The DOI matches its Crossref record, with a small difference in title or year; 56 of the 56 references it cites were found in a registry or an index.
Neuromodulation of conditioned placebo/nocebo in heat pain: anodal vs cathodal transcranial direct current stimulation to the right dorsolateral prefrontal cortex
Open accessAbstract
Placebo and nocebo play an important role in clinical practice and medical research. Modulating placebo/nocebo responses using noninvasive brain stimulation methods, such as transcranial direct current stimulation (tDCS), has the potential to harness these effects to therapeutic benefit in a clinical setting. In this study, we assessed the effect of anodal and cathodal tDCS over the right dorsolateral prefrontal cortex (rDLPFC) on conditioned placebo/nocebo cue response to heat pain. Two matched groups of healthy volunteers were subjected to an identical session of conditioning, during which low and high cues (abstract images) were associated with low and high pain levels, respectively. Twenty-minute 2-mA tDCS (either anodal or cathodal) over the rDLPFC was applied. The influence of tDCS current polarity (anodal vs cathodal) on placebo and nocebo was assessed, using subjects' pain ratings in response to identical pain preceded by the conditioned high or low cues. The duration of cue presentation varied to allow either fully conscious or subliminal processing. Significant placebo and nocebo effects in the anodal but not the cathodal group were elicited with the conditioning paradigm. This study provides evidence of a possibility to modulate the conditioned placebo and nocebo effect by changing the excitability of the rDLPFC using tDCS.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Pain is influenced by social interactions and can be modulated through the observation of others.37”
From Nocebo and pain: an overview of the psychoneurobiological mechanisms (2017) · cites this paper as [37]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Placebo-Induced Changes in fMRI in the Anticipation and Experience of Pain
Wager, T. D., Rilling, J. K., Smith, E. E., Sokolik, A., Casey, K. L., Davidson, R. J., Kosslyn, S. M., Rose, R. M., & Cohen, J. D. (2004) · Science · doi:10.1126/science.1093065 · Cited by 1,992
Biological, clinical, and ethical advances of placebo effects
Finniss, D. G., Kaptchuk, T. J., Miller, F. G., & Benedetti, F. (2010) · The Lancet · doi:10.1016/s0140-6736(09)61706-2 · Cited by 1,309
Keeping pain out of mind: The role of the dorsolateral prefrontal cortex in pain modulation
Lorenz, J., Minoshima, S., & Casey, K. L. (2003) · Brain · doi:10.1093/brain/awg102 · Cited by 952
Activation of the Opioidergic Descending Pain Control System Underlies Placebo Analgesia
Eippert, F., Bingel, U., Schoell, E. D., Yacubian, J., Klinger, R., Lorenz, J., & Büchel, C. (2009) · Neuron · doi:10.1016/j.neuron.2009.07.014 · Cited by 839
Exacerbation of Pain by Anxiety Is Associated with Activity in a Hippocampal Network
Ploghaus, A., Narain, C., Beckmann, C. F., Clare, S., Bantick, S., Wise, R., Matthews, P. M., Rawlins, J. N. P., & Tracey, I. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-24-09896.2001 · Cited by 822
Neurobiological Mechanisms of the Placebo Effect
Benedetti, F., Mayberg, H. S., Wager, T. D., Stohler, C. S., & Zubieta, J.-K. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.3458-05.2005 · Cited by 812
Nonspecific medication side effects and the nocebo phenomenon
Barsky, A. J. (2002) · JAMA · doi:10.1001/jama.287.5.622 · Cited by 784
Placebo Effects Mediated by Endogenous Opioid Activity on μ-Opioid Receptors
Zubieta, J.-K., Bueller, J. A., Jackson, L. R., Scott, D. J., Xu, Y., Koeppe, R. A., Nichols, T. E., & Stohler, C. S. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.0439-05.2005 · Cited by 779
Keeser, D., Meindl, T., Bor, J., Palm, U., Pogarell, O. M., Mulert, C., Brunelin, J., Möller, H., Reiser, M. F., & Padberg, F. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.0542-11.2011 · Cited by 615
Conflict-induced behavioural adjustment: a clue to the executive functions of the prefrontal cortex
Mansouri, F. A., Tanaka, K., & Buckley, M. J. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2538 · Cited by 559
Ratio scales of sensory and affective verbal pain descriptors
Gracely, R. H., McGrath, P., & Dubner, R. (1978) · Pain · doi:10.1016/0304-3959(78)90020-9 · Cited by 553
Getting the pain you expect: mechanisms of placebo, nocebo and reappraisal effects in humans
Tracey, I. (2010) · Nature Medicine · doi:10.1038/nm.2229 · Cited by 553
New Insights into the Placebo and Nocebo Responses
Enck, P., Benedetti, F., & Schedlowski, M. (2008) · Neuron · doi:10.1016/j.neuron.2008.06.030 · Cited by 547
Coffman, B. A., Clark, V. P., & Parasuraman, R. (2013) · NeuroImage · doi:10.1016/j.neuroimage.2013.07.083 · Cited by 466
tDCS-enhanced motor and cognitive function in neurological diseases
Flöel, A. (2013) · NeuroImage · doi:10.1016/j.neuroimage.2013.05.098 · Cited by 414
The role of learning in nocebo and placebo effects
Colloca, L., Sigaudo, M., & Benedetti, F. (2008) · Pain · doi:10.1016/j.pain.2008.02.006 · Cited by 411
Altered Placebo and Drug Labeling Changes the Outcome of Episodic Migraine Attacks
Kam-Hansen, S., Jakubowski, M., Kelley, J. M., Kirsch, I., Hoaglin, D. C., Kaptchuk, T. J., & Burstein, R. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3006175 · Cited by 399 · cited 1×
“desirable and their interaction with treatment produces better results compared with treatment only.(26) At the same time, nocebo effects are mostly harmful and related to anxiety.”
Mechanisms of Placebo and Placebo-Related Effects Across Diseases and Treatments
Benedetti, F. (2007) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.48.113006.094711 · Cited by 398
Kong, J., Gollub, R. L., Rosman, I. S., Webb, J. M., Vangel, M. G., Kirsch, I., & Kaptchuk, T. J. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.3556-05.2006 · Cited by 395
Self-citationBrain mediators of predictive cue effects on perceived pain
Atlas, L. Y., Bolger, N., Lindquist, M. A., & Wager, T. D. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.0057-10.2010 · Cited by 389
Prefrontal cortex modulates placebo analgesia
Krummenacher, P., Candia, V., Folkers, G., Schedlowski, M., & Schönbächler, G. (2010) · Pain · doi:10.1016/j.pain.2009.09.033 · Cited by 337
Wager, T. D., Atlas, L. Y., Leotti, L. A., & Rilling, J. K. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.3420-10.2011 · Cited by 328
How placebo responses are formed: a learning perspective
Colloca, L., & Miller, F. G. (2011) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2010.0398 · Cited by 323
Nonconscious activation of placebo and nocebo pain responses
Jensen, K. B., Kaptchuk, T. J., Kirsch, I., Raicek, J., Lindstrom, K. M., Berna, C., Gollub, R. L., Ingvar, M., & Kong, J. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1202056109 · Cited by 305
Self-citationNelson, J. T., McKinley, R. A., Golob, E. J., Warm, J. S., & Parasuraman, R. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2012.11.061 · Cited by 301
How the number of learning trials affects placebo and nocebo responses
Colloca, L., Petrovic, P., Wager, T. D., Ingvar, M., & Benedetti, F. (2010) · Pain · doi:10.1016/j.pain.2010.08.007 · Cited by 300
The neural correlates of placebo effects: a disruption account
Lieberman, M. D., Jarcho, J. M., Berman, S. M., Naliboff, B. D., Suyenobu, B. Y., Mandelkern, M. A., & Mayer, E. A. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2004.01.037 · Cited by 293
Stagg, C. J., Lin, R. L., Mezue, M., Segerdahl, A., Kong, Y., Xie, J., & Tracey, I. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.3887-12.2013 · Cited by 279
Boggio, P. S., Zaghi, S., Lopes, M. P., & Fregni, F. (2008) · European Journal of Neurology · doi:10.1111/j.1468-1331.2008.02270.x · Cited by 275
The Nocebo Phenomenon: Concept, Evidence, and Implications for Public Health
Hahn, R. A. (1997) · Preventive Medicine · doi:10.1006/pmed.1996.0124 · Cited by 275
Miniussi, C., Cappa, S., Cohen, L., Flöel, A., Fregni, F., Nitsche, M., Oliveri, M., Pascual-Leone, Á., Paulus, W., Priori, A., et al. (2008) · Brain Stimulation · doi:10.1016/j.brs.2008.07.002 · Cited by 265
A functional magnetic resonance imaging study on the neural mechanisms of hyperalgesic nocebo effect
Kong, J., Gollub, R. L., Polich, G., Kirsch, I., LaViolette, P., Vangel, M., Rosen, B., & Kaptchuk, T. J. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.2944-08.2008 · Cited by 263
Self-citationThe Placebo Effect: Illness and Interpersonal Healing
Miller, F. G., Colloca, L., & Kaptchuk, T. J. (2009) · Perspectives in biology and medicine · doi:10.1353/pbm.0.0115 · Cited by 254
The power of context: reconceptualizing the placebo effect
Miller, F. G., & Kaptchuk, T. J. (2008) · Journal of the Royal Society of Medicine · doi:10.1258/jrsm.2008.070466 · Cited by 228
Amanzio, M., Benedetti, F., Porro, C. A., Palermo, S., & Cauda, F. (2013) · Human Brain Mapping · doi:10.1002/hbm.21471 · Cited by 202 · cited 1×
“ditioned placebo and nocebo have been directly related to associative learning(11) subserved by the prefrontal cortex during cue learning, cue anticipation, pain perception, and subjective pain reports.(1,32,37) Substantial evidence(18,46) suggests that the cognitive modulation of pain observed during placebo/nocebo e…”
BackgroundFunctional connectivity of the frontoparietal network predicts cognitive modulation of pain
Kong, J., Jensen, K. B., Loiotile, R. E., Cheetham, A., Wey, H., Tan, Y. H. V., Rosen, B. R., Smoller, J. W., Kaptchuk, T. J., & Gollub, R. L. (2012) · Pain · doi:10.1016/j.pain.2012.12.004 · Cited by 191
Self-citationWatson, A., El‐Deredy, W., Iannetti, G. D., Lloyd, D. M., Tracey, I., Vogt, B. A., Nadeau, V. J., & Jones, A. K. P. (2009) · Pain · doi:10.1016/j.pain.2009.04.003 · Cited by 189
Valle, A. C., Roizenblatt, S., Botte, S., Zaghi, S., Riberto, M., Tufik, S., Boggio, P. S., & Fregni, F. (2009) · PubMed · Cited by 175
Neuroenhancement: Enhancing brain and mind in health and in disease
Clark, V. P., & Parasuraman, R. (2013) · NeuroImage · doi:10.1016/j.neuroimage.2013.08.071 · Cited by 158
A Neural Mechanism for Nonconscious Activation of Conditioned Placebo and Nocebo Responses
Jensen, K. B., Kaptchuk, T. J., Chen, X., Kirsch, I., Ingvar, M., Gollub, R. L., & Kong, J. (2014) · Cerebral Cortex · doi:10.1093/cercor/bhu275 · Cited by 152
Self-citationNeural bases of conditioned placebo analgesia
Lui, F., Colloca, L., Duzzi, D., Anchisi, D., Benedetti, F., & Porro, C. A. (2010) · Pain · doi:10.1016/j.pain.2010.09.021 · Cited by 149
Craggs, J. G., Price, D. D., Verne, G. N., Perlstein, W. M., & Robinson, M. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2007.07.057 · Cited by 133
Immediate Effects of tDCS on the μ-Opioid System of a Chronic Pain Patient
DosSantos, M. F. H., Love, T., Martikainen, I. K., Nascimento, T. D., Fregni, F., Kaplan, C. M., Deboer, M. D., Zubieta, J., & DaSilva, A. F. M. (2012) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2012.00093 · Cited by 132
Modulating the brain at work using noninvasive transcranial stimulation
McKinley, R. A., Bridges, N. R., Walters, C. M., & Nelson, J. T. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2011.07.075 · Cited by 120
Modulation of pain perception by transcranial magnetic stimulation of left prefrontal cortex
Brighina, F., De Tommaso, M., Giglia, F., Scalia, S., Cosentino, G., Puma, A., Panetta, M., Giglia, G., & Fierro, B. (2011) · The Journal of Headache and Pain · doi:10.1007/s10194-011-0322-8 · Cited by 115
Placebo analgesia: findings from brain imaging studies and emerging hypotheses
Kong, J., Kaptchuk, T. J., Polich, G., Kirsch, I., & Gollub, R. L. (2007) · Reviews in the Neurosciences · doi:10.1515/revneuro.2007.18.3-4.173 · Cited by 97
Self-citationHarty, S., Robertson, I. H., Miniussi, C., Sheehy, O. C., Devine, C. A., McCreery, S., & O’Connell, R. G. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.5308-13.2014 · Cited by 94
Expectations and anxiety as mediators of placebo effects in pain
Wager, T. D. (2005) · Pain · doi:10.1016/j.pain.2005.03.018 · Cited by 79
Putative physiological mechanisms underlying tDCS analgesic effects
Knotková, H., Nitsche, M. A., & Cruciani, R. A. (2013) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2013.00628 · Cited by 75
tDCS modulates cortical nociceptive processing but has little to no impact on pain perception
Ihle, K., Rodriguez‐Raecke, R., Luedtke, K., & May, A. (2014) · Pain · doi:10.1016/j.pain.2014.07.018 · Cited by 51
Placebo analgesia as a case of a cognitive style driven by prior expectation
Morton, D. L., El‐Deredy, W., Watson, A., & Jones, A. K. P. (2010) · Brain Research · doi:10.1016/j.brainres.2010.08.046 · Cited by 51
It's All in Your Head: Reinforcing the Placebo Response With tDCS
Schambra, H. M., Bikson, M., Wager, T. D., DosSantos, M. F. H., & DaSilva, A. F. M. (2014) · Brain stimulation · doi:10.1016/j.brs.2014.04.002 · Cited by 43
Placebo analgesia and nocebo hyperalgesia – Two sides of the same coin?
Petrović, P. (2008) · Pain · doi:10.1016/j.pain.2008.03.004 · Cited by 34
How Is Pain Influenced by Cognition? Neuroimaging Weighs In
Wager, T. D., & Atlas, L. Y. (2013) · Perspectives on Psychological Science · doi:10.1177/1745691612469631 · Cited by 30
Implicit versus explicit associative learning and experimentally induced placebo hypoalgesia
Martin-Pichora, Mankovsky-Arnold, T., & Katz, J. D. (2011) · Journal of Pain Research · doi:10.2147/jpr.s15966 · Cited by 24
S.3.02 Mechanisms of placebo and placebo related effects across diseases and treatments
Benedetti, F. (2010) · European Neuropsychopharmacology · doi:10.1016/s0924-977x(10)70072-9 · Cited by 3
Cited by
Sorted by citations
Nocebo and pain: an overview of the psychoneurobiological mechanisms
Blasini, M., Corsi, N., Klinger, R., & Colloca, L. (2017) · PAIN Reports · doi:10.1097/pr9.0000000000000585 · Cited by 139
Metadata
- Authors
- Egorova, N., Yu, R., Kaur, N., Vangel, M., Gollub, R. L., Dougherty, D. D., Kong, J., & Camprodon, J. A.
- Affiliations
- Harvard University (US)
- Massachusetts General Hospital (US)
- Corresponding author
- Kong, Jian
- ORCID
- Venue
- Pain
- Published
- 2015-07
- Volume
- 156
- Issue
- 7
- Pages
- 1342-1347
- ISSN
- 0304-3959 (ISSN-L)
- PMC
- PMC4474770
- OpenAlex
- W2024441125
- Cited by
- 63
- References
- 56
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 9 · 2023: 6 · 2022: 8 · 2021: 6 · 2020: 5 · 2019: 8 · 2018: 7 · 2017: 3 · 2016: 3 · 2015: 2
- FWCI
- 3.01
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Pain (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (R25MH094612)
- National Center for Complementary and Integrative Health (R01AT006364, P01AT006663, R01AT005280)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Pain Management and Placebo Effect
- Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
- Keywords
- placebo effect, nocebo effect, thermal pain, transcranial direct current stimulation, dorsolateral prefrontal cortex, anodal tDCS, cathodal tDCS, current polarity, pain anticipation
- MeSH terms
- Adult, Conditioning, Psychological, Female, Hot Temperature, Humans, Male, Pain, Pain Measurement, Photic Stimulation, Placebo Effect, Prefrontal Cortex, Young Adult, Nocebo Effect, Transcranial Direct Current Stimulation
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
