The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index.
Abnormal trigeminal sensory processing in obese mice
Open accessAbstract
Obesity is associated with several pain disorders including headache. The effects of obesity on the trigeminal nociceptive system, which mediates headache, remain unknown. We used 2 complementary mouse models of obesity (high-fat diet and leptin deficiency) to examine this. We assessed capsaicin-induced nocifensive behavior and photophobia in obese and control mice. Calcium imaging was used to determine the effects of obesity on the activity of primary trigeminal afferents in vitro. We found that obese mice had a normal acute response to a facial injection of capsaicin, but they developed photophobic behavior at doses that had no effect on control mice. We observed higher calcium influx in cultured trigeminal ganglia neurons from obese mice and a higher percentage of medium to large diameter capsaicin-responsive cells. These findings demonstrate that obesity results in functional changes in the trigeminal system that may contribute to abnormal sensory processing. Our findings provide the foundation for in-depth studies to improve the understanding of the effects of obesity on the trigeminal system and may have implications for the pathophysiology of headache disorders.
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“The reductions in nerve endings and network complexity suggest a potential mechanism for sensory alterations in obesity, including the reduced sensitivity to whisker stimulation observed by us and the aberrant sensory and pain processing previously observed in obese mice30–32.”
From A deep-learning framework reveals whole-body perturbations at cell level (2026) · cites this paper as [31]
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SoilGrids1km — Global Soil Information Based on Automated Mapping
Hengl, T., de Jesus, J. M., MacMillan, R. A., Batjes, N. H., Heuvelink, G. B. M., Ribeiro, E., Samuel-Rosa, A., Kempen, B., Leenaars, J. G. B., Walsh, M. G., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0105992 · Cited by 1,268
Scher, I., Stewart, F. W., Rícci, A., & Lipton, B. R. (2003) · Pain · doi:10.1016/s0304-3959(03)00293-8 · Cited by 714
Migraine Headache Triggered Specifically by Sunlight: Report of 16 Cases
Tekataş, A., & Mungen, B. (2013) · European Neurology · doi:10.1159/000354165 · Cited by 665
A neural mechanism for exacerbation of headache by light
Noseda, R., Kainz, V., Jakubowski, M., Gooley, J. J., Saper, C. B., Digre, K., & Burstein, R. (2010) · Nature Neuroscience · doi:10.1038/nn.2475 · Cited by 565
Dose-dependent pain and mechanical hyperalgesia in humans after intradermal injection of capsaicin
Simone, D. A., Baumann, T., & LaMotte, R. H. (1989) · Pain · doi:10.1016/0304-3959(89)90079-1 · Cited by 507
BIGAL, M. E., Liberman, J. N., & Lipton, R. B. (2006) · Neurology · doi:10.1212/01.wnl.0000197218.05284.82 · Cited by 372
Obesity is a risk factor for transformed migraine but not chronic tension-type headache
BIGAL, M. E., & Lipton, R. B. (2006) · Neurology · doi:10.1212/01.wnl.0000225052.35019.f9 · Cited by 308
Hc, H., McMillen, R. C., Neaves, T. T., Koch, K., & Cosby, A. G. (2007) · Journal of Pain · doi:10.1016/j.jpain.2006.12.003 · Cited by 268
Intracellular Signaling in Primary Sensory Neurons and Persistent Pain
Cheng, J.-K., & Ji, R.-R. (2008) · Neurochemical Research · doi:10.1007/s11064-008-9711-z · Cited by 266
Strassman, A. M., & Vos, B. P. (1993) · The Journal of Comparative Neurology · doi:10.1002/cne.903310406 · Cited by 250
Research works printed but not linked: 1
- Eckardt, 1943, Experimental studies on headache: the genesis of pain from the eye., Res Publ Assoc Res Nerv Ment Dis, 23, 209
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Martins-Oliveira, M., Akerman, S., Holland, P. R., Hoffmann, J., Tavares, I., & Goadsby, P. J. (2017) · Neurobiology of Disease · doi:10.1016/j.nbd.2017.01.005 · Cited by 58
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Takayama, Y., Derouiche, S., Maruyama, K., & Tominaga, M. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20143411 · Cited by 57
Westgate, C. S. J., Israelsen, I. M. E., Jensen, R., & Eftekhari, S. (2021) · The Journal of Headache and Pain · doi:10.1186/s10194-021-01337-0 · Cited by 57
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Metadata
- Authors
- Rossi, H. L., Broadhurst, K. A., Luu, A. S. K., Lara, O., Kothari, S. D., Mohapatra, D. P., & Recober, A.
- Affiliations
- University of Iowa (US)
- Corresponding author
- Recober, Ana
- Venue
- Pain
- Published
- 2016-01
- Volume
- 157
- Issue
- 1
- Pages
- 235-246
- ISSN
- 0304-3959 (ISSN-L)
- PMC
- PMC4933294
- OpenAlex
- W2399243407
- Cited by
- 26
- References
- 52
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 3 · 2023: 2 · 2022: 2 · 2021: 5 · 2020: 1 · 2019: 4 · 2017: 4 · 2016: 2
- FWCI
- 1.62
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Pain (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (K08NS066087, NS066087, R01NS069898, NS069898)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Migraine and Headache Studies
- Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
- Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
- Keywords
- obesity, trigeminal nociception, headache, photophobia, capsaicin, trigeminal ganglion neurons, calcium influx, high-fat diet, leptin deficiency, trigeminal afferents, sensory processing
- MeSH terms
- Animals, Behavior, Animal, Capsaicin, Mice, Obese, Neurons, Obesity, Pain, Sensory Receptor Cells, Trigeminal Ganglion, Sensation, Sensation Disorders, Mice
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