Remodeling of lipid metabolism by dietary restriction of essential amino acids

Anthony, Tracy G.; Morrison, Christopher D.; Gettys, Thomas W.

doi:10.2337/db12-1613

Cited by 52Dietary Effects on HealthLipid metabolism and biosynthesisDiet, Metabolism, and Disease

Remodeling of lipid metabolism by dietary restriction of essential amino acids

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Anthony, Tracy G., Morrison, Christopher D., Gettys, Thomas W.·2013·Diabetes

DOI 10.2337/db12-1613PMC PMC3717867

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Abstract

All forms of life share the ability to sense envi-ronmental change and respond in real time byengaging adaptive homeostatic programs. Inhigher organisms, the composition of consumed meals presents a complex, constantly changing nutritional environment, and we are only beginning to understand the sensing and signaling systems that detect and coordinate the transcriptional, physiological, and behavioral respon-ses to meal components. Although it has long been axi-omatic that dietary composition plays a deterministic role in overall health, the growing prevalence of obesity and metabolic syndrome has prompted a refocus of attention on the significance of dietary macronutrients to health outcomes. Findings from earlier investigations of potential roles for dietary carbohydrates and fat in disease pro-gression or remediation (1–4) are now being reframed by experimental evidence linking dilution of dietary protein to compensatory increases in ingestive behavior (5,6). Recent

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A large and growing literature clearly demonstrates that animals selectively detect and adaptively respond to the restriction of dietary protein.
“there is a large and growing literature that rather clearly demonstrates that animals selectively detect and adaptively respond to the restriction of dietary protein”
From FGF21 and the physiological regulation of macronutrient preference (2020) · cites this paper as [58]

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Coping with stress: eIF2 kinases and translational control
Wek, R. C., Jiang, H.-Y., & Anthony, T. G. (2006) · Biochemical Society Transactions · doi:10.1042/bst0340007 · Cited by 1,290 · see citing works
Hypothalamic mTOR Signaling Regulates Food Intake
Cota, D., Proulx, K., Smith, K. A. B., Kozma, S. C., Thomas, G., Woods, S. C., & Seeley, R. J. (2006) · Science · doi:10.1126/science.1124147 · Cited by 1,278 · see citing works
Leucyl-tRNA Synthetase Is an Intracellular Leucine Sensor for the mTORC1-Signaling Pathway
Han, J. M., Jeong, S. J., Park, M. C., Kim, G., Kwon, N. H., Kim, H. K., Ha, S. H., Ryu, S. H., & Kim, S. (2012) · Cell · doi:10.1016/j.cell.2012.02.044 · Cited by 824 · see citing works
Amino-acid imbalance explains extension of lifespan by dietary restriction in Drosophila
Grandison, R. C., Piper, M. D. W., & Partridge, L. (2009) · Nature · doi:10.1038/nature08619 · Cited by 777 · see citing works
Methionine‐deficient diet extends mouse lifespan, slows immune and lens aging, alters glucose, T4, IGF‐I and insulin levels, and increases hepatocyte MIF levels and stress resistance
Miller, R. A., Buehner, G., Chang, Y., Harper, J. M., Sigler, R. E., & Smith‐Wheelock, M. (2005) · Aging Cell · doi:10.1111/j.1474-9726.2005.00152.x · Cited by 734 · see citing works
Low methionine ingestion by rats extends life span.
Orentreich, N., Matias, J. R., Felice, A. D., & Zimmerman, J. (1993) · Journal of NutriLife · doi:10.1093/jn/123.2.269 · Cited by 608 · see citing works
The Nature of Nutrition
Simpson, S. J., & Raubenheimer, D. (2012) · Princeton University Press eBooks · doi:10.1515/9781400842803 · Cited by 599 · see citing works
Obesity: the protein leverage hypothesis
Simpson, S. J., & Raubenheimer, D. (2005) · Obesity Reviews · doi:10.1111/j.1467-789x.2005.00178.x · Cited by 591 · see citing works
Dietary protein, weight loss, and weight maintenance
Westerterp-Plantenga, M. S., Nieuwenhuizen, A., Tomé, D., Soenen, S., & Westerterp, K. R. (2009) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-080508-141056 · Cited by 570 · see citing works
Integrative models of nutrient balancing: application to insects and vertebrates
Raubenheimer, D., & Simpson, S. J. (1997) · Nutrition Research Reviews · doi:10.1079/nrr19970009 · Cited by 454 · see citing works
Phosphorylation of eIF2 Facilitates Ribosomal Bypass of an Inhibitory Upstream ORF to Enhance CHOP Translation
Palam, L. R., Baird, T. D., & Wek, R. C. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.216093 · Cited by 441 · see citing works
The GCN2 eIF2α Kinase Is Required for Adaptation to Amino Acid Deprivation in Mice
Zhang, P., McGrath, B. C., Reinert, J., Olsen, D. S., Li, L., Gill, S., Wek, S. A., Vattem, K. M., Wek, R. C., Kimball, S. R., et al. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.19.6681-6688.2002 · Cited by 439 · see citing works
Signaling Pathways Involved in Translational Control of Protein Synthesis in Skeletal Muscle by Leucine
Anthony, J. C., Anthony, T. G., Kimball, S. R., & Jefferson, L. S. (2001) · The Journal of Nutrition · doi:10.1093/jn/131.3.856s · Cited by 434 · see citing works
The relationship between high-fat dairy consumption and obesity, cardiovascular, and metabolic disease
Kratz, M., Baars, T., & Guyenet, S. (2013) · European Journal of Nutrition · doi:10.1007/s00394-012-0418-1 · Cited by 422 · see citing works
Comparative review of diets for the metabolic syndrome: implications for nonalcoholic fatty liver disease
Zivkovic, A. M., German, J. B., & Sanyal, A. J. (2007) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/86.2.285 · Cited by 418 · see citing works
Dietary Proteins in the Regulation of Food Intake and Body Weight in Humans
Anderson, G. H., & Moore, S. E. (2004) · Journal of Nutrition · doi:10.1093/jn/134.4.974s · Cited by 380 · see citing works
Uncharged tRNA and Sensing of Amino Acid Deficiency in Mammalian Piriform Cortex
Hao, S., Sharp, J. W., Ross‐Inta, C., McDaniel, B. J., Anthony, T. G., Wek, R. C., Cavener, D. R., McGrath, B. C., Rudell, J. B., Koehnle, T. J., et al. (2005) · Science · doi:10.1126/science.1104882 · Cited by 341 · see citing works
The GCN2 eIF2α Kinase Regulates Fatty-Acid Homeostasis in the Liver during Deprivation of an Essential Amino Acid
Guo, F., & Cavener, D. R. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.01.001 · Cited by 301 · see citing works
Life-Span Extension in Mice by Preweaning Food Restriction and by Methionine Restriction in Middle Age
Sun, L. Y., Akha, A. A. S., Miller, R. A., & Harper, J. M. (2009) · The Journals of Gerontology Series A · doi:10.1093/gerona/glp051 · Cited by 286 · see citing works
Leucine Deprivation Increases Hepatic Insulin Sensitivity via GCN2/mTOR/S6K1 and AMPK Pathways
Xiao, F., Huang, Z., Li, H., Yu, J., Wang, C., Chen, S., Meng, Q., Cheng, Y., Gao, X., Li, J., et al. (2011) · Diabetes · doi:10.2337/db10-1246 · Cited by 284 · see citing works
Nutritional control of aging
Zimmerman, J. A. (2003) · Experimental Gerontology · doi:10.1016/s0531-5565(02)00149-3 · Cited by 279 · see citing works
Methionine restriction decreases visceral fat mass and preserves insulin action in aging male Fischer 344 rats independent of energy restriction
Malloy, V. L., Krajcik, R. A., Bailey, S. J., Hristopoulos, G., Plummer, J. D., & Orentreich∥, N. (2006) · Aging Cell · doi:10.1111/j.1474-9726.2006.00220.x · Cited by 266 · see citing works
Testing Protein Leverage in Lean Humans: A Randomised Controlled Experimental Study
Gosby, A. K., Conigrave, A. D., Lau, N. S., Iglesias, M. A., Hall, R. M., Jebb, S. A., Brand-Miller, J. C., Caterson, I. D., Raubenheimer, D., & Simpson, S. J. (2011) · PLoS ONE · doi:10.1371/journal.pone.0025929 · Cited by 254 · see citing works
Mediobasal Hypothalamic Leucine Sensing Regulates Food Intake through Activation of a Hypothalamus-Brainstem Circuit
Blouet, C., Jo, Y., Li, X., & Schwartz, G. J. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.1668-09.2009 · Cited by 240 · see citing works
The GCN2 kinase biases feeding behavior to maintain amino acid homeostasis in omnivores
Maurin, A., Jousse, C., Avérous, J., Parry, L., Bruhat, A., Chérasse, Y., Zeng, H., Zhang, Y., Harding, H. P., Ron, D., et al. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.03.004 · Cited by 240 · see citing works
Preservation of Liver Protein Synthesis during Dietary Leucine Deprivation Occurs at the Expense of Skeletal Muscle Mass in Mice Deleted for eIF2 Kinase GCN2
Anthony, T. G., McDaniel, B. J., Reinert, R. B., McGrath, B. C., Cavener, D. R., McNurlan, M. A., & Wek, R. C. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m404559200 · Cited by 225 · see citing works
Dietary methionine restriction enhances metabolic flexibility and increases uncoupled respiration in both fed and fasted states
Hasek, B. E., Stewart, L. K., Henagan, T. M., Boudreau, A., Lenard, N. R., Black, C. L., Shin, J., Huypens, P., Malloy, V. L., Plaisance, E. P., et al. (2010) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00837.2009 · Cited by 218 · see citing works
Dietary macronutrients and food consumption as determinants of long-term weight change in adult populations: a systematic literature review
Fogelholm, M., Anderssen, S. A., Gunnarsdóttir, I., & Lahti‐Koski, M. (2012) · Food & Nutrition Research · doi:10.3402/fnr.v56i0.19103 · Cited by 214 · see citing works
Amino Acid Deprivation Induces the Transcription Rate of the Human Asparagine Synthetase Gene through a Timed Program of Expression and Promoter Binding of Nutrient-responsive Basic Region/Leucine Zipper Transcription Factors as Well as Localized Histone Acetylation
Chen, H., Pan, Y., Dudenhausen, E. E., & Kilberg, M. S. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m409173200 · Cited by 197 · see citing works
Dietary Restriction and Aging: A Unifying Perspective
Piper, M. D. W., Partridge, L., Raubenheimer, D., & Simpson, S. J. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.06.013 · Cited by 190 · see citing works
C/EBP Homology Protein (CHOP) Interacts with Activating Transcription Factor 4 (ATF4) and Negatively Regulates the Stress-dependent Induction of the Asparagine Synthetase Gene
Su, N. Y., & Kilberg, M. S. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m806874200 · Cited by 186 · see citing works
Cysteine supplementation reverses methionine restriction effects on rat adiposity: Significance of stearoyl-coenzyme A desaturase
Elshorbagy, A. K., Valdivia-Garcia, M., Mattocks, D. A. L., Plummer, J. D., Smith, A. D., Drevon, C. A., Refsum, H., & Perrone, C. E. (2011) · Journal of Lipid Research · doi:10.1194/jlr.m010215 · Cited by 177 · see citing works
Leucine Deprivation Decreases Fat Mass by Stimulation of Lipolysis in White Adipose Tissue and Upregulation of Uncoupling Protein 1 (UCP1) in Brown Adipose Tissue
Cheng, Y., Meng, Q., Wang, C., Li, H., Huang, Z., Chen, S., Xiao, F., & Guo, F. (2009) · Diabetes · doi:10.2337/db09-0929 · Cited by 167 · see citing works
Neural Mechanisms in the Responses to Amino Acid Deficiency
Gietzen, D. W. (1993) · Journal of Nutrition · doi:10.1093/jn/123.4.610 · Cited by 165 · see citing works
TRB3 Inhibits the Transcriptional Activation of Stress-regulated Genes by a Negative Feedback on the ATF4 Pathway
Jousse, C., Deval, C., Maurin, A., Parry, L., Chérasse, Y., Chaveroux, C., LeFloch, R., Lenormand, P., Bruhat, A., & Fafournoux, P. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m611723200 · Cited by 163 · see citing works
Protein status elicits compensatory changes in food intake and food preferences
Griffioen-Roose, S., Mars, M., Siebelink, E., Finlayson, G., Tomé, D., & de Graaf, C. (2012) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.111.020503 · Cited by 163 · see citing works
Dietary methionine restriction increases fat oxidation in obese adults with metabolic syndrome.
Plaisance, E., Greenway, F., Boudreau, A., Hill, K., Johnson, W., Krajcik, R., Perrone, C. E., Orentreich, N., Cefalu, W., & Gettys, T. (2011) · Journal of Clinical Endocrinology and Metabolism · doi:10.1210/jc.2010-2493 · Cited by 161 · see citing works
Food Intake, Energy Balance and Serum Leptin Concentrations in Rats Fed Low-Protein Diets
Du, F., Higginbotham, D. A., & White, B. D. (2000) · Journal of Nutrition · doi:10.1093/jn/130.3.514 · Cited by 156 · see citing works
Mechanisms of Food Intake Repression in Indispensable Amino Acid Deficiency
Gietzen, D. W., Hao, S., & Anthony, T. G. (2007) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.27.061406.093726 · Cited by 143 · cited 1× · see citing works
“The hypothalamus is also an important target and mediator of the effects of EAA deprivation on energy intake because it both receives axonal projections from the anterior piriform cortex (67,68) and responds directly to depletion and repletion of EAAs (69).”
BackgroundSelf-citation
Methionine restriction effects on mitochondrial biogenesis and aerobic capacity in white adipose tissue, liver, and skeletal muscle of F344 rats
Perrone, C. E., Mattocks, D. A. L., Jarvis-Morar, M., Plummer, J. D., & Orentreich, N. (2010) · Metabolism · doi:10.1016/j.metabol.2009.10.023 · Cited by 136 · see citing works
Amino acid limitation regulates the expression of genes involved in several specific biological processes through GCN2‐dependent and GCN2‐independent pathways
Deval, C., Chaveroux, C., Maurin, A., Chérasse, Y., Parry, L., Carraro, V., Milenković, D., Ferrara, M., Bruhat, A., Jousse, C., et al. (2008) · FEBS Journal · doi:10.1111/j.1742-4658.2008.06818.x · Cited by 134 · see citing works
Mechanisms of thermogenesis induced by low protein diets
Rothwell, N. J., Stock, M. J., & Tyzbir, R. S. (1983) · Metabolism · doi:10.1016/0026-0495(83)90190-7 · Cited by 124 · see citing works
Amino acids as regulators of gene expression: molecular mechanisms
Jousse, C., Avérous, J., Bruhat, A., Carraro, V., Mordier, S. B., & Fafournoux, P. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2003.07.020 · Cited by 118 · see citing works
Isoleucine or valine deprivation stimulates fat loss via increasing energy expenditure and regulating lipid metabolism in WAT
Du, Y., Meng, Q., Zhang, Q., & Guo, F. (2011) · Amino Acids · doi:10.1007/s00726-011-1123-8 · Cited by 113 · see citing works
Amino Acid Deprivation and Endoplasmic Reticulum Stress Induce Expression of Multiple Activating Transcription Factor-3 mRNA Species That, When Overexpressed in HepG2 Cells, Modulate Transcription by the Human Asparagine Synthetase Promoter
Pan, Y., Chen, H., Siu, F., & Kilberg, M. S. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m304574200 · Cited by 112 · see citing works
GCN2 Protein Kinase Is Required to Activate Amino Acid Deprivation Responses in Mice Treated with the Anti-cancer Agent l-Asparaginase
Bunpo, P., Dudley, A., Cundiff, J. K., Cavener, D. R., Wek, R. C., & Anthony, T. G. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.047910 · Cited by 111 · see citing works
Geometric analysis of macronutrient selection in the rat
SIMPSON, S. J., & RAUBENHEIMER, D. (1997) · Appetite · doi:10.1006/appe.1996.0077 · Cited by 110 · see citing works
Deficiency of dietary EAA preferentially inhibits mRNA translation of ribosomal proteins in liver of meal-fed rats
Anthony, T. G., Reiter, A. K., Anthony, J. C., Kimball, S. R., & Jefferson, L. S. (2001) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2001.281.3.e430 · Cited by 102 · see citing works
Specificity of amino acid regulated gene expression: analysis of genes subjected to either complete or single amino acid deprivation
Palii, S. S., Kays, C. E., Deval, C., Bruhat, A., Fafournoux, P., & Kilberg, M. S. (2008) · Amino Acids · doi:10.1007/s00726-008-0199-2 · Cited by 101 · see citing works
Genomic and Metabolic Responses to Methionine-Restricted and Methionine-Restricted, Cysteine-Supplemented Diets in Fischer 344 Rat Inguinal Adipose Tissue, Liver and Quadriceps Muscle
Perrone, C. E., Mattocks, D. A. L., Plummer, J. D., Chittur, S. V., Mohney, R. P., Vignola, K. S., Orentreich, D. S., & Orentreich∥, N. (2012) · Lifestyle Genomics · doi:10.1159/000339347 · Cited by 100 · see citing works
Homeostatic regulation of protein intake: in search of a mechanism
Morrison, C. D., Reed, S. D., & Henagan, T. M. (2012) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00609.2011 · Cited by 99 · see citing works
Role of β-adrenergic receptors in the hyperphagic and hypermetabolic responses to dietary methionine restriction
Plaisance, E. P., Henagan, T. M., Echlin, H., Boudreau, A., Hill, K. L., Lenard, N. R., Hasek, B. E., Orentreich∥, N., & Gettys, T. W. (2010) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00838.2009 · Cited by 95 · see citing works
Rats Rapidly Reject Diets Deficient in Essential Amino Acids
Koehnle, T. J., Russell, M., & Gietzen, D. W. (2003) · Journal of Nutrition · doi:10.1093/jn/133.7.2331 · Cited by 94 · see citing works
Role of lipogenesis in nonshivering thermogenesis.
Masoro, E. J. (1998) · PubMed · Cited by 93 · see citing works
Energy Balance and Mitochondrial Function in Liver and Brown Fat of Rats Fed “Cafeteria” Diets of Varying Protein Content
Rothwell, N. J., Stock, M. J., & Tyzbir, R. S. (1982) · Journal of Nutrition · doi:10.1093/jn/112.9.1663 · Cited by 92 · see citing works
Protein selection, food intake, and body composition in response to the amount of dietary protein
White, B. D., Porter, M. H., & Martin, R. J. (2000) · Physiology & Behavior · doi:10.1016/s0031-9384(99)00232-2 · Cited by 91 · see citing works
Activation of the ATF3 gene through a co-ordinated amino acid-sensing response programme that controls transcriptional regulation of responsive genes following amino acid limitation
Pan, Y., Chen, H., Thiaville, M. M., & Kilberg, M. S. (2006) · Biochemical Journal · doi:10.1042/bj20061261 · Cited by 86 · see citing works
Low protein diet changes the energetic balance and sympathetic activity in brown adipose tissue of growing rats
de França, S. A., dos Santos, M. P., Garófalo, M. A. R., Navegantes, L. C. C., Kettelhut, Í. D. C., Lopes, C. F., & Kawashita, N. H. (2009) · Nutrition · doi:10.1016/j.nut.2009.03.011 · Cited by 79 · see citing works
Neurochemical Changes after Imbalanced Diets Suggest a Brain Circuit Mediating Anorectic Responses to Amino Acid Deficiency in Rats , ,
Gietzen, D. W., Erecius, L. F., & Rogers, Q. R. (1998) · Journal of Nutrition · doi:10.1093/jn/128.4.771 · Cited by 77 · see citing works
The mTOR signaling pathway mediates control of ribosomal protein mRNA translation in rat liver
Reiter, A. K., Anthony, T. G., Anthony, J. C., Jefferson, L. S., & Kimball, S. R. (2004) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2004.04.004 · Cited by 70 · see citing works
Characterization of rat liver malonyl-CoA decarboxylase and the study of its role in regulating fatty acid metabolism
Dyck, J. R. B., Berthiaume, L. G., Thomas, P. D., Kantor, P. F., Barr, A., Barr, R. L., Singh, D., Hopkins, T. A., Voilley, N., Prentki, M., et al. (2000) · Biochemical Journal · doi:10.1042/bj3500599 · Cited by 69 · see citing works
Methionine restriction effects on 11β-HSD1 activity and lipogenic/lipolytic balance in F344 rat adipose tissue
Perrone, C. E., Mattocks, D. A. L., Hristopoulos, G., Plummer, J. D., Krajcik, R. A., & Orentreich∥, N. (2007) · Journal of Lipid Research · doi:10.1194/jlr.m700194-jlr200 · Cited by 69 · see citing works
Amino Acid Availability Controls TRB3 Transcription in Liver through the GCN2/eIF2α/ATF4 Pathway
Carraro, V., Maurin, A., Lambert-Langlais, S., Avérous, J., Chaveroux, C., Parry, L., Jousse, C., Örd, D., Örd, T., Fafournoux, P., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0015716 · Cited by 68 · see citing works
Leucine deprivation stimulates fat loss via increasing CRH expression in the hypothalamus and activating the sympathetic nervous system
Cheng, Y., Zhang, Q., Meng, Q., Xia, T., Huang, Z., Wang, C., Liu, B., Chen, S., Xiao, F., Du, Y., et al. (2011) · Molecular Endocrinology · doi:10.1210/me.2011-0028 · Cited by 65 · see citing works
Effects of age on the feeding response to moderately low dietary protein in rats
White, B. D., Porter, M. H., & Martin, R. J. (2000) · Physiology & Behavior · doi:10.1016/s0031-9384(99)00229-2 · Cited by 63 · see citing works
Elevated ATF4 Expression, in the Absence of Other Signals, Is Sufficient for Transcriptional Induction via CCAAT Enhancer-binding Protein-activating Transcription Factor Response Elements
Shan, J., Örd, D., Örd, T., & Kilberg, M. S. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.011338 · Cited by 61 · see citing works
Role of dietary carbohydrates and macronutrients in the pathogenesis of nonalcoholic fatty liver disease
Lê, K.-A., & Bortolotti, M. (2008) · Current Opinion in Clinical Nutrition and Metabolic Care · doi:10.1097/mco.0b013e328302f3ec · Cited by 60 · see citing works
ATF4-dependent Regulation of the JMJD3 Gene during Amino Acid Deprivation Can Be Rescued in Atf4-deficient Cells by Inhibition of Deacetylation
Shan, J., Fu, L., Balasubramanian, M. N., Anthony, T. G., & Kilberg, M. S. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.399600 · Cited by 56 · see citing works
Expression profiling after activation of amino acid deprivation response in HepG2 human hepatoma cells
Shan, J., Lopez, M.-C., Baker, H. V., & Kilberg, M. S. (2010) · Physiological Genomics · doi:10.1152/physiolgenomics.00217.2009 · Cited by 54 · see citing works
Detection of amino acid deprivation in the central nervous system
Anthony, T. G., & Gietzen, D. W. (2012) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e32835b618b · Cited by 51 · see citing works
Testing the Protein Leverage Hypothesis in a free-living human population
Martinez-Cordero, C., Kuzawa, C. W., Sloboda, D. M., Stewart, J., Simpson, S. J., & Raubenheimer, D. (2012) · Appetite · doi:10.1016/j.appet.2012.05.013 · Cited by 50 · see citing works
The Brain's Response to an Essential Amino Acid-Deficient Diet and the Circuitous Route to a Better Meal
Gietzen, D. W., & Aja, S. M. (2012) · Molecular Neurobiology · doi:10.1007/s12035-012-8283-8 · Cited by 48 · see citing works
S6K1 in the Central Nervous System Regulates Energy Expenditure via MC4R/CRH Pathways in Response to Deprivation of an Essential Amino Acid
Xia, T., Cheng, Y., Zhang, Q., Xiao, F., Liu, B., Chen, S., & Guo, F. (2012) · Diabetes · doi:10.2337/db11-1278 · Cited by 48 · see citing works
Gene expression and integrated stress response in HepG2/C3A cells cultured in amino acid deficient medium
Sikalidis, A. K., Lee, J.-I., & Stipanuk, M. H. (2010) · Amino Acids · doi:10.1007/s00726-010-0571-x · Cited by 46 · see citing works
Essential Amino Acids Regulate Fatty Acid Synthase Expression through an Uncharged Transfer RNA-dependent Mechanism
Dudek, S. M., & Semenkovich, C. F. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.49.29323 · Cited by 40 · see citing works
Diet mediates the relationship between longevity and reproduction in mammals
Wilder, S. M., Couteur, D. G. L., & Simpson, S. J. (2012) · AGE · doi:10.1007/s11357-011-9380-8 · Cited by 37 · see citing works
Somatostatin is involved in anorexia in mice fed a valine-deficient diet
Nakahara, K., Takata, S., Ishii, A., Nagao, K., Bannai, M., Takahashi, M., & Murakami, N. (2011) · Amino Acids · doi:10.1007/s00726-011-0836-z · Cited by 34 · see citing works
Dietary protein in weight management: a review proposing protein spread and change theories
Bosse, J. D., & Dixon, B. M. (2012) · Nutrition & Metabolism · doi:10.1186/1743-7075-9-81 · Cited by 31 · see citing works
Anorexia in rats caused by a valine-deficient diet is not ameliorated by systemic ghrelin treatment
Goto, S., Nagao, K., Bannai, M., Takahashi, M., Nakahara, K., Kangawa, K., & MURAKAMI, N. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.12.013 · Cited by 29 · see citing works
Effects of Amino Acid Deficiency on Monoamines in the Lateral Hypothalamus (LH) in Rats
Blevins, J. E., Teh, P. S., Wang, C. X., & Gietzen, D. W. (2003) · Nutritional Neuroscience · doi:10.1080/10284150310001622248 · Cited by 19 · see citing works
5 Nutrient signaling through mammalian GCN2
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Effects of Dietary Protein and Exercise on Brown Adipose Tissue and Energy Balance in Experimental Animals
Bell, R. R., McGill, T. J., Digby, P. W., & Bennett, S. A. (1984) · Journal of Nutrition · doi:10.1093/jn/114.10.1900 · Cited by 16 · see citing works

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Essential amino acid restriction dictates the systemic metabolic response to dietary protein dilution
Yap, Y. W., Rusu, P. M., Schmoll, D., Kiens, B., Piper, M. D. W., Heikenwälder, M. F., Bröer, S., & Rose, A. J. (2019) · Obesity Research & Clinical Practice · doi:10.1016/j.orcp.2018.11.180
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Gettys, T. W. (2018)
10 Modulation of Feeding Behavior by Amino Acid- Deficient Diets: Present Findings and Future Directions
Koehnle, T. J., & Gietzen, D. W. (2005) · Cited by 3 · see citing works
Amino Acid Sensing in Metabolic Homeostasis and Health.
Hu, X.-M., & Guo, F. (2020) · Endocrine reviews · doi:10.1210/endrev/bnaa026 · Cited by 123 · see citing works
Protein status modulates the rewarding value of foods and meals to maintain an adequate protein intake
Tomé, D., Chaumontet, C., Even, P. C., Darcel, N., & Azzout-Marniche, D. (2019) · Physiology & Behavior · doi:10.1016/j.physbeh.2019.03.012 · Cited by 24 · see citing works

Authors: Anthony, T. G., Morrison, C. D., & Gettys, T. W.
Affiliations: Rutgers, The State University of New Jersey (US)
Pennington Biomedical Research Center (US)
Corresponding author: Gettys, Thomas W.
ORCID: Anthony, Tracy G.
Morrison, Christopher D.
Gettys, Thomas W.
Venue: Diabetes
Publisher: American Diabetes Association
Published: 2013-07-17
Volume: 62
Issue: 8
Pages: 2635-2644
ISSN: 0012-1797 (ISSN-L)
1939-327X
DOI: 10.2337/db12-1613
PMC: PMC3717867
OpenAlex: W1974634361
Cited by: 52
References: 82
Citations by year: 2026: 1 · 2025: 3 · 2023: 5 · 2022: 6 · 2021: 5 · 2020: 3 · 2019: 5 · 2018: 3 · 2017: 3 · 2016: 7 · 2015: 5 · 2014: 5 · 2013: 1
FWCI: 0.66
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-nd
creativecommons.org/licenses/by-nc-nd/3.0/ (vor, 2966 d)
Locations: Diabetes (publishedVersion, cc-by-nc-nd)
PubMed Central (publishedVersion, cc-by-nc-nd)
PubMed (publishedVersion)
Rutgers University Community Repository (Rutgers University) (submittedVersion)
Funders: National Institute of General Medical Sciences (P20GM103528, NIH P20-GM-103528)
National Institute of Diabetes and Digestive and Kidney Diseases (NIH U24 DK-076169, NIH P30-DK072476, U24DK076169, R01DK096311, R01DK081563, P30DK072476)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD070487)
Topics: Health Sciences › Medicine › Physiology › Dietary Effects on Health
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
Keywords: essential amino acids, dietary restriction, lipid metabolism, dietary protein, macronutrients, obesity, metabolic syndrome, nutrient sensing, homeostatic regulation
MeSH terms: Amino Acids, Amino Acids, Essential, Animals, Diet, Humans, Lipid Metabolism

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Remodeling of lipid metabolism by dietary restriction of essential amino acids

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