Calcatelli, E., Ancona, C., Cirafici, P., & Manni, G. (2020) · Journal of Glaucoma · doi:10.1097/ijg.0000000000001565 · Cited by 50 · see citing works

Glaucoma After Corneal Trauma or Surgery—A Rapid, Inflammatory, IOP-Independent Pathway

Dohlman, C. H., Zhou, C., Lei, F., Cade, F., Regatieri, C. V., Črnej, A., Dohlman, J. G., Shen, L. Q., & Paschalis, E. I. (2019) · Cornea · doi:10.1097/ico.0000000000002106 · Cited by 49 · see citing works

Intraocular nano-microscale drug delivery systems for glaucoma treatment: design strategies and recent progress

Shen, Y., Sun, J., & Sun, X. (2023) · Journal of Nanobiotechnology · doi:10.1186/s12951-023-01838-x · Cited by 45 · see citing works

Signalling pathways and cell death mechanisms in glaucoma: Insights into the molecular pathophysiology

Basavarajappa, D. K., Galindo‐Romero, C., Gupta, V., Agudo‐Barriuso, M., Gupta, V. B., Graham, S. L., & Chitranshi, N. (2023) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2023.101216 · Cited by 44 · see citing works

Microglial cGAS–STING signaling underlies glaucoma pathogenesis

Liu, Y., Wang, A., Chen, C., Zhang, Q., Shen, Q., Zhang, D., Xiao, X., Chen, S., Lian, L., Le, Z., et al. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2409493121 · Cited by 45 · see citing works

Focused Update on AAV-Based Gene Therapy Clinical Trials for Inherited Retinal Degeneration

Fuller-Carter, P. I., Basiri, H., Harvey, A. R., & Carvalho, L. S. (2020) · BioDrugs · doi:10.1007/s40259-020-00453-8 · Cited by 41 · see citing works

Protective effect of the natural flavonoid naringenin in mouse models of retinal injury

Zeng, L., Qian, Y., Lou, H., Wang, F., Pang, Y., Hu, H., Zhang, Z., Song, Y., Liu, P., & Zhang, X. (2023) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2023.176231 · Cited by 40 · see citing works

i Drugs and i Devices Discovery Research: Preclinical Assays, Techniques, and Animal Model Studies for Ocular Hypotensives and Neuroprotectants

Sharif, N. A. (2018) · Journal of Ocular Pharmacology and Therapeutics · doi:10.1089/jop.2017.0125 · Cited by 40 · see citing works

Controlling donor and newborn neuron migration and maturation in the eye through microenvironment engineering

Soucy, J. R., Todd, L. J., Kriukov, E., Phay, M. H., Malechka, V. V., Rivera, J. D., Reh, T. A., & Baranov, P. Y. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2302089120 · Cited by 36 · see citing works

Circular RNA-based therapy provides sustained and robust neuroprotection for retinal ganglion cells

Jiang, W., Xiao, D., Wu, C., Yang, J., Peng, X., Chen, L., Zhang, J., Zha, G.-F., Li, W., Ju, R., et al. (2024) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2024.102258 · Cited by 37 · see citing works

Nicotinamide riboside as a neuroprotective therapy for glaucoma: study protocol for a randomized, double-blind, placebo-control trial

Leung, C. K.-S., Ren, S. T., Chan, P. P. M., Wan, K. H.-N., Kam, A. K. W., Lai, G. W. K., Chiu, V. S. M., Ko, M. W. L., Yiu, K. F. C., & Yu, M. (2022) · Trials · doi:10.1186/s13063-021-05968-1 · Cited by 33 · see citing works

Neuroprotective effect of mesenchymal stem cell-derived extracellular vesicles on optic nerve injury in chronic ocular hypertension

Yu, F., Wang, Y., Huang, C.-Q., Lin, S.-J., Gao, R.-X., & Wu, R.-Y. (2023) · Neural Regeneration Research · doi:10.4103/1673-5374.369121 · Cited by 29 · see citing works

A Multi-Locus Genetic Risk Score for Primary Open-Angle Glaucoma (POAG) Variants Is Associated with POAG Risk in a Mediterranean Population: Inverse Correlations with Plasma Vitamin C and E Concentrations

Zanón‐Moreno, V., Ortega‐Azorín, C., Asensio, E. M., García‐Medina, J. J., Pinazo-Duran, M. D., Coltell, Ó., Ordovás, J. M., & Corella, D. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18112302 · Cited by 27 · see citing works

Treatment choices for newly diagnosed primary open angle and ocular hypertension patients

Garg, A., & Gazzard, G. (2019) · Eye · doi:10.1038/s41433-019-0633-6 · Cited by 27 · see citing works

Retinal Cell Protection in Ocular Excitotoxicity Diseases. Possible Alternatives Offered by Microparticulate Drug Delivery Systems and Future Prospects

Villanueva, J. R., Esteban, J. M., & Villanueva, L. R. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12020094 · Cited by 26 · see citing works

Molecular Targets Involved in the Neuroprotection Mediated by Terpenoids

González‐Cofrade, L., Heras, B. D. L., Ticona, L. A., & Palomino, O. M. (2019) · Planta Medica · doi:10.1055/a-0953-6738 · Cited by 26 · see citing works

Nanoparticles for the treatment of glaucoma-associated neuroinflammation

Lambuk, L., Suhaimi, N. A. A., Sadikan, M. Z., Jafri, A. J. A., Ahmad, S., Nasir, N. A. A., Uskoković, V., Kadir, R., & Mohamud, R. (2022) · Eye and Vision · doi:10.1186/s40662-022-00298-y · Cited by 26 · see citing works

Bio-tactics for neuroprotection of retinal ganglion cells in the treatment of glaucoma

Yadav, K. S., Sharma, S., & Londhe, V. Y. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.117303 · Cited by 24 · see citing works

Neuroprotection: A versatile approach to combat glaucoma

Naik, S., Pandey, A. P., Lewis, S. A., Rao, B. S. S., & Mutalik, S. (2020) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2020.173208 · Cited by 25 · see citing works

Novel frontiers in neuroprotective therapies in glaucoma: Molecular and clinical aspects

Boccaccini, A., Cavaterra, D., Carnevale, C., Tanga, L., Marini, S., Bocedi, A., Lacal, P. M., Manni, G., Graziani, G., Sbardella, D., et al. (2023) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2023.101225 · Cited by 26 · see citing works

The neuroprotective effects of novel estrogen receptor GPER1 in mouse retinal ganglion cell degeneration

Jiang, M., Ma, X., Zhao, Q., Li, Y., Xing, Y., Deng, Q., & Shen, Y. (2019) · Experimental Eye Research · doi:10.1016/j.exer.2019.107826 · Cited by 25 · see citing works

Optogenetic Stimulation of the Superior Colliculus Confers Retinal Neuroprotection in a Mouse Glaucoma Model

Geeraerts, E., Claes, M., Dekeyster, E., Salinas‐Navarro, M., Groef, L. D., den Haute, C. V., Scheyltjens, I., Baekelandt, V., Arckens, L., & Moons, L. (2019) · Journal of Neuroscience · doi:10.1523/jneurosci.0872-18.2018 · Cited by 24 · see citing works

C3 Transferase-Expressing scAAV2 Transduces Ocular Anterior Segment Tissues and Lowers Intraocular Pressure in Mouse and Monkey

Tan, J., Wang, X., Cai, S., He, F., Zhang, D., Li, D., Zhu, X., Zhou, L., Fan, N., & Liu, X. (2019) · Molecular Therapy — Methods & Clinical Development · doi:10.1016/j.omtm.2019.11.017 · Cited by 24 · see citing works

The Role of MicroRNAs in Mitochondria-Mediated Eye Diseases

Carrella, S., Massa, F., & Indrieri, A. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.653522 · Cited by 23 · see citing works

Retinal Neuroprotection: Overcoming the Translational Roadblocks

Wubben, T. J., Besirli, C. G., Johnson, M. W., & Zacks, D. N. (2018) · American Journal of Ophthalmology · doi:10.1016/j.ajo.2018.04.012 · Cited by 19 · see citing works

Modeling Retinal Ganglion Cell Dysfunction in Optic Neuropathies

Porciatti, V., & Chou, T.-H. (2021) · Cells · doi:10.3390/cells10061398 · Cited by 18 · see citing works

Glaucoma: neuroprotection with NAD-based therapeutic interventions

Chiarugi, A. (2023) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2023.09.010 · Cited by 18 · see citing works

New perspectives of immunomodulation and neuroprotection in glaucoma

Skopiński, P., Radomska-Leśniewska, D. M., Izdebska, J., Kamińska, A., Kupis, M., Kubiak, A. J., & Samelska, K. (2021) · Central European Journal of Immunology · doi:10.5114/ceji.2021.104329 · Cited by 17 · see citing works

Neurodegeneration Markers Galectin-3 and Apolipoprotein E Are Elevated in the Aqueous Humor of Eyes With Glaucoma

Pitts, K. M., Neeson, C. E., Hall, N. E., Lin, J. B., Falah, H. K., Wang, S. L., Lo, K., Song, C., Margeta, M. A., & Valle, D. S.-D. (2022) · Translational Vision Science & Technology · doi:10.1167/tvst.11.11.1 · Cited by 16 · see citing works

Role of mammalian target of rapamycin in regulating HIF-1α and vascular endothelial growth factor signals in glaucoma

Zhou, J., Chen, F., Yan, A.-M., & Xia, X. (2019) · Archives of Physiology and Biochemistry · doi:10.1080/13813455.2019.1609996 · Cited by 16 · see citing works

Mutation-independent therapies for retinal diseases: focus on gene-based approaches

Carrella, S., Indrieri, A., Franco, B., & Banfi, S. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.588234 · Cited by 14 · see citing works

Association of APOE Haplotypes With Common Age-Related Ocular Diseases in 412,171 Individuals

Liuska, P. J., Rämö, J. T., Lemmelä, S. M., Kaarniranta, K., Uusitalo, H. M. T., Lahtela, E., Daly, M. J., Harju, M. P., Palotie, A. V., Turunen, J. A., et al. (2023) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.64.14.33 · Cited by 14 · see citing works

Molecular changes in glaucomatous trabecular meshwork. Correlations with retinal ganglion cell death and novel strategies for neuroprotection

Saccà, S. C., Vernazza, S., Iorio, E. L., Tirendi, S., Bassi, A. M., Gandolfi, S., & Izzotti, A. (2020) · Progress in brain research · doi:10.1016/bs.pbr.2020.06.003 · Cited by 14 · see citing works

A Robust Microbead Occlusion Model of Glaucoma for the Common Marmoset

Kumar, S., Benavente-Pérez, A., Ablordeppey, R. K., Lin, C. R., Viswanáthan, S., Akopian, A., & Bloomfield, S. A. (2022) · Translational Vision Science & Technology · doi:10.1167/tvst.11.1.14 · Cited by 13 · see citing works

Axonal and Myelin Neuroprotection by the Peptoid BN201 in Brain Inflammation

Villoslada, P., Vila, G., Colafrancesco, V., Moreno, B., Fernández-Díez, B., Vázquez, R., Pertsovskaya, I., Zubizarreta, I., Pulido-Valdeolivas, I., Messeguer, J., et al. (2019) · Neurotherapeutics · doi:10.1007/s13311-019-00717-4 · Cited by 14 · see citing works

Organotypic cultures as aging associated disease models

Sanchez, M. M., Bagdasarian, I. A., Darch, W., & Morgan, J. T. (2022) · Aging · doi:10.18632/aging.204361 · Cited by 12 · see citing works

A Deep Learning Approach to Improve Retinal Structural Predictions and Aid Glaucoma Neuroprotective Clinical Trial Design

Christopher, M. A., Hoseini, P., Walker, E., Proudfoot, J. A., Bowd, C., Fazio, M. A., Girkin, C. A., Moraes, C. G. D., Liebmann, J. M., Weinreb, R. N., et al. (2022) · Ophthalmology Glaucoma · doi:10.1016/j.ogla.2022.08.014 · Cited by 12 · see citing works

Using Noninvasive Electrophysiology to Determine Time Windows of Neuroprotection in Optic Neuropathies

Porciatti, V., & Chou, T.-H. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23105751 · Cited by 11 · see citing works

The Prevalence Trend of Glaucoma by Age and Sex Difference in South Asia: A Systematic Review and Meta‐Analysis of Population‐Based Studies

Banik, S., Ghosh, A., & Debi, H. (2025) · Health Science Reports · doi:10.1002/hsr2.70542 · Cited by 10 · see citing works

Neuroprotection in glaucoma‑electrophysiology (Review)

Lešt�k, J., & Fůs, M. (2020) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2020.8509 · Cited by 9 · see citing works

The Effect of Dietary Vitamin K1 Supplementation on Trabecular Meshwork and Retina in a Chronic Ocular Hypertensive Rat Model

Deng, C., Yao, K., Peng, F., Zhao, B., Chen, Z., Chen, W., Zhao, Y., Zhang, H., & Wang, J. (2020) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.61.8.40 · Cited by 9 · see citing works

Neuronal p58IPK Protects Retinal Ganglion Cells Independently of Macrophage/Microglia Activation in Ocular Hypertension

McLaughlin, T., Wang, J., Jia, L., Wu, F., Wang, Y., Wang, J. J., Mu, X., & Zhang, S. X. (2023) · Cells · doi:10.3390/cells12121558 · Cited by 8 · see citing works

Proteomics-Based Identification of Retinal Protein Networks Impacted by Elevated Intraocular Pressure in the Hypertonic Saline Injection Model of Experimental Glaucoma

Zaman, K., Nguyen, V., Prókai-Tátrai, K., & Prókai, L. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241612592 · Cited by 8 · see citing works

Apelin-13 attenuates optic nerve damage in glaucomatous mice by regulating glucose metabolism

Zhang, Y., Zhao, J., Zhou, J., Jiang, Z., Cheng, K., Lei, C., & Yu, L. (2025) · Journal of Translational Medicine · doi:10.1186/s12967-025-06212-z · Cited by 8 · see citing works

Neuroprotective Strategies in Glaucoma - Translation to Clinical Trials

Fang, C. E. H., Guo, L., Hill, D., Yap, T. E., & Cordeiro, M. F. (2020) · OBM Neurobiology · doi:10.21926/obm.neurobiol.2002062 · Cited by 9 · see citing works

Biomechanical Properties of the Sclera

Campbell, I. C., Lovald, S. T., Garcia, M. B., & Coudrillier, B. (2021) · Springer eBooks · doi:10.1007/978-3-030-64422-2_6 · Cited by 8 · see citing works

Cell-Based Neuroprotection of Retinal Ganglion Cells in Animal Models of Optic Neuropathies

Hu, Y., Grodzki, L. M., Bartsch, S., & Bartsch, U. (2021) · Biology · doi:10.3390/biology10111181 · Cited by 8 · see citing works

Formulation and evaluation of polymer-coated bimatoprost-chitosan matrix ocular inserts for sustained lowering of IOP in rabbits

Jadhav, C., & Yadav, K. S. (2022) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2022.103885 · Cited by 8 · see citing works

The Anti-Inflammatory and Antioxidant Properties of Acebuche Oil Exert a Retinoprotective Effect in a Murine Model of High-Tension Glaucoma

Lucchesi, M., Marracci, S., Amato, R., Lapi, D., Garrido, Á. S., Espinosa‐Martín, P., Vázquez, C. M., Mate, A., & Monte, M. D. (2024) · Nutrients · doi:10.3390/nu16030409 · Cited by 7 · see citing works

Neuroprotection of the Inner Retina Also Prevents Secondary Outer Retinal Pathology in a Mouse Model of Glaucoma

Kumar, S., Ramakrishnan, H., Viswanáthan, S., Akopian, A., & Bloomfield, S. A. (2021) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.62.9.35 · Cited by 7 · see citing works

Targeted Delivery of Mitochondrial Calcium Channel Regulators: The Future of Glaucoma Treatment?

Cheung, L. T. Y., Manthey, A. L., Lai, J. S. M., & Chiu, K. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00648 · Cited by 7 · see citing works

Neuroprotection in Glaucoma

Sigireddi, R. R., & Frankfort, B. J. (2018) · International Ophthalmology Clinics · doi:10.1097/iio.0000000000000228 · Cited by 7 · see citing works

Multi-loaded PLGA microspheres as neuroretinal therapy in a chronic glaucoma animal model

Aragón-Navas, A., Rodrigo, M. J., Munuera, I., García-Herranz, D., Subías, M., Villacampa, P., García-Feijoo, J., Pablo, L. E., García‐Martín, E., Herrero‐Vanrell, R., et al. (2024) · Drug Delivery and Translational Research · doi:10.1007/s13346-024-01702-x · Cited by 6 · see citing works

Fluoxetine Protects Retinal Ischemic Damage in Mice

Romano, G. L., Gozzo, L., Maurel, O. M., Martino, S. D., Riolo, V., Micale, V., Drago, F., & Bucolo, C. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15051370 · Cited by 6 · see citing works

Reduced Plasma BDNF Levels in Normal Tension Glaucoma Compared to Open Angle Glaucoma

Sato, K., Takada, N., Fujioka, A., Himori, N., Yokoyama, Y., Tsuda, S., Omodaka, K., Kirihara, T., Ishikawa, M., Kunikata, H., et al. (2023) · Journal of Glaucoma · doi:10.1097/ijg.0000000000002257 · Cited by 6 · see citing works

Role of APOE in glaucoma.

Yi, W.-H., Lv, D., Sun, Y., Mu, J.-Y., & Lu, X. (2023) · Biochemical and Biophysical Research Communications - BBRC · doi:10.1016/j.bbrc.2023.149414 · Cited by 7 · see citing works

Sustained Neurotrophic Factor Co-Treatment Enhances Donor and Host Retinal Ganglion Cell Survival in Mice

Soucy, J. R., Oswald, J., Kriukov, E., Phay, M. H., Masland, J., Pernstich, C., & Baranov, P. Y. (2025) · Translational Vision Science & Technology · doi:10.1167/tvst.14.9.27 · Cited by 5 · see citing works

Refractive adaptive optics scanning light ophthalmoscope with fast 2D MEMS scanner

Kunala, K., Xia, Y., Ayubi, G. A., Kowalski, B., Desai, A. X., Lippman, D. H., Bentley, J., & Dubra, A. (2025) · Biomedical Optics Express · doi:10.1364/boe.576969 · Cited by 4 · see citing works

AAV-IKV mediated expression of decorin inhibits EMT and fibrosis in a murine model of Glaucoma and AAV-IKV transduction in Non-Human Primates

Rao, P., Mishra, M., Cashman, S. M., Walton, D. S., & Kumar‐Singh, R. (2025) · Scientific Reports · doi:10.1038/s41598-025-92273-5 · Cited by 4 · see citing works

Statistical Analysis on Time to Blindness of Glaucoma Patients at Jimma University Specialized Hospital: Application of Accelerated Failure Time Model

Bambo, M. M., & Gebremariam, M. G. (2022) · Journal of Ophthalmology · doi:10.1155/2022/9145921 · Cited by 4 · see citing works

The Impact of Hindlimb Suspension on the Rat Eye: A Molecular and Histological Analysis of the Retina

Theriot, C. A., Chévez‐Barrios, P., Loughlin, T., Beheshti, A., Mercaldo, N. D., & Zanello, S. B. (2021) · Gravitational and Space Research · doi:10.2478/gsr-2021-0007 · Cited by 4 · see citing works

Oxidative Stress in Glaucoma: From Pathogenic Mechanisms to Emerging Antioxidant Therapies

Hanyuda, A., Tsuda, S., Takahashi, N., Sato, M., Sato, K., Himori, N., & Nakazawa, T. (2026) · Antioxidants · doi:10.3390/antiox15060751 · Cited by 3 · see citing works

Artificial intelligence and neural networks in the diagnosis of glaucoma

Александрович, Д. Д., Kazanova, S. Y., Movsisyan, A. B., & Poleva, R. P. (2023) · National Journal glaucoma · doi:10.53432/2078-4104-2023-22-1-115-128 · Cited by 5 · see citing works

Exploring Therapeutic Frontiers: Unveiling the Potential of Natural Diterpenoid Derivatives in Addressing Neurological Disorders

Singh, K., Gupta, J. K., Jain, D., Kumar, S., Saha, S., & Sharma, A. (2024) · Current Pharmaceutical Biotechnology · doi:10.2174/0113892010304266240507050825 · Cited by 3 · see citing works

Decellularizing the Porcine Optic Nerve Head: Toward a Model to Study the Mechanobiology of Glaucoma

Liou, J., Drewry, M. D., Sweeney, A. M., Brown, B. N., & Geest, J. P. V. (2020) · Translational Vision Science & Technology · doi:10.1167/tvst.9.8.17 · Cited by 3 · see citing works

Etiological spectrum of irreversible blindness in Kashmir in North India

Kaushik, M., Nawaz, S., Mufti, H., & Qureshi, T. S. (2021) · Indian Journal of Ophthalmology · doi:10.4103/ijo.ijo_3818_20 · Cited by 3 · see citing works

Automated animal gimbal steering for retinal imaging and stimulation

Kunala, K., Ayubi, G. A., Franco, J. A., Mahajan, V. B., & Dubra, A. (2025) · Biomedical Optics Express · doi:10.1364/boe.582530 · Cited by 2 · see citing works

Natural products as alternative therapies for eye disorders: from traditional use to modern formulations

Elbadry, A. M. M., Aly, S. H., Abdelrazek, N. A., El‐Shiekh, R. A., Salman, A., Nabil, A., Reda, A., Eid, O., Manaa, E. G., Abdel-All, S. R., et al. (2026) · Beni-Suef University Journal of Basic and Applied Sciences · doi:10.1186/s43088-026-00757-8 · Cited by 2 · see citing works

Barriers to IOP-independent treatments in glaucoma clinical trials

Gherghel, D., & Moraes, G. D. (2022) · Eye · doi:10.1038/s41433-022-02305-x · Cited by 2 · see citing works

Chronic Glaucoma Induced in Rats by a Single Injection of Fibronectin-Loaded PLGA Microspheres: IOP-Dependent and IOP-Independent Neurodegeneration

Munuera, I., Aragón-Navas, A., Villacampa, P., González-Cela-Casamayor, M. A., Subías, M., Pablo, L. E., Garcia-Feijoo, J., Herrero‐Vanrell, R., García‐Martín, E., Bravo‐Osuna, I., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms25010009 · Cited by 2 · see citing works

Anti-scarring effect of sodium hyaluronate at filtration pathway after filtering surgery in rabbits

Wang, Y., Zhang, C., Zhang, W.-L., & Song, W. (2022) · International Journal of Ophthalmology · doi:10.18240/ijo.2022.04.04 · Cited by 2 · see citing works

Cultures of glial cells from optic nerve of two adult teleost fish: Astatotilapia burtoni and Danio rerio

DeOliveira‐Mello, L., Mack, A. F., Lara, J. M., & Arévalo, R. (2021) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2021.109096 · Cited by 2 · see citing works

Tauroursodeoxycholic Acid Protects Retinal Ganglion Cells and Reduces Inflammation in Mice Following Optic Nerve Crush

Zhang, N., Li, Y., Zhang, X., Chrenek, M. A., Wang, J., Girardot, P. E., Sellers, J. T., Geisert, E. E., Nickerson, J. M., & Boatright, J. H. (2025) · Pharmaceuticals · doi:10.3390/ph18040569 · Cited by 1 · see citing works

Effect of antioxidants on primary open-angle glaucoma: a systematic review and meta-analysis

Bao, J., Yu, Y., Chen, G., Chen, H., Zhao, C., & Li, X. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1625735 · Cited by 1 · see citing works

Protective Effects of Cord Blood Serum (CBS) on Retinal Pigment Epithelium (ARPE-19) and Retinal Photoreceptor-like (661W) Cell Line Viability Under In Vitro Oxidative Stress

Motta, I., Corsi, F., Piano, I., Bisti, S., Bergantin, E., Buzzi, M., Gargini, M. C., & Versura, P. (2026) · Biomolecules · doi:10.3390/biom16010131 · Cited by 1 · see citing works

Effect of adlay seed extract on the level of neuroprotection gene expression in human nasal orbital mesenchymal stem cells

Sanie‐Jahromi, F., Azimi, A., Hassanipour, H., Bostanian, P., & Khademi, B. (2024) · European Journal of Integrative Medicine · doi:10.1016/j.eujim.2024.102397 · Cited by 1 · see citing works

A Novel and Reversible Experimental Primate Ocular Hypertension Model: Blocking Schlemm’s Canal

Jiang, J., Xu, J., Tao, Y., Hu, C., Zhang, C., Sun, X., Ye, C., Zhang, S., & Liang, Y. (2022) · Ophthalmic Research · doi:10.1159/000527099 · Cited by 1 · see citing works

Faculty Opinions recommendation of Reprogramming to recover youthful epigenetic information and restore vision.

Maden, M. (2021) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.739135920.793582270

Faculty Opinions recommendation of Reprogramming to recover youthful epigenetic information and restore vision.

Liu, P. (2020) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.739135920.793580966

Primāras atvērta kakta glaukomas ķirurģiskās ārstēšanas ietekme uz redzes nerva strukturālajiem un funkcionālajiem rādītājiem un saistība ar ātrija nātrijurētiskā peptīda līmeni. Promocijas darbs

Baumane, K. (2019) · doi:10.25143/prom-rsu_2019-13_pd

Retina–brain axis and neuroprotection

Li, Y. M., Cheng, A. K., Manzar, H., Yap, T. E., & Cordeiro, M. F. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-819291-7.00023-x

Various forms of glaucoma and their treatments

Sharif, N. A. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-819291-7.00032-0

Neuroprotection in Glaucoma

Caprioli, J., & Piri, N. (2008) · Elsevier eBooks · doi:10.1016/b978-012370585-3.50021-2

Protection of retinal ganglion cells in glaucoma: Current status and future

Shen, J., Wang, Y., & Yao, K. (2021) · Experimental Eye Research · doi:10.1016/j.exer.2021.108506 · Cited by 63 · see citing works

Neuroprotection of Optic Nerve in Glaucoma

Chen, Y.-F. (2009) · 北市醫學雜誌

Neuroprotective Strategies in Glaucoma

Gossman, C. A., Christie, J., Webster, M. K., Linn, D. M., & Linn, C. L. (2016) · Current Pharmaceutical Design · doi:10.2174/1381612822666160128144747 · Cited by 20 · see citing works

Contribution of intraocular pressure‐dependent and pressure‐independent glaucoma models to neuroprotection

Avilés‐Trigueros, M. (2022) · Acta Ophthalmologica · doi:10.1111/j.1755-3768.2022.15570