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Cited by 298

The DOI matches its Crossref record; 188 of the 188 references it cites were found in a registry or an index.

Renal interstitial fibrosis: mechanisms and evaluation

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Farris, Alton B., Colvin, Robert B.·2012·Current Opinion in Nephrology and Hypertension
DOI 10.1097/mnh.0b013e3283521cfa
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Abstract

PURPOSE OF REVIEW: Tubulointerstitial injury in the kidney is complex, involving a number of independent and overlapping cellular and molecular pathways, with renal interstitial fibrosis and tubular atrophy (IFTA) as the final common pathway. Furthermore, there are multiple ways to assess IFTA. RECENT FINDINGS: Cells involved include tubular epithelial cells, fibroblasts, fibrocytes, myofibroblasts, monocyte/macrophages, and mast cells with complex and still incompletely characterized cell-molecular interactions. Molecular mediators involved are numerous and involve pathways such as transforming growth factor (TGF)-β, bone morphogenic protein (BMP), platelet-derived growth factor (PDGF), and hepatocyte growth factor (HGF). Recent genomic approaches have shed insight into some of these cellular and molecular pathways. Pathologic evaluation of IFTA is central in assessing the severity of chronic disease; however, there are a variety of methods used to assess IFTA. Most assessment of IFTA relies on pathologist assessment of special stains such as trichrome, Sirius Red, and collagen III immunohistochemistry. Visual pathologist assessment can be prone to intra and interobserver variability, but some methods employ computerized morphometery, without a clear consensus as to the best method. SUMMARY: IFTA results from on orchestration of cell types and molecular pathways. Opinions vary on the optimal qualitative and quantitative assessment of IFTA.

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Metadata

Authors
Farris, A. B., & Colvin, R. B.
Venue
Current Opinion in Nephrology and Hypertension
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2012-05
Volume
21
Issue
3
Pages
289-300
ISSN
1062-4821 (ISSN-L)
DOI
10.1097/mnh.0b013e3283521cfa
OpenAlex
W19843932
Cited by
298
References
188
FWCI
16.25
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Renal interstitial fibrosis: mechanisms and evaluation. https://app.cochat.ai/papers/10.1097/mnh.0b013e3283521cfa
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Farris, A. B., & Colvin, R. B. (2012). Renal interstitial fibrosis: mechanisms and evaluation. Current Opinion in Nephrology and Hypertension. https://doi.org/10.1097/mnh.0b013e3283521cfa

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