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Abnormal trigeminal sensory processing in obese mice
Open accessAbstract
Obesity is associated with several pain disorders including headache. The effects of obesity on the trigeminal nociceptive system, which mediates headache, remain unknown. We used 2 complementary mouse models of obesity (high-fat diet and leptin deficiency) to examine this. We assessed capsaicin-induced nocifensive behavior and photophobia in obese and control mice. Calcium imaging was used to determine the effects of obesity on the activity of primary trigeminal afferents in vitro. We found that obese mice had a normal acute response to a facial injection of capsaicin, but they developed photophobic behavior at doses that had no effect on control mice. We observed higher calcium influx in cultured trigeminal ganglia neurons from obese mice and a higher percentage of medium to large diameter capsaicin-responsive cells. These findings demonstrate that obesity results in functional changes in the trigeminal system that may contribute to abnormal sensory processing. Our findings provide the foundation for in-depth studies to improve the understanding of the effects of obesity on the trigeminal system and may have implications for the pathophysiology of headache disorders.
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“The reductions in nerve endings and network complexity suggest a potential mechanism for sensory alterations in obesity, including the reduced sensitivity to whisker stimulation observed by us and the aberrant sensory and pain processing previously observed in obese mice30–32.”
From A deep-learning framework reveals whole-body perturbations at cell level (2026) · cites this paper as [31]
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Metadata
- Authors
- Rossi, H. L., Broadhurst, K. A., Luu, A. S. K., Lara, O., Kothari, S. D., Mohapatra, D. P., & Recober, A.
- Affiliations
- University of Iowa (US)
- Corresponding author
- Recober, Ana
- Venue
- Pain
- Published
- 2016-01
- Volume
- 157
- Issue
- 1
- Pages
- 235-246
- ISSN
- 0304-3959 (ISSN-L)
- PMC
- PMC4933294
- OpenAlex
- W2399243407
- Cited by
- 26
- References
- 52
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 3 · 2023: 2 · 2022: 2 · 2021: 5 · 2020: 1 · 2019: 4 · 2017: 4 · 2016: 2
- FWCI
- 1.62
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Pain (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (K08NS066087, NS066087, R01NS069898, NS069898)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Migraine and Headache Studies
- Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
- Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
- Keywords
- obesity, trigeminal nociception, headache, photophobia, capsaicin, trigeminal ganglion neurons, calcium influx, high-fat diet, leptin deficiency, trigeminal afferents, sensory processing
- MeSH terms
- Animals, Behavior, Animal, Capsaicin, Mice, Obese, Neurons, Obesity, Pain, Sensory Receptor Cells, Trigeminal Ganglion, Sensation, Sensation Disorders, Mice
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