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Cited by 106Biochemical effects in animalsMuscle metabolism and nutritionSports Performance and Training

The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.

Beta-alanine supplementation, muscle carnosine and exercise performance

Open access
Blancquaert, Laura, Everaert, Inge, Derave, Wim·2015·Current Opinion in Clinical Nutrition and Metabolic Care
DOI 10.1097/mco.0000000000000127
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Abstract

Purpose of review The use of dietary supplements in sports is widespread as athletes are continuously searching for strategies to increase performance at the highest level. Beta-alanine is such a supplement that became increasingly popular during the past years. This review examines the available evidence regarding the optimization of supplementation, the link between beta-alanine and exercise performance and the underlying ergogenic mechanism. Recent findings It has been repeatedly demonstrated that chronic beta-alanine supplementation can augment intramuscular carnosine content. Yet, the factors that determine the loading process, as well as the mechanism by which this has an ergogenic effect, are still debated. On the basis of its biochemical properties, several functions are ascribed to carnosine, of which intramuscular pH buffer and calcium regulator are the most cited ones. In addition, carnosine has antiglycation and antioxidant properties, suggesting it could have a therapeutic potential. Summary On the basis of the millimolar presence of carnosine in mammalian muscles, it must play a critical role in skeletal muscle physiology. The recent number of studies shows that this is related to an improved exercise homeostasis and excitation-contraction coupling. Recent developments have led to the optimization of the beta-alanine supplementation strategies to elevate muscle carnosine content, which are helpful in its application in sports and to potential future therapeutic…

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Crossref · 10.1097/mco.0000000000000127

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7 of 7 references verified0 citation errors · 0 not checkable

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  • During high-intensity exercise, such as a soccer game, blood lactate concentration increases as a product of the glycolytic pathway used to provide energy and maintain exercise intensity.

    “During the high-intensity exercise, a soccer game for example, there is an increase in blood lactate concentration, a product of the glycolytic pathway used to provide energy and maintain the intensity of the exercise [21, 22]”

    From Dietary and Ergogenic Supplementation to Improve Elite Soccer Players’ Performance (2021) · cites this paper as [22]

  • Sodium bicarbonate supplementation attenuates the decline in muscle pH, decreasing acidity and improving performance.

    “supplementation with sodium bicarbonate (NaHCO3) has been used, a buffering agent that attenuates the decline in muscle pH, decreasing acidity and improving performance [22, 23].”

    From Dietary and Ergogenic Supplementation to Improve Elite Soccer Players’ Performance (2021) · cites this paper as [22]

Citations

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Metadata

Authors
Blancquaert, L., Everaert, I., & Derave, W.
Affiliations
Ghent University (BE)
Corresponding author
Derave, Wim
ORCID
Venue
Current Opinion in Clinical Nutrition and Metabolic Care
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2015-01
Volume
18
Issue
1
Pages
63-70
ISSN
1363-1950 (ISSN-L)
DOI
10.1097/mco.0000000000000127
OpenAlex
W1998064777
Cited by
106
References
7
Citations by year
2026: 2 · 2025: 5 · 2024: 3 · 2023: 12 · 2022: 11 · 2021: 16 · 2020: 10 · 2019: 7 · 2018: 10 · 2017: 11 · 2016: 14 · 2015: 5
FWCI
1.17
Type
journal article
Language
en
Open access
Licence
other-oa
Locations
  • Current Opinion in Clinical Nutrition & Metabolic Care (publishedVersion)
  • PubMed (publishedVersion)
  • Ghent University Academic Bibliography (Ghent University) (submittedVersion)
  • Griffith Research Online (submittedVersion, other-oa)
Funders
  • Fonds Wetenschappelijk Onderzoek (G.0243.11, FWO G.0243.11, G.0352.13N)
  • Vlaamse regering
Topics
  • Health Sciences › Medicine › Physiology (medical) › Biochemical effects in animals
  • Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Sports Performance and Training
Keywords
beta-alanine supplementation, muscle carnosine, exercise performance, ergogenic aids, skeletal muscle, calcium regulation, excitation-contraction coupling, antiglycation, antioxidant activity
MeSH terms
Animals, Antioxidants, Carnosine, Humans, beta-Alanine, Exercise, Muscle, Skeletal, Dietary Supplements

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