Nuclear apoptosis contributes to sarcopenia
Open accessAbstract
In Brief Apoptosis results in DNA fragmentation and, subsequently, destruction of cells containing a single nucleus. Our hypothesis is that multinucleated cells such as muscle fibers can experience apoptotic-induced loss of single nuclei (nuclear apoptosis) without destruction of the entire fiber. The loss of nuclei likely contributes to atrophy and sarcopenia. Furthermore, increased chronic activity attenuates apoptotic signaling, which may reduce sarcopenia. Sarcopenia appears to involve selective loss of nuclei involving signaling from both intrinsic (mitochondrial) and extrinsic apoptotic pathways.
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Apoptosis regulated by mitochondria forms a potent signaling network that plays a role in sarcopenia.
“Mitochondrial-regulated apoptosis provides a strong signaling network that contributes to sarcopenia (8).”
From Mitochondria initiate and regulate sarcopenia (2017) · cites this paper as [8]
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“CONCLUSIONS Mitochondrial-regulated apoptosis provides a strong signaling network that contributes to sarcopenia (8).”
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- Authors
- Alway, S. E., & Siu, P. M.
- Affiliations
- West Virginia University (US)
- Hong Kong Polytechnic University (HK)
- Corresponding author
- Alway, Stephen E.
- Venue
- Exercise and Sport Sciences Reviews
- Published
- 2008-04
- Volume
- 36
- Issue
- 2
- Pages
- 51-57
- ISSN
- 0091-6331 (ISSN-L)
- PMC
- PMC2778230
- OpenAlex
- W1996457757
- Cited by
- 144
- References
- 30
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 7 · 2023: 7 · 2022: 6 · 2021: 6 · 2020: 4 · 2019: 5 · 2018: 7 · 2017: 8 · 2016: 8 · 2015: 5 · 2014: 3 · 2013: 6 · 2012: 11
- FWCI
- 6.99
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Exercise and Sport Sciences Reviews (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- The HKU Scholars Hub (University of Hong Kong) (submittedVersion)
- PolyU Institutional Research Archive (Hong Kong Polytechnic University) (submittedVersion)
- Funders
- Hong Kong Polytechnic University
- National Institute on Aging (R01AG021530)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Keywords
- sarcopenia, muscle atrophy, multinucleated muscle fibers, DNA fragmentation, mitochondrial apoptosis, extrinsic apoptotic pathway, mitochondrial signaling, exercise training, skeletal muscle
- MeSH terms
- Aging, Animals, Cell Nucleus, Humans, Muscle Contraction, Muscular Atrophy, Exercise, Apoptosis, Muscle, Skeletal, Satellite Cells, Skeletal Muscle, Cytochromes c
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