Improved Alertness Is Associated with Early Increase in Serum Brain-Derived Neurotrophic Factor and Antidepressant Treatment Outcome in Major Depression
Abstract
Background/Aims: In major depression cognitive impairment is common and may persist despite improvement in psychopathology. So far it is unclear how closely related improvement in cognitive functioning is to the clinical course of depression. Further, it is unclear whether recovery from cognitive impairment is linked to changes in serum brain-derived neurotrophic factor (sBDNF). The objectives of this study were (1) to explore the predictive value of cognitive impairment for therapeutic outcome, and (2) to assess the association between cognitive performance and sBDNF levels over a 6-week course of antidepressant treatment. Methods: Twenty-five adult patients suffering from major depression underwent standardized treatment with duloxetine. Both severity of depression as assessed by the Hamilton Depression Rating Scale and sBDNF levels were measured at baseline, and after 1, 2 and 6 weeks of treatment. Cognitive performance, i.e. alertness, working memory, and divided attention, was assessed at baseline, after 1 week, and at the end of treatment after 6 weeks. Results: Higher performance in alertness and divided attention at baseline correlated with less severe depression at week 6. During the first week of treatment, a greater increase in sBDNF was associated with a greater improvement in alertness at week 6. Conclusion: Greater alertness at baseline was a predictor of favorable antidepressive treatment outcome. Moreover, the early increase in sBDNF correlated with improvement in attention functioning. Thus, recovery from cognitive impairment and an early increase in sBDNF seem to be associated.
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Better divided attention appears to predict treatment efficacy independently of baseline depression severity.
“Better divided attention appears to predict treatment efficacy independently of baseline depression severity36”
From Paying attention to attention in depression (2019) · cites this paper as [36]
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Paying attention to attention in depression
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- Authors
- Mikoteit, T., Hemmeter, U., Eckert, A., Brand, S., Bischof, R., Delini-Stula, A., Holsboer-Trachsler, E., & Beck, J.
- Affiliations
- California Center for Sleep Disorders (US)
- Kantonale Psychiatrische Dienste St Gallen (CH)
- University of Basel (CH)
- Venue
- Neuropsychobiology
- Publisher
- S. Karger AG
- Published
- 2015
- Volume
- 72
- Issue
- 1
- Pages
- 16-28
- ISSN
- 0302-282X (ISSN-L)
- 1423-0224
- OpenAlex
- W1793700335
- Cited by
- 25
- References
- 85
- Citations by year
- 2026: 2 · 2025: 3 · 2023: 1 · 2022: 1 · 2021: 5 · 2020: 4 · 2019: 1 · 2018: 3 · 2017: 2 · 2016: 3
- FWCI
- 1.92
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuropsychobiology (publishedVersion)
- PubMed (publishedVersion)
- edoc (University of Basel) (submittedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Keywords
- major depressive disorder, cognitive impairment, alertness, brain-derived neurotrophic factor, serum BDNF, antidepressant treatment outcome, duloxetine, working memory, divided attention, treatment outcome prediction
- MeSH terms
- Duloxetine Hydrochloride, Adult, Analysis of Variance, Antidepressive Agents, Attention Deficit Disorder with Hyperactivity, Cognition Disorders, Major Depressive Disorder, Female, Humans, Male, Memory Disorders, Memory, Short-Term, Middle Aged, Neuropsychological Tests, Brain-Derived Neurotrophic Factor
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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