Role of leisure-time physical activity in nonalcoholic fatty liver disease: A population-based study
Open accessAbstract
Physical activity (PA) is commonly recommended for nonalchoholic fatty liver disease (NAFLD) patients. However, there is limited evidence on the independent role of PA in NAFLD. The aim of this study was to examine the association between PA and NAFLD. We conducted a cross-sectional study of a subsample (n = 375) of the Israeli National Health and Nutrition Survey. Exclusion criteria were any known etiology for liver disease. Participants underwent an abdominal ultrasound examination; biochemical tests, including leptin, adiponectin, and resistin; and the noninvasive biomarker SteatoTest and anthropometric evaluations. A semiquantitative food frequency questionnaire and a detailed PA questionnaire were administered. Three hundred forty-nine patients (52.7% men, 30.9% primary NAFLD) were included. The NAFLD group engaged in less aerobic, resistance, or other kinds of PA ( P ≤ 0.03). The SteatoTest was significantly lower among subjects engaging in any PA or resistance PA at least once a week ( P ≤ 0.01). PA at least once a week in all categories was associated with a reduced risk for abdominal obesity. Adjusting for sex, engaging in any kind of sports (odds ratio [OR] 0.66, 95% confidence interval [CI] 0.44-0.96 per 1 standard deviation increment in PA score) and resistance exercise (OR 0.61, 95% CI 0.38-0.85) were inversely associated with NAFLD. These associations remained unchanged after adjusting for homeostasis model assessment, most nutritional factors, adiponectin, and resistin. Only the association with resistance PA remained significant with further adjustment for body mass index (OR 0.61, 95% CI 0.44-0.85). Adding leptin or waist circumference to the model eliminated the statistical significance. Conclusion: Habitual leisure-time PA, especially anaerobic, may play a protective role in NAFLD. This association appears to be mediated by a reduced rate of abdominal obesity. (Hepatology 2008;48:1791-1798.)
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Habitual leisure-time physical activity, especially anaerobic activity, may play a protective role in NAFLD by reducing abdominal obesity in 24-70-year-old humans.
“Habitual leisure-time physical activity, especially anaerobic, may play a protective role in NAFLD by a reduced rate of abdominal obesity in 24–70-yr old human subjects (578).”
From Lack of Exercise Is a Major Cause of Chronic Diseases (2012) · cites this paper as [578]
In the NAFLD study, only the association with resistance physical activity remained significant after further adjustment for BMI.
“Further, only the association with resistance physical activity remained significant with further adjustment for BMI.”
From Lack of Exercise Is a Major Cause of Chronic Diseases (2012) · cites this paper as [578]
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- Authors
- Zelber-Sagi, S., Nitzan-Kaluski, D., Goldsmith, R., Webb, M., Zvibel, I., Goldiner, I., Blendis, L., Halpern, Z., & Oren, R.
- Affiliations
- Israel Ministry of Health (IL)
- Tel Aviv Sourasky Medical Center (IL)
- Tel Aviv University (IL)
- Corresponding author
- Oren, Ran
- Venue
- Hepatology
- Published
- 2008-12
- Volume
- 48
- Issue
- 6
- Pages
- 1791-1798
- ISSN
- 0270-9139 (ISSN-L)
- OpenAlex
- W2164604426
- Cited by
- 296
- References
- 52
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 7 · 2023: 8 · 2022: 10 · 2021: 13 · 2020: 12 · 2019: 14 · 2018: 69 · 2017: 11 · 2016: 21 · 2015: 27 · 2014: 25 · 2013: 17 · 2012: 20
- FWCI
- 8.19
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Hepatology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
- Health Sciences › Medicine › Physiology › Physical Activity and Health
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Keywords
- non-alcoholic fatty liver disease, leisure-time physical activity, resistance training, aerobic exercise, abdominal obesity, leptin, adiponectin, resistin, body mass index, waist circumference, HOMA-IR, NAFLD risk factors
- MeSH terms
- Adult, Cross-Sectional Studies, Fatty Liver, Female, Homeostasis, Humans, Israel, Leisure Activities, Male, Middle Aged, Models, Biological, Motor Activity, Nutritional Status, Obesity, Body Mass Index, Multivariate Analysis, Case-Control Studies, Leptin, Adiponectin, Resistin
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