The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
The Role of Macrophages and Dendritic Cells in the Initiation of Inflammation in IBD
Open accessAbstract
In the healthy gastrointestinal tract, homeostasis is an active process that requires a careful balance of host responses to the enteric luminal contents. Intestinal macrophages and dendritic cells (DCs) comprise a unique group of tissue immune cells that are ideally situated at the interface of the host and the enteric luminal environment to appropriately respond to microbes and ingested stimuli. However, intrinsic defects in macrophage and DC function contribute to the pathogenesis of inflammatory bowel diseases, as highlighted by recent genome-wide association studies. Gastrointestinal macrophages and DCs participate in inflammatory bowel disease development through inappropriate responses to enteric microbial stimuli, inefficient clearance of microbes from host tissues, and impaired transition from appropriate proinflammatory responses to anti-inflammatory responses that promote resolution. By understanding how intestinal macrophages and DCs initiate chronic inflammation, new pathogenesis-based therapeutic strategies to treat human inflammatory bowel diseases will be elucidated.
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Cites
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Cited by
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Metadata
- Authors
- Steinbach, E. C., & Plevy, S. E.
- Venue
- Inflammatory Bowel Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2014-01
- Volume
- 20
- Issue
- 1
- Pages
- 166-175
- ISSN
- 1078-0998 (ISSN-L)
- OpenAlex
- W2038122919
- Cited by
- 249
- References
- 23
- FWCI
- 6.27
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: The Role of Macrophages and Dendritic Cells in the Initiation of Inflammation in IBD. https://app.cochat.ai/papers/10.1097/mib.0b013e3182a69dca
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- Steinbach, E. C., & Plevy, S. E. (2014). The Role of Macrophages and Dendritic Cells in the Initiation of Inflammation in IBD. Inflammatory Bowel Diseases. https://doi.org/10.1097/mib.0b013e3182a69dca
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
