Associations of ozone and PM2. 5 concentrations with Parkinson's disease among participants in the agricultural health study
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OBJECTIVE: This study describes associations of ozone and fine particulate matter with Parkinson's disease observed among farmers in North Carolina and Iowa. METHODS: We used logistic regression to determine the associations of these pollutants with self-reported, doctor-diagnosed Parkinson's disease. Daily predicted pollutant concentrations were used to derive surrogates of long-term exposure and link them to study participants' geocoded addresses. RESULTS: We observed positive associations of Parkinson's disease with ozone (odds ratio = 1.39; 95% CI: 0.98 to 1.98) and fine particulate matter (odds ratio = 1.34; 95% CI: 0.93 to 1.93) in North Carolina but not in Iowa. CONCLUSIONS: The plausibility of an effect of ambient concentrations of these pollutants on Parkinson's disease risk is supported by experimental data demonstrating damage to dopaminergic neurons at relevant concentrations. Additional studies are needed to address uncertainties related to confounding and to examine temporal aspects of the associations we observed.
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Neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease, have been linked to ozone exposures in recent epidemiologic studies.
“Neurodegenerative disorders, such as Alzheimer's disease (AD) and Parkinson's disease, have been linked to ozone exposures in recent epidemiologic studies (66, 67).”
From Ozone pollution: A Major health hazard worldwide (2019) · cites this paper as [67]
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- Authors
- Kirrane, E. F., Bowman, C., Davis, J. A., Hoppin, J. A., Blair, A., Chen, H., Patel, M. M., Sandler, D. P., Tanner, C. M., Vinikoor-Imler, L., Ward, M. H., Luben, T. J., & Kamel, F.
- Affiliations
- United States Department of Health and Human Services (US)
- Corresponding author
- Kirrane, Ellen F.
- ORCID
- Venue
- Journal of Occupational & Environmental Medicine
- Published
- 2015-05
- Volume
- 57
- Issue
- 5
- Pages
- 509-517
- ISSN
- 1076-2752 (ISSN-L)
- PMC
- PMC4428683
- OpenAlex
- W2293228695
- Cited by
- 100
- References
- 43
- Citations by year
- 2026: 11 · 2025: 9 · 2024: 14 · 2023: 8 · 2022: 9 · 2021: 11 · 2020: 9 · 2019: 7 · 2018: 8 · 2017: 7 · 2016: 7
- FWCI
- 4.59
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Occupational and Environmental Medicine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Institutes of Health (Z01-CP010119)
- National Cancer Institute (Z01CP010119)
- National Institute of Environmental Health Sciences (Z01ES049030, ZIAES049030)
- Topics
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Air Quality and Health Impacts
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Health, Environment, Cognitive Aging
- Keywords
- Parkinson's disease, ozone, PM2.5, air pollution exposure, farmers, occupational exposure, dopaminergic neuron damage, long-term exposure, North Carolina, Iowa
- MeSH terms
- Farmers, Adolescent, Adult, Aged, Aged, 80 and over, Agriculture, Air Pollutants, Occupational, Air Pollution, Child, Female, Follow-Up Studies, Humans, Iowa, Male, Middle Aged, North Carolina, Occupational Diseases, Ozone, Parkinson Disease, Logistic Models, Occupational Exposure, Particulate Matter, Young Adult
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