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Cited by 105Dementia and Cognitive Impairment ResearchCancer-related cognitive impairment studiesTreatment of Major Depression

Patterns of Mild Cognitive Impairment After Treatment of Depression in the Elderly

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Bhalla, Rishi K., Butters, Meryl A., Becker, James T., Houck, Patricia R., Snitz, Beth E., Lopez, Oscar L., Aizenstein, Howard J., Raina, Ketki D. +2 more·2009·The American Journal of Geriatric Psychiatry
DOI 10.1097/jgp.0b013e318190b8d8PMC PMC2782929
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Abstract

Objectives Late-life depression (LLD) is associated with persistent cognitive impairment in a subset of individuals. The purpose of this study was to 1) examine the frequency and characteristics of cognitive diagnoses (Mild Cognitive Impairment [MCI], dementia) among remitted elderly depressed subjects and 2) to compare the prevalence rate and correlates of cognitive diagnoses with those of comparison subjects. Design Crosssectional. Setting Outpatient geriatric mental health clinic. Participants The authors examined cognitive diagnoses among 109 subjects age 65 and older, after depression treatment response and 65 never-depressed, age- and education-equated comparison subjects. Measurements Cognitive diagnoses were independently established by the University of Pittsburgh's Alzheimer's Disease Research Center. Bivariate and multivariate analyses were conducted to examine the role of specific risk factors for cognitive diagnosis among depressed subjects. Results Relative to comparison subjects, nearly twice as many depressed subjects were diagnosed with MCI or dementia (48% versus 28%). Of the 109 depressed subjects, 38% were diagnosed with MCI (63% amnestic, 37% nonamnestic). The majority of amnestic MCI subjects (85%) had the multiple domain subtype. Age, but not age of onset or lifetime depression duration, predicted cognitive diagnosis. Conclusions Despite adequate depression treatment response, 48% of remitted depressed subjects had a cognitive diagnosis. Of the 38% diagnosed with MCI, there was high representation among both the amnestic and the nonamnestic subtypes, suggesting heterogeneity in cognitive course and outcomes in LLD.

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Authors
Bhalla, R. K., Butters, M. A., Becker, J. T., Houck, P. R., Snitz, B. E., Lopez, O. L., Aizenstein, H. J., Raina, K. D., DeKosky, S. T., & Reynolds, C. F.
Affiliations
University of Pittsburgh Medical Center (US)
Corresponding author
Butters, Meryl A.
ORCID
Venue
The American Journal of Geriatric Psychiatry
Publisher
Elsevier BV
Published
2009-04
Volume
17
Issue
4
Pages
308-316
ISSN
1064-7481 (ISSN-L)
DOI
10.1097/jgp.0b013e318190b8d8
PMC
PMC2782929
OpenAlex
W2012202426
Cited by
105
References
5
Citations by year
2026: 3 · 2025: 2 · 2024: 4 · 2023: 5 · 2022: 3 · 2021: 7 · 2020: 7 · 2019: 4 · 2018: 2 · 2017: 3 · 2016: 8 · 2015: 10 · 2014: 8 · 2013: 10 · 2012: 6
FWCI
5.50
Type
journal article
Language
en
Open access
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • American Journal of Geriatric Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institute on Aging (P50AG005133, P30AG024827)
  • National Institute of Mental Health (R01MH072947, R37MH043832, P30MH071944, R01MH043832, T32MH019986)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cancer-related cognitive impairment studies
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
Keywords
geriatric depression, mild cognitive impairment, dementia, amnestic MCI, non-amnestic MCI, age as risk factor, geriatric mental health
MeSH terms
Activities of Daily Living, Aged, Aging, Cognition Disorders, Cross-Sectional Studies, Dementia, Depression, Female, Humans, Male, Psychiatric Status Rating Scales, Severity of Illness Index, Geriatric Assessment, Prevalence, Treatment Outcome, Age of Onset

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