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Cited by 59Gastrointestinal motility and disordersGut microbiota and healthPelvic floor disorders treatments

Breath methane positivity is more common and higher in patients with objectively proven delayed transit constipation

Lee, Kang-Moon, Paik, Chang-Nyol, Chung, Woo Chul, Yang, Jin-Mo, Choi, Myung-Gyu·2013·European Journal of Gastroenterology & Hepatology
DOI 10.1097/meg.0b013e32835eb916
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Abstract

OBJECTIVES: Methane (CH4)-producing intestinal bacteria might be related to constipation. This study was carried out to evaluate the association between breath CH4, colonic transit, and anorectal pressure in constipated patients. METHODS: A database of consecutive 62 constipated patients fulfilling the Rome III with the lactulose CH4 breath test (LMBT), a colon marker study, and anorectal manometry was studied. The profile of LMBT in patients was compared with 49 healthy controls. The positivity to LMBT (LMBT+) was defined as CH4 of at least 10 ppm in baseline or above baseline within 90 min. There were two types of constipation: normal and delayed transit. RESULTS: There were significant differences in the breath CH4 between patients with delayed transit and (a) normal transit from 0 to 135 min or (b) healthy controls from 0 to 180 min. The LMBT+ was higher in delayed transit patients than in healthy controls (58.8 vs.12.2%) or in normal transit patients (vs. 13.3%), respectively (P<0.01). The delayed transit was the only independent factor for LMBT+ [odds ratio (95% confidence interval), 27.8 (3.32-250.00), P<0.01]. The left and total colonic transit time were significantly increased in LMBT-positive than in LMBT-negative patients. Significant correlations were found between total CH4 and the time of left or total colonic transit. However, no difference was found in the parameters of manometry by LMBT status. CONCLUSION: A positive breath CH4 was associated with delayed colonic transit and left colon, and it could be a new therapeutic target for the management of constipated patients with delayed colonic transit.

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  • Functional constipation patients carry gut microbiota enriched with methanogenic bacteria.

    “The hypothesis has been supported by the observations that FC patients carry gut microbiota enriched with methanogenic bacteria [ 74 , 75 ].”

    From Role of gut microbiota in functional constipation (2021) · cites this paper as [74]

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Authors
Lee, K.-M., Paik, C.-N., Chung, W. C., Yang, J.-M., & Choi, M.-G.
Affiliations
  • St Vincent's Hospital Melbourne (AU)
  • The Catholic University of Korea Seoul St. Mary's Hospital (KR)
Corresponding author
Paik, Chang-Nyol
ORCID
Venue
European Journal of Gastroenterology & Hepatology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2013-06
Volume
25
Issue
6
Pages
726-732
ISSN
0954-691X (ISSN-L)
DOI
10.1097/meg.0b013e32835eb916
OpenAlex
W1974660257
Cited by
59
References
28
Citations by year
2026: 3 · 2025: 4 · 2024: 2 · 2023: 1 · 2022: 9 · 2021: 5 · 2020: 7 · 2019: 5 · 2018: 4 · 2017: 2 · 2016: 3 · 2015: 8 · 2014: 4 · 2013: 2
FWCI
5.34
Type
journal article
Language
en
Open access
closed
Locations
  • European Journal of Gastroenterology & Hepatology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Health Sciences › Medicine › Rheumatology › Pelvic floor disorders treatments
Keywords
breath methane, colonic transit time, anorectal manometry, constipation treatment
MeSH terms
Adult, Aged, Aged, 80 and over, Anal Canal, Breath Tests, Constipation, Female, Gastrointestinal Transit, Humans, Male, Manometry, Methane, Middle Aged, Pressure, Rectum, Retrospective Studies, Young Adult

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