The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Zinc: role in immunity, oxidative stress and chronic inflammation
Abstract
PURPOSE OF REVIEW: Zinc is essential for multiple cellular functions including immunity. Many investigators have used zinc supplementation in an attempt to affect the outcome of various diseases. These efforts were aimed at either supporting immunity by zinc administration or correcting the zinc dependent immune functions in zinc deficient individuals. RECENT FINDINGS: In this review, recent findings of zinc supplementation in various diseases have been presented. Beneficial therapeutic response of zinc supplementation has been observed in the diarrhea of children, chronic hepatitis C, shigellosis, leprosy, tuberculosis, pneumonia, acute lower respiratory tract infection, common cold, and leishmaniasis. Zinc supplementation was effective in decreasing incidences of infections in the elderly, in patients with sickle cell disease (SCD) and decreasing incidences of respiratory tract infections in children. Zinc supplementation has prevented blindness in 25% of the elderly individuals with dry type of AMD. Zinc supplementation was effective in decreasing oxidative stress and generation of inflammatory cytokines such as TNF-alpha and IL-1beta in elderly individuals and patients with SCD. SUMMARY: Zinc supplementation has been successfully used as a therapeutic and preventive agent for many conditions. Zinc functions as an intracellular signal molecule for immune cells.
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Cites
Zinc and immune function: the biological basis of altered resistance to infection
Shankar, A. H., & Prasad, A. S. (1998) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/68.2.447s · Cited by 1,606
Self-citationSyndrome of iron deficiency anemia, hepatosplenomegaly, hypogonadism, dwarfism, and geophagia
Prasad, A. S., Halsted, J. A., & Nadimi, M. (1961) · The American Journal of Medicine · doi:10.1016/0002-9343(61)90137-1 · Cited by 791
Self-citationPrasad, A. S., Beck, F. W., Bao, B., Fitzgerald, J. T., Snell, D. C., Steinberg, J. D., & Cardozo, L. J. (2007) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/85.3.837 · Cited by 516
Self-citationClinical, immunological, anti-inflammatory and antioxidant roles of zinc
Prasad, A. S. (2008) · Experimental Gerontology · doi:10.1016/j.exger.2007.10.013 · Cited by 454
Self-citationSerum thymulin in human zinc deficiency
Prasad, A. S., Meftah, S., Abdallah, J., Kaplan, J., Brewer, G. J., Bach, J. F., & Dardenne, M. (1988) · Journal of Clinical Investigation · doi:10.1172/jci113717 · Cited by 335
Self-citation(2004) · Archives of Ophthalmology · doi:10.1001/archopht.122.5.716 · Cited by 215
Prasad, A. S., Beck, F. W. J., Bao, B., Snell, D., & Fitzgerald, J. T. (2008) · The Journal of Infectious Diseases · doi:10.1086/528803 · Cited by 121
Cited by
Zinc and its role in immunity and inflammation
Bonaventura, P., Benedetti, G., Albarède, F., & Miossec, P. (2015) · Autoimmunity Reviews · doi:10.1016/j.autrev.2014.11.008 · Cited by 798
The role of zinc in neurodegenerative inflammatory pathways in depression
Szewczyk, B., Kubera, M., & Nowak, G. (2011) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2010.02.010 · Cited by 176
Dietary zinc and iron intake and risk of depression: a meta-analysis
Li, Z., Li, B., Song, X., & Zhang, D. (2017) · Psychiatry Research · doi:10.1016/j.psychres.2017.02.006 · Cited by 156
Potential roles of zinc in the pathophysiology and treatment of major depressive disorder
Swardfager, W., Herrmann, N., McIntyre, R. S., Mazereeuw, G., Goldberger, K., Cha, D. S., Schwartz, Y., & Lanctôt, K. L. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.03.018 · Cited by 116
Abioye, A. I., Bromage, S., & Fawzi, W. (2021) · BMJ Global Health · doi:10.1136/bmjgh-2020-003176 · Cited by 96
Metadata
- Authors
- Prasad, A. S.
- Venue
- Current Opinion in Clinical Nutrition and Metabolic Care
- Published
- 2009-11
- Volume
- 12
- Issue
- 6
- Pages
- 646-652
- ISSN
- 1363-1950 (ISSN-L)
- OpenAlex
- W2043865650
- Cited by
- 551
- References
- 8
- FWCI
- 18.30
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
