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A randomized controlled trial on the effectiveness of 8-week high-intensity interval exercise on intrahepatic triglycerides, visceral lipids, and health-related quality of life in diabetic obese patients with nonalcoholic fatty liver disease
Open accessAbstract
BACKGROUND: Medications are limited for patients with nonalcoholic fatty liver disease (NAFLD). It has been reported that aerobic exercise is effective in reducing the characteristics of NAFLD, although unclear data have ascertained the effects of high-intensity interval aerobic exercise on health-related quality of life (HRQoL) in diabetic obese patients with NAFLD. OBJECTIVES: This a randomized controlled trial aimed to ascertain the effectiveness of 8-week high-intensity interval exercise on intrahepatic triglycerides (IHTG), visceral lipids and HRQoL in diabetic obese patients with NAFLD. STUDY DESIGN: Between August and December 2017, 32 diabetic obese patients with NAFLD aged 45 to 60 years (21 men and 11 women) were enrolled in this study. They were randomly assigned to 2 groups, 16 patients in each group, high-intensity interval (HII) exercise and control groups. The HII group received a program of HII aerobic exercise for 8 weeks with medications of NAFLD and the control group received only medications without any type of exercise intervention. The test of IHTG, visceral lipids, and HRQoL were recorded at the initial assessment and at the end of the program after 8 weeks. RESULTS: There were significant differences between the 2 groups at the end of the study. These study findings exhibited significant improvements in IHTG, VO2peak, visceral lipids, glycohemoglobin, plasma glucose, and all dimensions of HRQoL in the HII group (P <.05), But there was non-significant improvement in any measure in the control group (P >.05) after the 8-week intervention. CONCLUSION: Eight-week high-intensity interval aerobic exercise has a beneficial effect on IHTG, visceral lipids, and HRQoL in diabetic obese patients with NAFLD. Effort and awareness should be dedicated to encouraging the active lifestyle among different population, especially diabetic obese patients with NAFLD.
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“However, RCTs in individuals with MASLD show that exercise improves quality of life, cardiorespiratory fi tness, reduces visceral fat, and improves muscle mass and function even in advanced liver disease. 320,321”
From EASL-EASD-EASO Clinical Practice Guidelines on the management of metabolic dysfunction-associated steatotic liver disease (MASLD). (2024) · cites this paper as [321]
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Cites
Ford, E. S., Giles, W. H., & Dietz, W. H. (2002) · JAMA · doi:10.1001/jama.287.3.356 · Cited by 6,698
Prevalence of Hepatic Steatosis in An Urban Population in the United States: Impact of Ethnicity
Browning, J. D., Szczepaniak, L. S., Dobbins, R., Nuremberg, P., Horton, J. D., Cohen, J. C., Grundy, S. M., & Hobbs, H. H. (2004) · Hepatology · doi:10.1002/hep.20466 · Cited by 3,664
Wisløff, U., Støylen, A., Loennechen, J. P., Bruvold, M., Rognmo, Ø., Haram, P. M., Tjønna, A. E., Helgerud, J., Slørdahl, S. A., Lee, S. J., et al. (2007) · Circulation · doi:10.1161/circulationaha.106.675041 · Cited by 1,996
Dixon, J. B., Bhathal, P. S., & O’Brien, P. E. (2001) · Gastroenterology · doi:10.1053/gast.2001.25540 · Cited by 1,369
Mechanism of hepatic insulin resistance in non-alcoholic fatty liver disease
Samuel, V. T., Liu, Z.-X., Qu, X., Elder, B. D., Bilz, S., Befroy, D., Romanelli, A. J., & Shulman, G. I. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m313478200 · Cited by 1,322
Lim, E. L., Hollingsworth, K. G., Aribisala, B. S., Chen, M. J., Mathers, J. C., & Taylor, R. (2011) · Diabetologia · doi:10.1007/s00125-011-2204-7 · Cited by 1,164
Weight loss, exercise, or both and physical function in obese older adults
Villareal, D. T., Chode, S., Parimi, N., Sinacore, D. R., Hilton, T., Armamento-Villareal, R., Napoli, N., Qualls, C., & Shah, K. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1008234 · Cited by 1,096
Targher, G., Bertolini, L., Padovani, R., Rodella, S., Tessari, R., Zenari, L., Day, C. P., & Arcaro, G. (2007) · Diabetes Care · doi:10.2337/dc06-2247 · Cited by 1,004
Petersen, K. F., Dufour, S., Befroy, D., Lehrke, M., Hendler, R. E., & Shulman, G. I. (2005) · Diabetes · doi:10.2337/diabetes.54.3.603 · Cited by 911
The Obesity Epidemic: Pathophysiology and Consequences of Obesity
Pi‐Sunyer, F. X. (2002) · Obesity Research · doi:10.1038/oby.2002.202 · Cited by 885
Overproduction of large VLDL particles is driven by increased liver fat content in man
Adiels, M., Taskinen, M.-R., Packard, C., Caslake, M. J., Soro-Paavonen, A., Westerbacka, J., Vehkavaara, S., Häkkinen, A., Olofsson, S.-O., Yki-Järvinen, H., et al. (2006) · Diabetologia · doi:10.1007/s00125-005-0125-z · Cited by 690
Fabbrini, E., Mohammed, B. S., Magkos, F., Korenblat, K. M., Patterson, B. W., & Klein, S. (2008) · Gastroenterology · doi:10.1053/j.gastro.2007.11.038 · Cited by 631
Johnson, N. A., Sachinwalla, T., Walton, D. W., Smith, K., Armstrong, A., Thompson, M. W., & George, J. (2009) · Hepatology · doi:10.1002/hep.23129 · Cited by 631
van der Poorten, D., Milner, K., Hui, J. M., Hodge, A. D., Trenell, M. I., Kench, J. G., London, R. M., Peduto, T., Chisholm, D. J., & George, J. (2008) · Hepatology · doi:10.1002/hep.22350 · Cited by 611
Therapeutic effects of restricted diet and exercise in obese patients with fatty liver
Ueno, T., Sugawara, H., Sujaku, K., Hashimoto, O., Tsuji, R., Tamaki, S., Torimura, T., Inuzuka, S., Sata, M., & Tanikawa, K. (1997) · Journal of Hepatology · doi:10.1016/s0168-8278(97)80287-5 · Cited by 608
Targher, G., Bertolini, L., Poli, F., Rodella, S., Scala, L., Tessari, R., Zenari, L., & Falezza, G. (2005) · Diabetes · doi:10.2337/diabetes.54.12.3541 · Cited by 582
Tang, A., Tan, J. K. S., Sun, M. Y., Hamilton, G., Bydder, M., Wolfson, T. J., Gamst, A. C., Middleton, M. S., Brunt, E. M., Loomba, R. S., et al. (2013) · Radiology · doi:10.1148/radiol.12120896 · Cited by 539
Hallsworth, K., Fattakhova, G., Hollingsworth, K. G., Thoma, C., Moore, S., Taylor, R., Day, C. P., & Trenell, M. I. (2011) · Gut · doi:10.1136/gut.2011.242073 · Cited by 529
Farrell, G. C., Chitturi, S., Lau, G. K. K., Sollano, J. D., & NAFLD, F. T. A. W. P. O. (2007) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2007.05002.x · Cited by 518
Nonalcoholic fatty liver disease in patients with type 2 diabetes
Younossi, Z. M., Gramlich, T., Matteoni, C. A., Boparai, N., & McCullough, A. J. (2004) · Clinical Gastroenterology and Hepatology · doi:10.1016/s1542-3565(04)00014-x · Cited by 446
Ibañez, J., Izquierdo, M., Argüelles, I., Forga, L., Larrión, J. L., García-Unciti, M., Idoate, F., & Gorostiaga, E. M. (2005) · Diabetes Care · doi:10.2337/diacare.28.3.662 · Cited by 442
Alanine Aminotransferase, γ-Glutamyltransferase, and Incident Diabetes
Fraser, A., Harris, R., Sattar, N. A., Ebrahim, S. B. J., Smith, G. D., & Lawlor, D. A. (2009) · Diabetes Care · doi:10.2337/dc08-1870 · Cited by 391
Why Visceral Fat is Bad: Mechanisms of the Metabolic Syndrome
Bergman, R. N., Kim, S. P., Catalano, K. J., Hsu, I. R., Chiu, J. D., Kabir, M., Hucking, K., & Ader, M. (2006) · Obesity · doi:10.1038/oby.2006.277 · Cited by 371
Lazo, M., Solga, S. F., Horska, A., Bonekamp, S., Diehl, A. M., Brancati, F. L., Wagenknecht, L. E., Pi-Sunyer, F. X., Kahn, S. E., Clark, J. M., et al. (2010) · Diabetes Care · doi:10.2337/dc10-0856 · Cited by 367
Suspected Nonalcoholic Fatty Liver Disease and Mortality Risk in a Population-Based Cohort Study
Dunn, W., Xu, R., Wingard, D. L., Rogers, C., Angulo, P., Younossi, Z. M., & Schwimmer, J. B. (2008) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2008.02034.x · Cited by 323
Independent effects of physical activity in patients with nonalcoholic fatty liver disease #
St. George, A., Bauman, A., Johnston, A., Farrell, G., Chey, T., & George, J. (2009) · Hepatology · doi:10.1002/hep.22940 · Cited by 318
Role of leisure-time physical activity in nonalcoholic fatty liver disease: A population-based study
Zelber-Sagi, S., Nitzan-Kaluski, D., Goldsmith, R., Webb, M., Zvibel, I., Goldiner, I., Blendis, L., Halpern, Z., & Oren, R. (2008) · Hepatology · doi:10.1002/hep.22525 · Cited by 296
DiPietro, L., Dziura, J., Yeckel, C. W., & Neufer, P. D. (2005) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00474.2005 · Cited by 270
Church, T. S., Kuk, J. L., Ross, R., Priest, E. L., Biltoff, E., & Blair, S. N. (2006) · Gastroenterology · doi:10.1053/j.gastro.2006.03.019 · Cited by 268
Nonalcoholic Fatty Liver Disease: A Clinical Review
Sass, D. A., Chang, P., & Chopra, K. B. (2005) · Digestive Diseases and Sciences · doi:10.1007/s10620-005-1267-z · Cited by 267
Effect of PRESS and STEAM sequences on magnetic resonance spectroscopic liver fat quantification
Hamilton, G., Middleton, M. S., Bydder, M., Yokoo, T., Schwimmer, J. B., Kono, Y., Patton, H. M., Lavine, J. E., & Sirlin, C. B. (2009) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.21809 · Cited by 215
Dixon, J., Bhathal, P., & O'Brien, P. (2006) · Obesity Surgery · doi:10.1381/096089206778663805 · Cited by 212
Warkentin, L. M., Das, D., Majumdar, S. R., Johnson, J. A., & Padwal, R. S. (2013) · Obesity Reviews · doi:10.1111/obr.12113 · Cited by 206
Mechanisms of association between obesity and chronic pain in the elderly
Ray, L., Lipton, R. B., Zimmerman, M. E., Katz, M. J., & Derby, C. A. (2010) · Pain · doi:10.1016/j.pain.2010.08.043 · Cited by 192
Hwang, J.-H., Stein, D. T., Barzilai, N., Cui, M.-H., Tonelli, J., Kishore, P., & Hawkins, M. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00590.2006 · Cited by 188
Predictors of health‐related quality of life in patients with chronic liver disease
Afendy, A., Kallman, J. B., Stepanova, M., Younoszai, Z., Aquino, R. D., Bianchi, G. P., Marchesini, G., & Younossi, Z. M. (2009) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2009.04061.x · Cited by 161
Oh, S., Shida, T., Yamagishi, K., Tanaka, K., So, R., Tsujimoto, T., & Shoda, J. (2014) · Hepatology · doi:10.1002/hep.27544 · Cited by 160
Health‐related fitness and physical activity in patients with nonalcoholic fatty liver disease†‡
Krasnoff, J. B., Painter, P. L., Wallace, J. P., Bass, N. M., & Merriman, R. B. (2008) · Hepatology · doi:10.1002/hep.22137 · Cited by 148
Effects of a lifestyle intervention in metabolically benign and malign obesity
Kantartzis, K., Machann, J., Schick, F., Rittig, K., Machicao, F. E., Fritsche, A., Häring, H., & Stefan, N. (2010) · Diabetologia · doi:10.1007/s00125-010-2006-3 · Cited by 141
Cuthbertson, D. J., Shojaee-Moradie, F., Sprung, V. S., Jones, H., Pugh, C. J. A., Richardson, P., Kemp, G. J., Barrett, M., Jackson, N. C., Thomas, E. L., et al. (2016) · Clinical Science · doi:10.1042/cs20150447 · Cited by 138
Effects of a Low-Volume Aerobic-Type Interval Exercise on V˙O2max and Cardiac Mass
Matsuo, T., Saotome, K., Seino, S., Shimojo, N., Matsushita, A., Iemitsu, M., Ohshima, H., Tanaka, K., & Mukai, C. N. (2013) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e3182a38da8 · Cited by 132
Health‐related quality of life in patients with non‐alcoholic fatty liver disease
Dan, A., Kallman, J. B., Wheeler, A. G., Younoszai, Z., Collantes, R. S., Bondini, S., Gerber, L. H., & Younossi, Z. M. (2007) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2007.03426.x · Cited by 117
VILAR GOMEZ, E., RODRIGUEZ DE MIRANDA, A., GRA ORAMAS, B., ARUS SOLER, E., LLANIO NAVARRO, R., CALZADILLA BERTOT, L., YASELLS GARCIA, A., & DEL ROSARIO ABREU VAZQUEZ, M. (2009) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2009.04122.x · Cited by 105
Kistler, K. D., Molleston, J. P., Ünalp, A., ABRAMS, S. H., Behling, C. A., & Schwimmer, J. B. (2009) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2009.04181.x · Cited by 102
Changes in Health State Utilities With Changes in Body Mass in the Diabetes Prevention Program
Ackermann, R. T., Edelstein, S. L., Narayan, K. M. V., Zhang, P., Engelgau, M. M., Herman, W. H., & Marrero, D. G. (2009) · Obesity · doi:10.1038/oby.2009.114 · Cited by 88
Exercise in Aging: Its Important Role in Mortality, Obesity and Insulin Resistance
Ryan, A. S. (2010) · Aging Health · doi:10.2217/ahe.10.46 · Cited by 78
Koot, B. G. P., van der Baan‐Slootweg, O. H., Tamminga-Smeulders, C. L. J., Rijcken, T. H. P., Korevaar, J. C., van Aalderen, W. M. C., Jansen, P. L. M., & Benninga, M. A. (2011) · Archives of Disease in Childhood · doi:10.1136/adc.2010.199760 · Cited by 73
Have guidelines addressing physical activity been established in nonalcoholic fatty liver disease?
Finelli, C. (2012) · World Journal of Gastroenterology · doi:10.3748/wjg.v18.i46.6790 · Cited by 63
Kim, H.-K., Park, J., Lee, K.-U., Lee, G., Jeon, S.-H., Kim, J.-H., & Kim, C. (2009) · American Journal of the Medical Sciences · doi:10.1097/maj.0b013e3181812879 · Cited by 61
Effects of Therapeutic Lifestyle Program on Ultrasound-diagnosed Nonalcoholic Fatty Liver Disease
Chen, S., Liu, C., Li, S.-R., Huang, H.-T., Tsai, C.-Y., & Jou, H. (2008) · Journal of the Chinese Medical Association · doi:10.1016/s1726-4901(08)70168-0 · Cited by 60
Adiposopathy is a more rational treatment target for metabolic disease than obesity alone
Bays, H. E., & Dujovne, C. A. (2006) · Current Atherosclerosis Reports · doi:10.1007/s11883-006-0052-6 · Cited by 51
McMillan, K. P., Kuk, J. L., Church, T. S., Blair, S. N., & Ross, R. L. (2007) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/h06-112 · Cited by 45
Matsuo, T., So, R., Shimojo, N., & Tanaka, K. (2015) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2015.05.009 · Cited by 44
Benatti, F. B. (2011) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s12143 · Cited by 39
Omagari, K., Takamura, R., Matsutake, S., Ichimura‐Shimizu, M., Kato, S., Morikawa, S.-I., Nagaoka, S., & Osabe, M. (2011) · Journal of Clinical Biochemistry and Nutrition · doi:10.3164/jcbn.11-27 · Cited by 29
Aoi, W., Naito, Y., & Yoshikawa, T. (2011) · Journal of Nutrition and Metabolism · doi:10.1155/2011/676208 · Cited by 28
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Metadata
- Authors
- Abdelbasset, W. K., Tantawy, S. A., Kamel, D. M., Alqahtani, B. A., & Soliman, G. S.
- Affiliations
- Prince Sattam Bin Abdulaziz University (SA)
- Ahlia University (BH)
- Cairo University (EG)
- Corresponding author
- Abdelbasset, Walid Kamal
- Venue
- Medicine
- Published
- 2019-03
- Volume
- 98
- Issue
- 12
- Pages
- e14918
- ISSN
- 0025-7974 (ISSN-L)
- 1536-5964
- PMC
- PMC6708753
- OpenAlex
- W2924614539
- Cited by
- 109
- References
- 56
- Citations by year
- 2026: 13 · 2025: 18 · 2024: 13 · 2023: 20 · 2022: 13 · 2021: 12 · 2020: 15 · 2019: 4
- FWCI
- 8.37
- Type
- journal article
- Language
- en
- Update notices
- correction (2020-09-11)
- Open access
- gold
- doi.org
- Licence
- Locations
- Medicine (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hepatology › Liver Disease Diagnosis and Treatment
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Physical Activity and Health
- Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
- Keywords
- high-intensity interval training, non-alcoholic fatty liver disease, intrahepatic triglyceride, visceral fat, health-related quality of life, type 2 diabetes, obesity, aerobic exercise, peak oxygen uptake, glycohemoglobin, plasma glucose
- MeSH terms
- Cardiorespiratory Fitness, High-Intensity Interval Training, Blood Glucose, Body Weights and Measures, Diabetes Mellitus, Female, Humans, Lipids, Liver, Male, Middle Aged, Obesity, Quality of Life, Socioeconomic Factors, Triglycerides
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