Role of dietary carbohydrates and macronutrients in the pathogenesis of nonalcoholic fatty liver disease
Abstract
PURPOSE OF REVIEW: The prevalence of nonalcoholic fatty liver disease is increasing worldwide and there is strong evidence that dietary factors play a role in its pathogenesis. The present review aims to provide a better understanding of how carbohydrates and other macronutrients may affect the disease. RECENT FINDINGS: The effects of carbohydrates on the development of nonalcoholic fatty liver disease differ depending upon the carbohydrate type; high-glycemic index foods are related to increased hepatic fat in both rodents and humans. Similarly, simple carbohydrates, such as fructose, stimulate hepatic de-novo lipogenesis and decrease lipid oxidation, thus leading to increased fat deposition. The underlying mechanisms may involve the activation of transcription factors. Fat intake broadly leads to hepatic fat deposition in rodents but few data are available on humans. Both carbohydrates and fat trigger inflammatory factors, which are closely related to metabolic disorders and nonalcoholic fatty liver disease. Lifestyle interventions appear to be the most appropriate first-line treatment for nonalcoholic fatty liver disease. SUMMARY: There is strong evidence that the diet may affect the development of nonalcoholic fatty liver disease. Although simple carbohydrates are clearly shown to have deleterious effects in humans, the role of fat remains controversial. Further studies will be required to evaluate the effects of macronutrient composition on the development of nonalcoholic fatty liver disease.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
This rapid digestion may induce multiple adverse effects, potentially stimulating reward/craving areas in the brain, activating hepatic de novo lipogenesis, increasing uric acid production, and promoting visceral adiposity.
“This rapid digestion may induce multiple adverse effects, potentially stimulating reward/craving areas in the brain, activating hepatic de novo lipogenesis, increasing uric acid production, and promoting visceral adiposity.49, 162-166”
From Dietary and Policy Priorities for Cardiovascular Disease, Diabetes, and Obesity: A Comprehensive Review (2016) · cites this paper as [162]
Poor quality carbohydrates are associated with long-term weight gain, diabetes, and CVD.
“Consistent with this constellation of adverse effects, poor quality carbohydrates are associated with long-term weight gain, diabetes, and CVD.29, 89, 158, 167”
From Dietary and Policy Priorities for Cardiovascular Disease, Diabetes, and Obesity: A Comprehensive Review (2016) · cites this paper as [162]
Cites
1 retracted
Tsukumo, D. M. L., Carvalho-Filho, M. A., Carvalheira, J. B. C., Prada, P. O., Hirabara, S. M., Schenka, A. A., Araújo, E. P., Vassallo, J., Curi, R., Velloso, L. A., et al. (2007) · Diabetes · doi:10.2337/db06-1595 · Cited by 826 · see citing works
RetractedSteatohepatitis: A tale of two “hits”?
Day, C. P., & James, O. F. W. (1998) · Gastroenterology · doi:10.1016/s0016-5085(98)70599-2 · Cited by 4,285 · see citing works
Nonalcoholic Fatty Liver Disease
Marchesini, G., Brizi, M., Bianchi, G., Tomassetti, S., Bugianesi, E., Lenzi, M., McCullough, A. J., Natale, S., Forlani, G., & Melchionda, N. (2001) · Diabetes · doi:10.2337/diabetes.50.8.1844 · Cited by 2,581 · see citing works
Nonalcoholic Fatty Liver Disease: From Steatosis to Cirrhosis
Farrell, G. C., & Larter, C. Z. (2006) · Hepatology · doi:10.1002/hep.20973 · Cited by 2,413 · see citing works
Inflammation: the link between insulin resistance, obesity and diabetes
Dandona, P. (2004) · Trends in Immunology · doi:10.1016/j.it.2003.10.013 · Cited by 2,170 · see citing works
Consumption of high-fructose corn syrup in beverages may play a role in the epidemic of obesity
Bray, G. A., Nielsen, S. J., & Popkin, B. M. (2004) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/79.4.537 · Cited by 1,990 · see citing works
Mechanism of hepatic insulin resistance in non-alcoholic fatty liver disease
Samuel, V. T., Liu, Z.-X., Qu, X., Elder, B. D., Bilz, S., Befroy, D., Romanelli, A. J., & Shulman, G. I. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m313478200 · Cited by 1,322 · see citing works
Liu, S., Willett, W. C., Stampfer, M. J., Hu, F. B., Franz, M., Sampson, L., Hennekens, C. H., & Manson, J. E. (2000) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/71.6.1455 · Cited by 1,166 · see citing works
Fructose, weight gain, and the insulin resistance syndrome,,
Elliott, S. S., Keim, N. L., Stern, J. S., Teff, K. L., & Havel, P. J. (2002) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/76.5.911 · Cited by 1,031 · see citing works
Befroy, D. E., Petersen, K. F., Dufour, S., Mason, G. F., de Graaf, R. A., Rothman, D. L., & Shulman, G. I. (2007) · Diabetes · doi:10.2337/db06-0783 · Cited by 453 · see citing works
Savage, D. B. (2006) · Journal of Clinical Investigation · doi:10.1172/jci27300 · Cited by 447 · see citing works
Liver-Specific Inhibition of ChREBP Improves Hepatic Steatosis and Insulin Resistance in ob/ob Mice
Dentin, R., Benhamed, F., Hainault, I., Fauveau, V., Foufelle, F., Dyck, J. R. B., Girard, J. R., & Postic, C. (2006) · Diabetes · doi:10.2337/db06-0200 · Cited by 429 · see citing works
Zivkovic, A. M., German, J. B., & Sanyal, A. J. (2007) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/86.2.285 · Cited by 418 · see citing works
Carbohydrate response element binding protein directly promotes lipogenic enzyme gene transcription
Ishii, S., Iizuka, K., Miller, B. C., & Uyeda, K. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0405238101 · Cited by 416 · see citing works
Faeh, D., Minehira, K., Schwarz, J., Periasamy, R., Park, S., & Tappy, L. (2005) · Diabetes · doi:10.2337/diabetes.54.7.1907 · Cited by 387 · see citing works
Ota, T., Gayet, C., & Ginsberg, H. N. (2008) · Journal of Clinical Investigation · doi:10.1172/jci32752 · Cited by 376 · see citing works
Treatment of non-alcoholic fatty liver disease
Adams, L. A., & Angulo, P. (2006) · Postgraduate Medical Journal · doi:10.1136/pgmj.2005.042200 · Cited by 349 · see citing works
Foxo1 mediates insulin action on apoC-III and triglyceride metabolism
Altomonte, J., Lin, C., Harbaran, S., Richter, A. M., Xu, J., Meseck, M. L., & Dong, H. H. (2004) · Journal of Clinical Investigation · doi:10.1172/jci19992 · Cited by 310 · see citing works
Dietary Factors Alter Hepatic Innate Immune System in Mice With Nonalcoholic Ratty Liver Disease * #
Li, Z., Soloski, M. J., & Diehl, A. M. (2005) · Hepatology · doi:10.1002/hep.20826 · Cited by 294 · see citing works
Nonalcoholic fatty liver disease: predisposing factors and the role of nutrition
Cave, M. C., Deaciuc, I. V., Mendez, C. M., Song, Z., Joshi‐Barve, S., Barve, S. S., & McClain, C. J. (2007) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2006.12.006 · Cited by 290 · see citing works
Lê, K., Faeh, D., Stettler, R., Ith, M., Kreis, R., Vermathen, P., Boesch, C., Ravussin, É., & Tappy, L. (2006) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/84.6.1374 · Cited by 289 · see citing works
Self-citationKlein, S., Mittendorfer, B., Eagon, J. C., Patterson, B. W., Grant, L. M., Feirt, N. M., Seki, E., Brenner, D. A., Korenblat, K., & McCrea, J. (2006) · Gastroenterology · doi:10.1053/j.gastro.2006.01.042 · Cited by 288 · see citing works
Pathogenesis and management issues for non-alcoholic fatty liver disease
Duvnjak, M. (2007) · World Journal of Gastroenterology · doi:10.3748/wjg.v13.i34.4539 · Cited by 265 · see citing works
Dietary habits and nutrient intake in non-alcoholic steatohepatitis
Toshimitsu, K., Matsuura, B., Ohkubo, I., Niiya, T., Furukawa, S., Hiasa, Y., Kawamura, M., Ebihara, K., & Onji, M. (2006) · Nutrition · doi:10.1016/j.nut.2006.09.004 · Cited by 264 · see citing works
Foxo1 mediates insulin action on apoC-III and triglyceride metabolism
Altomonte, J., Lin, C., Harbaran, S., et al. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200419992 · Cited by 260 · see citing works
Lê, K., & Tappy, L. (2006) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/01.mco.0000232910.61612.4d · Cited by 249 · see citing works
Self-citationHow different is the dietary pattern in non-alcoholic steatohepatitis patients?
Cortez‐Pinto, H., Jesus, L., Barros, H., Lopes, C. M. M., de Moura, M. C., & Camilo, M. (2006) · Clinical Nutrition · doi:10.1016/j.clnu.2006.01.027 · Cited by 245 · see citing works
High-fat emulsion-induced rat model of nonalcoholic steatohepatitis
Zou, Y., Li, J., Lü, C., Wang, J., Ge, J., Huang, Y., Zhang, L., & Wang, Y. (2006) · Life Sciences · doi:10.1016/j.lfs.2006.03.021 · Cited by 239 · see citing works
Approach to the Pathogenesis and Treatment of Nonalcoholic Steatohepatitis
Medina, J., Fernández-Salazar, L. I., García-Buey, L., & Moreno‐Otero, R. (2004) · Diabetes Care · doi:10.2337/diacare.27.8.2057 · Cited by 229 · see citing works
Impairment of hepatic Stat-3 activation and reduction of PPARα activity in fructose-fed rats
Roglans, N., Vilà, L., Farré, M., Alegret, M., Sánchez, R. M., Vázquez‐Carrera, M., & Laguna, J. C. (2007) · Hepatology · doi:10.1002/hep.21499 · Cited by 221 · see citing works
The myth of the metabolic syndrome
Gale, E. A. (2005) · Diabetologia · doi:10.1007/s00125-005-1873-5 · Cited by 217 · see citing works
Dietary Composition and Nonalcoholic Fatty Liver Disease
Solga, S. F., Alkhuraishe, A. R., Clark, J. M., TORBENSON, M., Greenwald, A., Diehl, A. M., & Magnuson, T. H. (2004) · Digestive Diseases and Sciences · doi:10.1023/b:ddas.0000043367.69470.b7 · Cited by 214 · see citing works
Macrophage TNF-α contributes to insulin resistance and hepatic steatosis in diet-induced obesity
De Taeye, B. M., Novitskaya, T., McGuinness, O. P., Gleaves, L., Medda, M., Covington, J. W., & Vaughan, D. E. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00194.2007 · Cited by 208 · see citing works
Effects of bariatric surgery on nonalcoholic fatty liver disease: Preliminary findings after 2 years
Furuya, C. K., De Oliveira, C. P. M. S., De Mello, E. S., Faintuch, J., Raskovski, A., Matsuda, M., Vezozzo, D. C. P., Halpern, A., Garrido, A. B., Alves, V. A. F., et al. (2007) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2007.04833.x · Cited by 193 · see citing works
Kang, H., Greenson, J. K., Omo, J. T., Chao, C., Peterman, D., Anderson, L., Foess-Wood, L., Sherbondy, M. A. H., & Conjeevaram, H. S. (2006) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2006.00719.x · Cited by 178 · see citing works
Plasma PAI-1 Levels Are More Strongly Related to Liver Steatosis Than to Adipose Tissue Accumulation
Alessi, M., Bastelica, D., Mavri, A., Morange, P., Berthet, B., Grino, M., & Juhan-Vague, I. (2003) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000077401.36885.bb · Cited by 178 · see citing works
Animal models of steatohepatitis
Koteish, A. A., & Diehl, A. M. (2002) · Best Practice & Research Clinical Gastroenterology · doi:10.1053/bega.2002.0332 · Cited by 175 · see citing works
Seppala-Lindroos, A. (2002) · Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.87.7.3023 · Cited by 168 · see citing works
Resolution of nonalcoholic steatohepatits after gastric bypass surgery
Liu, X., Lazenby, A. J., Clements, R. H., Jhala, N., & Abrams, G. A. (2007) · Obesity Surgery · doi:10.1007/s11695-007-9086-2 · Cited by 149 · see citing works
Is weight reduction an effective therapy for nonalcoholic fatty liver?
Wang, R. T., Koretz, R. L., & Yee, H. F. (2003) · The American Journal of Medicine · doi:10.1016/s0002-9343(03)00449-2 · Cited by 148 · see citing works
Non-alcoholic steatohepatitis and metabolic syndrome
Machado, M. V., & Cortez‐Pinto, H. (2006) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/01.mco.0000241677.40170.17 · Cited by 133 · see citing works
PPARα mediates the hypolipidemic action of fibrates by antagonizing FoxO1
Qu, S., Su, D., Altomonte, J., Kamagaté, A., He, J., Perdomo, G., Tse, T. E., Jiang, Y., & Dong, H. H. (2006) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00157.2006 · Cited by 111 · see citing works
Roux-en-Y Gastric Bypass Improves the Nonalcoholic Steatohepatitis (NASH) of Morbid Obesity
Sanches, S. R. D. A., Rocha, P. S., Sanches, M. D., Leite, V. R., Pinto-Silva, R. A., Diniz, M. T. C., Diniz, M. D. F. H. S., & Rocha, A. S. (2006) · Obesity Surgery · doi:10.1381/096089206776116462 · Cited by 107 · see citing works
Thomas, E. L. (2006) · World Journal of Gastroenterology · doi:10.3748/wjg.v12.i36.5813 · Cited by 102 · see citing works
Ryan, M. C., Abbasi, F., Lamendola, C. A., Carter, S., & McLaughlin, T. (2007) · Diabetes Care · doi:10.2337/dc06-2169 · Cited by 100 · see citing works
Fructose-mediated stress signaling in the liver: implications for hepatic insulin resistance
Wei, Y., Wang, D., Topczewski, F., & Pagliassotti, M. J. (2006) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2006.03.013 · Cited by 97 · see citing works
Heilbronn, L. K., Gregersen, S., Shirkhedkar, D., Hu, D., & Campbell, L. V. (2007) · Diabetes · doi:10.2337/db06-1687 · Cited by 70 · see citing works
Hepatic Steatosis and Increased Adiposity in Mice Consuming Rapidly vs. Slowly Absorbed Carbohydrate
Scribner, K. B., Pawlak, D. B., & Ludwig, D. S. (2007) · Obesity · doi:10.1038/oby.2007.260 · Cited by 69 · see citing works
EFFECTS OF FENOFIBRATE AND XUEZHIKANG ON HIGH‐FAT DIET‐INDUCED NON‐ALCOHOLIC FATTY LIVER DISEASE
Hong, X., Li, L. D., & Wu, L. M. (2006) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.2007.04547.x · Cited by 54 · see citing works
Yamazaki, T., Nakamori, A., Sasaki, E., Wada, S., & Ezaki, O. (2007) · Hepatology · doi:10.1002/hep.21934 · Cited by 50 · see citing works
Choudhury, J. (2005) · Frontiers in bioscience · doi:10.2741/1636 · Cited by 48 · see citing works
Xu, P., Zhang, X., Li, Y., Yu, C., Xu, L., & Xu, G.-Y. (2006) · Journal of Zhejiang University SCIENCE B · doi:10.1631/jzus.2006.b0627 · Cited by 46 · see citing works
Gill, H., & Wu, G. Y. (2006) · World Journal of Gastroenterology · doi:10.3748/wjg.v12.i3.345 · Cited by 42 · see citing works
Effects of four-week high-fructose diet on gene expression in skeletal muscle of healthy men
Lê, K., Faeh, D., Stettler, R., Debard, C., Loizon, E., Vidal, H., Boesch, C., Ravussin, É., & Tappy, L. (2007) · Diabetes & Metabolism · doi:10.1016/j.diabet.2007.08.004 · Cited by 41 · see citing works
Self-citationChanges in Gene Expression in Skeletal Muscle in Response to Fat Overfeeding in Lean Men
Meugnier, E., Bossu, C., Oliel, M., Jeanne, S., Michaut, A., Sothier, M., Brozek, J., Rome, S., Laville, M., & Vidal, H. (2007) · Obesity · doi:10.1038/oby.2007.310 · Cited by 39 · see citing works
Biological evaluation of crab meat (Scylla-Serrata)in the rat
Gangal, S. V., & Magar, N. G. (1967) · British Journal Of Nutrition · doi:10.1079/bjn19670003 · Cited by 36 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Mozaffarian, D. (2016) · Circulation · doi:10.1161/circulationaha.115.018585 · Cited by 2,216 · see citing works
The role of fructose in the pathogenesis of NAFLD and the metabolic syndrome
Lim, J. S., Mietus-Snyder, M., Valente, A., Schwarz, J.-M., & Lustig, R. H. (2010) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2010.41 · Cited by 771 · see citing works
Toll-Like Receptor 4 Is Involved in the Development of Fructose-Induced Hepatic Steatosis in Mice†
Spruss, A., Kanuri, G., Wagnerberger, S., Haub, S., Bischoff, S. C., & Bergheim, I. (2009) · Hepatology · doi:10.1002/hep.23122 · Cited by 563 · see citing works
Trauner, M., Arrese, M. A., & Wagner, M. (2009) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2009.10.007 · Cited by 291 · see citing works
Volynets, V., Küper, M. A., Strahl, S., Maier, I. B., Spruss, A., Wagnerberger, S., Königsrainer, A., Bischoff, S. C., & Bergheim, I. (2012) · Digestive Diseases and Sciences · doi:10.1007/s10620-012-2112-9 · Cited by 268 · see citing works
Oddy, W. H., Herbison, C. E., Jacoby, P., Ambrosini, G. L., O’Sullivan, T. A., Ayonrinde, O. T., Olynyk, J. K., Black, L. J., Beilin, L. J., Mori, T. A., et al. (2013) · The American Journal of Gastroenterology · doi:10.1038/ajg.2013.95 · Cited by 259 · see citing works
Diet and liver cancer risk: a narrative review of epidemiological evidence
Yang, W., Zeng, X., Liu, Z., Zhao, Q.-H., Tan, Y., Gao, J., Li, H., & Xiang, Y. (2020) · British Journal Of Nutrition · doi:10.1017/s0007114520001208 · Cited by 164 · see citing works
Ullah, R., Rauf, N., Nabi, G., Ullah, H., Shen, Y., Zhou, Y., & Fu, J. (2019) · International Journal of Biological Sciences · doi:10.7150/ijbs.30121 · Cited by 157 · see citing works
Rizvi, A. A. (2009) · The American Journal of the Medical Sciences · doi:10.1097/maj.0b013e3181a4158c · Cited by 137 · see citing works
Fedirko, V., Lukanova, A., Bamia, C., Trichopolou, A., Trépo, E., Nöthlings, U., Schlesinger, S., Aleksandrova, K., Boffetta, P., Tjønneland, A. M., et al. (2012) · Annals of Oncology · doi:10.1093/annonc/mds434 · Cited by 130 · see citing works
Trouwborst, I., Bowser, S. M., Goossens, G. H., & Blaak, E. E. (2018) · Frontiers in Nutrition · doi:10.3389/fnut.2018.00077 · Cited by 115 · see citing works
Grattagliano, I., DʼAmbrosio, G., D'Ambrozio, G., Palmieri, V. O., Moschetta, A., Palasciano, G., & Portincasa, P. (2008) · PubMed · Cited by 104 · see citing works
Mesirow, M. S. C., & Welsh, J. A. (2015) · Journal of the Academy of Nutrition and Dietetics · doi:10.1016/j.jand.2014.09.004 · Cited by 100 · see citing works
Diet high in fructose leads to an overexpression of lipocalin-2 in rat fatty liver
Alwahsh, S. M. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i7.1807 · Cited by 91 · see citing works
ATF4 deficiency protects mice from high-carbohydrate-diet-induced liver steatosis
Li, H., Meng, Q., Xiao, F., Chen, S., Du, Y., Yu, J., Wang, C., & Guo, F. (2011) · Biochemical Journal · doi:10.1042/bj20110263 · Cited by 87 · see citing works
Choi, Y., Abdelmegeed, M. A., & Song, B. (2017) · Food and Chemical Toxicology · doi:10.1016/j.fct.2017.02.039 · Cited by 81 · see citing works
Al‐Okbi, S. Y., Mohamed, D. A., Hamed, T. E.-S., & Edris, A. E. (2014) · Journal of Medicinal Food · doi:10.1089/jmf.2013.0033 · Cited by 58 · see citing works
Wanders, D., Stone, K. P., Dille, K., Simon, J., Pierse, A., & Gettys, T. W. (2015) · BioFactors · doi:10.1002/biof.1240 · Cited by 57 · see citing works
Ströhle, A., & Hahn, A. (2011) · Nutrition Research · doi:10.1016/j.nutres.2011.05.003 · Cited by 57 · see citing works
Remodeling of lipid metabolism by dietary restriction of essential amino acids
Anthony, T. G., Morrison, C. D., & Gettys, T. W. (2013) · Diabetes · doi:10.2337/db12-1613 · Cited by 52 · see citing works
Protective effect of bile acids on the onset of fructose-induced hepatic steatosis in mice
Volynets, V., Spruss, A., Kanuri, G., Wagnerberger, S., Bischoff, S. C., & Bergheim, I. (2010) · Journal of Lipid Research · doi:10.1194/jlr.m007179 · Cited by 51 · see citing works
Luo, Y., Hu, C.-T., Qiao, F., Wang, X., Qin, J. G., Du, Z., & Chen, L. (2020) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2020.113537 · Cited by 49 · see citing works
Dietary recommendations for patients with nonalcoholic fatty liver disease
Kargulewicz, A., Stankowiak-Kulpa, H., & Grzymislawski, M. B. (2014) · Gastroenterology Review · doi:10.5114/pg.2014.40845 · Cited by 42 · see citing works
Ricci, G., Canducci, E., Pasini, V., Rossi, A., Bersani, G., Ricci, E., & Alvisi, V. (2010) · Nutrition · doi:10.1016/j.nut.2010.07.014 · Cited by 38 · see citing works
Potential protective effect of Nigella sativa crude oils towards fatty liver in rats
Al‐Okbi, S. Y., Mohamed, D. A., Hamed, T. E.-S., & Edris, A. E. (2013) · European Journal of Lipid Science and Technology · doi:10.1002/ejlt.201200256 · Cited by 35 · see citing works
Oxidative stress induced by high-glucose diet in liver of C57BL/6J mice and its underlying mechanism
Du, D., Shi, Y., & Le, G. (2010) · Molecular Biology Reports · doi:10.1007/s11033-010-0039-9 · Cited by 33 · see citing works
McCarty, M. F. (2011) · Medical Hypotheses · doi:10.1016/j.mehy.2011.06.029 · Cited by 30 · see citing works
Bariatric surgery and nonalcoholic fatty liver disease
Bower, G., Athanasiou, T., Isla, A., Harling, L., Li, J. V., Holmes, E. C., Efthimiou, E., Darzi, A. W., & Ashrafian, H. (2015) · European Journal of Gastroenterology & Hepatology · doi:10.1097/meg.0000000000000375 · Cited by 26 · see citing works
İskender, H., Yenice, G., Dokumacıoğlu, E., Hayırlı, A., Sevim, Ç., Dokumacıoğlu, A., & Kapakin, K. A. T. (2018) · Archives of Physiology and Biochemistry · doi:10.1080/13813455.2018.1493609 · Cited by 25 · see citing works
Arefhosseini, S. R., Ebrahimi‐Mameghani, M., Farsad-Naeimi, A., Khoshbaten, M., & rashid, J. (2011) · Europe PMC (PubMed Central) · doi:10.5681/hpp.2011.016 · Cited by 24 · see citing works
Nutritional Status and Nutrition Quality in Patients with Non-Alcoholic Fatty Liver Disease
Bender, D. V. (2017) · Acta Clinica Croatica · doi:10.20471/acc.2017.56.04.07 · Cited by 22 · see citing works
Kunde, S. S., Roede, J. R., Vos, M. B., Orr, M. L., Go, Y., Park, Y. H., Ziegler, T. R., & Jones, D. P. (2011) · Nutrients · doi:10.3390/nu3110987 · Cited by 21 · see citing works
Lim, D., & Wang, J. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph192013076 · Cited by 20 · see citing works
Pixner, T., Stummer, N., Schneider, A.-M., Lukas, A., Gramlinger, K., Julian, V., Thivel, D., Mörwald, K., Maruszczak, K., Mangge, H., et al. (2022) · Life · doi:10.3390/life12060839 · Cited by 15 · see citing works
Collison, K. S., Zaidi, M. Z., Saleh, S. M., Makhoul, N. J., Inglis, A. L., Burrows, J., Araujo, J. A., & Al-Mohanna, F. A. (2011) · Genes & Nutrition · doi:10.1007/s12263-011-0261-7 · Cited by 14 · see citing works
Aktary, M. L., Eller, L. K., Nicolucci, A. C., & Reimer, R. A. (2020) · Food & Nutrition Research · doi:10.29219/fnr.v64.4548 · Cited by 12 · see citing works
Magalhães, G. C. B., Feitoza, F., Moreira, S., Carmo, A. V., Souto, F. J. D., Reis, S. R. L., Martins, M. S. F., & da Silva, M. H. G. G. (2013) · Journal of Human Nutrition and Dietetics · doi:10.1111/jhn.12110 · Cited by 10 · see citing works
Balstad, T. R., Paur, I., Poulsen, M., Markowski, J., Kołodziejczyk, K., Dragsted, L. O., Myhrstad, M. C. W., & Blomhoff, R. (2010) · Nutrition and Cancer · doi:10.1080/01635581003695749 · Cited by 9 · see citing works
Mohseni, F., Moghbelinejad, S., & Najafipour, R. (2017) · PubMed Central · Cited by 9 · see citing works
Freire, T., Boulhosa, R. S. S. B., de Oliveira, L. P. M., de Jesús, R. P., Cavalcante, L. N., Lemaire, D. C., Toralles, M. B. P., Lyra, L. G. C., & Lyra, A. C. (2015) · Journal of Human Nutrition and Dietetics · doi:10.1111/jhn.12327 · Cited by 7 · see citing works
Sheng, Y., Su, S., Li, Q. F., Zhang, X., & Xie, Z. (2013) · Poultry Science · doi:10.3382/ps.2012-02900 · Cited by 7 · see citing works
NUTRITIONAL STATUS, DIET AND NON-ALCOHOLIC FATTY LIVER DISEASE IN ELDERS.
Portela, C. L. D. M., Sampaio, H. A. D. C., de Melo, M. L. P., Carioca, A. A. F., Pinto, F. J. M., & Arruda, S. P. M. (2015) · PubMed · doi:10.3305/nh.2015.32.5.9674 · Cited by 7 · see citing works
Jalilian, M., Rasad, R., & Rotbeh, A. (2022) · Obesity Medicine · doi:10.1016/j.obmed.2022.100455 · Cited by 6 · see citing works
Metro, D., Buda, M., Manasseri, L., Corallo, F., Cardile, D., Buono, V. L., Quartarone, A., & Bonanno, L. (2023) · Medicina · doi:10.3390/medicina59030638 · Cited by 6 · see citing works
Farhangi, M. A., Mohseni, F., Farajnia, S., & Jafarabadi, M. A. (2016) · Journal of Translational Medicine · doi:10.1186/s12967-016-0936-3 · Cited by 5 · see citing works
Liccardo, D., Alisi, A., Porta, G., & Nobili, V. (2013) · Expert Review of Gastroenterology & Hepatology · doi:10.1586/17474124.2013.827483 · Cited by 5 · see citing works
The Effect of Weight Loss on Pediatric Nonalcoholic Fatty Liver Disease
St-Jules, D. E., Watters, C. A., Nagamori, K., & King, J. (2013) · ISRN Gastroenterology · doi:10.1155/2013/398297 · Cited by 3 · see citing works
Alcohol and Nutrition as Risk Factors for Chronic Liver Disease
Bellentani, S., Tiribelli, C., & Bedogni, G. (2012) · Humana Press eBooks · doi:10.1007/978-1-62703-047-2_38 · Cited by 3 · see citing works
OMEGA-3 FATTY ACIDS AND NON-ALCOHOLIC FATTY LIVER DISEASE
Mehdi, F., & Azadbakht, L. (2013) · Cited by 2 · see citing works
Abdoulaye, A. I., Mbaye, B., Wasfy, R. M., Carmarans, L., Beye, M., Andrieu, C., Bakour, S., Hamieh, A., Armstrong, N., Borentain, P., et al. (2026) · Gut Microbes Reports · doi:10.1080/29933935.2026.2664983 · Cited by 1 · see citing works
Ricci, G., Canducci, E., Guida, A., Arena, R., Frascari, A., Ravani, B., & Alvisi, V. (2017) · Modern Clinical Medicine Research · doi:10.22606/mcmr.2017.12002 · Cited by 1 · see citing works
Lehtonen, H.-M. (2010) · UTUPub (University of Turku) · Cited by 1 · see citing works
Levi, M. (2009) · Wiley eBooks · doi:10.1002/9780470747919.ch40
Effect of maternal diet on offspring metabolic programming: Changes induced by carbohydrate quality
Sideratou, T., Bell-Anderson, K. S., Petocz, P., & Miller, J. C. B. (2014) · Journal of Nutrition & Intermediary Metabolism · doi:10.1016/j.jnim.2014.10.121
OUTCOME OF A LOW-CARBOHYDRATE DIET ON EGYPTIAN PATIENTS WITH NON ALCOHOLIC FATTY LIVER DISEASE
Zaky, D. S. E., & MANSOUR, K. (2019) · Journal of the Egyptian Society of Parasitology · doi:10.21608/jesp.2019.68075
Adipocinas e consumo alimentar de mulheres obesas com doença hepática gordurosa não alcoólica
Magalhães, G. C. B. (2011)
Pinheiro, L. A., Sampaio, H. A. D. C., Carioca, A. A. F., Portela, C. L. D. M., Sabry, M. O. D., Passos, T. U., de Melo, M. L. P., & Pereira, I. B. (2013) · PubMed
Efeito da fibra dietética e do exercício físico resistido na doença hepática gordurosa
Peresi, V. L. (2011) · Americanae (AECID Library)
- Authors
- Lê, K.-A., & Bortolotti, M.
- Affiliations
- University of Lausanne (CH)
- Corresponding author
- Lê, Kim-Anne
- ORCID
- Lê, Kim-Anne
- Venue
- Current Opinion in Clinical Nutrition and Metabolic Care
- Published
- 2008-07
- Volume
- 11
- Issue
- 4
- Pages
- 477-482
- ISSN
- 1363-1950 (ISSN-L)
- OpenAlex
- W1977763144
- Cited by
- 60
- References
- 55
- Citations by year
- 2025: 1 · 2023: 1 · 2022: 3 · 2020: 3 · 2019: 2 · 2018: 3 · 2017: 4 · 2016: 2 · 2015: 4 · 2014: 5 · 2013: 10 · 2012: 3
- FWCI
- 0.68
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Opinion in Clinical Nutrition & Metabolic Care (publishedVersion)
- PubMed (publishedVersion)
- IRIS (submittedVersion)
- SERVAL (Université de Lausanne) (submittedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Keywords
- non-alcoholic fatty liver disease, dietary carbohydrates, macronutrients, fructose, hepatic de novo lipogenesis, hepatic lipid oxidation, hepatic lipid accumulation, high glycemic index foods, dietary fat, inflammation, lifestyle intervention, pathogenesis
- MeSH terms
- Dietary Carbohydrates, Dietary Fats, Fatty Liver, Humans, Inflammation, Insulin Resistance, Glycemic Index
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
