Microbiota-gut brain axis involvement in neuropsychiatric disorders
Open accessAbstract
Introduction: The microbiota-gut brain (MGB) axis is the bidirectional communication between the intestinal microbiota and the brain. An increasing body of preclinical and clinical evidence has revealed that the gut microbial ecosystem can affect neuropsychiatric health. However, there is still a need of further studies to elucidate the complex gene–environment interactions and the role of the MGB axis in neuropsychiatric diseases, with the aim of identifying biomarkers and new therapeutic targets, to allow early diagnosis and improving treatments.Areas covered: To review the role of MGB axis in neuropsychiatric disorders, prediction and prevention of disease through exploitation, integration, and combination of data from existing gut microbiome/microbiota projects and appropriate other International ‘-Omics’ studies. The authors also evaluated the new technological advances to investigate and modulate, through nutritional and other interventions, the gut microbiota.Expert opinion: The clinical studies have documented an association between alterations in gut microbiota composition and/or function, whereas the preclinical studies support a role for the gut microbiota in impacting behaviors which are of relevance to psychiatry and other central nervous system (CNS) disorders. Targeting MGB axis could be an additional approach for treating CNS disorders and all conditions in which alterations of the gut microbiota are involved.
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The gut-brain axis: how microbiota and host inflammasome influence brain physiology and pathology
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Self-citationZhao, Z., Wang, B., Mu, L., Wang, H., Luo, J., Yang, Y., Yang, H., Li, M., Zhou, L., & Tao, C. (2020) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.00258 · Cited by 57 · see citing works
Chen, G.-Q., Peng, C.-L., Lian, Y., Wang, B.-W., Chen, P.-Y., & Wang, G.-P. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2021.662357 · Cited by 55 · see citing works
“It is demonstrated that pro-inflammatory diet can modify the gut microbiota composition and activity (56), and gut microbiota can potentially influence immune system activation, production of neurotransmitters, and regulation of neuroendocrine pathways, which in turn influence mental health (57, 58).”
BackgroundSavino, R., Carotenuto, M., Polito, A. N., Di Noia, S., Albenzio, M., Scarinci, A., Ambrosi, A., Sessa, F., Tartaglia, N., & Messina, G. (2020) · doi:10.20944/preprints202007.0425.v1 · Cited by 54 · see citing works
Self-citation
- Authors
- Iannone, L. F., Preda, A., Blottière, H. M., Clarke, G., Albani, D., Belcastro, V., Carotenuto, M., Cattaneo, A., Citraro, R., Ferraris, C., Ronchi, F., Luongo, G., Santocchi, E., Guiducci, L., Baldelli, P., Iannetti, P., Pedersen, S., Petretto, A., Provasi, S., Selmer, K., Spalice, A., Tagliabue, A., Verrotti, A., Segata, N., Zimmermann, J., Minetti, C., Mainardi, P., Giordano, C., Sisodiya, S., Zara, F., Russo, E., & Striano, P.
- Affiliations
- Magna Graecia University (IT)
- Istituto Giannina Gaslini (IT)
- AgroParisTech (FR)
- University College Cork (IE)
- Mario Negri Institute for Pharmacological Research (IT)
- Ospedale Sant'Anna (IT)
- University of Campania "Luigi Vanvitelli" (IT)
- King's College London (GB)
- University of Pavia (IT)
- University of Bern (CH)
- Ordine dei Tecnologi Alimentari Campania e Lazio, Napoli, Italy
- Fondazione Stella Maris (IT)
- Istituto di Fisiologia Clinica (IT)
- University of Genoa (IT)
- Sapienza University of Rome (IT)
- Oslo University Hospital (NO)
- Centro San Giovanni di Dio Fatebenefratelli (IT)
- Department of Pediatrics, University of L’Aquila, L’Aquila, Italy
- University of Trento (IT)
- Kolfarma SRL, Genova, Italy
- Politecnico di Milano (IT)
- National Hospital for Neurology and Neurosurgery (GB)
- Corresponding author
- Striano, Pasquale
- ORCID
- Iannone, Luigi Francesco
- Preda, Alberto
- Blottière, Hervé M.
- Clarke, Gerard
- Albani, Diego
- Belcastro, Vincenzo
- Carotenuto, Marco
- Cattaneo, Annamaria
- Citraro, Rita
- Ferraris, Cinzia
- Ronchi, Francesca
- Santocchi, Elisa
- Guiducci, Letizia
- Baldelli, Pietro
- Pedersen, Sigrid
- Petretto, Andrea
- Provasi, Stefania
- Selmer, Kaja
- Spalice, Alberto
- Tagliabue, Anna
- Segata, Nicola
- Zimmermann, Jakob
- Minetti, Carlo
- Mainardi, Paolo
- Giordano, Carmen
- Sisodiya, Sanjay
- Zara, Federico
- Russo, Emilio
- Striano, Pasquale
- Venue
- Expert Review of Neurotherapeutics
- Publisher
- Informa UK Limited
- Published
- 2019-07-11
- Volume
- 19
- Issue
- 10
- Pages
- 1037-1050
- ISSN
- 1473-7175 (ISSN-L)
- 1744-8360
- OpenAlex
- W2953681499
- Cited by
- 177
- References
- 182
- Citations by year
- 2026: 13 · 2025: 27 · 2024: 27 · 2023: 26 · 2022: 28 · 2021: 24 · 2020: 21 · 2019: 11
- FWCI
- 1.85
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- other-oa
- Locations
- Expert Review of Neurotherapeutics (publishedVersion)
- PubMed (publishedVersion)
- Virtual Community of Pathological Anatomy (University of Castilla La Mancha) (submittedVersion, other-oa)
- HAL (submittedVersion)
- Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano) (submittedVersion, other-oa)
- BORIS (University Library Bern) (submittedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Florence Research (University of Florence) (submittedVersion)
- Archivio Istituzionale della Ricerca - Università degli Studi della Campania "Luigi Vanvitelli" (submittedVersion)
- CINECA IRIS Institutial Research Information System (University of Genoa) (submittedVersion)
- Institutional Research Information System (Università degli Studi di Trento) (submittedVersion)
- Research Portal (King's College London) (submittedVersion)
- Funders
- Helmut Horten Fundation
- Novo Nordic Foundation (NNF17OC0027260)
- Ministry of Health, Tuscany Region (GR-2011-02348280)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- microbiota-gut-brain axis, gut microbiota, neuropsychiatric disorders, mental illness, gene-environment interaction, biomarkers, therapeutic target, dietary intervention, multi-omics, central nervous system disorders
- MeSH terms
- Gastrointestinal Microbiome, Mental Disorders, Central Nervous System Diseases, Humans
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