Equol: a bacterial metabolite from the daidzein isoflavone and its presumed beneficial health effects
Open accessAbstract
Epidemiological data suggest that regular intake of isoflavones from soy reduces the incidence of estrogen-dependent and aging-associated disorders, such as menopause symptoms in women, osteoporosis, cardiovascular diseases and cancer. Equol, produced from daidzein, is the isoflavone-derived metabolite with the greatest estrogenic and antioxidant activity. Consequently, equol has been endorsed as having many beneficial effects on human health. The conversion of daidzein into equol takes place in the intestine via the action of reductase enzymes belonging to incompletely characterized members of the gut microbiota. While all animal species analyzed so far produce equol, only between one third and one half of human subjects (depending on the community) are able to do so, ostensibly those that harbor equol-producing microbes. Conceivably, these subjects might be the only ones who can fully benefit from soy or isoflavone consumption. This review summarizes current knowledge on the microorganisms involved in, the genetic background to, and the biochemical pathways of, equol biosynthesis. It also outlines the results of recent clinical trials and meta-analyses on the effects of equol on different areas of human health and discusses briefly its presumptive mode of action.
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Upwards of half of the population lack the microbiota composition to produce equol.
“A further example is the isoflavone metabolite equol, which has considerable estrogenic properties, but upwards of half of the population lack the microbiota composition to produce it (509).”
From Diet and the Microbiota–Gut–Brain Axis: Sowing the Seeds of Good Mental Health (2021) · cites this paper as [509]
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Bile salt biotransformations by human intestinal bacteria
Ridlon, J. M., Kang, D.-J., & Hylemon, P. B. (2006) · Journal of Lipid Research · doi:10.1194/jlr.r500013-jlr200 · Cited by 2,829 · see citing works
Del Rio, D., Rodriguez-Mateos, A., Spencer, J. P. E., Tognolini, M., Borges, G., & Crozier, A. (2013) · Antioxidants & Redox Signaling · doi:10.1089/ars.2012.4581 · Cited by 2,601 · see citing works
Setchell, K. D. R., Brown, N. M., Desai, P. B., Zimmer-Nechemias, L., Wolfe, B., Brashear, W. T., Kirschner, A. S., Cassidy, A., & Heubi, J. E. (2001) · Journal of Nutrition · doi:10.1093/jn/131.4.1362s · Cited by 974 · see citing works
Estrogen receptors alpha (ERα) and beta (ERβ): Subtype-selective ligands and clinical potential
Paterni, I., Granchi, C., Katzenellenbogen, J. A., & Minutolo, F. (2014) · Steroids · doi:10.1016/j.steroids.2014.06.012 · Cited by 736 · see citing works
Ramawat, K. G., & Mérillon, J. (2013) · Springer eBooks · doi:10.1007/978-3-642-22144-6 · Cited by 652 · see citing works
Thomas, P., & Dong, J. (2006) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2006.09.017 · Cited by 604 · see citing works
Glucagon-like peptide 1 in health and disease
Andersen, A., Lund, A., Knop, F. K., & Vilsbøll, T. (2018) · Nature Reviews Endocrinology · doi:10.1038/s41574-018-0016-2 · Cited by 543 · see citing works
Soy and Health Update: Evaluation of the Clinical and Epidemiologic Literature
Messina, M. (2016) · Nutrients · doi:10.3390/nu8120754 · Cited by 537 · see citing works
Equol: History, Chemistry, and Formation
Setchell, K. D. R., & Clerici, C. (2010) · The Journal of Nutrition · doi:10.3945/jn.109.119776 · Cited by 519 · see citing works
Isoflavones: estrogenic activity, biological effect and bioavailability
Vitale, D. C., Piazza, C., Melilli, B., Drago, F., & Salomone, S. (2012) · European Journal of Drug Metabolism and Pharmacokinetics · doi:10.1007/s13318-012-0112-y · Cited by 500 · see citing works
Flavonoid metabolism: the interaction of metabolites and gut microbiota
Murota, K., Nakamura, Y., & Uehara, M. (2018) · Bioscience Biotechnology and Biochemistry · doi:10.1080/09168451.2018.1444467 · Cited by 487 · see citing works
Setchell, K. D., Clerici, C., Lephart, E. D., Cole, S. J., Heenan, C., Castellani, D., Wolfe, B. E., Nechemias-Zimmer, L., Brown, N. M., Lund, T. D., et al. (2005) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/81.5.1072 · Cited by 471 · see citing works
Estimated Asian adult soy protein and isoflavone intakes
Messina, M., Nagata, C., & Wu, A. H. (2006) · Nutrition and Cancer · doi:10.1207/s15327914nc5501_1 · Cited by 435 · see citing works
Antioxidant Activities of Isoflavones and Their Biological Metabolites in a Liposomal System
Arora, A., Nair, M. G., & Strasburg, G. M. (1998) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1998.0783 · Cited by 404 · see citing works
Interactions of gut microbiota with dietary polyphenols and consequences to human health
Tomás-Barberán, F. A., Selma, M. V., & Espı́n, J. C. (2016) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0000000000000314 · Cited by 359 · see citing works
Method of Defining Equol-Producer Status and Its Frequency among Vegetarians
Setchell, K. D. R., & Cole, S. J. (2006) · Journal of Nutrition · doi:10.1093/jn/136.8.2188 · Cited by 351 · see citing works
Setchell, K. D. R., Faughnan, M. S., Avades, T. Y., Zimmer-Nechemias, L., Brown, N. M., Wolfe, B., Brashear, W. T., Desai, P., Oldfield, M. F., Botting, N. P., et al. (2003) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/77.2.411 · Cited by 320 · see citing works
Harmsen, H. J. M., Wildeboer-Veloo, A. C. M., Grijpstra, J., Knol, J., Degener, J. E., & Welling, G. W. (2000) · Applied and Environmental Microbiology · doi:10.1128/aem.66.10.4523-4527.2000 · Cited by 309 · see citing works
Maruo, T., Sakamoto, M., Ito, C., Toda, T., & Benno, Y. (2008) · INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY · doi:10.1099/ijs.0.65404-0 · Cited by 308 · see citing works
Casagrande, F., & Darbon, J.-M. (2001) · Biochemical Pharmacology · doi:10.1016/s0006-2952(01)00583-4 · Cited by 305 · see citing works
Phytoestrogens for menopausal vasomotor symptoms
Lethaby, A. E., Marjoribanks, J., Kronenberg, F., Roberts, H., Eden, J., & Brown, J. (2013) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd001395.pub4 · Cited by 288 · see citing works
Soy isoflavones and prostate cancer: A review of molecular mechanisms
Mahmoud, A. M., Yang, W., & Bosland, M. C. (2013) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2013.12.010 · Cited by 283 · see citing works
Malonyl Isoflavone Glycosides in Soybean Seeds(Glycine max MERRILL).
Kudou, S., Fleury, Y., Welti, D. H., Magnolato, D., UCHIDA, T., Kitamura, K., & Ōkubo, K. (1991) · Agricultural and Biological Chemistry · doi:10.1271/bbb1961.55.2227 · Cited by 279 · see citing works
Hur, H.-G., Lay, J. O., Beger, R. D., Freeman, J. P., & Rafii, F. (2000) · Archives of Microbiology · doi:10.1007/s002030000222 · Cited by 271 · see citing works
An insight into the health benefits of fermented soy products
Jayachandran, M., & Xu, B. (2018) · Food Chemistry · doi:10.1016/j.foodchem.2018.07.158 · Cited by 268 · see citing works
Grace, P. B., Taylor, J. I., Low, Y.-L., Luben, R. N., Mulligan, A. A., Botting, N. P., Dowsett, M., Welch, A. A., Khaw, K.-T., Wareham, N. J., et al. (2004) · Cancer Epidemiology, Biomarkers & Prevention · doi:10.1158/1055-9965.698.13.5 · Cited by 264 · see citing works
Critical review of health effects of soyabean phyto-oestrogens in post-menopausal women
Cassidy, A., Albertazzi, P., Nielsen, I. L. F., Hall, W. L., Williamson, G., Tetens, I., Atkins, S., Cross, H. S., Μanios, Y., Wolk, A., et al. (2006) · Proceedings of The Nutrition Society · doi:10.1079/pns2005476 · Cited by 257 · see citing works
Equol Is a Novel Anti-Androgen that Inhibits Prostate Growth and Hormone Feedback1
Lund, T. D., Munson, D. J., Haldy, M. E., Setchell, K. D. R., Lephart, E. D., & Handa, R. J. (2004) · Biology of Reproduction · doi:10.1095/biolreprod.103.023713 · Cited by 250 · see citing works
Akaza, H. (2004) · Japanese Journal of Clinical Oncology · doi:10.1093/jjco/hyh015 · Cited by 246 · see citing works
He, F.-J., & Chen, J. (2013) · Food Science and Human Wellness · doi:10.1016/j.fshw.2013.08.002 · Cited by 242 · see citing works
A Meta-Analysis of the Effect of Soy Protein Supplementation on Serum Lipids
Reynolds, K., Chin, A., Lees, K. A., Nguyen, A., Bujnowski, D., & He, J. (2006) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2006.03.042 · Cited by 237 · see citing works
Decroos, K., Vanhemmens, S., Cattoir, S., Boon, N., & Verstraete, W. (2004) · Archives of Microbiology · doi:10.1007/s00203-004-0747-4 · Cited by 234 · see citing works
Duffy, R., Wiseman, H., & File, S. E. (2003) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(03)00116-3 · Cited by 199 · see citing works
Wang, X.-L., Hur, H.-G., Lee, J. H., Kim, K. T., & Kim, S.-I. (2005) · Applied and Environmental Microbiology · doi:10.1128/aem.71.1.214-219.2005 · Cited by 196 · see citing works
Emerging evidence of the health benefits of S-equol, an estrogen receptor β agonist
Jackson, R. L., Greiwe, J. S., & Schwen, R. J. (2011) · Nutrition Reviews · doi:10.1111/j.1753-4887.2011.00400.x · Cited by 195 · see citing works
The Role of Colonic Bacteria in the Metabolism of the Natural Isoflavone Daidzin to Equol
Rafii, F. (2015) · Metabolites · doi:10.3390/metabo5010056 · Cited by 194 · see citing works
Thompson, F. L., Stackebrandt, E. S., Lory, S. J., DeLong, E. F., & ROSENBERG, E. B. (2014) · Springer eBooks · doi:10.1007/978-3-642-30138-4 · Cited by 190 · see citing works
Soy, Red Clover, and Isoflavones and Breast Cancer: A Systematic Review
Fritz, H., Seely, D., Flower, G., Skidmore, B., Fernandes, R., Vadeboncoeur, S., Kennedy, D., Cooley, K., Wong, R., Sagar, S., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0081968 · Cited by 188 · see citing works
Plasma phytoestrogens and subsequent breast cancer risk
Verheus, M., van Gils, C. H., Keinan-Boker, L., Grace, P. B., Bingham, S. A., & Peeters, P. H. M. (2007) · Journal of Clinical Oncology · doi:10.1200/jco.2006.06.0244 · Cited by 166 · see citing works
Isolation of a human intestinal bacterium capable of daidzein and genistein conversion
Matthies, A., Blaut, M., & Braune, A. (2009) · Applied and Environmental Microbiology · doi:10.1128/aem.01795-08 · Cited by 161 · see citing works
Cao, Y., Calafat, A. M., Doerge, D. R., Umbach, D. M., BERNBAUM, J. C., Twaddle, N. C., Ye, X., & Rogan, W. J. (2008) · Journal of Exposure Science & Environmental Epidemiology · doi:10.1038/jes.2008.44 · Cited by 160 · see citing works
Systematic review of soy isoflavone supplements on osteoporosis in women
Wei, P., Liu, M., Chen, Y., & Chen, D. (2012) · Asian Pacific Journal of Tropical Medicine · doi:10.1016/s1995-7645(12)60033-9 · Cited by 159 · see citing works
Metabolism of the soy isoflavones daidzein, genistein and glycitein in human subjects.
Heinonen, S., Hoikkala, A., Wähälä, K., & Adlercreutz, H. (2003) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2003.09.003 · Cited by 157 · see citing works
Harland, J. I., & Haffner, T. A. (2008) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2008.04.006 · Cited by 154 · see citing works
Isoflavones and Functional Foods Alter the Dominant Intestinal Microbiota in Postmenopausal Women
Clavel, T., Fallani, M., Lepage, P., Levenez, F., Mathey, J., Rochet, V., SEREZAT, M., Sutren, M., Henderson, G., Bennetau‐Pelissero, C., et al. (2005) · Journal of Nutrition · doi:10.1093/jn/135.12.2786 · Cited by 151 · see citing works
Bolca, S., Possemiers, S., Herregat, A., Huybrechts, I., Heyerick, A., Vriese, S. D., Verbruggen, M. A., Depypere, H. T., Keukeleire, D. D., Bracke, M., et al. (2007) · Journal of Nutrition · doi:10.1093/jn/137.10.2242 · Cited by 146 · see citing works
The Isoflavone Equol Mediates Rapid Vascular Relaxation
Joy, S., Siow, R. C. M., Rowlands, D. J., Becker, M., Wyatt, A. W., Aaronson, P. I., Coen, C. W., Kalló, I., Jacob, R., & Mann, G. E. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m602803200 · Cited by 141 · see citing works
Matthies, A., Clavel, T., Gütschow, M., Engst, W., Haller, D., Blaut, M., & Braune, A. (2008) · Applied and Environmental Microbiology · doi:10.1128/aem.00555-08 · Cited by 141 · see citing works
New equol supplement for relieving menopausal symptoms
Ishiwata, N., Melby, M. K., Mizuno, S., & Watanabe, S. (2009) · Menopause The Journal of The North American Menopause Society · doi:10.1097/gme.0b013e31818379fa · Cited by 139 · see citing works
Phytoestrogens and cognitive function: a review
Soni, M., Rahardjo, T. B. W., Soekardi, R., Sulistyowati, Y., Lestariningsih, Yesufu-Udechuku, A., Irsan, A., & Hogervorst, E. (2014) · Maturitas · doi:10.1016/j.maturitas.2013.12.010 · Cited by 139 · see citing works
Wiseman, H., Casey, K., Bowey, E. A., Duffy, R., Davies, M., Rowland, I. R., Lloyd, A. S., Murray, A., Thompson, R., & Clarke, D. B. (2004) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/80.3.692 · Cited by 138 · see citing works
Usui, T., Tochiya, M., Sasaki, Y., Muranaka, K., Yamakage, H., Himeno, A., Shimatsu, A., Inaguma, A., Ueno, T., Uchiyama, S., et al. (2012) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2012.04400.x · Cited by 138 · see citing works
Atkinson, C., Humbert, O., Lampe, J. W., & Berman, S. H. (2004) · Journal of Nutrition · doi:10.1093/jn/134.3.596 · Cited by 137 · see citing works
Matthies, A., Loh, G., Blaut, M., & Braune, A. (2011) · Journal of Nutrition · doi:10.3945/jn.111.148247 · Cited by 137 · see citing works
Rietjens, I. M. C. M., Sotoca, A. M., Vervoort, J. J. M., & Louisse, J. (2012) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201200439 · Cited by 135 · see citing works
Soy isoflavone intake and breast cancer risk in Japan: From the Takayama study
Wada, K., Nakamura, K., Tamai, Y., Tsuji, M., Kawachi, T., Hori, A., Takeyama, N., Tanabashi, S., Matsushita, S., Tokimitsu, N., et al. (2013) · International Journal of Cancer · doi:10.1002/ijc.28088 · Cited by 134 · see citing works
Wu, J., Oka, J., Ezaki, J., Ohtomo, T., Ueno, T., Uchiyama, S., Toda, T., Uehara, M., & Ishimi, Y. (2007) · Menopause The Journal of The North American Menopause Society · doi:10.1097/gme.0b013e3180305299 · Cited by 133 · see citing works
Zamora‐Ros, R., Knaze, V., Luján‐Barroso, L., Kuhnle, G., Mulligan, A. A., Touillaud, M. S., Slimani, N., Romieu, I., Powell, N., Tumino, R., et al. (2012) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2012.36 · Cited by 132 · see citing works
Equol, a new inactive phenol isolated from the ketohydroxyoestrin fraction of mares' urine
Marrian, G. F., & Haslewood, G. A. D. (1932) · Biochemical Journal · doi:10.1042/bj0261227 · Cited by 131 · see citing works
van Die, M. D., Bone, K. M., Williams, S., & Pirotta, M. V. (2013) · British Journal of Urology · doi:10.1111/bju.12435 · Cited by 130 · see citing works
Hazim, S., Curtis, P. J., Schär, M. Y., Ostertag, L. M., Kay, C. D., Minihane, A. M., & Cassidy, A. (2016) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.115.125690 · Cited by 130 · see citing works
Natural S-equol decreases bone resorption in postmenopausal, non-equol-producing Japanese women
Tousen, Y., Ezaki, J., Fujii, Y., Ueno, T., Nishimuta, M., & Ishimi, Y. (2011) · Menopause The Journal of The North American Menopause Society · doi:10.1097/gme.0b013e3181f85aa7 · Cited by 130 · see citing works
(ANS), E. P. O. F. A. A. N. S. A. T. F. (2015) · EFSA Journal · doi:10.2903/j.efsa.2015.4246 · Cited by 130 · see citing works
Nakatsu, C. H., Armstrong, A. P., Clavijo, A. P., Martin, B. R., Barnes, S., & Weaver, C. M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0108924 · Cited by 129 · see citing works
Isolation and Characterization of a Novel Equol-Producing Bacterium from Human Feces
Yokoyama, S., & Suzuki, T. (2008) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.80329 · Cited by 128 · see citing works
Clavel, T., Lepage, P., & Charrier, C. (2014) · Springer eBooks · doi:10.1007/978-3-642-30138-4_343 · Cited by 126 · see citing works
Schröder, C., Matthies, A., Engst, W., Blaut, M., & Braune, A. (2013) · Applied and Environmental Microbiology · doi:10.1128/aem.03693-12 · Cited by 124 · see citing works
Asô, T., Uchiyama, S., Matsumura, Y., Taguchi, M., Nozaki, M., Takamatsu, K., Ishizuka, B., Kubota, T., Mizunuma, H., & Ohta, H. (2011) · Journal of Women s Health · doi:10.1089/jwh.2011.2753 · Cited by 121 · see citing works
Soy isoflavones’ osteoprotective role in postmenopausal women: mechanism of action
Arjmandi, B. H., & Smith, B. J. (2002) · The Journal of Nutritional Biochemistry · doi:10.1016/s0955-2863(02)00172-9 · Cited by 120 · see citing works
Oxidative metabolism and genotoxic potential of major isoflavone phytoestrogens
Kulling, S. E., Lehmann, L., & Metzler, M. (2002) · Journal of Chromatography B · doi:10.1016/s1570-0232(02)00215-5 · Cited by 116 · see citing works
Production of equol from daidzein by gram-positive rod-shaped bacterium isolated from rat intestine
Minamida, K., Tanaka, M., Abe, A., Sone, T., Tomita, F., Hara, H., & Asano, K. (2006) · Journal of Bioscience and Bioengineering · doi:10.1263/jbb.102.247 · Cited by 114 · see citing works
Disposition of soy isoflavones in normal human breast tissue
Bolca, S., Urpí-Sardà, M., Blondeel, P. N., Roche, N. A., Vanhaecke, L., Possemiers, S., Al‐Maharik, N., Botting, N. P., Keukeleire, D. D., Bracke, M., et al. (2010) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2009.28854 · Cited by 113 · see citing works
Absorption, distribution, metabolism, and excretion of isoflavonoids after soy intake
Franke, A. A., Lai, J. F., & Halm, B. M. (2014) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2014.06.007 · Cited by 112 · see citing works
Soy isoflavones versus placebo in the treatment of climacteric vasomotor symptoms
Bolaños, R., Castillo, A. D., & Romero, J. F. (2010) · Menopause The Journal of The North American Menopause Society · doi:10.1097/gme.0b013e3181cb4fb5 · Cited by 104 · see citing works
Slackia equolifaciens sp. nov., a human intestinal bacterium capable of producing equol
Jin, J., Kitahara, M., Sakamoto, M., Hattori, M., & Benno, Y. (2009) · INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY · doi:10.1099/ijs.0.016774-0 · Cited by 104 · see citing works
The antioxidant activity of daidzein metabolites, O-desmethylangolensin and equol, in HepG2 cells
Choi, E. J., & Kim, G. (2013) · Molecular Medicine Reports · doi:10.3892/mmr.2013.1752 · Cited by 100 · see citing works
Tai, T. Y., Tsai, K., Tu, S., Wu, J., Chang, C., Chen, C., Shaw, N.-S., Peng, H.-Y., Wang, S. Y., & Wu, C.-H. (2011) · Osteoporosis International · doi:10.1007/s00198-011-1750-7 · Cited by 100 · see citing works
Effect of S-equol and Soy Isoflavones on Heart and Brain
Sekikawa, A. M., Ihara, M., López, O. L., Kakuta, C., Lopresti, B. J., Higashiyama, A., Aizenstein, H. J., Chang, Y., Mathis, C. A., Miyamoto, Y., et al. (2018) · Current Cardiology Reviews · doi:10.2174/1573403x15666181205104717 · Cited by 99 · see citing works
Acharjee, S., Zhou, J., Elajami, T. K., & Welty, F. K. (2014) · Metabolism · doi:10.1016/j.metabol.2014.09.005 · Cited by 96 · see citing works
Variations in Plasma Phytoestrogen Concentrations in European Adults
Peeters, P. H. M., Slimani, N., van der Schouw, Y. T., Grace, P. B., Navarro, C., Tjønneland, A. M., Olsen, A., Clavel‐Chapelon, F., Touillaud, M. S., Boutron‐Ruault, M., et al. (2007) · Journal of Nutrition · doi:10.1093/jn/137.5.1294 · Cited by 96 · see citing works
O-Desmethylangolensin: The Importance of Equol's Lesser Known Cousin to Human Health
Frankenfeld, C. L. (2011) · Advances in Nutrition · doi:10.3945/an.111.000539 · Cited by 95 · see citing works
Taku, K., Melby, M. K., Kurzer, M. S., Mizuno, S., Watanabe, S., & Ishimi, Y. (2010) · Bone · doi:10.1016/j.bone.2010.05.001 · Cited by 94 · see citing works
Charles, C. P., Yuskavage, J., Carlson, O. D., John, M., Tagalicud, A., Maggio, M. G., Muller, D. C., Egan, J. M., & Basaria, S. S. (2009) · Menopause The Journal of The North American Menopause Society · doi:10.1097/gme.0b013e3181857979 · Cited by 93 · see citing works
Soukup, S. T., Helppi, J., Müller, D. R., Zierau, O., Watzl, B., Vollmer, G., Diel, P. R., Bub, A., & Kulling, S. E. (2016) · Archives of Toxicology · doi:10.1007/s00204-016-1663-5 · Cited by 93 · see citing works
Phytoestrogens and prevention of breast cancer: The contentious debate
Bilal, I. (2014) · World Journal of Clinical Oncology · doi:10.5306/wjco.v5.i4.705 · Cited by 92 · see citing works
Hüser, S., Guth, S., Joost, H., Soukup, S. T., Köhrle, J., Kreienbrock, L., Diel, P. R., Lachenmeier, D. W., Eisenbrand, G., Vollmer, G., et al. (2018) · Archives of Toxicology · doi:10.1007/s00204-018-2279-8 · Cited by 92 · see citing works
Shimada, Y., Yasuda, S., Takahashi, M., Hayashi, T., Miyazawa, N., Sato, I., Abiru, Y., Uchiyama, S., & Hishigaki, H. (2010) · Applied and Environmental Microbiology · doi:10.1128/aem.01101-10 · Cited by 91 · see citing works
Pawlowski, J. W., Martin, B. R., McCabe, G. P., McCabe, L. D., Jackson, G. S., Peacock, M., Barnes, S., & Weaver, C. M. (2015) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.114.093906 · Cited by 91 · see citing works
Jou, H., Wu, S., Chang, F.-W., Ling, P., Chu, K. S., & Wu, W.-H. (2008) · International Journal of Gynecology & Obstetrics · doi:10.1016/j.ijgo.2008.01.028 · Cited by 90 · see citing works
Mizushina, Y., Shiomi, K., Kuriyama, I., Takahashi, Y., & Yoshida, H. (2013) · International Journal of Oncology · doi:10.3892/ijo.2013.2032 · Cited by 88 · see citing works
Production of phytoestrogen S-equol from daidzein in mixed culture of two anaerobic bacteria
Wang, X., Kim, H.-J., Kang, S.-I., Kim, S., & Hur, H. (2006) · Archives of Microbiology · doi:10.1007/s00203-006-0183-8 · Cited by 82 · see citing works
Rowlands, D. J., Chapple, S. J., Siow, R. C. M., & Mann, G. E. (2011) · Hypertension · doi:10.1161/hypertensionaha.110.162198 · Cited by 82 · see citing works
Fournier, L. R., Ryan-Borchers, T., Robison, L. M., Wiediger, M. D., Park, J. S., Chew, B. P., McGuire, S., Sclar, D. A., Skaer, T. L., & Beerman, K. A. (2007) · PubMed · Cited by 81 · see citing works
Frankenfeld, C. L., Atkinson, C., Thomas, W. K., Goode, E., Gonzalez, A. J., Jokela, T., Wähälä, K., Schwartz, S. M., Li, S. S., & Lampe, J. W. (2004) · Experimental Biology and Medicine · doi:10.1177/153537020422900906 · Cited by 80 · see citing works
Shimada, Y., Takahashi, M., Miyazawa, N., Abiru, Y., Uchiyama, S., & Hishigaki, H. (2012) · Applied and Environmental Microbiology · doi:10.1128/aem.00410-12 · Cited by 79 · see citing works
Isolation and characterization of the equol-producing bacterium Slackia sp. strain NATTS
Tsuji, H., Moriyama, K., Nomoto, K., Miyanaga, N., & Akaza, H. (2010) · Archives of Microbiology · doi:10.1007/s00203-010-0546-z · Cited by 78 · see citing works
Isolation of an isoflavone-metabolizing, Clostridium-like bacterium, strain TM-40, from human faeces
Tamura, M., Tsushida, T., & Shinohara, K. (2006) · Anaerobe · doi:10.1016/j.anaerobe.2006.10.001 · Cited by 77 · see citing works
Daily, J. W., Ko, B., Ryuk, J., Liu, M., Zhang, W., & Park, S. (2018) · Journal of Medicinal Food · doi:10.1089/jmf.2018.4265 · Cited by 76 · see citing works
Ward, H. A., Chapelais, G., Kuhnle, G. G., Luben, R., Khaw, K., & Bingham, S. A. (2008) · Breast Cancer Research · doi:10.1186/bcr1995 · Cited by 75 · see citing works
Kim, M., Kim, S., Han, J., Wang, X., Song, D., & Kim, S.-U. (2009) · Applied and Environmental Microbiology · doi:10.1128/aem.02058-08 · Cited by 73 · see citing works
Health impact of childhood and adolescent soy consumption
Messina, M. J., Rogero, M. M., Fisberg, M., & Waitzberg, D. L. (2017) · Nutrition Reviews · doi:10.1093/nutrit/nux016 · Cited by 73 · see citing works
Gopaul, R., Knaggs, H. E., & Lephart, E. D. (2012) · BioFactors · doi:10.1002/biof.191 · Cited by 72 · see citing works
Do soy isoflavones improve cognitive function in postmenopausal women? A meta-analysis
Cheng, P.-F., Chen, J., Zhou, X., Ren, Y., Huang, W. C., Zhou, J.-J., & Xie, P. (2014) · Menopause The Journal of The North American Menopause Society · doi:10.1097/gme.0000000000000290 · Cited by 71 · see citing works
Zhou, J., & Wei‐jie, Y. (2015) · Clinical Nutrition · doi:10.1016/j.clnu.2015.03.012 · Cited by 71 · see citing works
Akhlaghi, M., Zare, M., & Nouripour, F. (2017) · Advances in Nutrition · doi:10.3945/an.117.015370 · Cited by 71 · see citing works
Guadamuro, L., Delgado, S., Redruello, B., Flórez, A. B., Suárez, A., Martínez‐Camblor, P., & Mayo, B. (2015) · Frontiers in Microbiology · doi:10.3389/fmicb.2015.00777 · Cited by 68 · see citing works
Self-citationJenks, B. H., Iwashita, S., Nakagawa, Y., Ragland, K., Lee, J., Carson, W. H., Ueno, T., & Uchiyama, S. (2012) · Journal of Women s Health · doi:10.1089/jwh.2011.3153 · Cited by 67 · see citing works
Isolation and identification of equol-producing bacterial strains from cultures of pig faeces
Yu, Z., Yao, W., & Zhu, W. (2008) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.2008.01108.x · Cited by 66 · see citing works
Lehmann, L., Esch, H. L., Wagner, J., Rohnstock, L., & Metzler, M. (2005) · Toxicology Letters · doi:10.1016/j.toxlet.2005.02.011 · Cited by 64 · see citing works
Identification of an Enzyme System for Daidzein-to-Equol Conversion in Slackia sp. Strain NATTS
Tsuji, H., Moriyama, K., Nomoto, K., & Akaza, H. (2011) · Applied and Environmental Microbiology · doi:10.1128/aem.06779-11 · Cited by 64 · see citing works
Dietary Phytoestrogen Intake and Cognitive Function in Older Women
Kreijkamp‐Kaspers, S., Kok, L., Grobbee, D. E., de Haan, E. H. F., Aleman, A., & van der Schouw, Y. T. (2007) · The Journals of Gerontology Series A · doi:10.1093/gerona/62.5.556 · Cited by 64 · see citing works
Pugazhendhi, D., Watson, K. A., Mills, S. E. E., Botting, N. P., Pope, G. S., & Darbre, P. D. (2008) · Journal of Endocrinology · doi:10.1677/joe-07-0384 · Cited by 63 · see citing works
Nettleton, J. A., Greany, K. A., Thomas, W., Wangen, K. E., Adlercreutz, H., & Kurzer, M. S. (2005) · The Journal of Nutrition · doi:10.1093/jn/135.3.603 · Cited by 62 · see citing works
Equol production changes over time in postmenopausal women
Franke, A. A., Lai, J. F., Halm, B. M., Pagano, I., Kono, N., Mack, W. J., & Hodis, H. N. (2011) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2011.03.002 · Cited by 62 · see citing works
Decroos, K., Eeckhaut, E., Possemiers, S., & Verstraete, W. (2006) · Journal of Nutrition · doi:10.1093/jn/136.4.946 · Cited by 61 · see citing works
Gou, Z., Jiang, S., Zheng, C., Tian, Z., & Lin, X. (2015) · Cellular Physiology and Biochemistry · doi:10.1159/000430124 · Cited by 59 · see citing works
Lu, Z., Zhou, R., Kong, Y., Wang, J., Xia, W., Guo, J., Liu, J., Sun, H., Liu, K., Yang, J., et al. (2016) · Current Cancer Drug Targets · doi:10.2174/1568009616666151207105720 · Cited by 59 · see citing works
Heng, Y., Kim, M. J., Yang, H. J., Kang, S., & Park, S. (2019) · Archives of Microbiology · doi:10.1007/s00203-019-01665-5 · Cited by 58 · see citing works
The effects of natural S-equol supplementation on skin aging in postmenopausal women
Oyama, A., Ueno, T., Uchiyama, S., Aihara, T., Miyake, A., Kondo, S., & Matsunaga, K. (2011) · Menopause The Journal of The North American Menopause Society · doi:10.1097/gme.0b013e318227427b · Cited by 57 · see citing works
Wu, A. H. (2003) · Carcinogenesis · doi:10.1093/carcin/bgg189 · Cited by 57 · see citing works
Hermenegildo, C., Oviedo, P. J., García‐Pérez, M. Á., Tarín, J. J., & Cano, A. (2005) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.105.090456 · Cited by 57 · see citing works
Kawada, Y., Yokoyama, S., Yanase, E., Niwa, T., & Suzuki, T. (2016) · Bioscience of Microbiota Food and Health · doi:10.12938/bmfh.2015-023 · Cited by 55 · see citing works
Yamori, Y. (2006) · PubMed · Cited by 54 · see citing works
Tousen, Y., Abe, F., Ishida, T., Uehara, M., & Ishimi, Y. (2011) · Metabolism · doi:10.1016/j.metabol.2011.02.009 · Cited by 52 · see citing works
Gonzalez-Granillo, M. A., Steffensen, K. R., Granados, O., Torres, N., Korach-André, M., Ortíz-Ortega, V. M., Aguilar-Salinas, C., Jakobsson, T., Díaz‐Villaseñor, A., Loza‐Valdes, A., et al. (2012) · Diabetologia · doi:10.1007/s00125-012-2599-9 · Cited by 51 · see citing works
Frankenfeld, C. L. (2011) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.111.011825 · Cited by 51 · see citing works
Soy food consumption does not lower LDL cholesterol in either equol or nonequol producers
Thorp, A. A., Howe, P. R. C., Mori, T. A., Coates, A. M., Buckley, J. D., Hodgson, J. M., Mansour, J., & Meyer, B. J. (2008) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/88.2.298 · Cited by 51 · see citing works
Fang, K., Dong, H., Wang, D., Gong, J., Huang, W., & Lu, F. (2016) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201501024 · Cited by 51 · see citing works
Yoshikata, R., Myint, K. Z. Y., & Ohta, H. (2018) · The Journal of Alternative and Complementary Medicine · doi:10.1089/acm.2018.0050 · Cited by 51 · see citing works
Identification of Two Novel Reductases Involved in Equol Biosynthesis in Lactococcus Strain 20–92
Shimada, Y., Takahashi, M., Miyazawa, N., Ohtani, T., Abiru, Y., Uchiyama, S., & Hishigaki, H. (2011) · Microbial Physiology · doi:10.1159/000335049 · Cited by 49 · see citing works
Rosell, M., Appleby, P. N., Spencer, E. A., & Key, T. J. (2004) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/80.5.1391 · Cited by 49 · see citing works
Cho, G., Ritzmann, F., Eckstein, M., Huch, M., Briviba, K., Behsnilian, D., Neve, H., & Franz, C. M. A. P. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.00658 · Cited by 49 · see citing works
Wong, J. M., Kendall, C. W., Marchie, A., Liu, Z., Vidgen, E., Holmes, C., Jackson, C.-J., Josse, R. G., Pencharz, P. B., Rao, A. V., et al. (2012) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.111.017418 · Cited by 47 · see citing works
Itsumi, M., Shiota, M., Takeuchi, A., Kashiwagi, E., Inokuchi, J., Tatsugami, K., Kajioka, S., Uchiumi, T., Naito, S., Eto, M., et al. (2016) · Cancer Science · doi:10.1111/cas.12948 · Cited by 47 · see citing works
Yokoyama, S., Oshima, K., Nomura, I., Hattori, M., & Suzuki, T. (2011) · Journal of Bacteriology · doi:10.1128/jb.05626-11 · Cited by 46 · see citing works
van der Velpen, V., Geelen, A., Hollman, P. C. H., Schouten, E. G., Veer, P. V. ’., & Afman, L. A. (2014) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.114.088484 · Cited by 46 · see citing works
Vázquez, L., Guadamuro, L., Giganto, F., Mayo, B., & Flórez, A. B. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.01155 · Cited by 46 · see citing works
Self-citationYoshikata, R., Myint, K. Z. Y., Ohta, H., & Ishigaki, Y. (2018) · Menopause The Journal of The North American Menopause Society · doi:10.1097/gme.0000000000001202 · Cited by 46 · see citing works
Liu, Z., Ho, S. C., Woo, J., Chen, Y., & Wong, C. (2013) · Menopause The Journal of The North American Menopause Society · doi:10.1097/gme.0000000000000102 · Cited by 45 · see citing works
Zhang, T., Hu, Q., Shi, L., Li, Q., Zhang, Q., & Mi, M. (2016) · PLoS ONE · doi:10.1371/journal.pone.0167020 · Cited by 44 · see citing works
Lee, P., Kim, J., Kim, E., Lee, S.-H., Choi, K.-Y., Kazlauskas, R. J., & Kim, B. (2017) · ACS Chemical Biology · doi:10.1021/acschembio.7b00624 · Cited by 44 · see citing works
Bioconversion of daidzein to equol by Bifidobacterium breve 15700 and Bifidobacterium longum BB536
Elghali, S., Mustafa, S., Amid, M., Manap, M. Y. A., Ismail, A., & Abas, F. (2012) · Journal of Functional Foods · doi:10.1016/j.jff.2012.04.013 · Cited by 42 · see citing works
Ahuja, V., Miura, K., Vishnu, A., Fujiyoshi, A., Evans, R., Zaid, M., Miyagawa, N., Hisamatsu, T., Kadota, A., Okamura, T., et al. (2017) · British Journal Of Nutrition · doi:10.1017/s000711451600458x · Cited by 42 · see citing works
Equol suppresses inflammatory response and bone erosion due to rheumatoid arthritis in mice
Lin, I.-C., Yamashita, S., Murata, M., Kumazoe, M., & Tachibana, H. (2016) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2016.02.012 · Cited by 41 · see citing works
A cross-sectional study of equol producer status and self-reported vasomotor symptoms
Newton, K. M., Reed, S. D., Uchiyama, S., Qu, C., Ueno, T., Iwashita, S., Gunderson, G., Fuller, S., & Lampe, J. W. (2014) · Menopause The Journal of The North American Menopause Society · doi:10.1097/gme.0000000000000363 · Cited by 41 · see citing works
Elucidation of the metabolic pathway of S-equol in rat, monkey and man
Schwen, R. J., Nguyen, L., & Jackson, R. L. (2012) · Food and Chemical Toxicology · doi:10.1016/j.fct.2012.03.048 · Cited by 40 · see citing works
Prevalence of Dementia in China
Liu, L., Guo, X.-E., Zhou, Y.-Q., & Xia, J. (2003) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000068784 · Cited by 40 · see citing works
Sarkaki, A., Amani, R., Badavi, M., Moghadd, A. Z., Aligholi, H., Safahani, M., & Haghigh, M. H. (2008) · Pakistan Journal of Biological Sciences · doi:10.3923/pjbs.2008.1114.1119 · Cited by 40 · see citing works
Alfa, H. H., & Arroo, R. (2019) · Phytochemistry Reviews · doi:10.1007/s11101-019-09632-0 · Cited by 40 · see citing works
Crawford, S. L., Jackson, E. A., Churchill, L., Lampe, J. W., Leung, K., & Ockene, J. K. (2013) · Menopause The Journal of The North American Menopause Society · doi:10.1097/gme.0b013e3182829413 · Cited by 39 · see citing works
Horiuchi, H., Usami, A., Shirai, R., Harada, N., Ikushiro, S., Sakaki, T., Nakano, Y., Inui, H., & Yamaji, R. (2017) · Journal of Nutrition · doi:10.3945/jn.117.250860 · Cited by 38 · see citing works
Lee, P., Kim, J., Kim, E.-J., Jung, E., Pandey, B. P., & Kim, B. (2016) · Applied and Environmental Microbiology · doi:10.1128/aem.03584-15 · Cited by 36 · see citing works
Kwon, J. E., Lim, J., Kim, I., Kim, D., & Kang, S. C. (2018) · PLoS ONE · doi:10.1371/journal.pone.0192490 · Cited by 36 · see citing works
Flórez, A. B., Vázquez, L., Rodríguez, J., Redruello, B., & Mayo, B. (2019) · Nutrients · doi:10.3390/nu11050993 · Cited by 36 · see citing works
Self-citationHertrampf, T., Schmidt, S., Laudenbach-Leschowsky, U., Seibel, J., & Diel, P. R. (2005) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2005.08.007 · Cited by 35 · see citing works
Fuhrman, B. J., Teter, B. E., Barba, M., Byrne, C., Cavalleri, A., Grant, B. J. B., Horvath, P. J., Morelli, D., Venturelli, E., & Muti, P. C. (2008) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-07-0193 · Cited by 35 · see citing works
S-(−)equol production is developmentally regulated and related to early diet composition
Brown, N. M., Galandi, S. L., Summer, S. S., Zhao, X., Heubi, J. E., King, E. C., & Setchell, K. D. R. (2014) · Nutrition Research · doi:10.1016/j.nutres.2014.03.005 · Cited by 34 · see citing works
Low, Y.-L., Dunning, A. M., Dowsett, M., Luben, R., Khaw, K., Wareham, N. J., & Bingham, S. A. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-2432 · Cited by 33 · see citing works
Distribution of Soy-Derived Phytoestrogens in Human Breast Tissue and Biological Fluids
Maubach, J., Depypere, H. T., Goeman, J., der Eycken, J. V., Heyerick, A., Bracke, M. E., Blondeel, P., & Keukeleire, D. D. (2004) · Obstetrics and Gynecology · doi:10.1097/01.aog.0000124983.66521.6a · Cited by 33 · see citing works
Ono, M., Ejima, K., Higuchi, T., Takeshima, M., Wakimoto, R., & Nakano, S. (2017) · Nutrition and Cancer · doi:10.1080/01635581.2017.1367945 · Cited by 32 · see citing works
Mulligan, A. A., Kuhnle, G., Lentjes, M. A. H., van Scheltinga, V., Powell, N., McTaggart, A., Bhaniani, A., & Khaw, K. (2012) · Public Health Nutrition · doi:10.1017/s1368980012003904 · Cited by 31 · see citing works
Kolátorová, L., Cihlářová, P., Bičı́ková, M., Kaňová, N., & Lapčı́k, O. (2012) · Food and Chemical Toxicology · doi:10.1016/j.fct.2012.05.037 · Cited by 31 · see citing works
Antioxidant effect of a phytoestrogen equol on cultured muscle cells of embryonic broilers
Wei, X., Wu, J., Ni, Y., Lu, L., & Zhao, R. (2011) · In Vitro Cellular & Developmental Biology - Animal · doi:10.1007/s11626-011-9464-x · Cited by 31 · see citing works
Bioavailability of glycitein relatively to other soy isoflavones in healthy young Caucasian men
Shinkaruk, S., Durand, M., Lamothe, V., Carpaye, A., Martinet, A., Chantre, P., Vergne, S., Noguès, X., Moore, N. D., & Bennetau‐Pelissero, C. (2012) · Food Chemistry · doi:10.1016/j.foodchem.2012.03.135 · Cited by 30 · see citing works
EFSA Panel on Dietetic Products, N. A. A. (. (2012) · EFSA Journal · doi:10.2903/j.efsa.2012.2847 · Cited by 30 · see citing works
Yang, Z., Zhao, Y., Yao, Y., Li, J., Wang, W., & Wu, X. (2016) · Molecules and Cells · doi:10.14348/molcells.2016.0162 · Cited by 30 · see citing works
Effects of Equol on Oxidized Low-Density Lipoprotein-Induced Apoptosis in Endothelial Cells
Kamiyama, M., Kishimoto, Y., Tani, M., Utsunomiya, K., & Kondo, K. N. (2009) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.1057 · Cited by 29 · see citing works
Complete Genome Sequence of the Equol-Producing Bacterium Adlercreutzia equolifaciens DSM 19450 T
Toh, H., Oshima, K., Suzuki, T., Hattori, M., & Morita, H. (2013) · Genome Announcements · doi:10.1128/genomea.00742-13 · Cited by 29 · see citing works
de Aguiar, C. L., Baptista, A. S., de Alencar, S. M., Haddad, R., & Eberlin, M. N. (2007) · International Journal of Food Sciences and Nutrition · doi:10.1080/09637480601149350 · Cited by 28 · see citing works
Abiru, Y., Ueno, T., & Uchiyama, S. (2013) · International Journal of Food Sciences and Nutrition · doi:10.3109/09637486.2013.816936 · Cited by 28 · see citing works
Dietary Soy Isoflavone: A Mechanistic Insight
Chadha, R., Bhalla, Y., Jain, A., Chadha, K., & Karan, M. (2017) · Natural Product Communications · doi:10.1177/1934578x1701200439 · Cited by 28 · see citing works
Hall, M. C., O’Brien, B., & McCormack, T. (2007) · Steroids · doi:10.1016/j.steroids.2006.10.010 · Cited by 27 · see citing works
To Construct an Engineered (S)-Equol Resistant E. coli for in Vitro (S)-Equol Production
HaiLiang, L., Mao, S., Chen, H., Zhu, L., Liu, W., Wang, X., & Yin, Y. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.01182 · Cited by 26 · see citing works
de la Parra, C., Otero-Franqui, E., Martínez, M., & Dharmawardhane, S. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.393470 · Cited by 25 · see citing works
Shinkaruk, S., Carreau, C., Flouriot, G., Bennetau‐Pelissero, C., & Potier, M. (2010) · Nutrients · doi:10.3390/nu2030340 · Cited by 24 · see citing works
Iwasaki, M., Hamada, G. S., Nishimoto, I. N., Netto, M. M., Mottola, J., Laginha, F. M., Kasuga, Y., Yokoyama, S., Onuma, H., Nishimura, H., et al. (2010) · Nutrition and Cancer · doi:10.1080/01635580903441279 · Cited by 23 · see citing works
Gardana, C., Canzi, E., & Simonetti, P. (2014) · Journal of Chromatography B · doi:10.1016/j.jchromb.2014.01.048 · Cited by 23 · see citing works
Equol inhibits proliferation of human gastric carcinoma cellsviamodulating Akt pathway
Yang, Z. (2015) · World Journal of Gastroenterology · doi:10.3748/wjg.v21.i36.10385 · Cited by 22 · see citing works
Topical equol preparation improves structural and molecular skin parameters
Magnet, U., Urbanek, C., Gaisberger, D., Tomeva, E., Dum, E., Pointner, A., & Haslberger, A. G. (2017) · International Journal of Cosmetic Science · doi:10.1111/ics.12408 · Cited by 22 · see citing works
Lee, P., Lee, S., Kim, J., Kim, E.-J., Choi, K., & Kim, B. (2018) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-018-9137-8 · Cited by 21 · see citing works
Zheng, W., Hou, Y., Su, Y., & Yao, W. (2013) · Anaerobe · doi:10.1016/j.anaerobe.2013.11.011 · Cited by 20 · see citing works
Sugiyama, Y., Nagata, Y., Fukuta, F., Takayanagi, A., Masumori, N., Tsukamoto, T., Akasaka, H., Ohnishi, H., Saito, S., Miura, T., et al. (2014) · Asian Pacific Journal of Cancer Prevention · doi:10.7314/apjcp.2014.15.6.2693 · Cited by 19 · see citing works
Harada, K., Sada, S., Sakaguchi, H., Takizawa, M., Ishida, R., & Tsuboi, T. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.05.100 · Cited by 18 · see citing works
Mustafa, S. A. H., Mustafa, S., Abas, F., Manap, M. Y. A., Ismail, A., Amid, M., & Ibraheem, S. E. (2018) · Food Chemistry · doi:10.1016/j.foodchem.2018.11.107 · Cited by 18 · see citing works
Braune, A., & Blaut, M. (2017) · Journal of Applied Microbiology · doi:10.1111/jam.13616 · Cited by 17 · see citing works
Gardana, C., & Simonetti, P. (2016) · International Journal of Food Sciences and Nutrition · doi:10.1080/09637486.2016.1256380 · Cited by 15 · see citing works
Pusparini, P., Yenny, Y., & Hidayat, A. (2015) · Endocrine Metabolic & Immune Disorders - Drug Targets · doi:10.2174/1871530314666141202123309 · Cited by 14 · see citing works
Relationship of equol production between children aged 5–7 years and their mothers
Wada, K., Ueno, T., Uchiyama, S., Abiru, Y., Tsuji, M., Konishi, K., Mizuta, F., Goto, Y., Tamura, T., Shiraki, M., et al. (2016) · European Journal of Nutrition · doi:10.1007/s00394-016-1233-x · Cited by 13 · see citing works
Positive effect of flavonoids to cardiovascular and central nervous system.
Karvaj, M., Beno, P., & Pg, F.-F. (2007) · PubMed · Cited by 11 · see citing works
Equol induces mitochondria-mediated apoptosis of human cervical cancer cells.
Kim, E. Y., Shin, J. Y., Park, Y. H., & Kim, A. K. (2014) · PubMed · Cited by 10 · see citing works
[Screening and identification of a bacterium capable of converting daidzein to S-equol].
Guo, Y., Huang, Y., Ye, J., Zhang, X., & Xiao, M. (2012) · PubMed · Cited by 5 · see citing works
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Diet and the Microbiota–Gut–Brain Axis: Sowing the Seeds of Good Mental Health
Berding, K., Vlckova, K., Marx, W., Schellekens, H., Stanton, C., Clarke, G., Jacka, F., Dinan, T. G., & Cryan, J. F. (2021) · Advances in Nutrition · doi:10.1093/advances/nmaa181 · Cited by 451 · see citing works
Dietary Polyphenol, Gut Microbiota, and Health Benefits
Wang, X., Qi, Y., & Zheng, H. (2022) · Antioxidants · doi:10.3390/antiox11061212 · Cited by 412 · see citing works
Kim, I.-S. (2021) · Antioxidants · doi:10.3390/antiox10071064 · Cited by 337 · see citing works
Prebiotic effect of dietary polyphenols: A systematic review
Alves, A. M., Sugizaki, C. S. D. A., Lima, G. C., & Naves, M. M. V. (2020) · Journal of Functional Foods · doi:10.1016/j.jff.2020.104169 · Cited by 316 · see citing works
Cortés‐Martín, A., Selma, M. V., Tomás-Barberán, F. A., González‐Sarrías, A., & Espı́n, J. C. (2020) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201900952 · Cited by 305 · see citing works
Gut microbial beta-glucuronidase: a vital regulator in female estrogen metabolism
Hu, S., Ding, Q., Zhang, W. K., Kang, M., Ma, J., & Zhao, L. (2023) · Gut Microbes · doi:10.1080/19490976.2023.2236749 · Cited by 304 · see citing works
Zhang, Z., Li, X., Sang, S., McClements, D. J., Chen, L., Long, J., Jiao, A., Jin, Z., & Qiu, C. (2022) · Foods · doi:10.3390/foods11152189 · Cited by 268 · see citing works
Therapeutic Potential of Isoflavones with an Emphasis on Daidzein
Alshehri, M. M., Sharifi‐Rad, J., Herrera‐Bravo, J., Jara, E. L., Salazar, L. A., Kręgiel, D., Uprety, Y., Akram, M., Iqbal, M., Martorell, M., et al. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/6331630 · Cited by 184 · see citing works
Santos-Marcos, J. A., Mora-Ortiz, M., Tena‐Sempere, M., López‐Miranda, J., & Camargo, A. (2023) · Biology of Sex Differences · doi:10.1186/s13293-023-00490-2 · Cited by 187 · see citing works
Postbiotics as the new frontier in food and pharmaceutical research
Sabahi, S., Rad, A. H., Maleki, L. A., Sangtarash, N., Ozma, M. A., Karimi, A., Hosseini, H., & Abbasi, A. (2022) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2022.2056727 · Cited by 174 · see citing works
Phytochemicals as modifiers of gut microbial communities
Dingeo, G., Alex Brito, O., Samouda, H., Iddir, M., Frano, M. R. L., & Bohn, T. (2020) · Food & Function · doi:10.1039/d0fo01483d · Cited by 170 · see citing works
A Guide to Diet-Microbiome Study Design
Johnson, A. J., Zheng, J. J., Kang, J. W., Saboe, A., Knights, D., & Zivkovic, A. M. (2020) · Frontiers in Nutrition · doi:10.3389/fnut.2020.00079 · Cited by 161 · see citing works
Lachnospiraceae are emerging industrial biocatalysts and biotherapeutics
Zaplana, T., Miele, S., & Tolonen, A. C. (2024) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2023.1324396 · Cited by 127 · see citing works
Dietary Phenolic Compounds: Their Health Benefits and Association with the Gut Microbiota
Matsumura, Y., Kitabatake, M., Kayano, S.-I., & Ito, T. (2023) · Antioxidants · doi:10.3390/antiox12040880 · Cited by 123 · see citing works
Álvarez, J., Fernández‐Real, J. M., Guarner, F., Gueimonde, M., Rodríguez, J. M., de Pipaón, M. S., & Sanz, Y. (2021) · Gastroenterología y Hepatología · doi:10.1016/j.gastrohep.2021.01.009 · Cited by 135 · see citing works
Iglesias‐Aguirre, C. E., Cortés‐Martín, A., Ávila‐Gálvez, M. Á., Giménez‐Bastida, J. A., Selma, M. V., González‐Sarrías, A., & Espı́n, J. C. (2021) · Food & Function · doi:10.1039/d1fo02033a · Cited by 117 · see citing works
Metabolomics and complementary techniques to investigate the plant phytochemical cosmos
Tsugawa, H., Rai, A., Saito, K., & Nakabayashi, R. (2021) · Natural Product Reports · doi:10.1039/d1np00014d · Cited by 116 · see citing works
Gut commensals and their metabolites in health and disease
Krishnamurthy, H. K., Pereira, M., Bosco, J., George, J., Jayaraman, V., Krishna, K., Wang, T., Bei, K., & Rajasekaran, J. J. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1244293 · Cited by 110 · see citing works
Li, M., Han, X., Sun, L.-J., Liu, X.-J., Zhang, W., & Hao, J.-Y. (2024) · Gut microbes · doi:10.1080/19490976.2024.2329147 · Cited by 104 · see citing works
Álvarez, J., Fernández‐Real, J. M., Guarner, F., Gueimonde, M., Rodríguez, J. M., de Pipaon, M. S., & Sanz, Y. (2021) · Gastroenterología y Hepatología (English Edition) · doi:10.1016/j.gastre.2021.01.002 · Cited by 109 · see citing works
Kumari, N., KUMARI, R. R., Dua, A., Singh, M., Kumar, R., Singh, P., Duyar‐Ayerdi, S., Pradeep, S., Ojesina, A. I., & Kumar, R. (2024) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202300688 · Cited by 113 · see citing works
Mechanisms of gut bacterial metabolism of dietary polyphenols into bioactive compounds
Alqudah, S., & Claesen, J. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2426614 · Cited by 100 · see citing works
Genistein: Dual Role in Women’s Health
Yu, L. C., Rios, E., Castro, L., Liu, J., Yan, Y., & Dixon, D. (2021) · Nutrients · doi:10.3390/nu13093048 · Cited by 94 · see citing works
Nutritional and health factors affecting the bioavailability of calcium: a narrative review
Wawrzyniak, N., & Suliburska, J. (2020) · Nutrition Reviews · doi:10.1093/nutrit/nuaa138 · Cited by 86 · see citing works
Potential roles of gut microbes in biotransformation of natural products: An overview
Zhao, Y., Zhong, X., Yan, J., Sun, C., Zhao, X., & Wang, X. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.956378 · Cited by 82 · see citing works
Estrogenic flavonoids and their molecular mechanisms of action
Kiyama, R. (2022) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2022.109250 · Cited by 82 · see citing works
Illescas, O., Rodríguez‐Sosa, M., & Gariboldi, M. (2021) · Nutrients · doi:10.3390/nu13072234 · Cited by 80 · see citing works
Multiomics Analysis Reveals the Impact of Microbiota on Host Metabolism in Hepatic Steatosis
Zeybel, M., Arif, M., Li, X., Altay, Ö., Yang, H., Shi, M., Akyıldız, M., Sağlam, B., Gönenli, M. G., Yiğit, B., et al. (2022) · Advanced Science · doi:10.1002/advs.202104373 · Cited by 77 · see citing works
Daidzein alleviates doxorubicin-induced heart failure via the SIRT3/FOXO3a signaling pathway
Li, H., Zhang, M., Wang, Y., Gong, K., Yan, T., Wang, D., Meng, X., Yang, X., Chen, Y., Han, J., et al. (2022) · Food & Function · doi:10.1039/d2fo00772j · Cited by 76 · see citing works
Pharmacokinetics, pharmacodynamics, toxicity, and formulations of daidzein: An important isoflavone
Laddha, A. P., & Kulkarni, Y. A. (2023) · Phytotherapy Research · doi:10.1002/ptr.7852 · Cited by 75 · see citing works
Fang, Y., Zhang, J., Zhu, S., He, M., Ma, S., Jia, Q., Sun, Q., Song, L., Wang, Y., & Duan, L. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105439 · Cited by 73 · see citing works
Larnder, A., Manges, A. R., & Murphy, R. A. (2025) · International Journal of Cancer · doi:10.1002/ijc.35427 · Cited by 70 · see citing works
Augusti, P. R., Conterato, G. M. M., Denardin, C. C., Prazeres, I. D., Serra, T., Bronze, M. R., & Emanuelli, T. (2021) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2021.108787 · Cited by 69 · see citing works
Polyphenol Extraction from Food (by) Products by Pulsed Electric Field: A Review
Athanasiadis, V., Chatzimitakos, T. G., Κωτσού, Κ., Kalompatsios, D., Bozinou, E., & Lalas, S. I. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242115914 · Cited by 71 · see citing works
Advancements in therapeutic drugs targeting of senescence
Zhu, M., Meng, P., Ling, X., & Zhou, L. (2020) · Therapeutic Advances in Chronic Disease · doi:10.1177/2040622320964125 · Cited by 68 · see citing works
Vivarelli, S., Costa, C., Teodoro, M., Giambò, F., Tsatsakis, A. M., & Fenga, C. (2022) · Archives of Toxicology · doi:10.1007/s00204-022-03391-2 · Cited by 69 · see citing works
Advances in the Metabolic Mechanism and Functional Characteristics of Equol
Gong, Y., Lv, J., Pang, X., Zhang, S., Zhang, G., Liu, L., Wang, Y., & Li, C. (2023) · Foods · doi:10.3390/foods12122334 · Cited by 68 · see citing works
Occurrence of isoflavones in soybean sprouts and strategies to enhance their content: A review
Wang, S., Zhang, Y., Zhu, G., Shi, X., Chen, X., Herrera‐Balandrano, D. D., Liu, F., & Laborda, P. (2022) · Journal of Food Science · doi:10.1111/1750-3841.16131 · Cited by 68 · see citing works
Current Perspectives on the Physiological Activities of Fermented Soybean-Derived Cheonggukjang
Kim, I.-S., Hwang, C., Yang, W., & Kim, C. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22115746 · Cited by 64 · see citing works
Boronat, A., Rodríguez-Morató, J., Serreli, G., Fitó, M., Tyndale, R. F., Deiana, M., & de la Torre, R. (2021) · Advances in Nutrition · doi:10.1093/advances/nmab085 · Cited by 65 · see citing works
Sekikawa, A. M., Wharton, W., Butts, B., Veliky, C. V., Garfein, J., Li, J., Goon, S., Fort, A., Li, M., & Hughes, T. M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231911921 · Cited by 63 · see citing works
Metabolism of Daidzein and Genistein by Gut Bacteria of the Class Coriobacteriia
Soukup, S. T., Stoll, D., Danylec, N., Schoepf, A., Kulling, S. E., & Huch, M. (2021) · Foods · doi:10.3390/foods10112741 · Cited by 60 · see citing works
Genistein—Opportunities Related to an Interesting Molecule of Natural Origin
Garbiec, E., Cielecka‐Piontek, J., Kowalówka, M., Hołubiec, M., & Zalewski, P. (2022) · Molecules · doi:10.3390/molecules27030815 · Cited by 59 · see citing works
Dietary Phytoestrogens and Their Metabolites as Epigenetic Modulators with Impact on Human Health
Ionescu, V., Popa, A., Alexandru, A., Manole, E., Neagu, M., & Pop, S. (2021) · Antioxidants · doi:10.3390/antiox10121893 · Cited by 58 · see citing works
Interactions between Gut Microbiota and Polyphenols: New Insights into the Treatment of Fatigue
Luo, C., Wei, X., Song, J., Xu, X., Huang, H., Fan, S., Zhang, D., Han, L., & Lin, J. (2022) · Molecules · doi:10.3390/molecules27217377 · Cited by 59 · see citing works
Unveiling roles of beneficial gut bacteria and optimal diets for health
Kumar, S., Mukherjee, R., Gaur, P., Leal, É., Lyu, X., Ahmad, S., Puri, P., Chang, C.-M., Raj, V., & Pandey, R. (2025) · Frontiers in Microbiology · doi:10.3389/fmicb.2025.1527755 · Cited by 57 · see citing works
Dietary Isoflavones Alter Gut Microbiota and Lipopolysaccharide Biosynthesis to Reduce Inflammation
Ghimire, S., Cady, N. M., Lehman, P., Peterson, S. R., Shahi, S. K., Rashid, F., Giri, S., & Mangalam, A. K. (2022) · Gut Microbes · doi:10.1080/19490976.2022.2127446 · Cited by 57 · see citing works
Equol: a metabolite of gut microbiota with potential antitumor effects
Lv, J., Jin, S., Zhang, Y., Zhou, Y., Li, M., & Feng, N. (2024) · Gut Pathogens · doi:10.1186/s13099-024-00625-9 · Cited by 57 · see citing works
Zhang, X., Veliky, C. V., Birru, R. L., Barinas‐Mitchell, E., Magnani, J. W., & Sekikawa, A. M. (2021) · Nutrients · doi:10.3390/nu13113739 · Cited by 54 · see citing works
Anti-obesity natural products and gut microbiota
Li, S., Zeng, S.-L., & Liu, E. (2021) · Food Research International · doi:10.1016/j.foodres.2021.110819 · Cited by 55 · see citing works
Equol exerts a protective effect on postmenopausal osteoporosis by upregulating OPG/RANKL pathway
Ni, X., Wu, B., Li, S., Zhu, W., Xu, Z., Zhang, G., Cui, H., Bai, Q., & Wang, J. (2022) · Phytomedicine · doi:10.1016/j.phymed.2022.154509 · Cited by 54 · see citing works
Modulatory Effect of Gut Microbiota on the Gut-Brain, Gut-Bone Axes, and the Impact of Cannabinoids
Ibrahim, I., Soumyakrishnan, S., Ayariga, J. A., Xu, J., Robertson, B. K., SREEPRIYA, M., & Ajayi, O. S. (2022) · Metabolites · doi:10.3390/metabo12121247 · Cited by 56 · see citing works
Langa, S., Peirotén, Á., Curiel, J. A., de la Bastida, A. R., & Landete, J. M. (2023) · Foods · doi:10.3390/foods12061293 · Cited by 50 · see citing works
Lü, C., Gao, R., Zhang, Y., Jiang, N., Chen, Y., Sun, J., Wang, Q., Fan, B., Liu, X., & Wang, F. (2021) · Food & Function · doi:10.1039/d1fo00547b · Cited by 52 · see citing works
Flavonoids and gastrointestinal health: single molecule for multiple roles
Lan, H., Wang, H., Chen, C., Hu, W., Ai, C., Chen, L., & Teng, H. (2023) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2023.2230501 · Cited by 48 · see citing works
Iglesias‐Aguirre, C. E., Vallejo, F., Beltrán, D., Aguilar-Aguilar, E., Puigcerver, J., Alajarı́n, M., Berná, J., Selma, M. V., & Espı́n, J. C. (2022) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.2c04518 · Cited by 48 · see citing works
The role of probiotics in personalized therapeutics: Advances in gut microbe-driven interventions
Manan, M. A. (2025) · The Microbe · doi:10.1016/j.microb.2025.100497 · Cited by 49 · see citing works
Xu, X., Cui, H., Xu, J., Yuan, Z., Liu, X., Fan, X., Li, J., Zhu, D., & Liu, H. (2022) · LWT · doi:10.1016/j.lwt.2022.113096 · Cited by 47 · see citing works
Functional biotransformation of phytoestrogens by gut microbiota with impact on cancer treatment
Farhat, E. K., Sher, E. K., Džidić-Krivić, A., Banjari, I., & Sher, F. (2023) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2023.109368 · Cited by 47 · see citing works
Wang, J., Zhang, J., Yu, Z., Chung, S. K., & Xu, B. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102416 · Cited by 47 · see citing works
Ticinesi, A., Nouvenne, A., Cerundolo, N., Parise, A., Mena, P. R., & Meschi, T. (2024) · Aging Clinical and Experimental Research · doi:10.1007/s40520-024-02707-9 · Cited by 45 · see citing works
Song, Z., Wu, H., Fang, X., Feng, X., & Zhou, L. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1336369 · Cited by 45 · see citing works
Dietary Bioactive Compounds and Human Health and Disease
González, S. (2020) · Nutrients · doi:10.3390/nu12020348 · Cited by 45 · see citing works
Zhang, B., Zhang, Y., Xing, X., & Wang, S. (2022) · Current Opinion in Food Science · doi:10.1016/j.cofs.2022.100941 · Cited by 43 · see citing works
Metabolic syndrome: molecular mechanisms and therapeutic interventions
Zheng, L., Zeng, A., Liu, L., Tian, W., Wang, R., Zhang, L., Hua, H., & Zhao, J. (2025) · Molecular Biomedicine · doi:10.1186/s43556-025-00303-5 · Cited by 44 · see citing works
Gaya, P., Peirotén, Á., & Landete, J. M. (2020) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-020-10588-x · Cited by 44 · see citing works
Flavonoid-Modifying Capabilities of the Human Gut Microbiome—An In Silico Study
Goris, T., Cuadrat, R. R. C., & Braune, A. (2021) · Nutrients · doi:10.3390/nu13082688 · Cited by 43 · see citing works
Asymmetric hydrogenation and transfer hydrogenation in the enantioselective synthesis of flavonoids
Caleffi, G. S., Demidoff, F. C., Nájera, C., & Costa, P. R. R. (2021) · Organic Chemistry Frontiers · doi:10.1039/d1qo01503f · Cited by 43 · see citing works
Silva, H. (2021) · Biology · doi:10.3390/biology10010049 · Cited by 43 · see citing works
Dietary exposure to endocrine disruptors in gut microbiota: A systematic review
Calero-Medina, L., Jiménez-Casquet, M. J., Heras-González, L., Conde-Pipó, J., López-Moro, A., Olea‐Serrano, F., & Mariscal‐Arcas, M. (2023) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2023.163991 · Cited by 41 · see citing works
Li, Z., Kanwal, R., Yue, X., Li, M., & Xie, A. (2024) · Food Bioscience · doi:10.1016/j.fbio.2024.105220 · Cited by 40 · see citing works
Diotallevi, C., Fava, F., Gobbetti, M., & Tuohy, K. M. (2020) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0000000000000697 · Cited by 39 · see citing works
Soy and Gastrointestinal Health: A Review
Belobrajdic, D. P., James‐Martin, G., Jones, D., & Tran, C. D. (2023) · Nutrients · doi:10.3390/nu15081959 · Cited by 39 · see citing works
Role of S-Equol, Indoxyl Sulfate, and Trimethylamine N-Oxide on Vascular Function
Matsumoto, T., Kojima, M., Takayanagi, K., Taguchi, K., & Kobayashi, T. (2020) · American Journal of Hypertension · doi:10.1093/ajh/hpaa053 · Cited by 37 · see citing works
Oh, K., Gupta, H., Min, B.-H., Ganesan, R., Sharma, S. P., Won, S., Jeong, J., Lee, S.-B., Cha, M., Kwon, G.-H., et al. (2022) · Cells · doi:10.3390/cells11182903 · Cited by 37 · see citing works
Soukup, S. T., Engelbert, A. K., Watzl, B., Bub, A., & Kulling, S. E. (2023) · Nutrients · doi:10.3390/nu15102352 · Cited by 37 · see citing works
Neuroprotective potential of formononetin, a naturally occurring isoflavone phytoestrogen
Singh, L., Kaur, H., Arya, G. C., & Bhatti, R. (2023) · Chemical Biology & Drug Design · doi:10.1111/cbdd.14353 · Cited by 38 · see citing works
Diet and cancer risk reduction: The role of diet-microbiota interactions and microbial metabolites
Weir, T. L., Trikha, S. R. J., & Thompson, H. J. (2020) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2020.06.007 · Cited by 37 · see citing works
Developmental exposure to phytoestrogens found in soy: New findings and clinical implications
Suen, A. A., Kenan, A. C., & Williams, C. J. (2021) · Biochemical Pharmacology · doi:10.1016/j.bcp.2021.114848 · Cited by 38 · see citing works
Qin, S., Zhang, K., Ding, X., Bai, S., Wang, J., Tian, G., Xuan, Y., Su, Z., & Zeng, Q. (2022) · Food Chemistry · doi:10.1016/j.foodchem.2022.134148 · Cited by 37 · see citing works
Isoflavone consumption reduces inflammation through modulation of phenylalanine and lipid metabolism
Shrode, R. L., Cady, N. M., Jensen, S. N., Borcherding, N. C., & Mangalam, A. K. (2022) · Metabolomics · doi:10.1007/s11306-022-01944-1 · Cited by 37 · see citing works
Speckmann, B., Ehring, E., Hu, J., & Rodriguez‐Mateos, A. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2305716 · Cited by 36 · see citing works
Phytoestrogens: Chemistry, potential health benefits, and their medicinal importance
Chavda, V. P., Chaudhari, A. Z., Balar, P. C., Gholap, A. D., & Vora, L. K. (2024) · Phytotherapy Research · doi:10.1002/ptr.8196 · Cited by 38 · see citing works
From the gut to the brain: the long journey of phenolic compounds with neurocognitive effects
Domínguez‐López, I., López‐Yerena, A., Vallverdú‐Queralt, A., Pallàs, M., Lamuela-Raventós, R. M., & Pérez, M. (2024) · Nutrition Reviews · doi:10.1093/nutrit/nuae034 · Cited by 42 · see citing works
Ticinesi, A., Nouvenne, A., Cerundolo, N., Parise, A., & Meschi, T. (2023) · Nutrients · doi:10.3390/nu15102367 · Cited by 37 · see citing works
Peirotén, Á., Gaya, P., Álvarez, I., & Landete, J. M. (2020) · Food Chemistry · doi:10.1016/j.foodchem.2020.126521 · Cited by 35 · see citing works
Iglesias‐Aguirre, C. E., Romo‐Vaquero, M., Selma, M. V., & Espı́n, J. C. (2023) · Food Research International · doi:10.1016/j.foodres.2023.113470 · Cited by 34 · see citing works
Yilmaz, Y. N. (2024) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202400754 · Cited by 34 · see citing works
Chen, P.-C., Lin, C., Chen, M.-H., & Chiang, P.-Y. (2020) · LWT · doi:10.1016/j.lwt.2020.109848 · Cited by 33 · see citing works
Wang, L., Wu, X., Ma, Y., Li, X., Zhang, J., & Zhao, L. (2021) · Food & Function · doi:10.1039/d0fo03254a · Cited by 33 · see citing works
Dietary phytochemicals, gut microbiota composition, and health outcomes in human and animal models
Mirmohammadali, S. N., & Rosenkranz, S. K. (2023) · Bioscience of Microbiota Food and Health · doi:10.12938/bmfh.2022-078 · Cited by 33 · see citing works
Soy Metabolism by Gut Microbiota from Patients with Precancerous Intestinal Lesions
Polimeno, L., Barone, M., Mosca, A., Viggiani, M. T., Joukar, F., Mansour‐Ghanaei, F., Mavaddati, S., Daniele, A., Debellis, L., Bilancia, M., et al. (2020) · Microorganisms · doi:10.3390/microorganisms8040469 · Cited by 33 · see citing works
Promotion of Healthy Aging Through the Nexus of Gut Microbiota and Dietary Phytochemicals
Beaver, L. M., Jamieson, P. E., Wong, C. P., Hosseinikia, M., Stevens, J. F., & Ho, E. (2025) · Advances in Nutrition · doi:10.1016/j.advnut.2025.100376 · Cited by 32 · see citing works
Edible plant by-products as source of polyphenols: prebiotic effect and analytical methods
García‐Alonso, A., López, M. S., Manzanares‐Palenzuela, C. L., Redondo, A., & López-Ruíz, B. (2022) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2022.2084028 · Cited by 31 · see citing works
The potential of β-glucosidases for aroma and flavor improvement in the food industry
Souto, B. D. M., Barbosa, M. F., Sales, R. A., Moura, S. C., Araújo, A. D. R. B., & Quirino, B. F. (2023) · The Microbe · doi:10.1016/j.microb.2023.100004 · Cited by 30 · see citing works
Wang, X., Chen, B., Fang, X., Zhong, Q., Liao, Z., Wang, J., Wu, X., Ma, Y., Li, P., Feng, X., et al. (2022) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2022.2154744 · Cited by 31 · see citing works
Wang, Q., Spenkelink, B., Boonpawa, R., Rietjens, I. M. C. M., & Beekmann, K. (2020) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201900912 · Cited by 29 · see citing works
Heterologous production of equol by lactic acid bacteria strains in culture medium and food
de la Bastida, A. R., Peirotén, Á., Langa, S., Arqués, J. L., & Landete, J. M. (2021) · International Journal of Food Microbiology · doi:10.1016/j.ijfoodmicro.2021.109328 · Cited by 29 · see citing works
Yamashita, Y., Nakamura, A., Nanba, F., Saito, S., Toda, T., Nakagawa, J., & Ashida, H. (2020) · Nutrients · doi:10.3390/nu12092755 · Cited by 28 · see citing works
The Influence of Plant Isoflavones Daidzein and Equol on Female Reproductive Processes
Sirotkin, A. V., Alwasel, S. H., & Harrath, A. H. (2021) · Pharmaceuticals · doi:10.3390/ph14040373 · Cited by 27 · see citing works
- Authors
- Mayo, B., Vázquez, L., & Flórez, A. B.
- Affiliations
- Consejo Superior de Investigaciones Científicas (ES)
- Corresponding author
- Mayo, Baltasar
- Venue
- Nutrients
- Publisher
- MDPI AG
- Published
- 2019-09-16
- Volume
- 11
- Issue
- 9
- Pages
- 2231
- ISSN
- 2072-6643 (ISSN-L)
- PMC
- PMC6770660
- OpenAlex
- W2972497746
- Cited by
- 416
- References
- 192
- Citations by year
- 2026: 56 · 2025: 55 · 2024: 71 · 2023: 75 · 2022: 74 · 2021: 50 · 2020: 33 · 2019: 1
- FWCI
- 5.88
- Type
- journal article
- Language
- en
- Open access
- gold
- dx.doi.org
- Licence
- Locations
- Nutrients (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Ministerio de Economía, Industria y Competitividad, Gobierno de España (AGL2011-24300-ALI and AGL-2014-57820-R)
- Gobierno del Principado de Asturias (GRUPIN14-137 and IDI/2018/000114)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Phytoestrogen effects and research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Keywords
- equol, daidzein, isoflavones, soybean, gut microbiota, estrogenic activity, antioxidant activity, menopausal symptoms, osteoporosis, cardiovascular disease, cancer prevention
- MeSH terms
- Gastrointestinal Microbiome, Animals, Bacteria, Diet, Health Status, Humans, Isoflavones, Equol
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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