The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Interactions of gut microbiota with dietary polyphenols and consequences to human health
Abstract
PURPOSE OF REVIEW: Dietary (poly)phenolic compounds have received attention over the last 20 years as antioxidants with preventive properties against chronic diseases. However, the evidence of these effects in clinical trials is weak, mainly because of a considerable interindividual variability. Polyphenols bioavailability is low, and gut microbiota metabolize them into simpler metabolites. As gut microbiota vary among individuals, such interindividual variability should be considered as a moderating factor in clinical trials. In this review, we show evidence of interactions with gut microbiota that help understanding polyphenols' health effects. RECENT FINDINGS: Recent studies indicate that dietary polyphenols are relevant in the modulation of gut microbiota and that these microorganisms convert polyphenols into active and bioavailable metabolites; hence, variations in gut microbiota can affect polyphenol activity. SUMMARY: The results show that study participants' stratification by their polyphenol-metabolizing phenotypes would be necessary for clinical trials as specific metabotypes produce the bioactive metabolites responsible for the health effects. Metabotypes can also reflect the gut microbiota composition and metabolic status, and could be biomarkers of the potential polyphenol health effects mediated through gut microbiota.
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Cites
Gut Microbiota from Twins Discordant for Obesity Modulate Metabolism in Mice
Ridaura, V. K., Faith, J. J., Rey, F. E., Cheng, J., Duncan, A. E., Kau, A. L., Griffin, N. W., Lombard, V., Henrissat, B., Bain, J. R., et al. (2013) · Science · doi:10.1126/science.1241214 · Cited by 3,788
The gut microbiota and host health: a new clinical frontier
Marchesi, J. R., Adams, D. H., Fava, F., Hermes, G. D. A., Hirschfield, G. M., Hold, G., Quraishi, M. N., Kinross, J., Smidt, H., Tuohy, K. M., et al. (2016) · Gut · doi:10.1136/gutjnl-2015-309990 · Cited by 2,302 · cited 2×
“A recent study [9] shows the relevance of polyphenols and introduces the three ‘Ps’ concept for interactions between microbiota and gut health: probiotics, prebiotics, and polyphenols.”
BackgroundPopulation-based metagenomics analysis reveals markers for gut microbiome composition and diversity
Zhernakova, A., Kurilshikov, A., Bonder, M. J., Tigchelaar, E. F., Schirmer, M., Vatanen, T., Mujagic, Z., Vila, A. V., Falony, G., Vieira-Silva, S., et al. (2016) · Science · doi:10.1126/science.aad3369 · Cited by 1,914
Anhê, F. F., Roy, D., Pilon, G., Dudonné, S., Matamoros, S., Varin, T. V., Garofalo, C., Moine, Q., Desjardins, Y., Levy, E., et al. (2015) · Gut · doi:10.1136/gutjnl-2014-307142 · Cited by 1,137
Etxeberria, U., Arias, N., Boqué, N., Macarulla, M. T., Portillo, M. P., Martínez, J. A., & Milagro, F. I. (2015) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2015.01.002 · Cited by 446 · cited 1×
“The flavonol quercetin counteracted gut microbiota dysbiosis in rats fed a high-fat sucrose diet [27] and prevented body weight gain, reduced serum insulin, attenuated the Firmicutes/ Bacteroidetes ratio, and inhibited the growth of bacteria associated with diet-induced obesity.”
BackgroundYuan, T., Ma, H., Liu, W., Niesen, D. B., Shah, N., Crews, R., Rose, K. N., Vattem, D. A., & Seeram, N. P. (2016) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.5b00260 · Cited by 219
Cited by
Potential Adverse Effects of Resveratrol: A Literature Review
Shaito, A., Posadino, A. M., Younes, N., Hasan, H., Halabi, S., Alhababi, D., Al-Mohannadi, A., Abdel-Rahman, W. M., Eid, A. H., Nasrallah, G. K., et al. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21062084 · Cited by 716
The gut microbiota: a key factor in the therapeutic effects of (poly)phenols
Espín, J. C., González-Sarrías, A., & Tomás-Barberán, F. A. (2017) · Biochemical Pharmacology · doi:10.1016/j.bcp.2017.04.033 · Cited by 603
Self-citationMetabolic and Functional Paths of Lactic Acid Bacteria in Plant Foods: Get out of the Labyrinth
Filannino, P., Di Cagno, R., & Gobbetti, M. (2018) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2017.07.016 · Cited by 420
Mayo, B., Vázquez, L., & Flórez, A. B. (2019) · Nutrients · doi:10.3390/nu11092231 · Cited by 416
Sharifi-Rad, J., Quispe, C., Durazzo, A., Lucarini, M., Souto, E. B., Santini, A., Imran, M., Moussa, A. Y., Mostafa, N. M., El-Shazly, M., et al. (2022) · Journal of Herbal Medicine · doi:10.1016/j.hermed.2022.100550 · Cited by 81
Metadata
- Authors
- Tomás-Barberán, F. A., Selma, M. V., & Espín, J. C.
- Venue
- Current Opinion in Clinical Nutrition & Metabolic Care
- Published
- 2016-11
- Volume
- 19
- Issue
- 6
- Pages
- 471-476
- ISSN
- 1363-1950 (ISSN-L)
- OpenAlex
- W2514248777
- Cited by
- 351
- References
- 6
- FWCI
- 13.09
- Type
- journal article
- Language
- en
- Open access
- closed
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