Exercise and Insulin: Convergence or Divergence at AS160 and TBC1D1?
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In Brief Akt substrate of 160 kDa (called AS160 or TBC1D4) and TBC1D1, Rab GTPase-activating proteins that regulate glucose transport, become phosphorylated with exercise or insulin stimulation. Evidence suggests that this convergence may prove to be imperfect, and each stimulus will produce a unique phosphosignature, providing a plausible mechanism for their apparently unique and overlapping roles in exercise- and insulin-stimulated glucose transport. AS160 and TBC1D1, with overlapping and unique responses to insulin and exercise, seem to play distinct roles in glucose transport.
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PAS-TBC1D4 phosphorylation is not essential for contraction-mediated glucose uptake.
“Alternative studies provide evidence that PAS-TBC1D4 phosphorylation is not essential for contraction-mediated glucose uptake given that increases in phosphorylation do not appear at the onset of exercise when glucose uptake is rapidly increased (reviewed in [73]).”
From AMPK and Exercise: Glucose Uptake and Insulin Sensitivity (2013) · cites this paper as [73]
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Exercise strategies to improve aerobic capacity, insulin sensitivity and mitochondrial biogenesis
Frank, P. (2014) · KTH Publication Database DiVA (KTH Royal Institute of Technology)
Hinkley, J. M. (2016) · The Scholarship East Carolina University's Institutional Repository (East Carolina University)
Clapp, E. L. (2010) · OpenGrey (Institut de l'Information Scientifique et Technique)
The effects of undercarboxylated osteocalcin on oxidative versus glycolytic skeletal muscle
Lin, X. (2018) · Victoria University Research Repository (Victoria University)
Hargreaves, M. (2012) · Springer eBooks · doi:10.1007/978-3-540-29807-6_90
Hargreaves, M. (2025) · Springer eBooks · doi:10.1007/978-3-032-05988-8_90
Endocrinological Aspects of Sarcopenia
Minnetti, M., Poggiogalle, E., Vincenzo, O. D., Migliaccio, S., & Donini, L. M. (2026) · Endocrinology · doi:10.1007/978-3-030-71067-5_22-1
Exercise and Insulin - Understanding the Molecular Interactions
Hargreaves, M. (2009) · Exercise and Sport Sciences Reviews · doi:10.1097/jes.0b013e3181b95462
- Authors
- Cartee, G. D., & Funai, K.
- Affiliations
- University of Michigan (US)
- Corresponding author
- Cartee, Gregory D.
- Venue
- Exercise and Sport Sciences Reviews
- Published
- 2009-10
- Volume
- 37
- Issue
- 4
- Pages
- 188-195
- ISSN
- 0091-6331 (ISSN-L)
- PMC
- PMC2789346
- OpenAlex
- W1528723737
- Cited by
- 77
- References
- 30
- Citations by year
- 2026: 4 · 2025: 1 · 2023: 3 · 2022: 1 · 2021: 2 · 2020: 3 · 2019: 3 · 2018: 3 · 2017: 2 · 2016: 4 · 2015: 8 · 2014: 11 · 2013: 6 · 2012: 12
- FWCI
- 3.49
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Exercise and Sport Sciences Reviews (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Aging (AG 10026, R01AG010026)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK071771, R01DK071771)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Keywords
- physical activity, insulin, glucose transport, AS160, TBC1D4, TBC1D1, Rab GTPase-activating protein, Akt signaling, protein phosphorylation, skeletal muscle
- MeSH terms
- Animals, Insulin, Muscle Contraction, Physical Conditioning, Animal, Proteins, Muscle, Skeletal, GTPase-Activating Proteins, Glucose Transporter Type 4, Mice, Rats
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