Cited by 77Metabolism, Diabetes, and CancerCellular transport and secretionAdipose Tissue and Metabolism

Exercise and Insulin: Convergence or Divergence at AS160 and TBC1D1?

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Cartee, Gregory D., Funai, Katsuhiko·2009·Exercise and Sport Sciences Reviews

Abstract

In Brief Akt substrate of 160 kDa (called AS160 or TBC1D4) and TBC1D1, Rab GTPase-activating proteins that regulate glucose transport, become phosphorylated with exercise or insulin stimulation. Evidence suggests that this convergence may prove to be imperfect, and each stimulus will produce a unique phosphosignature, providing a plausible mechanism for their apparently unique and overlapping roles in exercise- and insulin-stimulated glucose transport. AS160 and TBC1D1, with overlapping and unique responses to insulin and exercise, seem to play distinct roles in glucose transport.

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  • PAS-TBC1D4 phosphorylation is not essential for contraction-mediated glucose uptake.

    “Alternative studies provide evidence that PAS-TBC1D4 phosphorylation is not essential for contraction-mediated glucose uptake given that increases in phosphorylation do not appear at the onset of exercise when glucose uptake is rapidly increased (reviewed in [73]).”

    From AMPK and Exercise: Glucose Uptake and Insulin Sensitivity (2013) · cites this paper as [73]

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Authors
Cartee, G. D., & Funai, K.
Affiliations
University of Michigan (US)
Corresponding author
Cartee, Gregory D.
Venue
Exercise and Sport Sciences Reviews
Published
2009-10
Volume
37
Issue
4
Pages
188-195
ISSN
0091-6331 (ISSN-L)
OpenAlex
W1528723737
Cited by
77
References
30
Citations by year
2026: 4 · 2025: 1 · 2023: 3 · 2022: 1 · 2021: 2 · 2020: 3 · 2019: 3 · 2018: 3 · 2017: 2 · 2016: 4 · 2015: 8 · 2014: 11 · 2013: 6 · 2012: 12
FWCI
3.49
Type
journal article
Language
en
Open access
Locations
  • Exercise and Sport Sciences Reviews (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institute on Aging (AG 10026, R01AG010026)
  • National Institute of Diabetes and Digestive and Kidney Diseases (DK071771, R01DK071771)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
  • Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
Keywords
physical activity, insulin, glucose transport, AS160, TBC1D4, TBC1D1, Rab GTPase-activating protein, Akt signaling, protein phosphorylation, skeletal muscle
MeSH terms
Animals, Insulin, Muscle Contraction, Physical Conditioning, Animal, Proteins, Muscle, Skeletal, GTPase-Activating Proteins, Glucose Transporter Type 4, Mice, Rats

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