The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
Gut Microbiota in Multiple Sclerosis: Possible Influence of Immunomodulators
Open accessAbstract
Objectives: Differences in gut bacteria have been described in several autoimmune disorders. In this exploratory pilot study, we compared gut bacteria in patients with multiple sclerosis and healthy controls and evaluated the influence of glatiramer acetate and vitamin D treatment on the microbiota. Methods: Subjects were otherwise healthy white women with or without relapsing-remitting multiple sclerosis who were vitamin D insufficient. Patients with multiple sclerosis were untreated or were receiving glatiramer acetate. Subjects collected stool at baseline and after 90 days of vitamin D 3 (5000 IU/d) supplementation. The abundance of operational taxonomic units was evaluated by hybridization of 16S rRNA to a DNA microarray. Results: While there was overlap of gut bacterial communities, the abundance of some operational taxonomic units, including Faecalibacterium, was lower in patients with multiple sclerosis. Glatiramer acetate–treated patients with multiple sclerosis showed differences in community composition compared with untreated subjects, including Bacteroidaceae, Faecalibacterium, Ruminococcus, Lactobacillaceae, Clostridium, and other Clostridiales. Compared with the other groups, untreated patients with multiple sclerosis had an increase in the Akkermansia, Faecalibacterium, and Coprococcus genera after vitamin D supplementation. Conclusions: While overall bacterial communities were similar, specific operational taxonomic units differed between healthy controls and patients with multiple sclerosis. Glatiramer acetate and vitamin D supplementation were associated with differences or changes in the microbiota. This study was exploratory, and larger studies are needed to confirm these preliminary results.
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“Interestingly, even MS patients with active disease have an altered microbiota compared to patients in the remission phase, which in turn have a microbiota more similar to healthy controls (25, 134–138).”
From The gut-brain axis: how microbiota and host inflammasome influence brain physiology and pathology (2020) · cites this paper as [135]
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Metadata
- Authors
- Cantarel, B. L., Waubant, E., Chehoud, C., Kuczynski, J., DeSantis, T. Z., Warrington, J., Venkatesan, A., Fraser, C. M., & Mowry, E. M.
- Affiliations
- University of Maryland, Baltimore (US)
- University of California, San Francisco (US)
- Second Genome (United States) (US)
- Johns Hopkins University (US)
- ORCID
- Venue
- Journal of Investigative Medicine
- Publisher
- SAGE Publications
- Published
- 2015-06
- Volume
- 63
- Issue
- 5
- Pages
- 729-734
- ISSN
- 1081-5589 (ISSN-L)
- 1708-8267
- PMC
- PMC4439263
- OpenAlex
- W197804012
- Cited by
- 409
- References
- 20
- Citations by year
- 2026: 15 · 2025: 42 · 2024: 37 · 2023: 38 · 2022: 54 · 2021: 47 · 2020: 39 · 2019: 41 · 2018: 30 · 2017: 37 · 2016: 21 · 2015: 8
- FWCI
- 13.89
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Investigative Medicine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (K23NS067055)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
- Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
- Keywords
- gut microbiota, multiple sclerosis, relapsing-remitting multiple sclerosis, glatiramer acetate, vitamin D supplementation, immunomodulators, Faecalibacterium, Akkermansia, Coprococcus, Bacteroidaceae, Clostridiales, 16S rRNA gene sequencing, stool microbiome
- MeSH terms
- Glatiramer Acetate, Gastrointestinal Microbiome, Adjuvants, Immunologic, Adult, Cholecalciferol, Female, Humans, Immunologic Factors, Middle Aged, Pilot Projects, Dietary Supplements, Multiple Sclerosis, Relapsing-Remitting
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