Therapeutic faecal microbiota transplantation: current status and future developments
Open accessAbstract
PURPOSE OF REVIEW: Faecal microbiota transplantation (FMT) has undergone dramatic progression over the past year and continues to evolve as knowledge of the gastrointestinal microbiota (GiMb) develops. This review summarizes therapeutic advances in FMT, latest FMT therapies and presents the potential of FMT therapeutics in other gastrointestinal and extra-intestinal conditions. RECENT FINDINGS: The GiMb is now known to have a central role in the pathogenesis of many diseases. The success of FMT in curing Clostridium difficile infection (CDI) is well established and preliminary findings in other gastrointestinal conditions are promising. Published data from over 500 CDI cases suggest that FMT is generally well tolerated with minimal side effects. The commercial potential of FMT is being explored with several products under development, including frozen GiMb extract, which has been shown highly effective in treating relapsing CDI. Such products will likely become more available in coming years and revolutionize the availability and method of delivery of GiMb. SUMMARY: Recent literature unequivocally supports the use of FMT in treating relapsing CDI. Trials are underway to determine the therapeutic potential of FMT in other conditions, particularly inflammatory bowel disease. Therapeutic FMT is a dynamic field with new and emerging indications along with ongoing developments in optimal mode of administration.
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FMT represents an emerging therapy for disease states related to dysbiosis, and is a current, recommended treatment for relapsing and non-responding Clostridium difficile infection.
“However, FMT represents an emerging therapy for disease states related to dysbiosis, and is a current, recommended treatment for relapsing and non-responding CDI [28] .”
From Intestinal microbiota in health and disease: Role of bifidobacteria in gut homeostasis (2014) · cites this paper as [28]
Taken together, these data indicate that FMT is a promising treatment option for serious and recurrent CDI.
“Taken together, these data indicate that FMT is a promising treatment option for serious and recurrent CDI [309,310]”
From Gut microbiota role in irritable bowel syndrome: New therapeutic strategies (2016) · cites this paper as [309]
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- Authors
- Borody, T. J., Brandt, L. J., & Paramsothy, S.
- Affiliations
- Albert Einstein College of Medicine (US)
- St Vincent's Hospital Sydney (AU)
- Corresponding author
- Paramsothy, Sudarshan
- Venue
- Current Opinion in Gastroenterology
- Published
- 2014-01
- Volume
- 30
- Issue
- 1
- Pages
- 97-105
- ISSN
- 0267-1379 (ISSN-L)
- PMC
- PMC3868025
- OpenAlex
- W1991677478
- Cited by
- 114
- References
- 39
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 7 · 2023: 4 · 2022: 6 · 2021: 7 · 2020: 9 · 2019: 8 · 2018: 13 · 2017: 7 · 2016: 18 · 2015: 17 · 2014: 14
- FWCI
- 2.12
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc-nd
- Locations
- Current Opinion in Gastroenterology (publishedVersion, cc-by-nc-nd)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Clostridium difficile and Clostridium perfringens research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- fecal microbiota transplantation, Clostridium difficile infection, inflammatory bowel disease, gut microbiota, mode of administration
- MeSH terms
- Autoimmune Diseases, Enterocolitis, Pseudomembranous, Feces, Humans, Intestinal Diseases, Intestines, Recurrence, Inflammatory Bowel Diseases, Tissue Transplantation, Irritable Bowel Syndrome, Microbiota
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