Lactobacillus plantarum Lp3a improves functional constipation: evidence from a human randomized clinical trial and animal model
Open accessAbstract
Background: Functional constipation (FC) is a common gastrointestinal (GI) disorder characterized by symptoms of constipation without a clear physiologic or anatomic cause. Gut microbiome dysbiosis has been postulated to be a factor in the development of FC, and treatment with probiotic regimens, including strains of Lactobacillus plantarum (L. plantarum), has demonstrated efficacy in managing symptoms. To further understand the role of L. plantarum in GI health, we conducted an animal study and a randomized, double-blind, placebo-controlled clinical trial to evaluate the effect of a specific sub-strain, Lp3a, on FC. Methods: For the animal study, male Kunming mice were treated with doses of L. plantarum Lp3a ranging from 0.67 to 2.00 g/kg or an equivalent amount of placebo for 15 days prior to the induction of constipation via 20 mL/kg of 25% diphenoxylate solution. GI motility parameters including intestinal motion and stool amount were then assessed. In the human study, 120 patients with FC were randomized to treatment [L. plantarum Lp3a; 2×1.0×1010 (colony forming units; CFU) ×7 days] or control groups (n=60 each). The primary endpoint was survey information on FC signs/symptoms. Participants and observers were blinded to group allocation. A subset of 20 Lp3a treated patients underwent pre- and post-treatment 16 s ribosomal ribonucleic acid (rRNA) gene sequencing. Whole genome sequencing (WGS) of L. plantarum Lp3a was also performed. Results: Lp3a-treated mice showed significantly improved intestinal motion, reduced time to first defecation, and increased stool amounts. Similarly, patients in the treatment group (n=59) reported significant improvements in FC signs/symptoms compared to controls (n=58; all P<0.05). Although 16 s rRNA sequencing revealed no significant variations between pre- and post-treatment samples, WGS of Lp3a itself revealed several biological pathways that may underlie the relief of FC symptoms in animals and humans, including methane and fatty acid metabolism and bile acid biosynthesis. Conclusions: We found that the use of the novel probiotic sub-strain, L. plantarum Lp3a, led to clinically significant improvements in FC in both mice and humans, and identified the potential biological mechanisms underlying this activity.
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Cites
QIIME allows analysis of high-throughput community sequencing data
Caporaso, J. G., Kuczynski, J., Stombaugh, J., Bittinger, K., Bushman, F. D., Costello, E. K., Fierer, N., Peña, A. G., Goodrich, J. K., Gordon, J. I., et al. (2010) · Nature Methods · doi:10.1038/nmeth.f.303 · Cited by 34,887 · see citing works
Search and clustering orders of magnitude faster than BLAST
Edgar, R. C. (2010) · Bioinformatics · doi:10.1093/bioinformatics/btq461 · Cited by 20,617 · see citing works
Guide for the Care and Use of Laboratory Animals: Eighth Edition
(2011) · doi:10.17226/12910 · Cited by 16,199 · see citing works
FLASH: fast length adjustment of short reads to improve genome assemblies
Magoč, T., & Salzberg, S. L. (2011) · Bioinformatics · doi:10.1093/bioinformatics/btr507 · Cited by 15,366 · see citing works
UCHIME improves sensitivity and speed of chimera detection
Edgar, R. C., Haas, B. J., Clemente, J. C., Quince, C., & Knight, R. (2011) · Bioinformatics · doi:10.1093/bioinformatics/btr381 · Cited by 15,114 · see citing works
Klindworth, A., Pruesse, E., Schweer, T., Peplies, J., Quast, C., Horn, M., & Glöckner, F. O. (2013) · Nucleic Acids Research · doi:10.1093/nar/gks808 · Cited by 8,850 · see citing works
The 1996 Guide for the Care and Use of Laboratory Animals
Clark, J. D., Gebhart, G. F., Gonder, J. C., Keeling, M. E., & Kohn, D. F. (1997) · ILAR Journal · doi:10.1093/ilar.38.1.41 · Cited by 4,420 · see citing works
Nonhybrid, finished microbial genome assemblies from long-read SMRT sequencing data
Chin, C., Alexander, D., Marks, P., Klammer, A., Drake, J., Heiner, C., Clum, A., Copeland, A., Huddleston, J., Eichler, E., et al. (2013) · Nature Methods · doi:10.1038/nmeth.2474 · Cited by 4,008 · see citing works
Stool form scale as a useful guide to intestinal transit time
Lewis, S. J., & Heaton, K. W. (1997) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365529709011203 · Cited by 3,244 · see citing works
Lacy, B. E., Mearin, F., Chang, L., Chey, W. D., Lembo, A. J., Simren, M., & Spiller, R. (2016) · Gastroenterology · doi:10.1053/j.gastro.2016.02.031 · Cited by 2,866 · see citing works
Bacteriocins of gram-positive bacteria
Jack, R. W., Tagg, J. R., & Ray, B. (1995) · Microbiological Reviews · doi:10.1128/mr.59.2.171-200.1995 · Cited by 2,711 · see citing works
Rome IV—Functional GI Disorders: Disorders of Gut-Brain Interaction
Drossman, D. A., & Hasler, W. L. (2016) · Gastroenterology · doi:10.1053/j.gastro.2016.03.035 · Cited by 1,928 · see citing works
Exploring the bovine rumen bacterial community from birth to adulthood
Jami, E., Israel, A., Kotser, A., & Mizrahi, I. (2013) · The ISME Journal · doi:10.1038/ismej.2013.2 · Cited by 963 · see citing works
Suares, N. C., & Ford, A. C. (2011) · The American Journal of Gastroenterology · doi:10.1038/ajg.2011.164 · Cited by 906 · see citing works
Chronic constipation: a survey of the patient perspective
JOHANSON, J. F., & KRALSTEIN, J. (2007) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2006.03238.x · Cited by 617 · see citing works
Systematic review: impact of constipation on quality of life in adults and children
Belsey, J., Greenfield, S., Candy, D., & Geraint, M. (2010) · Alimentary Pharmacology and Therapeutics · doi:10.1111/j.1365-2036.2010.04273.x · Cited by 554 · see citing works
Chen, L., Xiong, Z., Sun, L., Yang, J., & Jin, Q. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkr989 · Cited by 545 · see citing works
Luu, M., Pautz, S., Kohl, V., Singh, R., Romero, R., Lucas, S., Hofmann, J., Raifer, H., Vachharajani, N., Carrascosa, L. C., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-08711-2 · Cited by 508 · see citing works
Dimidi, E., Christodoulides, S., Scott, S. M., & Whelan, K. (2017) · Advances in Nutrition · doi:10.3945/an.116.014407 · Cited by 468 · see citing works
Lactic acid bacteria as probiotics.
Ljungh, Å., & Wadström, T. (2006) · PubMed · Cited by 427 · see citing works
Lactobacillus plantarum and Its Probiotic and Food Potentialities
Seddik, H. A., Bendali, F., Gancel, F., Fliss, I., Spano, G., & Drider, D. (2017) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-017-9264-z · Cited by 420 · see citing works
Parthasarathy, G., Chen, J., Chen, X., Chia, N., O'Connor, H. M., Wolf, P. G., Gaskins, H. R., & Bharucha, A. E. (2016) · Gastroenterology · doi:10.1053/j.gastro.2015.10.005 · Cited by 396 · see citing works
KHALIF, I., QUIGLEY, E., KONOVITCH, E., & MAXIMOVA, I. (2005) · Digestive and Liver Disease · doi:10.1016/j.dld.2005.06.008 · Cited by 382 · see citing works
Structural changes in the gut microbiome of constipated patients
Zhu, L., Liu, W., Alkhouri, R., Baker, R. D., Bard, J. E., Quigley, E. M., & Baker, S. S. (2014) · Physiological Genomics · doi:10.1152/physiolgenomics.00082.2014 · Cited by 381 · see citing works
Gut Microbiota, Short-Chain Fatty Acids, and Herbal Medicines
Feng, W., Ao, H., & Peng, C. Y. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.01354 · Cited by 368 · see citing works
Diagnosis and management of chronic constipation in adults
Rao, S. S. C., Rattanakovit, K., & Patcharatrakul, T. (2016) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2016.53 · Cited by 337 · see citing works
Kunze, W. A., Mao, Y., Wang, B., Huizinga, J. D., Ma, X., Forsythe, P., & Bienenstock, J. (2009) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2009.00686.x · Cited by 328 · see citing works
Dimidi, E., Christodoulides, S., Fragkos, K. C., Scott, S. M., & Whelan, K. (2014) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.114.089151 · Cited by 316 · see citing works
Ducrotte, P. R. (2012) · World Journal of Gastroenterology · doi:10.3748/wjg.v18.i30.4012 · Cited by 273 · see citing works
Martino, M. E., Bayjanov, J. R., Caffrey, B. E., Wels, M., Joncour, P., Hughes, S., Gillet, B., Kleerebezem, M., van Hijum, S. A. F. T., & Leulier, F. (2016) · Environmental Microbiology · doi:10.1111/1462-2920.13455 · Cited by 245 · see citing works
Vlasova, A. N., Kandasamy, S., Chattha, K. S., Rajashekara, G., & Saif, L. J. (2016) · Veterinary Immunology and Immunopathology · doi:10.1016/j.vetimm.2016.01.003 · Cited by 197 · see citing works
Kim, S.-E., Choi, S. C., Park, K. S., Park, M. I., Shin, J. E., Lee, T. H., Jung, K. W., Koo, H. S., & Myung, S.-J. (2015) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm14048 · Cited by 180 · see citing works
Kumar, R., Grover, S., & Batish, V. K. (2010) · British Journal Of Nutrition · doi:10.1017/s0007114510003740 · Cited by 158 · see citing works
Jahng, J., Jung, I. S., Choi, E. J., Conklin, J. L., & Park, H. (2011) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2011.01819.x · Cited by 132 · see citing works
Ojetti, V., Ianiro, G., Tortora, A., D‘Angelo, G., Di Rienzo, T. A., Bibbò, S., Migneco, A., & Gasbarrini, A. (2014) · Journal of Gastrointestinal and Liver Diseases · doi:10.15403/jgld.2014.1121.234.elr · Cited by 125 · cited 2× · see citing works
“Numerous preclinical and clinical trials have explored the effect of probiotics in adult and pediatric patients with FC (20,22,28,41).”
BackgroundIbarra, A., Latreille-Barbier, M., Donazzolo, Y., Pelletier, X., & Ouwehand, A. C. (2018) · Gut Microbes · doi:10.1080/19490976.2017.1412908 · Cited by 121 · see citing works
Nakjang, S., Ndeh, D. A., Wipat, A., Bolam, D. N., & Hirt, R. P. (2012) · PLoS ONE · doi:10.1371/journal.pone.0030287 · Cited by 116 · see citing works
Chronic constipation: a critical review.
Basilisco, G., & Coletta, M. (2013) · Digestive and Liver Disease · doi:10.1016/j.dld.2013.03.016 · Cited by 113 · see citing works
Higashikawa, F., Noda, M., Awaya, T., Nomura, K., Oku, H., & Sugiyama, M. (2009) · Nutrition · doi:10.1016/j.nut.2009.05.008 · Cited by 104 · see citing works
Systematic review: probiotics for functional constipation in children
Wojtyniak, K., & Szajewska, H. (2017) · European Journal of Pediatrics · doi:10.1007/s00431-017-2972-2 · Cited by 100 · see citing works
Ma, H., Xiong, H., Zhu, X., Ji, C., Xue, J., Li, R., Ge, B., & Cui, H. (2019) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2019.04.209 · Cited by 100 · see citing works
Human Gut Microbiome Response Induced by Fermented Dairy Product Intake in Healthy Volunteers
Игоревна, В. О., Klimenko, N. S., Berezhnaya, Y., Tyakht, A., Nesterova, P., Popenko, A., & Alexeev, D. G. (2019) · Nutrients · doi:10.3390/nu11030547 · Cited by 85 · see citing works
Stevenson, C., Blaauw, R., Fredericks, E., Visser, J., & Roux, S. (2014) · Nutrition · doi:10.1016/j.nut.2014.02.010 · Cited by 84 · see citing works
Skardoon, G., Khera, A. J., Emmanuel, A. V., & Burgell, R. (2017) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.14174 · Cited by 82 · see citing works
Effect ofLactobacillus plantarumNCU116 on loperamide-induced constipation in mice
Li, C., Nie, S., Zhu, K.-X., Xiong, T., Li, C., Gong, J., & Xie, M. (2015) · International Journal of Food Sciences and Nutrition · doi:10.3109/09637486.2015.1024204 · Cited by 79 · see citing works
Intestinal Crosstalk between Microbiota and Serotonin and its Impact on Gut Motility
Ge, X., Pan, J., Liu, Y., Wang, H., Zhou, W., & Wang, X. (2018) · Current Pharmaceutical Biotechnology · doi:10.2174/1389201019666180528094202 · Cited by 77 · see citing works
Self-citationYoon, J. Y., Cha, J. M., Oh, J. K., Tan, P. L., Kim, S. H., Kwak, M. S., Jeon, J. W., & Shin, H. P. (2018) · Digestive Diseases and Sciences · doi:10.1007/s10620-018-5139-8 · Cited by 67 · see citing works
Laxative effect of probiotic chocolate on loperamide-induced constipation in rats
Eor, J. Y., Tan, P. L., Lim, S. M., Choi, D. H., Yoon, S. M., Yang, S. Y., & Kim, S. H. (2018) · Food Research International · doi:10.1016/j.foodres.2018.09.062 · Cited by 65 · see citing works
Lee, K.-M., Paik, C.-N., Chung, W. C., Yang, J.-M., & Choi, M.-G. (2013) · European Journal of Gastroenterology & Hepatology · doi:10.1097/meg.0b013e32835eb916 · Cited by 59 · see citing works
Lactobacillus plantarum YS-3 Prevents Activated Carbon-Induced Constipation in Mice
Zhao, X., Yi, R., Qian, Y., & Park, K.-Y. (2018) · Journal of Medicinal Food · doi:10.1089/jmf.2017.4109 · Cited by 55 · see citing works
Suri, J. S., Kataria, R. D., Malik, Z. A., Parkman, H. P., & Schey, R. (2018) · Medicine · doi:10.1097/md.0000000000010554 · Cited by 55 · see citing works
Żukiewicz-Sobczak, W. A., Wróblewska-Łuczka, P., Adamczuk, P., & Silny, W. (2014) · Central European Journal of Immunology · doi:10.5114/ceji.2014.42134 · Cited by 53 · see citing works
Botelho, P. B., Ferreira, M. V. R., Araújo, A. D. M., Mendes, M. M., & Nakano, E. Y. (2020) · Nutrition · doi:10.1016/j.nut.2020.110890 · Cited by 47 · see citing works
Gasior, A. C., Reck-Burneo, C. A., Vilanova-Sánchez, A., Diefenbach, K. A., Yacob, D., Lu, P. L., Vaz, K. K. H., Lorenzo, C. D., Levitt, M. A., & Wood, R. J. (2018) · Journal of Pediatric Surgery · doi:10.1016/j.jpedsurg.2018.02.074 · Cited by 43 · see citing works
Yi, R., Peng, P., Zhang, J., Du, M., Lan, L., Qian, Y., Zhou, J., & Zhao, X. (2019) · Journal of Medicinal Food · doi:10.1089/jmf.2019.4467 · Cited by 43 · see citing works
Anzawa, D., Mawatari, T., Tanaka, Y., Yamamoto, M., Genda, T., Takahashi, S., Nishijima, T., Kamasaka, H., Suzuki, S., & Kuriki, T. (2019) · Food Science & Nutrition · doi:10.1002/fsn3.1033 · Cited by 41 · see citing works
Zhao, X., Qian, Y., Li, G., Yi, R., Park, K., & Song, J. (2018) · Journal of Dairy Science · doi:10.3168/jds.2018-15206 · Cited by 41 · see citing works
Chingwaru, W., & Vidmar, J. (2016) · Asian Pacific Journal of Tropical Medicine · doi:10.1016/j.apjtm.2016.12.009 · Cited by 34 · see citing works
Hofman, D. L., Kudla, U., Miqdady, M. S., Nguyễn, T. V. H., Morán‐Ramos, S., & Vandenplas, Y. (2022) · Nutrients · doi:10.3390/nu14050974 · Cited by 33 · see citing works
Roles of Chinese Medicine and Gut Microbiota in Chronic Constipation
Xu, Z., Liu, T., Zhou, Q., Chen, J., Yuan, J., & Yang, Z. (2019) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2019/9372563 · Cited by 31 · see citing works
Self-citationThe complete genome sequence of Exiguobacterium arabatum W‐01 reveals potential probiotic functions
Cong, M., Jiang, Q., Xu, X., Huang, L., Su, Y., & Yan, Q. (2017) · MicrobiologyOpen · doi:10.1002/mbo3.496 · Cited by 26 · see citing works
Liu, B., Xiao, X., Zhou, X., Zhou, J., Lan, L., Long, X., Pan, Y., Du, M., & Zhao, X. (2019) · Food Science & Nutrition · doi:10.1002/fsn3.1048 · Cited by 26 · see citing works
Nemoto, M., Kuda, T., Eda, M., Yamakawa, H., Takahashi, H., & Kimura, B. (2016) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-016-9226-x · Cited by 26 · see citing works
Khuituan, P., Huipao, N., Jeanmard, N., Thantongsakul, S., Promjun, W., Chuthong, S., Tipbunjong, C., & Peerakietkhajorn, S. (2022) · Nutrients · doi:10.3390/nu14030496 · Cited by 18 · see citing works
Ito, D., Yamamoto, Y., Maekita, T., Yamagishi, N., Kawashima, S., Yoshikawa, T., Tanioka, K., Yoshida, T., Iguchi, M., Kunitatsu, K., et al. (2022) · Medicine · doi:10.1097/md.0000000000028858 · Cited by 12 · see citing works
Suri, J., Kataria, R., Malik, Z. A., Parkman, H. P., & Schey, R. (2017) · Gastroenterology · doi:10.1016/s0016-5085(17)31927-3 · Cited by 8 · see citing works
Liu, B., Xiao, X., Zhou, X., Zhou, J., Lan, L., Long, X., Pan, Y., Du, M., & Zhao, X. (2021) · HAL · Cited by 1 · see citing works
Flagged first, then by citations
4 of the 71 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Ma, T., Yang, N., Xie, Y., Li, Y., Xiao, Q., Li, Q., Jin, H., Zheng, L., Sun, Z., Zuo, K., et al. (2023) · Pharmacological Research · doi:10.1016/j.phrs.2023.106755 · Cited by 58 · see citing works
Shan, Y., Zheng, M., Liang, W., Ouyang, L., & Wang, S. (2025) · Food Research International · doi:10.1016/j.foodres.2025.116840 · Cited by 28 · see citing works
Zhang, T., Liu, W., Lu, H., Cheng, T., Wang, L., Wang, G., Zhang, H., & Chen, W. (2023) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2023.2278155 · Cited by 28 · see citing works
Self-citationDing, F., Hu, M., Ding, Y., Meng, Y., & Zhao, Y. (2024) · BMJ Open · doi:10.1136/bmjopen-2023-074557 · Cited by 22 · see citing works
“Fei Ding http://orcid.org/0000-0002-9396-8023 Mengyang Hu http://orcid.org/0000-0001-6338-8151 Yifei Ding http://orcid.org/0000-0001-9920-2320 Yingying Meng http://orcid.org/0000-0002-8594-4734 Yanchao Zhao http://orcid.org/0000-0002-2710-0824”
BackgroundInfluentialYin, H., Gao, X., Yang, H., Xu, Z.-K., Wang, X., Wang, X., Gao, Y., Shi, Z., Chen, X., Cao, L., et al. (2023) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2023.117420 · Cited by 21 · see citing works
Self-citationStrain-Specific Therapeutic Potential of Lactiplantibacillus plantarum: A Systematic Scoping Review
Chatsirisakul, O., Leenabanchong, N., Siripaopradit, Y., Chang, C.-W., Buhngamongkol, P., & Pongpirul, K. (2025) · Nutrients · doi:10.3390/nu17071165 · Cited by 20 · see citing works
Molecular chaperone function of three small heat-shock proteins from a model probiotic species
Rocchetti, M. T., Bellanger, T., Trecca, M. I., Weidmann, S., Scrima, R., Spano, G., Russo, P., Capozzi, V., & Fiocco, D. (2022) · Cell Stress and Chaperones · doi:10.1007/s12192-022-01309-6 · Cited by 21 · see citing works
Microbial exopolysaccharides as postbiotics: Structure, function, and translational potential
Pandey, K., Geethu Prakash, T. V., Gosai, H. B., Bhatia, D. D., & Patel, R. B. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.147956 · Cited by 18 · see citing works
Huang, Y., Guo, Y., Li, X., Xiao, Y., Wang, Z., Song, L., & Ren, Z. (2023) · Nutrients · doi:10.3390/nu15173741 · Cited by 16 · see citing works
Shi, X., Li, Y., Cheng, Y., Liu, W., Li, Z., Jin, H., Kwok, L., & Sun, Z. (2025) · Food Bioscience · doi:10.1016/j.fbio.2025.108088 · Cited by 12 · see citing works
Exploring the Molluscan Microbiome: Diversity, Function, and Ecological Implications
Makwarela, T. G., Seoraj-Pillai, N., & Nangammbi, T. C. (2025) · Biology · doi:10.3390/biology14081086 · Cited by 9 · see citing works
Gao, X., Guo, K., Liu, S., Yang, W., Sheng, J., Tian, Y., Lei, P., & Zhao, Y. M. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252312810 · Cited by 6 · see citing works
Lee, H., Hossain, M. K., Kim, S.-H., Jeong, P.-Y., Lee, G., Kim, D., Chung, M. J., & Chae, H. (2024) · Journal of Functional Foods · doi:10.1016/j.jff.2024.106444 · Cited by 6 · see citing works
Wang, N., Wu, P., & Chen, X. D. (2025) · Foods · doi:10.3390/foods14081335 · Cited by 4 · see citing works
Zhou, Y., & Tao, E. (2026) · Frontiers in Nutrition · doi:10.3389/fnut.2025.1694831 · Cited by 3 · see citing works
Xiao, R., He, Y., Mao, X., Sun, L., Ao, L., Wang, L., Zhai, Q., Zhao, J., Chen, W., Wang, G., et al. (2026) · Clinical Nutrition · doi:10.1016/j.clnu.2026.106598 · Cited by 2 · see citing works
Self-citationJiang, C., Wang, K. Z., & Yao, Y. (2026) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-026-11061-3 · Cited by 2 · see citing works
Jin, Y.-J., Park, Y.-J., Choi, J., Kim, M.-S., Min, U.-G., Lim, J.-H., Kang, J., Lee, D. Y., & Kim, B. (2025) · Journal of Microbiology and Biotechnology · doi:10.4014/jmb.2412.12056 · Cited by 2 · see citing works
Constipation targeted monostrain and multispecies probiotics: effects on symptoms and gut microbiota
Zeng, Y., He, P., Lyu, C., Wu, Y., Zhao, X., Gu, Q., Wu, S., Zhang, Y., Wei, X., An, R., et al. (2025) · Food Science and Human Wellness · doi:10.26599/fshw.2025.9250509 · Cited by 1 · see citing works
Self-citationProgress of Probiotics in Treating Functional Constipation through Intestinal Flora
那, 日. (2023) · Advances in Clinical Medicine · doi:10.12677/acm.2023.1351212
Cheah, A. S., Tan, J. W., Jaafar, F., & Yeo, W. W. Y. (2026) · Current Nutrition Reports · doi:10.1007/s13668-026-00739-3
Lactobacillus acidophilus C4 ameliorates constipation in mice
Yan, H., Jia, Q., Liu, J., Hua, X., Cui, Y., Jian, W., Tan, Y., Oduor, O. S., Thomas, P., Kawimbe, M., et al. (2026) · Microbiology spectrum · doi:10.1128/spectrum.02950-25
Önning, G., Vegge, C. S., Montelius, C., Lewis, E. D., Al‐Wahsh, H., Moulin, M., Crowley, D. C., & Guthrie, N. (2026) · World Journal of Gastroenterology · doi:10.3748/wjg.v32.i21.117959
Jiang, P., 杨小清, 张城浩, Li, Y., & Xu, C. (2026) · Frontiers in Microbiology · doi:10.3389/fmicb.2026.1941480
- Authors
- Zhang, C., Zhang, Y., Ma, K., Wang, G., Tang, M., Wang, R., Xia, Z., Xu, Z., Sun, M., Bao, X., Gui, H., & Wang, H.
- Affiliations
- Nantong University (CN)
- Renmin Hospital of Wuhan University (CN)
- Rutgers, The State University of New Jersey (US)
- Pennsylvania Hospital (US)
- Corresponding author
- Gui, Hongxing
- Wang, Hui
- ORCID
- Venue
- Annals of Translational Medicine
- Publisher
- AME Publishing Company
- Published
- 2022-03
- Volume
- 10
- Issue
- 6
- Pages
- 316-316
- ISSN
- 2305-5839 (ISSN-L)
- 2305-5847
- PMC
- PMC9011319
- OpenAlex
- W4224234777
- Cited by
- 25
- References
- 71
- Citations by year
- 2026: 7 · 2025: 8 · 2024: 3 · 2023: 5 · 2022: 2
- FWCI
- 3.94
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- cc-by-nc-nd
- Locations
- Annals of Translational Medicine (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (81801080, 31500845)
- Government of Jiangsu Province
- Qinglan Project of Jiangsu Province of China
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- functional constipation, probiotics, gut microbiota, intestinal motility, 16S rRNA gene sequencing, whole genome sequencing, methane metabolism, fatty acid metabolism, bile acid synthesis, mouse model, constipation symptoms, stool consistency
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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