A neural mechanism for exacerbation of headache by light
Open accessAbstract
The perception of migraine headache, which is mediated by nociceptive signals transmitted from the cranial dura mater to the brain, is uniquely exacerbated by exposure to light. We found that exacerbation of migraine headache by light is prevalent among blind individuals who maintain non-image-forming photoregulation in the face of massive rod/cone degeneration. Using single-unit recording and neural tract tracing in the rat, we identified dura-sensitive neurons in the posterior thalamus whose activity was distinctly modulated by light and whose axons projected extensively across layers I-V of somatosensory, visual and associative cortices. The cell bodies and dendrites of such dura/light-sensitive neurons were apposed by axons originating from retinal ganglion cells (RGCs), predominantly from intrinsically photosensitive RGCs, the principle conduit of non-image-forming photoregulation. We propose that photoregulation of migraine headache is exerted by a non-image-forming retinal pathway that modulates the activity of dura-sensitive thalamocortical neurons.
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In individuals with chronic migraine, central pain sensitization occurs between full-blown attacks and could explain the low-grade headache, allodynia, and other characteristic symptoms.
“In individuals with CM, central pain sensitization occurs between the full-blown attacks and could explain the low-grade headache, allodynia, and other symptoms that are characteristic of this disorder [72].”
From Effectiveness of acceptance and commitment therapy in central pain sensitization syndromes: A systematic review (2021) · cites this paper as [72]
The paper’s introductory passage (labeled Abstract in our copy; page unavailable) says prolonged activation during a migraine attack is thought to cause central sensitization and accompanying allodynia. It does not establish that sensitization occurs between attacks in people with chronic migraine or explains their low-grade headache. (LLM, conf=0.87)
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- Authors
- Noseda, R., Kainz, V., Jakubowski, M., Gooley, J. J., Saper, C. B., Digre, K., & Burstein, R.
- Affiliations
- Beth Israel Deaconess Medical Center (US)
- University of Utah (US)
- Harvard University (US)
- Corresponding author
- Burstein, Rami
- Venue
- Nature Neuroscience
- Published
- 2010-01-10
- Volume
- 13
- Issue
- 2
- Pages
- 239-245
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- PMC
- PMC2818758
- OpenAlex
- W2152412393
- Cited by
- 565
- References
- 46
- Citations by year
- 2026: 25 · 2025: 32 · 2024: 37 · 2023: 40 · 2022: 37 · 2021: 34 · 2020: 30 · 2019: 46 · 2018: 41 · 2017: 31 · 2016: 32 · 2015: 26 · 2014: 33 · 2013: 35 · 2012: 23
- FWCI
- 25.74
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (R01NS051484, NS-035611, R01NS033987, P01NS035611, NS051484)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Migraine and Headache Studies
- Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Keywords
- migraine, intrinsically photosensitive retinal ganglion cells, thalamus, thalamocortical neurons, blind people, nociceptive signaling, thalamocortical connections
- MeSH terms
- Adult, Animals, Axons, Blindness, Cerebral Cortex, Dendrites, Dura Mater, Female, Humans, Light, Male, Migraine Disorders, Neural Pathways, Neurons, Retina, Retinal Ganglion Cells, Thalamus, Incidence, Prevalence, Rats
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