A polyphenol-rich cranberry extract protects from diet-induced obesity, insulin resistance and intestinal inflammation in association with increased Akkermansia spp. population in the gut microbiota of mice
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Objective: The increasing prevalence of obesity and type 2 diabetes (T2D) demonstrates the failure of conventional treatments to curb these diseases. The gut microbiota has been put forward as a key player in the pathophysiology of diet-induced T2D. Importantly, cranberry (Vaccinium macrocarpon Aiton) is associated with a number of beneficial health effects. We aimed to investigate the metabolic impact of a cranberry extract (CE) on high fat/high sucrose (HFHS)-fed mice and to determine whether its consequent antidiabetic effects are related to modulations in the gut microbiota. Design: C57BL/6J mice were fed either a chow or a HFHS diet. HFHS-fed mice were gavaged daily either with vehicle (water) or CE (200 mg/kg) for 8 weeks. The composition of the gut microbiota was assessed by analysing 16S rRNA gene sequences with 454 pyrosequencing. Results: CE treatment was found to reduce HFHS-induced weight gain and visceral obesity. CE treatment also decreased liver weight and triglyceride accumulation in association with blunted hepatic oxidative stress and inflammation. CE administration improved insulin sensitivity, as revealed by improved insulin tolerance, lower homeostasis model assessment of insulin resistance and decreased glucose-induced hyperinsulinaemia during an oral glucose tolerance test. CE treatment was found to lower intestinal triglyceride content and to alleviate intestinal inflammation and oxidative stress. Interestingly, CE treatment markedly increased the proportion of the mucin-degrading bacterium Akkermansia in our metagenomic samples. Conclusions: CE exerts beneficial metabolic effects through improving HFHS diet-induced features of the metabolic syndrome, which is associated with a proportional increase in Akkermansia spp. population.
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A polyphenol-rich cranberry extract and metformin attenuate diet-induced metabolic syndrome in mice in a gut microbiota-dependent manner.
“Researchers have confirmed that a polyphenol-rich cranberry extract and metformin attenuate diet-induced metabolic syndrome in mice in a gut microbiota-dependent manner (16, 17).”
The polyphenol-associated improvements in mice were coupled to 7-to-10-fold blooms of Akkermansia muciniphila.
“These improvements were coupled to dramatic 7-to-10-fold blooms of Akkermansia muciniphila”
From The microbial pharmacists within us: a metagenomic view of xenobiotic metabolism (2016) · cites this paper as [96]
Mice fed high-fat diets supplemented with polyphenols showed reduced diet-induced weight gain and adiposity, improved insulin sensitivity, and diminished markers of intestinal inflammation and oxidative stress compared with controls.
“Mice fed high-fat diets supplemented with polyphenols showed reduced diet-induced weight gain and adiposity, improved insulin sensitivity, and diminished markers of intestinal inflammation and oxidative stress compared to controls20, 96.”
From The microbial pharmacists within us: a metagenomic view of xenobiotic metabolism (2016) · cites this paper as [96]
The metabolic benefits of dietary polyphenol, cranberry extract, and metformin are associated with increased amount of A muciniphila in the gut.
“Furthermore, the metabolic benefits of dietary polyphenol, cranberry extract, and metformin are associated with increased amount of this bacterial species in the gut.”
From <i>Akkermansia Muciniphila</i> Protects Against Atherosclerosis by Preventing Metabolic Endotoxemia-Induced Inflammation in <i>Apoe</i> <sup>−/−</sup> Mice (2016) · cites this paper as [37]
Increased Akkermansia abundance has been linked with reduced intestinal permeability and gut-to-blood leakage of endotoxins, thereby alleviating diet-induced obesity and insulin resistance.
“Increased Akkermansia abundance has been linked with reduced intestinal permeability and gut-to-blood leakage of endotoxins (eg, lipopolysaccharides), thereby alleviating diet-induced obesity and insulin resistance (49).”
From Senolytic Combination of Dasatinib and Quercetin Alleviates Intestinal Senescence and Inflammation and Modulates the Gut Microbiome in Aged Mice (2021) · cites this paper as [49]
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2 retracted
Gut Microbiota Is a Key Modulator of Insulin Resistance in TLR 2 Knockout Mice
Caricilli, A. M., Picardi, P. K., de Abreu, L. L., Ueno, M., Prada, P. O., Ropelle, E. R., Hirabara, S. M., Castoldi, Â., Moraes‐Vieira, P. M., Câmara, N. O. S., et al. (2011) · PLoS Biology · doi:10.1371/journal.pbio.1001212 · Cited by 281 · see citing works
RetractedApple Peel Polyphenols and Their Beneficial Actions on Oxidative Stress and Inflammation
Denis, M. C., Fürtös, A., Dudonné, S., Montoudis, A., Garofalo, C., Desjardins, Y., DELVIN, E. E., & Levy, E. H. (2013) · PLoS ONE · doi:10.1371/journal.pone.0053725 · Cited by 121 · see citing works
Self-citationRetractedMcCord, J. M., & Fridovich, I. (1969) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)63504-5 · Cited by 12,952 · see citing works
An obesity-associated gut microbiome with increased capacity for energy harvest
Turnbaugh, P. J., Ley, R. E., Mahowald, M. A., Magrini, V., Mardis, E. R., & Gordon, J. I. (2006) · Nature · doi:10.1038/nature05414 · Cited by 12,444 · see citing works
Obesity is associated with macrophage accumulation in adipose tissue
Weisberg, S. P., McCann, D., Desai, M., Rosenbaum, M., Leibel, R. L., & Ferrante, A. W. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319246 · Cited by 10,041 · see citing works
Human gut microbes associated with obesity
Ley, R. E., Turnbaugh, P. J., Klein, S., & Gordon, J. I. (2006) · Nature · doi:10.1038/4441022a · Cited by 8,785 · see citing works
Xu, H., Barnes, G. T., Yang, Q., Tan, G., Yang, D., Chou, C. J., Sole, J., Nichols, A., Ross, J. S., Tartaglia, L. A., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319451 · Cited by 6,760 · see citing works
Metabolic Endotoxemia Initiates Obesity and Insulin Resistance
Cani, P. D., Amar, J., Iglesias, M. A., Poggi, M., Knauf, C., Bastelica, D., Neyrinck, A. M., Fava, F., Tuohy, K. M., Chabo, C., et al. (2007) · Diabetes · doi:10.2337/db06-1491 · Cited by 6,638 · see citing works
Dose translation from animal to human studies revisited.
Reagan‐Shaw, S., Nihal, M., & Ahmad, N. (2008) · The FASEB Journal · doi:10.1096/fj.07-9574lsf · Cited by 6,524 · see citing works
Eckel, R. H., Alberti, K., Grundy, S. M., & Zimmet, P. (2010) · The Lancet · doi:10.1016/s0140-6736(09)61794-3 · Cited by 6,283 · see citing works
The gut microbiota as an environmental factor that regulates fat storage
Bäckhed, F., Ding, H., Wang, T., Hooper, L. V., Koh, G. Y., Nagy, A., Semenkovich, C. F., & Gordon, J. I. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407076101 · Cited by 6,245 · see citing works
Obesity alters gut microbial ecology
Ley, R. E., Bäckhed, F., Turnbaugh, P., Lozupone, C. A., Knight, R. D., & Gordon, J. I. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504978102 · Cited by 6,176 · see citing works
Eckel, R. H., Grundy, S. M., & Zimmet, P. (2005) · The Lancet · doi:10.1016/s0140-6736(05)66378-7 · Cited by 5,565 · see citing works
Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation
Arpaia, N., Campbell, C., Fan, X., Dikiy, S., van der Veeken, J., deRoos, P., Liu, H., Cross, J. R., Pfeffer, K., Coffer, P. J., et al. (2013) · Nature · doi:10.1038/nature12726 · Cited by 4,838 · see citing works
Cani, P. D., Bibiloni, R., Knauf, C., Waget, A., Neyrinck, A. M., Delzenne, N. M., & Burcelin, R. (2008) · Diabetes · doi:10.2337/db07-1403 · Cited by 4,819 · see citing works
Everard, A., Belzer, C., Geurts, L., Ouwerkerk, J. P., Druart, C., Bindels, L. B., Guiot, Y., Derrien, M., Muccioli, G. G., Delzenne, N. M., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1219451110 · Cited by 4,511 · see citing works
Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies
Manach, C., Williamson, G., Morand, C., Scalbert, A., & Rémésy, C. (2005) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/81.1.230s · Cited by 4,219 · see citing works
Inflammation, stress, and diabetes
Wellen, K. E., & Hotamisligil, G. S. (2005) · Journal of Clinical Investigation · doi:10.1172/jci25102 · Cited by 4,143 · see citing works
Cani, P. D., Possemiers, S., Van de Wiele, T., Guiot, Y., Everard, A., Rottier, O., Geurts, L., Naslain, D., Neyrinck, A., Lambert, D. M., et al. (2009) · Gut · doi:10.1136/gut.2008.165886 · Cited by 2,518 · see citing works
Obesity and Diabetes in the Developing World — A Growing Challenge
Hossain, P., Kawar, B., & El Nahas, M. (2007) · New England Journal of Medicine · doi:10.1056/nejmp068177 · Cited by 2,200 · see citing works
Dietary intervention impact on gut microbial gene richness
Cotillard, A., Kennedy, S. P., Kong, L. C., Prifti, E., Pons, N., Le Chatelier, E., Almeida, M., Quinquis, B., Levenez, F., Galleron, N., et al. (2013) · Nature · doi:10.1038/nature12480 · Cited by 1,832 · see citing works
Cani, P. D., Neyrinck, A. M., Fava, F., Knauf, C., Burcelin, R., Tuohy, K. M., Gibson, G. R., & Delzenne, N. M. (2007) · Diabetologia · doi:10.1007/s00125-007-0791-0 · Cited by 1,770 · see citing works
Benefits of polyphenols on gut microbiota and implications in human health
Cardona, F., Andrés‐Lacueva, C., Tulipani, S., Tinahones, F. J., & Queipo‐Ortuño, M. I. (2013) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2013.05.001 · Cited by 1,615 · see citing works
High-Fat Diet Determines the Composition of the Murine Gut Microbiome Independently of Obesity
Hildebrandt, M. A., Hoffmann, C., Sherrill–Mix, S. A., Keilbaugh, S. A., Hamady, M., Chen, Y., Knight, R., Ahima, R. S., Bushman, F., & Wu, G. D. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.08.042 · Cited by 1,576 · cited 1× · see citing works
“All procedures were previously approved by the Laval University Animal Ethics Committee.”
MethodShin, N.-R., Lee, J.-C., Lee, H.-Y., Kim, M.-S., Whon, T. W., Lee, M.-S., & Bae, J.-W. (2014) · Gut · doi:10.1136/gutjnl-2012-303839 · Cited by 1,550 · see citing works
Phenol Antioxidant Quantity and Quality in Foods: Fruits
Vinson, J. A., Su, X., Zubik, L., & Bose, P. (2001) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf0009293 · Cited by 1,191 · see citing works
Everard, A., Lazarevic, V., Derrien, M., Girard, M., Muccioli, G. G., Neyrinck, A. M., Possemiers, S., Van Holle, A., François, P., de Vos, W. M., et al. (2011) · Diabetes · doi:10.2337/db11-0227 · Cited by 1,076 · see citing works
Conserved shifts in the gut microbiota due to gastric bypass reduce host weight and adiposity
Liou, A. P., Paziuk, M., Luevano, J.-M., Machineni, S., Turnbaugh, P. J., & Kaplan, L. M. (2013) · Science Translational Medicine · doi:10.1126/scitranslmed.3005687 · Cited by 1,007 · see citing works
Microbes inside—from diversity to function: the case of Akkermansia
Belzer, C., & de Vos, W. M. (2012) · The ISME Journal · doi:10.1038/ismej.2012.6 · Cited by 715 · see citing works
Ding, S., Chi, M. M., Scull, B. P., Rigby, R., Schwerbrock, N. M. J., Magness, S., Jobin, C., & Lund, P. K. (2010) · PLoS ONE · doi:10.1371/journal.pone.0012191 · Cited by 713 · see citing works
The endocannabinoid system links gut microbiota to adipogenesis
Muccioli, G. G., Naslain, D., Bäckhed, F., Reigstad, C. S., Lambert, D. M., Delzenne, N. M., & Cani, P. D. (2010) · Molecular Systems Biology · doi:10.1038/msb.2010.46 · Cited by 691 · see citing works
Chylomicrons promote intestinal absorption of lipopolysaccharides
Ghoshal, S., Witta, J., Zhong, J., de Villiers, W., & Eckhardt, E. (2009) · Journal of Lipid Research · doi:10.1194/jlr.m800156-jlr200 · Cited by 662 · see citing works
The Mucin Degrader Akkermansia muciniphila Is an Abundant Resident of the Human Intestinal Tract
Derrien, M., Collado, M. C., Amor, K. B., Salminen, S., & de Vos, W. M. (2007) · Applied and Environmental Microbiology · doi:10.1128/aem.01226-07 · Cited by 659 · see citing works
Rabot, S., Membrez, M., Bruneau, A., Gérard, P., Harach, T., Moser, M., Raymond, F., Mansourian, R., & Chou, C. J. (2010) · The FASEB Journal · doi:10.1096/fj.10-164921 · Cited by 610 · see citing works
Rabot, S., Membrez, M., Bruneau, A., Gérard, P., Harach, T., Moser, M., Raymond, F., Mansourian, R., & Chou, C. J. (2010) · The FASEB Journal · doi:10.1096/fj.10.164921 · Cited by 610 · see citing works
Lam, Y. Y., Ha, C. W. Y., Campbell, C. R., Mitchell, A. J., Dinudom, A., Oscarsson, J., Cook, D. I., Hunt, N. H., Caterson, I. D., Holmes, A. J., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0034233 · Cited by 604 · see citing works
Cranberry and blueberry: Evidence for protective effects against cancer and vascular diseases
Neto, C. C. (2007) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200600279 · Cited by 460 · see citing works
Foo, L. Y., Lu, Y., Howell, A. B., & Vorsa, N. (2000) · Journal of Natural Products · doi:10.1021/np000128u · Cited by 431 · see citing works
The genetic contribution to non-syndromic human obesity
Walley, A. J., Asher, J. E., & Froguel, P. (2009) · Nature Reviews Genetics · doi:10.1038/nrg2594 · Cited by 402 · see citing works
Oligofructose Promotes Satiety in Rats Fed a High‐Fat Diet: Involvement of Glucagon‐Like Peptide‐1
Cani, P. D., Neyrinck, A. M., Maton, N., & Delzenne, N. M. (2005) · Obesity Research · doi:10.1038/oby.2005.117 · Cited by 382 · see citing works
Red wine procyanidins and vascular health
Corder, R., Mullen, W., Khan, N. Q., Marks, S. C., Wood, E. G., CARRIER, M. J., & Crozier, A. (2006) · Nature · doi:10.1038/444566a · Cited by 358 · see citing works
Geurts, L., Lazarević, V., Derrien, M., Everard, A., Roye, M. V., Knauf, C., Valet, P., Girard, M., Muccioli, G. G., François, P., et al. (2011) · Frontiers in Microbiology · doi:10.3389/fmicb.2011.00149 · Cited by 323 · see citing works
Cranberries and Their Bioactive Constituents in Human Health
Blumberg, J. B., Camesano, T. A., Cassidy, A., Kris‐Etherton, P. M., Howell, A. B., Manach, C., Ostertag, L. M., Sies, H., Skulas‐Ray, A. C., & Vita, J. A. (2013) · Advances in Nutrition · doi:10.3945/an.113.004473 · Cited by 313 · see citing works
Freedman, A. S., Freeman, G. J., Rhynhart, K. K., & Nadler, L. M. (1991) · Cellular Immunology · doi:10.1016/0008-8749(91)90091-o · Cited by 312 · see citing works
The Emerging Genetic Architecture of Type 2 Diabetes
Doria, A., Patti, M., & Kahn, C. R. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.08.006 · Cited by 303 · see citing works
Pathways in Microbe-Induced Obesity
Cox, L. M., & Blaser, M. J. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.05.004 · Cited by 266 · see citing works
Dubourg, G., Lagier, J., Armougom, F., Robert, C., Audoly, G., Papazian, L., & Raoult, D. (2013) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2012.10.012 · Cited by 235 · see citing works
Axling, U., Olsson, C., Xu, J., Fernandez, C., Larsson, S. M., Ström, K., Ahrné, S., Holm, C., Molin, G., & Berger, K. (2012) · Nutrition & Metabolism · doi:10.1186/1743-7075-9-105 · Cited by 228 · see citing works
Impact of polyphenols from black tea and red wine/grape juice on a gut model microbiome
Kemperman, R. A., Gross, G., Mondot, S., Possemiers, S., Marzorati, M., Van de Wiele, T., Doré, J., & Vaughan, E. E. (2013) · Food Research International · doi:10.1016/j.foodres.2013.01.034 · Cited by 223 · see citing works
Lipopolysaccharide (LPS)-Binding Protein Mediates LPS Detoxification by Chylomicrons
Vreugdenhil, A. C. E., Rousseau, C. H., Härtung, T., Greve, J. W. M., Veer, C. V. ′., & Buurman, W. A. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.3.1399 · Cited by 206 · see citing works
Microbiota and Gut–Liver Axis: Their Influences on Obesity and Obesity‐Related Liver Disease
Vajro, P., Paolella, G., & Fasano, A. (2013) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0b013e318284abb5 · Cited by 201 · see citing works
High polyphenol, low probiotic diet for weight loss because of intestinal microbiota interaction
Rastmanesh, R. (2010) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2010.10.002 · Cited by 180 · see citing works
Effect of cranberry extracts on lipid profiles in subjects with type 2 diabetes
Lee, I. T., Chan, Y. C., Lin, C. W., Lee, W. J., & Sheu, W. H. (2008) · Diabetic Medicine · doi:10.1111/j.1464-5491.2008.02588.x · Cited by 150 · see citing works
He, X., & Liu, R. H. (2006) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf061058l · Cited by 149 · see citing works
Mediators of cytokine-induced insulin resistance in obesity and other inflammatory settings
Marette, A. (2002) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/00075197-200207000-00005 · Cited by 149 · see citing works
Self-citationPolyphenols and type 2 diabetes: A prospective review
Anhê, F. F., Desjardins, Y., Pilon, G., Dudonné, S., Genovese, M. I., Lajolo, F. M., & Marette, A. (2013) · PharmaNutrition · doi:10.1016/j.phanu.2013.07.004 · Cited by 144 · see citing works
Self-citationSoft drink, 100% fruit juice, and vegetable juice intakes and risk of diabetes mellitus
Eshak, E. S., Iso, H., Mizoue, T., Inoue, M., Noda, M., & Tsugane, S. (2012) · Clinical Nutrition · doi:10.1016/j.clnu.2012.08.003 · Cited by 121 · see citing works
Anticancer activities of cranberry phytochemicals: An update
Neto, C. C., Amoroso, J., & Liberty, A. M. (2008) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200700433 · Cited by 119 · see citing works
Strawberries, Blueberries, and Cranberries in the Metabolic Syndrome: Clinical Perspectives
Basu, A., & Lyons, T. J. (2012) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf203488k · Cited by 116 · see citing works
Non-alcoholic fatty liver disease and insulin resistance: From bench to bedside
Gariani, K., Philippé, J., & Jornayvaz, F. R. (2012) · Diabetes & Metabolism · doi:10.1016/j.diabet.2012.11.002 · Cited by 112 · see citing works
Spahis, S., Vanasse, M., Bélanger, S. A., Ghadirian, P., Grenier, É., & Levy, E. H. (2008) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2008.07.005 · Cited by 100 · see citing works
Self-citationComparison of Health‐Relevant Flavonoids in Commonly Consumed Cranberry Products
Grace, M. H., Massey, A. R., Mbeunkui, F., Yousef, G. G., & Lila, M. A. (2012) · Journal of Food Science · doi:10.1111/j.1750-3841.2012.02788.x · Cited by 84 · see citing works
Pierre, J. F., Heneghan, A. F., Feliciano, R. P., Shanmuganayagam, D., Roenneburg, D. A., Krueger, C. G., Reed, J. D., & Kudsk, K. A. (2012) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/0148607112463076 · Cited by 81 · see citing works
Levy, E. H., Trudel, K., Bendayan, M., Seidman, E. G., DELVIN, E. E., Elchebly, M., Lavoie, J., Précourt, L., Amre, D. K., & Sinnett, D. (2007) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00369.2007 · Cited by 75 · see citing works
Self-citationVeilleux, A., Grenier, É., Marceau, P., Carpentier, A. C., Richard, D., & Levy, E. H. (2014) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.113.302993 · Cited by 72 · see citing works
Self-citationShidfar, F., Heydari, I., Hajimiresmaiel, S. J., Hosseini, S., Shidfar, S., & Amiri, F. (2012) · Europe PMC (PubMed Central) · Cited by 71 · see citing works
Feldman, M., & Grenier, D. (2012) · Journal of Applied Microbiology · doi:10.1111/j.1365-2672.2012.05329.x · Cited by 59 · see citing works
Morimoto, A., Ohno, Y., Tatsumi, Y., Mizuno, S., & Watanabe, S. (2012) · PubMed · Cited by 49 · see citing works
Dietary patterns and the risk of type 2 diabetes in overweight and obese individuals
Bauer, F., Beulens, J. W. J., van der A, D. L., Wijmenga, C., Grobbee, D. E., Spijkerman, A. M. W., van der Schouw, Y. T., & Onland‐Moret, N. C. (2012) · European Journal of Nutrition · doi:10.1007/s00394-012-0423-4 · Cited by 48 · see citing works
Kivimäki, A. S., Ehlers, P. I., Siltari, A., Turpeinen, A. M., Vapaatalo, H., & Korpela, R. (2012) · Journal of Functional Foods · doi:10.1016/j.jff.2012.02.010 · Cited by 45 · see citing works
Kim, M. J., Ohn, J., Kim, J. H., & Kwak, H. (2011) · Nutrition Research and Practice · doi:10.4162/nrp.2011.5.5.404 · Cited by 43 · see citing works
Déziel, B., MacPhee, J., Patel, K. D., Catalli, A., Kulka, M., Neto, C. C., Gottschall‐Pass, K. T., & Hurta, R. A. R. (2012) · Food & Function · doi:10.1039/c2fo10145a · Cited by 33 · see citing works
Madrigal‐Carballo, S., Rodríguez-Rodríguez, G., Sibaja, M., Reed, J. D., Vila, A. O., & Molina, F. (2009) · Journal of Liposome Research · doi:10.1080/08982100902729436 · Cited by 24 · see citing works
Chan, H. ‐., Yiu, K., Wong, C. Y., Li, S.-W., Tam, S., & Tse, H. (2012) · Diabetic Medicine · doi:10.1111/j.1464-5491.2012.03764.x · Cited by 19 · see citing works
Uberos, J., Iswaldi, I., Belmonte, R. R., Segura‐Carretero, A., Fernández-Puentes, V., Molina‐Carballo, A., & Muñoz‐Hoyos, A. (2011) · Microbiology Insights · doi:10.4137/mbi.s8526 · Cited by 11 · see citing works
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Dao, M. C., Everard, A., Aron-Wisnewsky, J., Sokolovska, N., Prifti, E., Verger, E. O., Kayser, B. D., Levenez, F., Chilloux, J., Hoyles, L., et al. (2016) · Gut · doi:10.1136/gutjnl-2014-308778 · Cited by 1,931 · see citing works
You are what you eat: Diet, health and the gut microbiota
Zmora, N., Suez, J., & Elinav, E. (2019) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-018-0061-2 · Cited by 1,792 · see citing works
Wu, H., Esteve, E., Tremaroli, V., Khan, M. T., Caesar, R., Mannerås-Holm, L., Ståhlman, M., Olsson, L. M., Serino, M., Planas-Fèlix, M., et al. (2017) · Nature Medicine · doi:10.1038/nm.4345 · Cited by 1,632 · see citing works
Human gut microbiome: Hopes, threats and promises
Cani, P. D. (2018) · Gut · doi:10.1136/gutjnl-2018-316723 · Cited by 1,386 · see citing works
The intestinal barrier: a fundamental role in health and disease
Vancamelbeke, M., & Vermeire, S. (2017) · Expert Review of Gastroenterology & Hepatology · doi:10.1080/17474124.2017.1343143 · Cited by 1,323 · see citing works
Gut Microbiome: Profound Implications for Diet and Disease
Hills, R. D., Pontefract, B., Mishcon, H. R., Black, C. A., Sutton, S. C., & Theberge, C. R. (2019) · Nutrients · doi:10.3390/nu11071613 · Cited by 1,107 · see citing works
Next-Generation Beneficial Microbes: The Case of Akkermansia muciniphila
Cani, P. D., & de Vos, W. M. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.01765 · Cited by 1,058 · see citing works
Akkermansia muciniphila and its role in regulating host functions
Derrien, M., Belzer, C., & de Vos, W. M. (2017) · Microbial Pathogenesis · doi:10.1016/j.micpath.2016.02.005 · Cited by 1,044 · see citing works
The gut microbiome: Relationships with disease and opportunities for therapy
Durack, J., & Lynch, S. V. (2018) · The Journal of Experimental Medicine · doi:10.1084/jem.20180448 · Cited by 955 · see citing works
Burokas, A., Arboleya, S., Moloney, R. D., Peterson, V. L., Murphy, K., Clarke, G., Stanton, C., Dinan, T. G., & Cryan, J. F. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.12.031 · Cited by 952 · see citing works
Towards a more comprehensive concept for prebiotics
Bindels, L. B., Delzenne, N. M., Cani, P. D., & Walter, J. (2015) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2015.47 · Cited by 914 · see citing works
Schneeberger, M., Everard, A., Gómez-Valadés, A. G., Matamoros, S., Ramírez, S., Delzenne, N. M., Gomis, R., Claret, M., & Cani, P. D. (2015) · Scientific Reports · doi:10.1038/srep16643 · Cited by 798 · see citing works
Self-citationLi, J., Lin, S., Vanhoutte, P. M., Woo, C. W., & Xu, A. (2016) · Circulation · doi:10.1161/circulationaha.115.019645 · Cited by 775 · see citing works
Chen, M.-L., Yi, L., Zhang, Y., Zhou, X., Ran, L., Yang, J., Zhu, J.-D., Zhang, Q.-Y., & Mi, M.-T. (2016) · mBio · doi:10.1128/mbio.02210-15 · Cited by 754 · see citing works
The microbial pharmacists within us: a metagenomic view of xenobiotic metabolism
Spanogiannopoulos, P., Bess, E. N., Carmody, R. N., & Turnbaugh, P. J. (2016) · Nature Reviews Microbiology · doi:10.1038/nrmicro.2016.17 · Cited by 717 · see citing works
Potential Health Benefits of Plant Food-Derived Bioactive Components: An Overview
Samtiya, M., Aluko, R. E., Dhewa, T., & Moreno‐Rojas, J. M. (2021) · Foods · doi:10.3390/foods10040839 · Cited by 686 · see citing works
Recent Research on the Health Benefits of Blueberries and Their Anthocyanins
Kalt, W., Cassidy, A., Howard, L. R., Krikorian, R., Stull, A. J., Tremblay, F., & Zamora‐Ros, R. (2019) · Advances in Nutrition · doi:10.1093/advances/nmz065 · Cited by 679 · see citing works
Roopchand, D. E., Carmody, R. N., Kuhn, P., Moskal, K., Rojas-Silva, P., Turnbaugh, P. J., & Raskin, I. (2015) · Diabetes · doi:10.2337/db14-1916 · Cited by 678 · see citing works
Shaping the Future of Probiotics and Prebiotics
Cunningham, M., Azcarate-Peril, M. A., Barnard, A., Benoit, V., Grimaldi, R., Guyonnet, D., Holscher, H. D., Hunter, K., Manurung, S., Obis, D., et al. (2021) · Trends in Microbiology · doi:10.1016/j.tim.2021.01.003 · Cited by 637 · see citing works
Liu, B., Liu, X., Liang, Z., & Wang, J. (2021) · World Journal of Gastroenterology · doi:10.3748/wjg.v27.i25.3837 · Cited by 625 · see citing works
Williamson, G., Kay, C. D., & Crozier, A. (2018) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.12351 · Cited by 607 · see citing works
The gut microbiota: a key factor in the therapeutic effects of (poly)phenols
Espín, J. C., González-Sarrías, A., & Tomás-Barberán, F. A. (2017) · Biochemical Pharmacology · doi:10.1016/j.bcp.2017.04.033 · Cited by 603 · see citing works
Inflammasome signaling affects anxiety- and depressive-like behavior and gut microbiome composition
Wong, M.-L., Inserra, A., Lewis, M. D., Mastronardi, C. A., Leong, L., Choo, J., Kentish, S., Xie, P., Morrison, M., Wesselingh, S. L., et al. (2016) · Molecular Psychiatry · doi:10.1038/mp.2016.46 · Cited by 568 · see citing works
Kawabata, K., Yoshioka, Y., & Terao, J. (2019) · Molecules · doi:10.3390/molecules24020370 · Cited by 563 · see citing works
The role of metabolism (and the microbiome) in defining the clinical efficacy of dietary flavonoids
Cassidy, A., & Minihane, A. M. (2016) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.116.136051 · Cited by 513 · see citing works
Role of dietary polyphenols on gut microbiota, their metabolites and health benefits
Aravind, S. M., Wichienchot, S., Tsao, R., Ramakrishnan, S., & Chakkaravarthi, S. (2021) · Food Research International · doi:10.1016/j.foodres.2021.110189 · Cited by 502 · see citing works
Influence of high-fat diet on gut microbiota
Murphy, E. A., Velázquez, K. T., & Herbert, K. (2015) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0000000000000209 · Cited by 495 · see citing works
Zhao, L., Zhang, Q., Ma, W., Tian, F., Shen, H., & Zhou, M. (2017) · Food & Function · doi:10.1039/c7fo01383c · Cited by 492 · see citing works
Polyphenol-Mediated Gut Microbiota Modulation: Toward Prebiotics and Further
Rodríguez-Daza, M.-C., Pulido-Mateos, E. C., Lupien‐Meilleur, J., Guyonnet, D., Desjardins, Y., & Roy, D. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2021.689456 · Cited by 490 · see citing works
Self-citationOscillospira - a candidate for the next-generation probiotics
Yang, J., Li, Y., Wen, Z., Liu, W., Meng, L., & Huang, H. (2021) · Gut Microbes · doi:10.1080/19490976.2021.1987783 · Cited by 484 · see citing works
The Intestinal Immune System in Obesity and Insulin Resistance
Winer, D. A., Luck, H., Tsai, S. J., & Winer, S. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.01.003 · Cited by 476 · see citing works
The Human Microbiome and Obesity: Moving beyond Associations
Maruvada, P., Leone, V., Kaplan, L. M., & Chang, E. B. (2017) · Cell Host & Microbe · doi:10.1016/j.chom.2017.10.005 · Cited by 468 · see citing works
Tomás‐Barberán, F. A., González‐Sarrías, A., García‐Villalba, R., Núñez‐Sánchez, M. A., Selma, M. V., García‐Conesa, M. T., & Espín, J. C. (2017) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201500901 · Cited by 465 · see citing works
Do, M. H., Lee, E., Oh, M.-J., Kim, Y., & Park, H.-Y. (2018) · Nutrients · doi:10.3390/nu10060761 · Cited by 441 · see citing works
Nutrients and Oxidative Stress: Friend or Foe?
Tan, B. L., Norhaizan, M. E., & Liew, W.-P.-P. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/9719584 · Cited by 437 · see citing works
A next generation probiotic, Akkermansia muciniphila
Zhai, Q., Feng, S., Narbad, A., & Chen, W. (2018) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2018.1517725 · Cited by 437 · see citing works
Rodrigues, V. F., Elias‐Oliveira, J., Pereira, Í. S., Pereira, J. A., Barbosa, S. C., Machado, M. S. G., & Carlos, D. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.934695 · Cited by 420 · see citing works
Dietary Polyphenol, Gut Microbiota, and Health Benefits
Wang, X., Qi, Y., & Zheng, H. (2022) · Antioxidants · doi:10.3390/antiox11061212 · Cited by 412 · see citing works
Kaliannan, K., Wang, B., Li, X., Kim, K., & Kang, J. X. (2015) · Scientific Reports · doi:10.1038/srep11276 · Cited by 362 · see citing works
Interactions of gut microbiota with dietary polyphenols and consequences to human health
Tomás-Barberán, F. A., Selma, M. V., & Espı́n, J. C. (2016) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0000000000000314 · Cited by 359 · see citing works
Rao, Y., Kuang, Z., Li, C., Guo, S., Xu, Y., Zhao, D., Hu, Y., Song, B., Jiang, Z., Ge, Z., et al. (2021) · Gut Microbes · doi:10.1080/19490976.2021.1927633 · Cited by 356 · see citing works
Gut symbionts alleviate MASH through a secondary bile acid biosynthetic pathway
Nie, Q., Luo, X., Wang, K., Ding, Y., Jia, S., Zhao, Q., Li, M., Zhang, J., Zhuo, Y., Lin, J., et al. (2024) · Cell · doi:10.1016/j.cell.2024.03.034 · Cited by 347 · see citing works
Çatalkaya, G., Venema, K., Lucini, L., Rocchetti, G., Delmas, D., Daglia, M., Filippis, A. D., Xiao, H., Quiles, J. L., Xiao, J., et al. (2020) · Food Frontiers · doi:10.1002/fft2.25 · Cited by 339 · see citing works
Curcumin, Quercetin, Catechins and Metabolic Diseases: The Role of Gut Microbiota
Shabbir, U., Rubab, M., Daliri, E. B., Chelliah, R., Javed, A., & Oh, D. (2021) · Nutrients · doi:10.3390/nu13010206 · Cited by 338 · see citing works
The gut microbiota in obesity and weight management: microbes as friends or foe?
Hul, M. V., & Cani, P. D. (2023) · Nature Reviews Endocrinology · doi:10.1038/s41574-022-00794-0 · Cited by 335 · see citing works
Meta-Analysis Reveals Reproducible Gut Microbiome Alterations in Response to a High-Fat Diet
Bisanz, J. E., Upadhyay, V., Turnbaugh, J. A., Ly, K., & Turnbaugh, P. J. (2019) · Cell Host & Microbe · doi:10.1016/j.chom.2019.06.013 · Cited by 333 · see citing works
How gut microbes talk to organs: The role of endocrine and nervous routes
Cani, P. D., & Knauf, C. (2016) · Molecular Metabolism · doi:10.1016/j.molmet.2016.05.011 · Cited by 329 · see citing works
Vallianou, N. G., Stratigou, T., Christodoulatos, G. S., & Dalamaga, Μ. (2019) · Current Obesity Reports · doi:10.1007/s13679-019-00352-2 · Cited by 320 · see citing works
Unraveling Anthocyanin Bioavailability for Human Health
Lila, M. A., Burton‐Freeman, B. M., Grace, M. H., & Kalt, W. (2016) · Annual Review of Food Science and Technology · doi:10.1146/annurev-food-041715-033346 · Cited by 318 · see citing works
Prebiotic effect of dietary polyphenols: A systematic review
Alves, A. M., Sugizaki, C. S. D. A., Lima, G. C., & Naves, M. M. V. (2020) · Journal of Functional Foods · doi:10.1016/j.jff.2020.104169 · Cited by 316 · see citing works
Jiao, X., Wang, Y., Lin, Y., Lang, Y., Li, E., Zhang, X., Zhang, Q., Feng, Y., Meng, X., & Li, B. (2018) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2018.07.008 · Cited by 310 · see citing works
TMAO: how gut microbiota contributes to heart failure
Zhang, Y., Wang, Y., Ke, B., & Du, J. (2020) · Translational research · doi:10.1016/j.trsl.2020.08.007 · Cited by 306 · see citing works
Zhou, K. (2017) · Journal of Functional Foods · doi:10.1016/j.jff.2017.03.045 · Cited by 305 · see citing works
Flavonoids, Dairy Foods, and Cardiovascular and Metabolic Health
Mozaffarian, D., & Wu, J. H. Y. (2018) · Circulation Research · doi:10.1161/circresaha.117.309008 · Cited by 305 · see citing works
Fujio, S., Vasquez, Y., Morales, P., Magne, F., Vera-Wolf, P., Ugalde, J. A., Navarrete, P., & Gotteland, M. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.01221 · Cited by 304 · see citing works
Dietary polyphenols as antidiabetic agents: Advances and opportunities
Sun, C., Zhao, C., Çapanoğlu, E., Paoli, P., Simal‐Gándara, J., Ramkumar, K. M., Wang, S., Buleu, F. N., Pah, A.-M., Turi, V., et al. (2020) · Food Frontiers · doi:10.1002/fft2.15 · Cited by 303 · see citing works
Resveratrol-induced gut microbiota reduces obesity in high-fat diet-fed mice
Wang, P., Li, D., Ke, W., Liang, D., Hu, X., & Chen, F. (2020) · International Journal of Obesity · doi:10.1038/s41366-019-0332-1 · Cited by 301 · see citing works
Gut liver brain axis in diseases: the implications for therapeutic interventions
Yan, M., Man, S., Sun, B., Ma, L., Guo, L., Huang, L., & Gao, W. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01673-4 · Cited by 301 · see citing works
Akkermansia muciniphila improves metabolic profiles by reducing inflammation in chow diet-fed mice
Zhao, S., Liu, W., Wang, J., Shi, J., Sun, Y., Wang, W., Ning, G., Liu, R., & Hong, J. (2017) · Journal of Molecular Endocrinology · doi:10.1530/jme-16-0054 · Cited by 298 · see citing works
Dietary polyphenols to combat the metabolic diseases via altering gut microbiota
Gowd, V., Karim, N., Shishir, M. R. I., Xie, L., & Chen, W. (2019) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2019.09.005 · Cited by 294 · see citing works
Lordan, C., Thapa, D., Ross, R. P., & Cotter, P. D. (2020) · Gut Microbes · doi:10.1080/19490976.2019.1613124 · Cited by 289 · see citing works
Polyphenols, food and pharma. Current knowledge and directions for future research
Tresserra‐Rimbau, A., Lamuela-Raventós, R. M., & Moreno, J. J. (2018) · Biochemical Pharmacology · doi:10.1016/j.bcp.2018.07.050 · Cited by 281 · see citing works
Pei, R., Liu, X., & Bolling, B. W. (2020) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2019.12.018 · Cited by 276 · see citing works
Anhê, F. F., Nachbar, R. T., Varin, T. V., Trottier, J., Dudonné, S., Barz, M. L., Feutry, P., Pilon, G., Barbier, O., Desjardins, Y., et al. (2018) · Gut · doi:10.1136/gutjnl-2017-315565 · Cited by 272 · see citing works
Self-citationRegulation of Gut Microbiota and Metabolic Endotoxemia with Dietary Factors
Fuke, N., Nagata, N., Suganuma, H., & Ota, T. (2019) · Nutrients · doi:10.3390/nu11102277 · Cited by 269 · see citing works
Berry polyphenols metabolism and impact on human gut microbiota and health
Lavefve, L., Howard, L. R., & Carbonero, F. G. (2019) · Food & Function · doi:10.1039/c9fo01634a · Cited by 269 · see citing works
Gut microorganisms as promising targets for the management of type 2 diabetes
Delzenne, N. M., Cani, P. D., Everard, A., Neyrinck, A. M., & Bindels, L. B. (2015) · Diabetologia · doi:10.1007/s00125-015-3712-7 · Cited by 264 · see citing works
Curtis, P. J., van der Velpen, V., Berends, L. M., Jennings, A., Feelisch, M., Umpleby, A. M., Evans, M. L., Fernandez, B. O., Meiss, M. S., Minnion, M., et al. (2018) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqy380 · Cited by 263 · see citing works
Mosele, J. I., Macià, A., & Motilva, M. (2015) · Molecules · doi:10.3390/molecules200917429 · Cited by 261 · see citing works
Pap, N., Fidelis, M., Azevedo, L. C., do Carmo, M. A. V., Wang, D., Mocan, A., Pereira, E. P. R., Xavier-Santos, D., Sant’Ana, A. S., Yang, B., et al. (2021) · Current Opinion in Food Science · doi:10.1016/j.cofs.2021.06.003 · Cited by 259 · see citing works
Rethinking healthy eating in light of the gut microbiome
Armet, A. M., Deehan, E. C., O’Sullivan, A. F., Mota, J. F., Field, C. J., Prado, C. M., Lucey, A. J., & Walter, J. (2022) · Cell Host & Microbe · doi:10.1016/j.chom.2022.04.016 · Cited by 252 · see citing works
Saccon, T. D., Nagpal, R., Yadav, H., Cavalcante, M. B., Nunes, A. D. D. C., Schneider, A., Gesing, A., Hughes, B., Yousefzadeh, M., Tchkonia, T., et al. (2021) · The Journals of Gerontology: Series A · doi:10.1093/gerona/glab002 · Cited by 247 · see citing works
Akkermansia muciniphila: biology, microbial ecology, host interactions and therapeutic potential
Ioannou, A., Berkhout, M. D., Geerlings, S. Y., & Belzer, C. (2024) · Nature Reviews Microbiology · doi:10.1038/s41579-024-01106-1 · Cited by 245 · see citing works
Impact of Fecal Microbiota Transplantation on Obesity and Metabolic Syndrome—A Systematic Review
Zhang, Z., Mocanu, V., Cai, C., Dang, J. T., Slater, L., Deehan, E. C., Walter, J., & Madsen, K. L. (2019) · Nutrients · doi:10.3390/nu11102291 · Cited by 235 · see citing works
Zhang, W., Zou, G.-L., Li, B., Du, X., Sun, Z., Sun, Y., & Jiang, X. (2020) · Journal of Microbiology and Biotechnology · doi:10.4014/jmb.2002.02044 · Cited by 233 · see citing works
Wang, P., Gao, J., Ke, W., Wang, J., Li, D., Liu, R., Jia, Y., Wang, X., Chen, X., Chen, F., et al. (2020) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2020.04.013 · Cited by 232 · see citing works
Review of Functional and Pharmacological Activities of Berries
Головинская, О., & Wang, C. (2021) · Molecules · doi:10.3390/molecules26133904 · Cited by 232 · see citing works
Gil‐Cardoso, K., Ginés, I., Pinent, M., Ardèvol, A., Blay, M., & Terra, X. (2016) · Nutrition Research Reviews · doi:10.1017/s0954422416000159 · Cited by 229 · see citing works
Newsholme, P., Keane, K. N., Carlessi, R., & Cruzat, V. F. (2019) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00141.2019 · Cited by 226 · see citing works
Eker, M. E., Aaby, K., Budić-Leto, I., Brnčić, S. R., El, S. N., Karakaya, S., Şimşek, Ş., Manach, C., Wiczkowski, W., & de Pascual‐Teresa, S. (2019) · Foods · doi:10.3390/foods9010002 · Cited by 222 · see citing works
The Interaction between Flavonoids and Intestinal Microbes: A Review
Xiong, H.-H., Lin, S.-Y., Chen, L., Ouyang, K., & Wang, W. (2023) · Foods · doi:10.3390/foods12020320 · Cited by 222 · see citing works
Sun, L., Wang, Y., & Miao, M. (2020) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2020.08.003 · Cited by 221 · see citing works
Masumoto, S., Terao, A., Yamamoto, Y., Mukai, T., Miura, T., & Shoji, T. (2016) · Scientific Reports · doi:10.1038/srep31208 · Cited by 218 · see citing works
Modulation of the human gut microbiota by phenolics and phenolic fiber‐rich foods
Loo, Y. T., Howell, K. S., Chan, M., Zhang, P., & Ng, K. (2020) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.12563 · Cited by 216 · see citing works
The gut microbiome: a core regulator of metabolism
Fujisaka, S., Watanabe, Y., & Tobe, K. (2022) · Journal of Endocrinology · doi:10.1530/joe-22-0111 · Cited by 217 · see citing works
Dey, P. (2019) · Pharmacological Research · doi:10.1016/j.phrs.2019.104367 · Cited by 215 · see citing works
Li, X., Watanabe, K., & Kimura, I. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01882 · Cited by 209 · see citing works
Fernandez, M. A., & Marette, A. (2017) · Advances in Nutrition · doi:10.3945/an.115.011114 · Cited by 207 · see citing works
Self-citationNie, Q., Chen, H., Hu, J., Fan, S., & Nie, S. (2018) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2018.1536646 · Cited by 205 · see citing works
Sun, L., Pang, Y., Wang, X., Wu, Q., Liu, H., Liu, B., Liu, C., Ye, M., Kong, W., & Jiang, C. (2019) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2019.02.004 · Cited by 205 · see citing works
Wang, K., Jin, X., Li, Q., Sawaya, A. C. H. F., Leu, R. K. L., Conlon, M. A., Wu, L., & Hu, F. (2018) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201800080 · Cited by 204 · see citing works
de Souza, E. L., de Albuquerque, T. M. R., dos Santos, A. S., Massa, N. M. L., & Alves, J. L. D. B. (2018) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2018.1425285 · Cited by 200 · see citing works
Interactions between CYP3A4 and Dietary Polyphenols
Basheer, L., & Kerem, Z. (2015) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2015/854015 · Cited by 198 · see citing works
Kang, I., Buckner, T., Shay, N. F., Gu, L., & Chung, S. (2016) · Advances in Nutrition · doi:10.3945/an.116.012575 · Cited by 198 · see citing works
Gut microbiome and metabolic syndrome
Mazidi, M., Rezaie, P., Kengne, A. P., Ghayour‐Mobarhan, M., & Ferns, G. A. (2016) · Diabetes & Metabolic Syndrome Clinical Research & Reviews · doi:10.1016/j.dsx.2016.01.024 · Cited by 194 · see citing works
Lyu, M., Wang, Y., Fan, G., Wang, X., Xu, S.-Y., & Zhu, Y. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.02146 · Cited by 193 · see citing works
Beneficial Effects of Phenolic Compounds on Gut Microbiota and Metabolic Syndrome
Kasprzak‐Drozd, K., Oniszczuk, T., Stasiak, M., & Oniszczuk, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22073715 · Cited by 193 · see citing works
Berry anthocyanin intake and cardiovascular health
Cassidy, A. (2017) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2017.05.002 · Cited by 192 · see citing works
Dietary cellulose prevents gut inflammation by modulating lipid metabolism and gut microbiota
Kim, Y., Hwang, S. W., Kim, S., Lee, Y., Kim, T., Lee, S.-H., Kim, S. J., Yoo, H. J., Kim, E. N., & Kweon, M. (2020) · Gut Microbes · doi:10.1080/19490976.2020.1730149 · Cited by 192 · see citing works
Alard, J., Lehrter, V., Rhimi, M., Mangin, I., Peucelle, V., Abraham, A., Mariadassou, M., Maguin, E., Waligora‐Dupriet, A., Pot, B., et al. (2015) · Environmental Microbiology · doi:10.1111/1462-2920.13181 · Cited by 190 · see citing works
- Authors
- Anhê, F. F., Roy, D., Pilon, G., Dudonné, S., Matamoros, S., Varin, T. V., Garofalo, C., Moine, Q., Desjardins, Y., Levy, E., & Marette, A.
- Affiliations
- Institut universitaire de cardiologie et de pneumologie de Québec (CA)
- Université Laval (CA)
- Centre Hospitalier Universitaire Sainte-Justine (CA)
- Corresponding author
- Marette, André
- ORCID
- Venue
- Gut
- Publisher
- BMJ
- Published
- 2014-07-30
- Volume
- 64
- Issue
- 6
- Pages
- 872-883
- ISSN
- 0017-5749 (ISSN-L)
- 1468-3288
- OpenAlex
- W2099456560
- Cited by
- 1,137
- References
- 75
- Citations by year
- 2026: 53 · 2025: 85 · 2024: 86 · 2023: 98 · 2022: 128 · 2021: 175 · 2020: 134 · 2019: 117 · 2018: 83 · 2017: 71 · 2016: 62 · 2015: 45
- FWCI
- 24.34
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Gut (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Université Laval
- Ministère du Développement Économique, de l’Innovation et de l’Exportation
- Agence Universitaire de la Francophonie
- Institut sur la Nutrition et les Aliments Fonctionnels
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- cranberry extract, cranberry, polyphenols, diet-induced obesity, insulin resistance, type 2 diabetes, gut microbiota, Akkermansia, high-fat high-sugar diet, visceral obesity, hepatic steatosis, hepatic oxidative stress, intestinal inflammation, metabolic syndrome, mucin-degrading bacteria
- MeSH terms
- Animals, Enteritis, Hepatitis, Homeostasis, Insulin Resistance, Intestines, Lipids, Lipopolysaccharides, Liver, Male, Mice, Inbred C57BL, Organ Size, Plant Extracts, Triglycerides, Endotoxemia, Vaccinium macrocarpon, Lipid Metabolism, Mice, Obesity, Abdominal, Diet, High-Fat, Polyphenols, Verrucomicrobia, Microbiota
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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